FORM 4
[ ] Check this box if no longer
subject to Section 16. Form 4 or Form
5 obligations may continue.
See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility
Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940

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Estimated average burden
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1. Name and Address of Reporting Person^*
PROULX, NORMAN R.

(Last) (First) (Middle)800 RESEARCH PARKWAY, SUITE 100

(Street)OKLAHOMA CITY, OK 73104

(City) (State) (Zip)USA

2. Issuer Name and Ticker
or Trading Symbol

ZYMETX, INC. ZMTX

3. I.R.S. Identification
    Number of Reporting
    Person, if an entity
    (voluntary)

4. Statement for
(Month/Year)

December 2001

5. If Amendment,
Date of Original
(Month/Year)

6. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer Other

Officer/Other
Description

7. Individual or Joint/Group
Filing (Check Applicable Line)

X Individual Filing
Joint/Group Filing

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	3. Transaction Code and Voluntary Code (Instr. 8) Code \| V	4. Securities Acquired (A) or Disposed (D) Of (Instr. 3, 4, and 5) Amount \| A/D \| Price	5. Amount of Securities Beneficially Owned at End of Month (Instr. 3 and 4)	6. Owner- ship Form: Direct(D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
COMMON STOCK, par value $.001	12/21/2001	G \|	1,400.00 \| D \| (1)	50,160.00	D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

(over)
SEC 1474 (3-99)

PROULX, NORMAN R. - December 2001

Form 4 (continued)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conver- sion or Exercise Price of Deri- vative Security	3. Transaction Date (Month/ Day/ Year)	4. Transaction Code and Voluntary (V) Code (Instr.8) Code \| V	5. Number of Derivative Securities Acquired (A) or Disposed (D) Of (Instr. 3,4 and 5)	6. Date Exercisable(DE) and Expiration Date(ED) (Month/Day/Year) (DE) \| (ED)	7. Title and Amount of Underlying Securities (Instr. 3 and 4)	8. Price of Derivative Security (Instr.5)	9. Number of Derivative Securities Beneficially Owned at End of Month (Instr.4)	10. Owner- ship Form of Deriv- ative Security: Direct (D) or Indirect (I)	11. Nature of Indirect Beneficial Ownership (Instr.4)
Non-Qualified Stock Options 2-00	$2.65				12/31/2000 \| 02/01/2010	COMMON STOCK, par value $.001 - 200,000.00		200,000.00	D
Non-Qualified Stock Options 9-99	$2.00				09/22/2000 \| 09/22/2009	COMMON STOCK, par value $.001 - 50,000.00		50,000.00	D

Explanation of Responses :

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations.
See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient,
See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not
required to respond unless the form displays a currently valid OMB number.

________________________________ 01-10-2002
** Signature of Reporting Person Date

/s/ Norman R. Proulx
NORMAN R. PROULX

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SEC 1474 (3-99)

PROULX, NORMAN R. - December 2001

Form 4 (continued)

FOOTNOTE Descriptions for ZYMETX, INC. ZMTX

Form 4 - December 2001

NORMAN R. PROULX
800 RESEARCH PARKWAY, SUITE 100

OKLAHOMA CITY, OK 73104
Explanation of responses:

(1) Mr. Proulx made gifts of 200 shares each to seven (7) individuals for no consideration.

Page 3

ZYMETX INC 4