United States

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 4)*

ESPERION THERAPEUTICS, INC.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

29664W105

(CUSIP Number)

December 31, 2018

(Date of Event Which Requires Filing This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed “ for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 29664W105

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CUSIP No. 29664W105

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Item 2

2(a) Name of Person Filing: BB Biotech AG (“BB Biotech”) on behalf of its wholly-owned subsidiary, Biotech Target N.V. (“Biotech Target”)

2(b) Address of Principal Business Office or, if none, Residence:

BB Biotech AG: Schwertstrasse 6, CH-8200 Schaffhausen, Switzerland

Biotech Target N.V.: Ara Hill Top Building, Unit A-5, Pletterijweg Oost 1, Curaçao

2(c) Citizenship: BB Biotech AG: Switzerland

Biotech Target N.V.: Curaçao

2(d) Title of Class of Securities Common Stock, $0.001 par value

2(e) CUSIP Number 29664W105

Item 4. Ownership

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a)

Amount beneficially owned: 3,392,964

(b)

Percent of class: 12.7%

(c)

Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote 0

(ii)

Shared power to vote or to direct the vote 3,392,964

(iii)

Sole power to dispose or to direct the disposition of 0

(iv)

Shared power to dispose or to direct the disposition of 3,392,964

Item 10. Certification

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

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SIGNATURES

After reasonable inquiry and the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

BB Biotech AG



Date:	February 11, 2019	By:	/s/ Michael Hutter
			Signatory Authority

		Name:	Michael Hutter

		Title:	Signatory Authority



Date:	February 11, 2019	By:	/s/ Ivo Betschart
			Signatory Authority

		Name:	Ivo Betschart

		Title:	Signatory Authority

Biotech Target N.V.



Date:	February 11, 2019	By:	/s/ Michael Hutter
			Signatory Authority

		Name:	Michael Hutter

		Title:	Signatory Authority



Date:	February 11, 2019	By:	/s/ Ivo Betschart
			Signatory Authority

		Name:	Ivo Betschart

		Title:	Signatory Authority

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Exhibit Index

Exhibit A: Agreement by and between BB Biotech AG and Biotech Target N.V. with respect to the filing of this disclosure statement.*

*	Previously filed as an exhibit to BB Biotech AG and Biotech Target N.V.’s Schedule 13G filed with the Securities and Exchange Commission on September 27, 2016.

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Names of Reporting Persons

BB Biotech AG

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) ☒ (b) ☐

SEC Use Only

Citizenship or Place of Organization

Switzerland

ESPERION THERAPEUTICS INC/MI SC 13G/A