O'NEIL PATRICK R. 4

What Happened
Patrick R. O'Neil, EVP, Chief Legal Officer & General Counsel of Ionis Pharmaceuticals (IONS), sold 3,069 shares on 2026-06-26 at $80.00 per share, generating proceeds of $245,520. The filing lists this as an open-market sale (code S). Sales are often routine (cashing out), while purchases typically signal stronger insider conviction.

Key Details

• Transaction date and price: 2026-06-26 — 3,069 shares sold at $80.00 each.
• Total proceeds: $245,520.
• Shares owned after transaction: Not specified in this Form 4 filing.
• Filing/Report: Form 4 filed with the SEC on 2026-06-30 (period of report 2026-06-26).
• Footnote: The shares were sold pursuant to a Rule 10b5-1 trading plan adopted by Mr. O'Neil on December 8, 2025 (pre-arranged sale).

Context
A Rule 10b5-1 plan lets insiders sell shares on a preset schedule and helps reduce the appearance that trades are based on nonpublic information; such sales are generally viewed as pre-planned and less informative about the insider’s current view of the company. For retail investors, single sales are routine; look for patterns of multiple insiders or recent purchases to infer stronger signals.