Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Commodore Applied Technologies, Inc., (the "Company") on Form 10-Q for the period ending September 30, 2008, as filed with the Securities and Exchange Commission on the date hereof (the "Report"), I, Shelby T. Brewer, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Commodore Applied Technologies, Inc.

/s/ Shelby T. Brewer

DATE: November 19, 2008

Dr. Shelby T. Brewer, Chief Executive Officer

A signed original of this written statement required by Section 906 has been provided to Commodore Applied Technologies Inc. and will be retained by Commodore Applied Technologies, Inc. to be furnished to the Securities and Exchange Commission or its staff upon request.

COMMODORE APPLIED TECHNOLOGIES INC 10-Q