HERMAN JOAN E 4

4 · IONIS PHARMACEUTICALS INC · Filed Nov 20, 2025

Form 4

Period: 2025-11-19

Director

Transactions

Exercise/Conversion
Common Stock
2025-11-19$40.05/sh+12,000$480,600→ 58,086 total
Sale
Common Stock
2025-11-19$72.13/sh−12,000$865,590→ 46,086 total
Exercise/Conversion
Non-Qualified Stock Option (right to buy)
2025-11-19−32,000→ 0 total
Exercise: $63.90From: 2020-06-10Exp: 2029-06-08→ Common Stock (32,000 underlying)
Exercise/Conversion
Common Stock
2025-11-19$63.90/sh+32,000$2,044,800→ 78,086 total
Sale
Common Stock
2025-11-19$72.13/sh−32,000$2,308,240→ 46,086 total
Exercise/Conversion
Non-Qualified Stock Option (right to buy)
2025-11-19−12,000→ 0 total
Exercise: $40.05From: 2022-07-01Exp: 2031-06-30→ Common Stock (12,000 underlying)

Footnotes (1)

[F1]The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $71.985 to $72.33 inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc. any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) on this Form 4.

Documents

1 file