UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

______________

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

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Date of Report (Date of earliest event reported): October 28, 2009

MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED

Initial Depositor

(Exact name of Registrant as specified in its charter)

Biotech HOLDRS (SM) Trust

[Issuer with respect to the receipts]

DELAWARE

(State or other jurisdiction of incorporation)

001-15044

Commission File Number

13-5674085

(I.R.S. Employer Identification No.)

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250 Vesey Street

New York, New York 10281

(Address of principal executive offices and zip code)

(212) 449-1000

(Registrant's telephone number, including area code)

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Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2.):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 8.01

Other Events

On October 20, 2009, the merger of Sepracor Inc. and Dainippon Sumitomo Pharma Co., Ltd. became effective. As a result, Sepracor Inc. will no longer be an underlying constituent of the Biotech HOLDRS Trust. In connection with the merger, Sepracor Inc. shareholders will receive $23.00 in cash for each share of Sepracor Inc. The Bank of New York Mellon will receive $138.00 in cash for the six shares of Sepracor Inc. per 100 share round lot of Biotech HOLDRS Trust.

Item 9.01.

Financial Statements and Exhibits

(d)

Exhibits

99.1

Biotech HOLDRS Trust Prospectus Supplement dated October 28, 2009 to Prospectus dated March 11, 2009.

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED

Date: October 28, 2009	By:	/s/ Ninon B. Marapachi
		Name:	Ninon B. Marapachi
		Title:	Director

EXHIBIT INDEX

Number and Description of Exhibit

(99.1)

Biotech HOLDRS Trust Prospectus Supplement dated October 28, 2009 to Prospectus dated March 11, 2009.

BIOTECH HOLDRS TRUST 8-K