EXHIBIT 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SS.1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of IR BioSciences Holdings, Inc. (the "Company") on Form 10-Q for the periods ended September 30, 2010 as filed with the Securities and Exchange Commission on the date hereof (the "Report"), I, Michael K. Wilhelm, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2. The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.


	IR BIOSCIENCES HOLDINGS, INC.

Date: November 22, 2010	By:	/s/ Michael K. Wilhelm
		President and Chief Executive Officer

A signed original of this written statement required by Section 906, another document authenticating, acknowledging, or otherwise adopting the signature that appears in typed form within the electronic version of this written statement required by Section 906, has been provided to Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

IR BIOSCIENCES HOLDINGS INC 10-Q