Securities and Exchange Commission

Washington, DC 20549

SCHEDULE 13G/A

Under the Securities Exchange Act of 1934

(Amendment No. 2)*

TCR2 Therapeutics Inc.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

87808K106

(CUSIP Number)

May 3, 2023

(Date of Event Which Requires Filing of This Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐

Rule 13d-1(b)

Rule 13d-1(c)

☐

Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

Page 1 of 8

CUSIP No. 87808K106

13G/A

Page 2 of 8 Pages

1	NameS of Reporting Persons I.R.S. Identification NOS. of Above Persons (ENTITIES ONLY) TANG CAPITAL PARTNERS, LP
2	Check the Appropriate Box if a Member of a Group*	(a) ¨ (b) ý
3	SEC Use Only
4	Citizenship or Place of Organization DELAWARE

Number of

BENEFICIALLY
Owned by

Each Reporting
Person with

Sole Voting Power

Shared Voting Power

4,215,864

Sole Dispositive Power

Shared Dispositive Power

4,215,864

9	Aggregate Amount Beneficially Owned by each Reporting Person 4,215,864
10	Check Box if the Aggregate Amount in Row (9) excludes certain shares ¨
11	Percent of Class represented by amount in row 9 10.7%
12	type of reporting person pN

Page 2 of 8

CUSIP No. 87808K106

13G/A

Page 3 of 8 Pages

1	NameS of Reporting Persons I.R.S. Identification NOS. of Above Persons (ENTITIES ONLY) TANG CAPITAL MANAGEMENT, LLC
2	Check the Appropriate Box if a Member of a Group*	(a) ¨ (b) ý
3	SEC Use Only
4	Citizenship or Place of Organization DELAWARE

Number of

BENEFICIALLY
Owned by

Each Reporting
Person with

Sole Voting Power

Shared Voting Power

4,215,864

Sole Dispositive Power

Shared Dispositive Power

4,215,864

9	Aggregate Amount Beneficially Owned by each Reporting Person 4,215,864
10	Check Box if the Aggregate Amount in Row (9) excludes certain shares ¨
11	Percent of Class represented by amount in row 9 10.7%
12	type of reporting person oo

Page 3 of 8

CUSIP No. 87808K106

13G/A

Page 4 of 8 Pages

1	NameS of Reporting Persons I.R.S. Identification NOS. of Above Persons (ENTITIES ONLY) KEVIN TANG
2	Check the Appropriate Box if a Member of a Group*	(a) ¨ (b) ý
3	SEC Use Only
4	Citizenship or Place of Organization UNITED STATES

Number of

BENEFICIALLY
Owned by

Each Reporting
Person with

Sole Voting Power

Shared Voting Power

4,215,864

Sole Dispositive Power

Shared Dispositive Power

4,215,864

9	Aggregate Amount Beneficially Owned by each Reporting Person 4,215,864
10	Check Box if the Aggregate Amount in Row (9) excludes certain shares ¨
11	Percent of Class represented by amount in row 9 10.7%
12	type of reporting person IN

Page 4 of 8

Item 1(a).

Name of Issuer:

TCR2 Therapeutics Inc., a Delaware corporation (the “Issuer”)

Item 1(b).

Address of Issuer’s Principal Executive Offices:

100 Binney Street, Suite 710, Cambridge, MA 02142

Item 2(a).

Name of Person Filing:

This Statement on Schedule 13G (this “Statement”) is filed by Tang Capital Partners, LP (“Tang Capital Partners”); Tang Capital Management, LLC, the general partner of Tang Capital Partners (“Tang Capital Management”); and Kevin Tang, the manager of Tang Capital Management.

Item 2(b).

Address of Principal Business Office or, if none, Residence:

4747 Executive Drive, Suite 210, San Diego, CA 92121

Item 2(c).

Citizenship:

Tang Capital Partners is a Delaware limited partnership. Tang Capital Management is a Delaware limited liability company. Mr. Tang is a United States citizen.

Item 2(d).

Title of Class of Securities:

Common Stock, par value $0.0001 per share (the “Common Stock”)

Item 2(e).

CUSIP Number: 87808K106

Item 3.

Not applicable.

Item 4.

Ownership.

(a)

Amount Beneficially Owned:

Tang Capital Partners. Tang Capital Partners beneficially owns 4,215,864 shares of the Issuer’s Common Stock.

Tang Capital Partners shares voting and dispositive power over such shares with Tang Capital Management and Kevin Tang.

Tang Capital Management. Tang Capital Management beneficially owns 4,215,864 shares of the Issuer’s Common Stock.

Tang Capital Management shares voting and dispositive power over such shares with Tang Capital Partners and Kevin Tang.

Kevin Tang. Kevin Tang beneficially owns 4,215,864 shares of the Issuer’s Common Stock.

Kevin Tang shares voting and dispositive power over such shares with Tang Capital Partners and Tang Capital Management.

Page 5 of 8

The percentages used herein are based on 39,261,745 shares of Common Stock outstanding as of April 17, 2023, as set forth in the Issuer’s Proxy Statement filed on Schedule 14A that was filed with the Securities and Exchange Commission on April 20, 2023.

(b)

Percent of Class:

Tang Capital Partners	10.7%
Tang Capital Management	10.7%
Kevin Tang	10.7%

(c)

Number of shares as to which such person has:

(i)

sole power to vote or to direct the vote:

Tang Capital Partners	0 shares
Tang Capital Management	0 shares
Kevin Tang	0 shares

(ii)

shared power to vote or to direct the vote:

Tang Capital Partners	4,215,864 shares
Tang Capital Management	4,215,864 shares
Kevin Tang	4,215,864 shares

(iii)

sole power to dispose or to direct the disposition of:

Tang Capital Partners	0 shares
Tang Capital Management	0 shares
Kevin Tang	0 shares

(iv)

shared power to dispose or to direct the disposition of:

Tang Capital Partners	4,215,864 shares
Tang Capital Management	4,215,864 shares
Kevin Tang	4,215,864 shares

Item 5.

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: o

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

Not applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company.

Not applicable.

Item 8.

Identification and Classification of Members of the Group.

Not applicable.

Item 9.

Notice of Dissolution of Group.

Not applicable.

Page 6 of 8

Item 10.

Certification.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

Page 7 of 8

Signature

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date:	May 5, 2023


TANG CAPITAL PARTNERS, LP

By:	Tang Capital Management, LLC, its General Partner


By:	/s/ Kevin Tang
	Kevin Tang, Manager


TANG CAPITAL MANAGEMENT, LLC


By:	/s/ Kevin Tang
	Kevin Tang, Manager


/s/ Kevin Tang
Kevin Tang

Page 8 of 8

TCR2 THERAPEUTICS INC. SC 13G/A