UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN ISSUER
PURSUANT TO RULE 13a-16 OR 15d-16 OF
THE SECURITIES EXCHANGE ACT OF 1934

For the month of ~~June~~September 2025

Commission file number: 001-38639

111, Inc.

3-4/F, No.295 ZuChongZhi Road,

Pudong New Area

Shanghai, 201203

The People’s Republic of China

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F. Form 20-F ☒ Form 40-F ☐

EXHIBIT INDEX

Exhibit No.	~~Description~~	Description
99.1	~~111, Inc. Announces First Quarter 2025 Unaudited Financial Results~~	111, Inc. Announces Second Quarter 2025 Unaudited Financial Results

Signature

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	~~111, INC.~~		111, INC.
Date: June 20, 2025	By:	/s/ Junling Liu
Date:	September 17, 2025		By:	/s/ Junling Liu
		~~Name:~~	~~Junling Liu~~	Name:	Junling Liu
		~~Title:~~	~~Chief Executive Officer~~	Title:	Chief Executive Officer

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