Exhibit 1

Agreement of Joint Filing

Pursuant to 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned persons hereby agree to file with the Securities and Exchange Commission the Statement on Schedule 13D (the “Statement”) to which this Agreement is attached as an exhibit, and agree that such Statement, as so filed, is filed on behalf of each of them.

IN WITNESS WHEREOF, the undersigned have executed this Agreement.

Dated: October 24, 2011

QVT FINANCIAL LP

QVT FUND LP

By: QVT Financial GP LLC, its General Partner

By: QVT Associates GP LLC, its General Partner

By:

/s/ Daniel Gold

By:

/s/ Daniel Gold

Name:

Daniel Gold

Name:

Daniel Gold

Title:

Managing Member

Title:

Managing Member

By:

/s/ Meg Eisner

By:

/s/ Meg Eisner

Name:

Meg Eisner

Name:

Meg Eisner

Title:

Authorized Signatory

Title:

Authorized Signatory

QVT FINANCIAL GP LLC

QVT ASSOCIATES GP LLC

By:

/s/ Daniel Gold

By:

/s/ Daniel Gold

Name:

Daniel Gold

Name:

Daniel Gold

Title:

Managing Member

Title:

Managing Member

By:

/s/ Meg Eisner

By:

/s/ Meg Eisner

Name:

Meg Eisner

Name:

Meg Eisner

Title:

Authorized Signatory

Title:

Authorized Signatory

ANADYS PHARMACEUTICALS INC SC 13D/A