Exhibit 32.1

CERTIFICATION PURSUANT TO

SECTION 1350, CHAPTER 63 OF TITLE 18, UNITED STATES CODE,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Pursuant to Section 1350, Chapter 63 of Title 18, United States Code, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, the undersigned, as chief executive officer of MacroChem Corporation (the “Company”), does hereby certify that to the undersigned’s knowledge:

1) the Company’s report on Form 10-Q for the period ended September 30, 2008 as filed with the Securities and Exchange Commission (the “ Form 10-Q “) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2) the information contained in the Company’s Form 10-Q fairly presents, in all material respects, the financial condition and results of operations of the Company.

	/s/ David P. Luci

	President & Chief Business Officer
	(Principal Executive and Financial Officer)

Dated: November 19, 2008

A signed original of this written statement required by Section 906 has been provided to MacroChem Corporation and will be retained by MacroChem Corporation and furnished to the Securities and Exchange Commission or its staff upon request.

MACROCHEM CORP 10-Q