SECURITIESTable ANDof EXCHANGE COMMISSIONContents

~~Washington,~~SECURITIES AND EXCHANGE COMMISSION ~~D.C. 20549~~

~~FORM~~Washington, ~~8-K~~D.C. 20549

~~CURRENT~~FORM ~~REPORT~~8-K

~~Pursuant~~CURRENT ~~to Section 13 or 15(d)~~REPORT

ofPursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): ~~November 14~~January 21, ~~2002~~2003

Variagenics, Inc.

(Exact name of registrant as specified in its charter)

Delaware		0-31035		04-3182077
(State or other jurisdiction of incorporation)		(Commission File Number)		(IRS Employer Identification No.)

60 Hampshire ~~Street~~ St. Cambridge, MA, 02139-1548 ~~(Address of principal executive offices) (Zip Code)~~

~~Registrant’s telephone~~(Address ~~number,~~of ~~including~~principal ~~area~~executive ~~code:~~offices) (~~617)~~Zip ~~588-5300~~Code)

~~ITEM~~Registrant’s ~~7. FINANCIAL STATEMENTS~~telephone ~~AND~~number, ~~EXHIBITS~~including area code: (617) 588-5300

~~(c) Exhibits~~TABLE OF CONTENTS

Exhibit
	ITEM 5. OTHER EVENTS AND REGULATION FD DISCLOSURE
No.		Description
	ITEM 7. FINANCIAL STATEMENTS AND EXHIBITS
99.1		Certification of Principal Executive Officer and Principal Financial Officer
SIGNATURES
EXHIBIT INDEX
EXHIBIT 99.1
EXHIBIT 99.2

ITEMTable 9.of REGULATION FD DISCLOSUREContents

~~In connection with the Quarterly Report on Form 10-Q of Variagenics, Inc~~Item 5. ~~(the~~Other ~~“Company”)~~Events ~~for the quarterly period ended September 30, 2002, as filed with the Securities~~ and ~~Exchange~~Regulation FD ~~Commission concurrently herewith, the Company hereby files the written statement required by Section 906 of the Sarbanes-Oxley Act of 2002~~Disclosure. ~~On November~~ 14, 2002, Joseph S. Mohr, President and Chief Business Officer of the Company and Richard P. Shea, Chief Operating Officer and Chief Financial Officer of the Company, each executed this written statement. A copy of the foregoing written statement is attached hereto as an exhibit and incorporated herein by reference.

2On January 21, 2003, Variagenics, Inc. (the “Company”) issued a press release announcing recent developments relating to its proposed merger with Hyseq, Inc., including the receipt of an unsolicited business combination proposal, the determination by its Board of Directors that the proposal was not in the best interests of the Company or its stockholders and the reaffirmation by its Board of Directors to recommend that its stockholders vote to approve the merger with Hyseq. A copy of the press release is attached to this Current Report on Form 8-K as Exhibit 99.1.

~~SIGNATURES~~In addition, on or about January 21, 2003, the Company filed and distributed to its stockholders, who are eligible to vote at the Company’s special meeting scheduled for January 28, 2003, a Supplement dated January 21, 2003 to the Joint Proxy Statement/Prospectus dated December 13, 2002. The Supplement contains information about recent developments relating to the Company’s proposed merger with Hyseq, including the receipt of an unsolicited business combination proposal. A copy of the Supplement is attached to this Current Report on Form 8-K as Exhibit 99.2.

~~Pursuant~~Item 7. toFinancial ~~the~~Statements ~~requirements~~and ofExhibits. ~~the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.~~

	Variagenics, Inc.
	(Registrant)
Date: November 14, 2002	By:	/s/ RICHARD P. SHEA
		Richard P. Shea
		Chief Operating Officer,
		Chief Financial Officer and Treasurer


Exhibit Number		Description

99.1		Press release of Variagenics, Inc. dated January 21, 2003.

99.2		Supplement dated January 21, 2003 to Joint Proxy Statement/Prospectus dated December 13, 2002.

~~EXHIBIT~~2 ~~INDEX~~

Exhibit
No.		Description
99.1	Certification of Principal Executive Officer and Principal Financial Officer

4SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.


	VARIAGENICS, INC.
	(Registrant)

Date: January 21, 2003	By:	/s/ Joseph S. (Jay) Mohr

		Joseph S. (Jay) Mohr President and Chief Business Officer

EXHIBIT INDEX


Exhibit Number		Description

99.1		Press release of Variagenics, Inc. dated January 21, 2003.

99.2		Supplement dated January 21, 2003 to Joint Proxy Statement/Prospectus dated December 13, 2002.

SECURITIESTable ANDof EXCHANGE COMMISSIONContents

ITEMTable 9.of REGULATION FD DISCLOSUREContents

Table of Contents

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