EXHIBIT 1

AGREEMENT

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of stock of Trevi Therapeutics, Inc.

EXECUTED this 11^th day of August, 2025.

NEW ENTERPRISE ASSOCIATES 16, L.P.

By:

NEA PARTNERS 16, L.P.

General Partner

By:

NEA 16 GP, LLC

General Partner

By:                     *

Anthony A. Florence, Jr.

Managing Partner and Co-Chief Executive Officer

By:                     *

Mohamad Makhzoumi

Managing Partner and Co-Chief Executive Officer

NEA PARTNERS 16, L.P.

By:

NEA 16 GP, LLC
General Partner

  By:                     *

 Anthony A. Florence, Jr.

 Managing Partner and Co-Chief Executive Officer

  By:                     *

 Mohamad Makhzoumi

 Managing Partner and Co-Chief Executive Officer

NEA 16 GP, LLC

By:                     *

Anthony A. Florence, Jr.

Managing Partner and Co-Chief Executive Officer

By:                     *

Mohamad Makhzoumi

Managing Partner and Co-Chief Executive Officer

Forest Baskett

Ali Behbahani

Carmen Chang

Anthony A. Florence, Jr.

Mohamad H. Makhzoumi

Scott D. Sandell

Paul Walker

NEA 18 VENTURE GROWTH EQUITY, L.P.

By:

NEA PARTNERS 18 VGE, L.P.

General Partner

By:

NEA 18 VGE GP, LLC

General Partner

By:                     *

Anthony A. Florence, Jr.

Managing Partner and Co-Chief Executive Officer

By:                     *

Mohamad Makhzoumi

Managing Partner and Co-Chief Executive Officer

NEA PARTNERS 18 VGE, L.P.

By:

NEA 18 VGE GP, LLC
General Partner

  By:                     *

 Anthony A. Florence, Jr.

 Managing Partner and Co-Chief Executive Officer

  By:                     *

 Mohamad Makhzoumi

 Managing Partner and Co-Chief Executive Officer

NEA 18 VGE GP, LLC

By:                     *

Anthony A. Florence, Jr.

Managing Partner and Co-Chief Executive Officer

By:                     *

Mohamad Makhzoumi

Managing Partner and Co-Chief Executive Officer

Ali Behbahani

Carmen Chang

Anthony A. Florence, Jr.

Mohamad H. Makhzoumi

Edward T. Mathers

Scott D. Sandell

Paul Walker

Rick Yang

*/s/ Zachary Bambach

Zachary Bambach

As attorney-in-fact

This Agreement relating to Schedule 13D was executed by Zachary Bambach on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which is attached hereto as Exhibit 2.

Trevi Therapeutics, Inc. SCHEDULE 13D/A