5 1 v69602e5.txt FORM 5 1 ------ -------------------------------------------- FORM 5 OMB APPROVAL ------ -------------------------------------------- OMB Number 3235-0362 Expires: December 31, 2001 [x] Check box if no U.S. SECURITIES AND EXCHANGE COMMISSION Estimated average burden longer subject to WASHINGTON, D.C. 20549 hours per response ................ 1.0 Section 16. Form -------------------------------------------- 4 or Form 5 ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP obligations may continue. See Filed pursuant to Section 16(a) of the Securities Instruction 1(b) Exchange Act of 1934, [ ] Form 3 Holdings Section 17(a) of the Public Utility Reported Holding Company Act of 1935 or Section 30(f) of [x] Form 4 the Investment Company Act Transactions of 1940 Reported

------------------------------------------------------------------------------------------------------------------------------------ 1. Name and Address of Reporting Person* 2. Issuer Name and Ticker or Trading Symbol 6. Relationship of Reporting Person to ALLEN PAUL G. Shaman Pharmaceuticals, Inc. (SHMN) Issuer (Check all applicable) ------------------------------------------- ---------------------------------------------- Director x 10% Owner (Last) (First) (Middle) 3. IRS or Social Security 4. Statement for ---- --- 505 UNION STATION, 505 FIFTH AVENUE, Number of Reporting Month/Year Officer (give Other (specify SUITE 990 Person (Voluntary) December 31, 2000 ---- title --- below) ------------------------------------------- ------------------- below) (Street) 5. If Amendment, SEATTLE, WASHINGTON 98104 Date of Original ------------------------------- ------------------------------------------- (Month/Year) (City) (State) (Zip) 7. Individual or Joint/Group Filing ------------------ (Check applicable line) Form Filed by one ---- Reporting Person x Form Filed by more than ---- one Reporting Person ------------------------------------------------------------------------------------------------------------------------------------ TABLE 1 -- NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED ------------------------------------------------------------------------------------------------------------------------------------ 1. Title of Security 2. Trans- 3. Transac- 4. Securities Acquired (A) 5. Amount of Se- 6. Owner- 7. Nature (Instr. 3) action tion or Disposed of (D) curities Benefi- ship of In- Date Code (Instr. 3, 4 and 5) cially Owned at Form: direct (Instr. 8) End of Month Direct Benefi- (Month/ (Instr. 3 and 4) (D) or cial Day/ ---------------------------- Indirect Owner- Year) Amount (A) or Price (I) ship (D) (Instr. 4) (Instr. 4) Code ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 2/1/2000 C4 3,418,153 A (1) 7,153,518(2) (I)(3) (3) ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ Explanation of Responses: (1) Automatically converted from Series R Preferred Stock on February 1, 2000. (2) Includes 946,506 shares paid as a dividend on the Series C Stock on June 1, 2000 and 2,788,506 shares paid as a dividend on the Series C Stock on November 30, 2000. (3) Owned directly by Vulcan Ventures, Inc. ("VVI") and indirectly by Paul G. Allen, the sole shareholder of VVI. *If the form is filed by more than one Reporting Person, see Instruction 4(b)(v). Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. (Over) (Print or Type Responses)

9. Number of 10. Ownership 11. Nature of Derivative of Derivative Indirect Securities Security Beneficial Beneficially Direct (D) Ownership Owned at End or Indirect (I) (Instr. 4) of Month (Instr. 4) (Instr. 4) -------------------------------------------------------------------------- -0- (1) (2) -------------------------------------------------------------------------- -------------------------------------------------------------------------- -------------------------------------------------------------------------- -------------------------------------------------------------------------- -------------------------------------------------------------------------- -------------------------------------------------------------------------- Explanation of Responses: (1) Automatically converted on February 1, 2000. (2) Owned directly by VVI and indirectly by Paul G. Allen, the sole shareholder of VVI **Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). /s/ WILLIAM D. SAVOY 2/14/2001 ------------------------------- --------- **Signature of Reporting Person Date William D. Savoy as Attorney-in Fact for Paul G. Allen pursuant to a Power of Attorney filed with the Reporting Persons' Schedule 13G for Parthogenesis, Inc. on August 30, 1999 and incorporated herein by reference. Note: File three copies of this Form, one of which must be manually signed. If space provided is insufficient, see Instruction 6 for procedure.

Page 2 of 3 3 JOINT FILER INFORMATION Name: Vulcan Ventures Incorporated Address: 505-Fifth Avenue, Suite 900 Seattle, WA 98104 Designated Filer: Paul G. Allen Issuer & Ticker Symbol: Shaman Pharmaceuticals, Inc. ("SHMN") Date of Event Requiring Statement: February 1, 2000 Signature: VULCAN VENTURES INCORPORATED By: /s/ WILLIAM D. SAVOY 2/14/2001 --------------------------------------------- William D. Savoy, Vice President Page 3 of 3

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