UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

NUVEEN MUNICIPAL HIGH INCOME OPPORTUNITY FUND

(Name of Issuer)

ADJUSTABLE RATE MUNIFUND TERM PREFERRED SHARES

(Title of Class of Securities)

670682 871, 670682 111

(CUSIP Number)

Deutsche Bank AG\

Taunusanlage 12

Frankfurt Am Main D-60325, Germany

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

June 9, 2022

(Date of Event Which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box ☐.

*	The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D

CUSIP No. 670682 871, 670682 111


1.		Names of Reporting Persons Deutsche Bank AG 13-2944988
2.		Check the Appropriate Box if a member of a Group (see instructions) a. ☐ b. ☒
3.		SEC Use Only
4.		Source of Funds (See Instructions): WC
5.		Check Box if Disclosure of Legal Proceedings Is Required pursuant to Items 2(d) or 2(e). ☒
6.		Citizenship or Place of Organization Delaware

SCHEDULE 13D

CUSIP No. 670682 871, 670682 111


1.		Names of Reporting Persons DB Municipal Holdings LLC 82-2633289
2.		Check the Appropriate Box if a member of a Group (see instructions) a. ☐ b. ☒
3.		SEC Use Only
4.		Source of Funds (See Instructions): WC
5.		Check Box if Disclosure of Legal Proceedings Is Required pursuant to Items 2(d) or 2(e). ☐
6.		Citizenship or Place of Organization Delaware

Item 1

Security and Issuer

This Amendment No. 1 (this “Amendment”) amends, as set forth below, the statement on Schedule 13D, dated April 19, 2021 and filed with the SEC on April 28, 2021 (the “Original Schedule 13D”), for Deutsche Bank AG (“DB AG”) and DB Municipal Holdings LLC (“DBMH”) (collectively, the “Reporting Persons”) with respect to the adjustable rate munifund term preferred shares (“AMTP Shares”) of Nuveen Municipal High Income Opportunity Fund (the “Issuer”).

This Amendment is being filed as a result of the purchase of AMTP Shares described as the Adjustable Rate MuniFund Term Preferred Shares, Series 2032 (the “2032 AMTP Shares”) of the Issuer (CUSIP No. 670682111) in the amount of 1,000 shares purchased by DBMH. In addition to the 2032 AMTP Shares, DBMH holds 1,700 AMTP Shares, Series 2031 (CUSIP No. 670682871).

Item 2

Identity and Background

Item 2 of the Original Schedule 13D is hereby amended by:

deleting Schedule I and Schedule II referenced therein and replacing them with Schedule I and Schedule II included with this Amendment; and

the address of the principal business office of DBMH is amended and restated as follows: DB Municipal Holdings LLC, 1 Columbus Circle, New York, NY 10019

Item 3

Source and Amount of Funds or Other Consideration

Item 3 of the Original Schedule 13D is hereby amended by adding the following paragraph at the end thereof:

“The Reporting Persons purchased 1,000 Adjustable Rate MuniFund Term Preferred Shares, Series 2032 (CUSIP No. 670682111) from the Issuer (the “Purchase”).

The aggregate amount of funds used by the Reporting Persons for the Purchase was approximately $100,000,000. The source of funds was the working capital of the Reporting Persons.”

Item 4

Purpose of the Transaction

Item 4 of the Original Schedule 13D is hereby amended by adding the following paragraph at the end thereof:

“DBMH made the Purchase for investment purposes. DBMH acquired the 2032 AMTP Shares (CUSIP No. 670682111) pursuant to a AMTP Purchase Agreement, dated June 9, 2022, between the Issuer and DBMH (the “Purchase Agreement”) on their initial issuance for a purchase price of $100,000,000.

The Reporting Persons have not acquired the subject securities with any purpose, or with the effect of, changing or influencing control of the Issuer, or in connection with or as a participant in any transaction having that purpose or effect.”

Item 6

Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer

Item 6 of the Original Schedule 13D is hereby amended by adding the following at the end of the first paragraph thereof:

“The voting and consent rights on of the 1,000 2032 AMTP Shares acquired in the Purchase by DBMH will be treated in the same manner as previously described in this Item 6.”

Item 7

Material to be Filed as Exhibits

Item 7 of the Original Schedule 13D is hereby amended by deleting Exhibit 99.1 thereto and the insertion of the following exhibits:


Exhibit		Description of Exhibit

99.1		Joint Filing Agreement

99.4		AMTP Shares Purchase Agreement, dated June 9, 2022

SIGNATURES

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: June 13, 2022


DEUTSCHE BANK AG

By:		/s/ David Ramos
Name: David Ramos
Title: Assistant Vice President

By:		/s/ Michael Caro
Name: Michael Caro
Title: Vice President

DB MUNICIPAL HOLDINGS LLC

By:		/s/ Svetlana Segal
Name: Svetlana Segal
Title: Managing Director

By:		/s/ John Werba
Name: John Werba
Title: Director

LIST OF EXHIBITS


Exhibit		Description of Exhibit

99.1		Joint Filing Agreement

99.4		AMTP Shares Purchase Agreement, dated June 9, 2022

SCHEDULE I

EXECUTIVE OFFICERS AND DIRECTORS OF

REPORTING PERSONS

The following sets forth the name and present principal occupation of each executive officer and board member of Deutsche Bank AG. The business address of each of the executive officers and directors of Deutsche Bank AG is Taunusanlage 12 Frankfurt Am Main D-60325, Germany.


Name	Position with Deutsche Bank AG	Principal Occupation/Citizenship
Christian Sewing	Chief Executive Officer	Chief Executive Officer, Management Board Member and responsible for Corporate Bank and Investment Bank German

Karl von Rohr	President	President, Management Board Member, responsible for Private Bank and Asset Management, responsible for Germany and Europe, Middle East and Africa German

Fabrizio Campelli	Head of Corporate Bank and Investment Bank	Head of Corporate Bank and Investment Bank, Management Board Member and responsible for Human Resources United Kingdom, Italian

Bernd Leukert	Chief Technology, Data and Innovation Officer	Chief Technology, Data and Innovation Office, Management Board Member and responsible for Technology, Data and Innovation German

Olivier Vigneron	Chief Risk Officer	Chief Risk Officer, Management Board Member France

James von Moltke	President and Chief Financial Officer	Chief Financial Officer, Management Board Member Australian, German

Alexander von zur Mühlen	Chief Executive Officer Asia Pacific	Chief Executive Officer for the Asia Pacific region and Management Board Member German

Rebecca Short	Chief Transformation Officer	Chief Transformation Officer, Management Board Member United Kingdom, New Zealand

Stefan Simon	Chief Administrative Officer	Chief Administrative Officer, Management Board Member and responsible for Government and Regulatory Affairs and Legal and Governance. German


Alexander Wynaendts	Chairman of the Supervisory Board	Chairman of the Supervisory Board of Deutsche Bank AG Dutch

Detlef Polaschek	Deputy Chairman of the Supervisory Board	Deputy Chairman of the Supervisory Board of Deutsche Bank AG and Member of the General Staff Council of Deutsche Bank German

Ludwig Blomeyer-Bartenstein	Spokesperson of the Management	Spokesperson of the Management and Head of the Market Region Bremen of Deutsche Bank AG German

Mayree Clark	Supervisory Board Member	Founder and Managing Partner of Eachwin Capital American

Jan Duscheck	Supervisory Board Member	Head of national working group Banking, trade union ver.di German

Manja Eifert	Supervisory Board Member	Chairperson of the Staff Council, Deutsche Bank AG, Berlin German

Sigmar Gabriel	Supervisory Board Member	Former German Federal Government Minister German

Timo Heider	Supervisory Board Member	Chairman of the General Staff Council of BHW Bausparkasse AG/Postbank Finanzberatung AG, Chairman of the General Staff Council of PCC Services GmbH der Deutschen Bank, Chairman of the Staff Council of BHW Bausparkasse AG, PCC Services GmbH der Deutschen Bank, Postbank Finanzberatung AG and BHW Holding GmbH, and Deputy Chairman of the Group Staff Council of Deutsche Bank AG German

Martina Klee	Supervisory Board Member	Deputy Chairperson of the Staff Council PWCC Center Frankfurt of Deutsche Bank German

Gabriele Platscher	Supervisory Board Member	Chairperson of the Staff Council Niedersachsen Ost of Deutsche Bank German


Bernd Rose	Supervisory Board Member	Chairman of the General Staff Council of Postbank Filialvertrieb AG, Member of the Group Staff Council of Deutsche Bank, Member of the European Staff Council of Deutsche Bank German

Yngve Slyngstad	Supervisory Board Member	Chief Executive Officer, Aker Asset Management AS

John Alexander Thain	Supervisory Board Member	Former Chairman and Chief Executive Officer, CIT Group Inc. American

Michele Trogni	Supervisory Board Member	Operating Partner of Eldridge Industries LLC United Kingdom

Dr. Dagmar Valcárcel	Supervisory Board Member	Supervisory Board Member, Former Chair of the Management Board, Andbank Asset Management Luxembourg S.A., Luxembourg German, Spanish

Stefan Viertel	Supervisory Board Member	Head of Institutional Cash Sales & Client Management (& ACO) Hungary, Deutsche Bank AG, Member of the General Staff Council, Staff Council Representative of the Corporate Bank and Investment Bank, Deutsche Bank AG German

Dr. Theodor Weimer	Supervisory Board Member	CEO, Deutsche Börse AG German

Frank Werneke	Supervisory Board Member	Chairman of the trade union ver.di, Berlin German

Prof. Dr. Norbert Winkeljohann	Supervisory Board Member	Self-employed corporate consultant, Norbert Winkeljohann Advisory & Investments German

Frank Witter	Supervisory Board Member	Supervisory Board Member German

The following sets forth the name and present principal occupation of each executive officer and director of Deutsche Bank Securities Inc. (“DBSI”), DBSI being the majority member of DBMH. The business address of each of the executive officers and directors of DBSI is 60 Wall Street New York, NY 10005 United States.


Name	Position with Deutsche Bank Securities Inc.	Principal Occupation/Citizenship

James Davies	Chief Executive Officer, President, Director	Chief Executive Officer, President and Member of Board of Directors of Deutsche Bank Securities Inc. United Kingdom, Australian

Anthony Stucchio	Chief Operations Officer, Director	Chief Operations Officer and Member of Board of Directors of Deutsche Bank Securities Inc. American

Tiberio Massaro	Chief Financial Officer, Director	Chief Financial Officer and Member of Board of Directors of Deutsche Bank Securities Inc. American

Wade Bicknell	Chief Security Officer, Chief Information Security Officer	Chief Security Officer, Chief Information Security Officer of Deutsche Bank Securities Inc. American

Peter Berardi	Chief Credit Officer	Chief Credit Officer of Deutsche Bank Securities Inc. American

Charles Green, Jr.	Chief Market Risk Officer, Chief Risk Officer, Director	Chief Market Risk Officer, Chief Risk Officer, and Member of Board of Directors of Deutsche Bank Securities Inc. American

James Mellstrom	Chief Administrative Officer	Chief Administrative Officer and Director of Deutsche Bank Securities Inc. American

Jonathan Banks	Chief Compliance Officer	Chief Compliance Officer and Managing Director of Deutsche Bank Securities Inc. American


Jason Monteiro	Chief Compliance Officer - Registered Investment Adviser	Chief Compliance Officer - Registered Investment Adviser of Deutsche Bank Securities Inc. American

Michael Koplowitz	Chief Compliance Officer - Futures Commission Merchant	Chief Compliance Officer - Futures Commission Merchant of Deutsche Bank Securities Inc. American

Robert Barisciano	Assistant Secretary, Vice President	Assistant Secretary, Vice President of Deutsche Bank Securities Inc. American

Kristian Beyer	Deputy Chief Market Risk Officer, Director	Deputy Chief Market Risk Officer, Director of Deutsche Bank Securities Inc. American

Patricia Carroll	Company Secretary, Vice President	Company Secretary, Vice President of Deutsche Bank Securities Inc. American

Taylor Chapman-Kennedy	Assistant Secretary, Vice President	Assistant Secretary, Vice President of Deutsche Bank Securities Inc. American

Yaelle Cregut Layani	Anti-Money Laundering Officer, Director	Anti-Money Laundering Officer, Director of Deutsche Bank Securities Inc. American

Joseph Silverberg	Treasurer	Managing Director of Deutsche Bank Securities Inc. American

Jason Rogers	Director	Managing Director of Deutsche Bank Securities Inc. American

SCHEDULE II

LITIGATION SCHEDULE

Deutsche Bank AG and Deutsche Bank Securities, Inc. (the majority Member of DB Municipal Holdings LLC) have been involved in a number of proceedings which concern matters arising in connection with the conduct of its business. Certain of such proceedings have resulted in findings of violations of federal or state securities laws. Such proceedings are reported and summarized in (i) the Deutsche Bank Securities, Inc. Form BD, (ii) Deutsche Bank AG’s annual reports on Form 20-F and periodic reports on Form 6-K filed with the SEC, and (iii) in other regulatory reports, which descriptions are hereby incorporated by reference.

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

Sole Voting Power:

0

Shared Voting Power:

2,700

Sole Dispositive Power:

0

Shared Dispositive Power:

2,700

NUVEEN MUNICIPAL HIGH INCOME OPPORTUNITY FUND SC 13D/A