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Note 5 - Income Taxes - Effective Income Tax Rate Reconciliation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
U.S. federal tax statutory rate	$ (13,796,353)	$ (18,029,558)	$ (25,428,097)
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent	34.00%	34.00%	34.00%
State taxes (net of federal benefit)	$ (801,406)	$ (1,034,566)	$ (1,936,719)
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent	2.00%	2.00%	2.60%
U.S. federal research and development tax credits	$ (1,038,768)	$ (1,368,171)	$ (2,135,940)
U.S. federal research and development tax credits, percentage	2.60%	2.60%	2.90%
Other nondeductible expenses	$ 1,973,462	$ 760,287	$ 1,032,480
Other nondeductible expenses, percentage	(4.90%)	(1.50%)	(1.40%)
Increase in unrecognized tax benefits	$ 311,630	$ 410,451	$ 640,782
Increase in unrecognized tax benefits, percentage	(0.80%)	(0.80%)	(0.90%)
Change in effective state tax rate	$ 12,871	$ 1,655,991	$ 1,190,519
Change in effective state tax rate, percentage	0.00%	(3.10%)	(1.60%)
Expiration of NOL & contribution carryforwards	$ 136,325		$ 9,590,101
Expiration of NOL & contribution carryforwards, percentage	(0.30%)	0.00%	(12.80%)
Adjustment for change in federal effective tax rate	$ 41,255,460
Adjustment for change in federal effective tax rate, percentage	(101.70%)	0.00%	0.00%
Change in fair value of warrant liability	$ (7,467,843)
Change in fair value of warrant liability, percentage	18.40%	0.00%	0.00%
Change in valuation allowance	$ (18,700,100)	$ 17,691,710	$ 16,705,784
Change in valuation allowance, percentage	46.10%	(33.40%)	(22.30%)
Deferred tax asset true-ups	$ (1,885,278)	$ (86,144)	$ 341,090
Deferred tax asset true-ups, percentage	4.60%	0.20%	(0.50%)
Provision for income taxes	$ 0	$ 0	$ 0
Provision for income taxes, percentage	0.00%	0.00%	0.00%

Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations, attributable to increase (decrease) in the effective state income tax rates.

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