Exhibit 1

JOINT FILING AGREEMENT

The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned, and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the other, except to the extent that it knows or has reason to believe that such information is inaccurate.

November 23, 2021

NEWTYN MANAGEMENT, LLC

By: /s/ Eugene Dozortsev

Name: Eugene Dozortsev

Title: Authorized Signatory

NEWTYN PARTNERS, LP

By: Newtyn Management, LLC

Investment Manager

By: /s/ Eugene Dozortsev

Name: Eugene Dozortsev

Title: Authorized Signatory

Flexion Therapeutics Inc SC 13G