POWER OF ATTORNEY
The undersigned, as a Section 16 reporting person of Pacific
Biosciences of California, Inc. (the "Company"), hereby constitutes
and appoints Susan K. Barnes, Brian Dow and Matthew Murphy,
and each of them, the undersigned's true and lawful attorney-in-fact to:
1. complete and execute Forms 3, 4, and 5 and other forms
and all amendments thereto as such attorney-in-fact shall in his
or her discretion determine to be required or advisable
pursuant to Section 16 of the Securities Exchange Act
of 1934 (as amended) and the rules and regulations
promulgated thereunder, or any successor laws and regulations,
as a consequence of the undersigned's ownership, acquisition
or disposition of securities of the Company; and
2. do all acts necessary in order to file such forms with the Securities
and Exchange Commission, any securities exchange or national association,
the Company and such other person or agency as the attorney-in-fact shall
deem appropriate.
   The undersigned also hereby constitutes and appoints the
responsible attorneys and paralegals of Wilson Sonsini Goodrich & Rosati
P.C., and each of them, the undersigned's true and lawful attorney-in-fact
and agent to complete, execute and file a Form ID Application
Acknowledgement on EDGAR or such other forms as prescribed by the
U.S. Securities and Exchange Commission in order for the undersigned
to apply for and obtain EDGAR filing codes.
   The undersigned hereby ratifies and confirms all that said
attorneys-in-fact and agents shall do or cause to be done by virtue hereof.
The undersigned acknowledges that the foregoing attorneys-in-fact, in
serving in such capacity at the request of the undersigned, are not
assuming, nor is the Company assuming, any of the undersigned's
responsibilities to comply with Section 16 of the Securities Exchange
Act of 1934 (as amended).
   This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file Forms ID, 3, 4, and 5
with respect to the undersigned's holdings of and transactions in securities
issued by the Company, unless earlier revoked by the undersigned in a
signed writing delivered to the Company and the foregoing attorneys-in-fact.
   IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of this 21 day of September, 2010.

Signature: /s/ Brook Byers
Name: Brook Byers

BYERS BROOK H 3