FORM 4
[ ] Check this box if no longer
subject to Section 16. Form 4 or Form
5 obligations may continue.
See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility
Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person*~~SHIMASAKI~~GIBSON, ~~CRAIG~~GILBERT ~~DAVID~~CARL JR. (Last) (First) (Middle)~~14200~~4804 S. ~~MacArthur~~LAKE DR.(Street)~~Edmond~~NORMAN, OK ~~73003~~73072 (City) (State) (Zip)USA 2. Issuer Name and Ticker or Trading SymbolZYMETX, INC. ZMTX3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary) 4. Statement for (Month/Year) ~~June~~May 20015. If Amendment, Date of Original (Month/Year) 6. Relationship of Reporting Person(s) to Issuer(Check all applicable) Director 10% Owner X Officer X OtherOfficer/Other Description ~~VICE~~FORMER ~~PRESIDENT OF RESEARCH7~~OFFICER7. Individual or Joint/Group Filing (Check Applicable Line) X Individual Filing Joint/Group Filing

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	3. Transaction Code and Voluntary Code (Instr. 8)Code \| V	4. Securities Acquired (A) or Disposed (D) Of (Instr. 3, 4, and 5) Amount \| A/D \| Price	5. Amount of Securities Beneficially Owned at End of Month (Instr. 3 and 4)	6. Owner- ship Form: Direct(D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
COMMON STOCK, par value $.001	0605/3021/2001	JS ~~(1)~~ \| V	12,~~830~~259.00 \| AD \| $0.3885	~~8,022~~0.00	D
COMMON STOCK, par value $.001	06/14/2001	P \|	230.00 \| A \| $0.64	1,000.00	I	By Daughter

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

(over)
SEC 1474 (3-99)

~~SHIMASAKI~~GIBSON, ~~CRAIG~~GILBERT ~~DAVID~~CARL JR. - ~~June~~May 2001

Form 4 (continued)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conver- sion or Exercise Price of Deri- vative Security	3. Transaction Date (Month/ Day/ Year)	4. Transaction Code and Voluntary (V) Code (Instr.8) Code \| V	5. Number of Derivative Securities Acquired (A) or Disposed (D) Of (Instr. 3,4 and 5)	6. Date Exercisable(DE) and Expiration Date(ED) (Month/Day/Year) (DE) \| (ED)	7. Title and Amount of Underlying Securities (Instr. 3 and 4)	8. Price of Derivative Security (Instr.5)	9. Number of Derivative Securities Beneficially Owned at End of Month (Instr.4)	10.Owner-shipForm ofDeriv-ativeSecurity:Direct(D)orIndirect(I)	11. Nature of Indirect Beneficial Ownership (Instr.4)
Incentive Stock Options 1-01 (2)	$2.00				01/19/2001 (3) \| 01/19/2011	COMMON STOCK, par value $.001 - 5,000.00		5,000.00	D
Incentive Stock Options 10-99 (1)	$2.25				10/01/2000 (2) \| 10/01/2009	COMMON STOCK, par value $.001 - 22,900.00		22,900.00	D
Incentive Stock Options 10-99 (2)	$2.25				10/01/2000 (4) \| 10/01/2009	COMMON STOCK, par value $.001 - 46,447.00		46,447.00	D
Incentive Stock Options 10-99a (1)	$2.25				10/01/2000 (2) \| 10/01/2009	COMMON STOCK, par value $.001 - 3,400.00		3,400.00	D
Incentive Stock Options 10-99a (2)	$2.25				10/01/2000 (4) \| 10/01/2009	COMMON STOCK, par value $.001 - 4,200.00		4,200.00	D
Incentive Stock Options 6-97 (1)	$2.00				06/05/1998 (3) \| 06/05/2007	COMMON STOCK, par value $.001 - 10,000.00		10,000.00	D
Incentive Stock Options 1-96 (2)	$1.00				01/03/1997 (5) \| 01/03/2006	COMMON STOCK, par value $.001 - 5,042.00		5,042.00	D
Incentive Stock Options 8-98 (1)	$4.94				08/18/1999 (4) \| 08/18/2008	COMMON STOCK, par value $.001 - 7,100.00		7,100.00	D
Incentive Stock Options 8-98 (2)	$2.00 (6)				08/18/1999 (7) \| 08/18/2008	COMMON STOCK, par value $.001 - 13,553.00		13,553.00	D

Explanation of Responses :

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.Potential persons who are to respond to the collection of information contained in this form are notrequired to respond unless the form displays a currently valid OMB number. ________________________________ 07-1126-2001 ** Signature of Reporting Person Date/s/ ~~Craig~~G. DCarl Gibson Jr.GILBERT ~~ShimasakiCRAIG~~CARL ~~DAVID~~JR. ~~SHIMASAKI~~GIBSON Page 2SEC 1474 (3-99)

~~SHIMASAKI~~GIBSON, ~~CRAIG~~GILBERT ~~DAVID~~CARL JR. - ~~June~~May 2001

Form 4 (continued)

FOOTNOTE Descriptions for ZYMETX, INC. ZMTX Form 4 - ~~June~~May 2001 ~~CRAIG~~GILBERT ~~DAVID~~CARL ~~SHIMASAKI14200~~JR. GIBSON4804 S. ~~MacArthurEdmond~~LAKE DR.NORMAN, OK ~~73003Explanation~~73072Explanation of responses: (1) ~~Acquired under the Employee Stock Purchase Plan. (2)~~ Issued under the ZymeTx, Inc. Stock ~~Option~~option Plan in consideration of Mr. ~~Shimasaki~~Gibson's service as a key employee of the Issuer. No transactions for the period of this report. (32) Vests at a rate of 50% on ~~January 19, 2002, and 50% on January 19, 2003. (4) Vests at a rate of 50% on~~ October 1, 2000, and 50% on October 1, 2001. (53) Vests at a rate of 25% onper ~~each~~year ofon ~~January~~June 35, ~~1997~~1998, ~~January~~June 35, ~~1998~~1999, ~~January~~June 35, ~~1999~~2000, and ~~January~~June 35, ~~2000~~2001. (~~6) Exercise Price of Derivative Security repriced from $~~4~~.94 per share to $2.00 per share. (7~~) Vests at a rate of 25% per year on August 18, 1999, August 18, 2000, August 18, 2001, and August 18, 2002.

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