v3.25.0.1

Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
Income Taxes - Narrative (Details) - USD ($)	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating Loss Carryforwards [Line Items]
Valuation allowance	$ 153,256,000	$ 140,236,000
Valuation allowance increased amount	13,000,000	8,100,000
Net operating loss carryovers	95,884,000	92,609,000
Unrecognized tax benefits	7,043,000	6,250,000	$ 5,785,000
Unrecognized tax benefits that would impact effective tax rate	6,200,000
Income tax penalties and interest accrued	0	$ 0
Internal Revenue Service (IRS)
Operating Loss Carryforwards [Line Items]
Net operating loss carryovers	405,200,000
Internal Revenue Service (IRS) \| Research Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Research and development tax credits carryforward	13,300,000
Internal Revenue Service (IRS) \| Orphan Drug Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Research and development tax credits carryforward	28,500,000
California
Operating Loss Carryforwards [Line Items]
Net operating loss carryovers	146,300,000
California \| Research Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Research and development tax credits carryforward	11,300,000
After 2017, No Expiration \| Internal Revenue Service (IRS)
Operating Loss Carryforwards [Line Items]
Net operating loss carryovers	$ 141,800,000

Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.

+ References

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-Section 50
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Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.

+ References

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Amount of unrecognized tax benefits.

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The total amount of unrecognized tax benefits that, if recognized, would affect the effective tax rate.

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Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.

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Regulus Therapeutics Inc. 10-K