UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No. 2)*

ESPERION THERAPEUTICS, INC.

(Name of Issuer)

Common Stock, par value $0.001 per share

(Title of Class of Securities)

29664W105

(CUSIP Number)

December 31, 2018

(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 29664W105

*	This number includes 100,000 shares of Common Stock that Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019.

Based on 26,911,002 shares of common stock outstanding which is the sum of (i) 26,811,002 shares of common stock reported to be outstanding as of October 31, 2018 on the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 1, 2018 and (ii) 100,000 shares of Common Stock which Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019.

CUSIP No. 29664W105

*	This number includes 100,000 shares of Common Stock that Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019.

CUSIP No. 29664W105

CUSIP No. 29664W105

CUSIP No. 29664W105

*	This number includes 100,000 shares of Common Stock that Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019.

This Amendment No. 2 (“Amendment No. 2”) amends and supplements the statement on Schedule 13G initially filed on March 23, 2017 (the “Original Filing”) by Boxer Capital, LLC (“Boxer Capital”), Boxer Asset Management Inc. (“Boxer Management”), Braslyn Ltd. (“Braslyn”), MVA Investors, LLC and Joe Lewis, as amended by Amendment No. 1 filed on February 14, 2018. This Amendment No. 2 is an original filing for Tuesday Thirteen, Inc. (“Tuesday Thirteen”). Boxer Capital, Boxer Management, Braslyn, Avid, Joe Lewis and Tuesday Thirteen are referred to herein as the “Reporting Persons”). The Original Filing remains in effect except to the extent that it is amended, restated or superseded by information contained in this Amendment No. 2. Capitalized terms used and not defined in this Amendment No. 2 have the meanings set forth in the Original Filing.

Item 1(a). Name of Issuer:

Esperion Therapeutics, Inc. (the “Issuer”)

Item 1(b). Address of Issuer’s Principal Executive Offices:

3891 Ranchero Drive, Suite 150

Ann Arbor, MI 48108

Item 2(a). Name of Person Filing:

This Schedule 13G is jointly filed by the Reporting Persons. Boxer Management is the managing member and majority owner of Boxer Capital. Joe Lewis is the sole indirect beneficial owner of and controls Boxer Management, Braslyn and Tuesday Thirteen.

Item 2(b). Address of Principal Business Office, or, if none, Residence:

The principal business address of Boxer Capital is: 11682 El Camino Real, Suite 320, San Diego, CA 92130. The principal business address of Boxer Management, Braslyn, Tuesday Thirteen and Joe Lewis is: Cay House, EP Taylor Drive N7776, Lyford Cay, New Providence, Bahamas.

Item 2(c). Citizenship:

Boxer Capital is a limited liability company organized under the laws of Delaware. Boxer Management, Braslyn and Tuesday Thirteen are corporations organized under the laws of the Bahamas. Joe Lewis is a citizen of the United Kingdom.

Item 2(d). Title of Class of Securities:

Common Stock, par value $0.001 per share (the “Common Stock”).

Item 2(e). CUSIP Number:

29664W105

Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:

Not applicable.

Item 4. Ownership.

(a)

Amount beneficially owned:

Boxer Capital and Boxer Management beneficially own 1,300,000 shares of Common Stock, including 100,000 shares of Common Stock that Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019. Pursuant to the call options, 50,000 shares of Common Stock may be acquired at a strike price of $50.00 per share and 50,000 shares of Common Stock may be acquired at a strike price of $60.00 per share. Braslyn beneficially owns 464,549 shares of Common Stock. Tuesday Thirteen beneficially owns 100 shares of Common Stock. Joe Lewis beneficially owns 1,764,649 shares of Common stock. The Reporting Persons may be deemed to beneficially own 1,764,649 shares of Common Stock in the aggregate.

(b)

Percent of class:

The shares of Common Stock beneficially owned by Boxer Capital and Boxer Management represent 4.8%* of the Issuer’s outstanding shares of Common Stock. The shares of Common Stock beneficially owned by Braslyn represents 1.7%* of the Issuer’s outstanding shares of Common Stock. The shares of Common Stock beneficially owned by Tuesday Thirteen represent 0.0%* of the outstanding shares of Common Stock. The shares of Common Stock beneficially owned by Joe Lewis represent 6.6%* of the Issuer’s outstanding shares of Common Stock. The shares of Common Stock that may be deemed to be beneficially owned by the Reporting Persons in the aggregate represent 6.6%* of the Issuer’s outstanding shares of Common Stock.

(c)

Number of shares as to which such person has:

(i)

Sole power to vote or to direct the vote:

None of the Reporting Persons has the sole power to vote or to direct the vote of any shares of Common Stock.

(ii)

Shared power to vote or to direct the vote:

Boxer Capital and Boxer Management have shared power to vote or to direct the vote of the 1,300,000 shares of Common Stock they beneficially own, including 100,000 shares of Common Stock that Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019. Pursuant to the call options, 50,000 shares of Common Stock may be acquired at a strike price of $50.00 per share and 50,000 shares of Common Stock may be acquired at a strike price of $60.00 per share. Braslyn has shared power to vote or to direct the vote of the 464,549 shares of Common Stock it beneficially owns. Tuesday Thirteen has shared power to vote or to direct the vote of the 100 shares of Common Stock it beneficially owns. Joe Lewis has shared power to vote or to direct the vote of the 1,764,649 shares of Common Stock he beneficially owns.

(iii)

Sole power to dispose or to direct the disposition of:

None of the Reporting Persons has the sole power to dispose or to direct the disposition of any shares of Common Stock.

(iv)

Shared power to dispose or to direct the disposition of:

Boxer Capital and Boxer Management have shared power to dispose or to direct the disposition of the 1,300,000 shares of Common Stock they beneficially own, including 100,000 shares of Common Stock that Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019. Pursuant to the call options, 50,000 shares of Common Stock may be acquired at a strike price of $50.00 per share and 50,000 shares of Common Stock may be acquired at a strike price of $60.00 per share. Braslyn has shared power to dispose or to direct the disposition of the 464,549 shares of Common Stock it beneficially owns. Tuesday Thirteen has shared power to dispose or to direct the disposition of the 100 shares of Common Stock it beneficially owns. Joe Lewis has shared power to dispose or to direct the disposition of the 1,764,649 shares of Common Stock he beneficially owns.

* All percentages are based on 26,911,002 shares of common stock outstanding which is the sum of (i) 26,811,002 shares of common stock reported to be outstanding as of October 31, 2018 on the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission on November 1, 2018 and (ii) 100,000 shares of Common Stock which Boxer Capital has the right to acquire pursuant to call options expiring on March 15, 2019.

Item 10. Certification.

(c) By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Exhibits

Joint Filing Agreement among the Reporting Persons dated February 14, 2019.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

February 14, 2019


BOXER CAPITAL, LLC

By:		/s/ Aaron I. Davis
Name:		Aaron I. Davis
Title:		Authorized Signatory

BOXER ASSET MANAGEMENT INC.

By:		/s/ Jason Callender
Name:		Jason Callender
Title:		Director

BRASLYN LTD.

By:		/s/ Joseph C. Lewis
Name:		Joseph C. Lewis
Title:		Director

TUESDAY THIRTEEN INC.

By:		/s/ Joseph C. Lewis
Name:		Joseph C. Lewis
Title:		Director

JOSEPH C. LEWIS

/s/ Joseph C. Lewis
Joseph C. Lewis, Individually

Name of reporting persons.

Boxer Capital, LLC

Check the appropriate box if a member of a group. (See instructions)

(a) ☐ (b) ☒

SEC use only.

Citizenship or place of organization.

Delaware

ESPERION THERAPEUTICS INC/MI SC 13G/A