O'NEIL PATRICK R. 4

What Happened
Patrick O'Neil, EVP, Chief Legal Officer & General Counsel of Ionis Pharmaceuticals (IONS), acquired 376 shares on February 27, 2026 at $48.87 per share (reported total ~$18,374). The transaction is recorded as an "other acquisition" (code J) and reflects shares purchased through the company's employee stock purchase plan.

Key Details

• Transaction date: February 27, 2026; Filing date: March 3, 2026 (Form 4 filed on time).
• Price: $48.87 per share; reported total value: $18,374.
• Transaction type/code: Other acquisition (J) — purchase via Employee Stock Purchase Plan (ESPP).
• Post-transaction shares owned: not specified in the provided filing data.
• Footnote: Shares were purchased under the Ionis Amended and Restated 2000 Employee Stock Purchase Plan and may not be sold until August 27, 2026.

Context
This was a direct purchase under the company ESPP, which typically involves payroll deductions and a lookback/discount mechanism; the shares are subject to a holding restriction noted in the filing. Employee purchases are different from open-market buys or option exercises and do not by themselves indicate broader insider sentiment beyond participation in the ESPP.