v3.25.4

Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($)
$ in Thousands

12 Months Ended

Dec. 31, 2025

Dec. 31, 2024

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Amounts computed at statutory federal rate

$ 29,308

$ 54,196

$ (10,718)

Stock-based compensation and other permanent differences

9,986

7,865

Branded pharmaceutical drug fee

2,122

1,848

Write-off of IP R&D

1,260

Other permanent differences

1,008

593

R&D credits

(10,600)

(18,406)

(5,827)

Change in valuation allowance

(247,298)

(27,013)

1,100

State taxes

(24,819)

^[1]

3,050

(977)

Contingencies

5,960

(2,071)

Foreign rate differential

(13,715)

(5,076)

Deferred adjustments for limits on executive compensation

2,375

2,112

Deferred rate adjustment

(528)

(438)

Expiration of attributes

3,264

17,225

GILTI

1,904

8,215

7,665

Other

154

(150)

(3,051)

Income tax expense

$ (252,096)

$ 31,624

$ 10,250

[1]	During the year ended December 31, 2025, state taxes in Tennessee and Kentucky comprised greater than 50% of the tax effect in this category.

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