Monia Brett P 4

What Happened
Monia Brett, Chief Executive Officer of Ionis Pharmaceuticals (IONS), acquired 484 shares on February 27, 2026 at $48.87 per share for a total of $23,651. The transaction is reported as an "other acquisition or disposition" (code J) and, per the filing footnote, these shares were purchased under Ionis’ Amended and Restated 2000 Employee Stock Purchase Plan.

Key Details

• Transaction date: 2026-02-27; Price: $48.87 per share; Shares acquired: 484; Total value: $23,651.
• Transaction code: J (other acquisition/disposition) — here used for an ESPP purchase.
• Purchased under the Ionis 2000 Employee Stock Purchase Plan (per footnote).
• Restriction: These shares may not be sold until August 27, 2026 (six-month holding restriction noted).
• Filing: Form 4 filed with the SEC on 2026-03-03. The filing reports the transaction; the filing does not state post-transaction total shares owned by the insider.

Context
ESPP purchases are a common way for employees and executives to buy company stock (often via payroll deductions) and can reflect routine participation rather than a new investment decision. The six-month restriction noted in the footnote limits immediate resale, so this purchase does not reflect a near-term sale.