UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

_______________________________________________

FORM 10-Q

[ X ] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended ~~December~~March 31, ~~2018~~2019

[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

_______________________________________________

Commission File Number: 001-16633

_______________________________________________

Array BioPharma Inc.

(Exact Name of Registrant as Specified in Its Charter)



Delaware	84-1460811
(State or Other Jurisdiction of Incorporation or Organization)	(I.R.S. Employer Identification No.)

3200 Walnut Street, Boulder, CO	80301
(Address of Principal Executive Offices)	(Zip Code)

(303) 381-6600
(Registrant’s Telephone Number, Including Area Code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No ¨

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes x No ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and "emerging growth company" in Rule 12b-2 of the Exchange Act.



Large Accelerated Filer x	Accelerated Filer ¨
Non-Accelerated Filer ¨	Smaller Reporting Company ¨
	Emerging Growth Company ¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ¨ No x

As of January 30, 2019, the registrant had 218,213,556 shares of common stock outstanding.



Title of each class	Trading Symbol	Name on each exchange on which registered
Common Stock, par value $0.001 per share	ARRY	Nasdaq Global Market

As of April 26, 2019, the registrant had 221,750,763 shares of common stock outstanding.

ARRAY BIOPHARMA INC.

QUARTERLY REPORT ON FORM 10-Q

FOR THE QUARTERLY PERIOD ENDED ~~DECEMBER~~MARCH 31, ~~2018~~2019

TABLE OF CONTENTS

		Page No.
PART I	FINANCIAL INFORMATION
Item 1.	Condensed Consolidated Financial Statements
	Condensed Consolidated Balance Sheets as of December 31, 2018 and June 30, 2018 (unaudited)	3
	Condensed Consolidated Balance Sheets as of March 31, 2019 and June 30, 2018 (unaudited)	3
	Condensed Consolidated Statements of Operations and Comprehensive Loss for thethree and six months ended December 31, 2018 and 2017 (unaudited)	4
	Condensed Consolidated Statements of Operations and Comprehensive Loss for thethree and nine months ended March 31, 2019 and 2018 (unaudited)	5
	Condensed Consolidated Statement of Stockholders' Equity for the three and sixmonths ended December 31, 2018 and 2017 (unaudited)	5
	Condensed Consolidated Statement of Stockholders' Equity for the three and ninemonths ended March 31, 2019 and 2018 (unaudited)	6
	Condensed Consolidated Statements of Cash Flows for the six months ended December 31, 2018 and 2017 (unaudited)	7
	Condensed Consolidated Statements of Cash Flows for the nine months ended March 31, 2019 and 2018 (unaudited)	8
	Notes to the Unaudited Condensed Consolidated Financial Statements	89
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	2426
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	3739
Item 4.	Controls and Procedures	3739
PART II	OTHER INFORMATION
Item 1.	Legal Proceedings	3841
Item 1A.	Risk Factors	3841
Item 6.	Exhibits	38
Item 5.	Other Information	41
SIGNATURES		40
Item 6.	Exhibits	41
SIGNATURES		44
EXHIBIT INDEX

Table of Contents

PART I. FINANCIAL INFORMATION

ITEM 1. CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

ARRAY BIOPHARMA INC.

Condensed Consolidated Balance Sheets

(In thousands, except share and per share data)

	December 31,			June 30,
	2018			2018
Assets
Current assets
Cash and cash equivalents	$	147,094		$	114,748
Marketable securities	329,964			297,739
Accounts receivable	22,245			32,084
Prepaid expenses and other current assets	31,537			6,972
Total current assets	530,840			451,543
Non-current assets
Marketable securities	1,095			919
Property and equipment, net	6,902			7,128
Other non-current assets	10,125			774
Total non-current assets	18,122			8,821
Total assets	$	548,962		$	460,364
Liabilities and Stockholders' Equity
Current liabilities
Accounts payable	$	10,420		$	14,059
Accrued outsourcing costs	41,535			31,853
Accrued compensation and benefits	14,105			16,695
Other accrued expenses	4,639			1,868
Deferred rent	725			707
Notes payable at fair value	—			15,899
Deferred revenue	12,761			12,350
Current portion of long-term debt	—			2,500
Total current liabilities	84,185			95,931
Non-current liabilities
Deferred rent	5,252			5,598
Deferred revenue	40,231			44,470
Long-term debt, net	132,654			93,376
Other non-current liabilities	1,289			1,246
Total non-current liabilities	179,426			144,690
Total liabilities	263,611			240,621
Commitments and contingencies
Stockholders' equity
Preferred stock, $0.001 par value; 10,000,000 shares authorized, no shares issued and outstanding	—			—
Common stock, $0.001 par value; 340,000,000 and 280,000,000 shares authorized as of December 31, 2018 and June 30, 2018, respectively, 217,860,411 and 211,289,922 shares issued and outstanding as of December 31, 2018 and June 30, 2018, respectively	218			211
Additional paid-in capital	1,387,422			1,286,000
Accumulated other comprehensive loss	(109		)	(461		)
Accumulated deficit	(1,102,180		)	(1,066,007		)
Total stockholders' equity	285,351			219,743
Total liabilities and stockholders' equity	$	548,962		$	460,364
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Table of Contents

(Unaudited)



	March 31,			June 30,
	2019			2018
Assets
Current assets
Cash and cash equivalents	$	96,636		$	114,748
Marketable securities	326,452			297,739
Accounts receivable	31,660			32,084
Inventory	4,397			121
Prepaid expenses and other current assets	34,769			6,851
Total current assets	493,914			451,543

Non-current assets
Marketable securities	56,008			919
Property and equipment, net	6,977			7,128
Other non-current assets	10,105			774
Total non-current assets	73,090			8,821
Total assets	$	567,004		$	460,364

Liabilities and Stockholders' Equity
Current liabilities
Accounts payable	$	9,128		$	14,059
Accrued outsourcing costs	39,359			31,853
Accrued compensation and benefits	16,444			16,695
Other accrued expenses	7,319			1,868
Deferred rent	783			707
Notes payable at fair value	—			15,899
Deferred revenue	13,627			12,350
Current portion of long-term debt	—			2,500
Total current liabilities	86,660			95,931

Non-current liabilities
Deferred rent	5,216			5,598
Deferred revenue	38,312			44,470
Long-term debt, net	134,245			93,376
Other non-current liabilities	946			1,246
Total non-current liabilities	178,719			144,690
Total liabilities	265,379			240,621

Commitments and contingencies

Stockholders' equity
Preferred stock, $0.001 par value; 10,000,000 shares authorized, no shares issued and outstanding	—			—
Common stock, $0.001 par value; 340,000,000 and 280,000,000 shares authorized as of March 31, 2019 and June 30, 2018, respectively, 221,548,492 and 211,289,922 shares issued and outstanding as of March 31, 2019 and June 30, 2018, respectively	221			211
Additional paid-in capital	1,440,913			1,286,000
Accumulated other comprehensive income (loss)	165			(461		)
Accumulated deficit	(1,139,674		)	(1,066,007		)
Total stockholders' equity	301,625			219,743
Total liabilities and stockholders' equity	$	567,004		$	460,364

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Table of Contents

ARRAY BIOPHARMA INC.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(In thousands, except per share data)

(Unaudited)

	Three Months Ended						~~Six~~Nine Months Ended
	December 31,						December 31,
	March 31,						March 31,
	2018			2017			2018			2017
	2019			2018			2019			2018
Revenue
Product sales, net	$	2235,~~713~~078		$	—		$	3671,~~706~~784		$	—
Collaboration and license revenue	50,924			19,823			81,952			31,377
Product royalties	937			—			1,261			—
Reimbursement revenue	8,912			22,395			20,801			40,587
Collaboration and license revenue	19,493			41,616			101,121			72,993
Total revenue	82,549			42,218			139,459			71,964
Reimbursement revenue	9,169			24,751			29,970			65,338
Total revenue	64,677			66,367			204,136			138,331
Operating expenses
Cost of goods sold	~~786~~1,042			—			~~981~~2,023			—
Research and development	6265,~~120~~541			5671,~~329~~348			~~117~~183,~~670~~211			~~109~~180,~~533~~881
Selling, general and administrative	3035,~~473~~548			1116,~~607~~773			5590,~~363~~911			2340,~~655~~428
Total operating expenses	93102,~~379~~131			6788,~~936~~121			~~174~~276,~~014~~145			~~133~~221,~~188~~309
Loss from operations	(1037,~~830~~454		)	(2521,~~718~~754		)	(3472,~~555~~009		)	(6182,~~224~~978		)
Other income (expense)
Loss on extinguishment and conversion of Notes	—			(6,457		)	—			(6,457		)
Interest income	2,912			1,295			6,722			3,075
Realized gain on investments	—			—			35			—
Interest expense	(2,863		)	(2,361		)	(8,261		)	(8,407		)
Change in fair value of notes payable	—			(300		)	(65		)	(100		)
Loss on extinguishment and conversion of notes	—			—			—			(6,457		)
Interest income	2,286			1,255			3,810			1,780
Change in fair value of notes payable	—			(100		)	(65		)	(200		)
Interest expense	(2,818		)	(2,833		)	(5,398		)	(6,046		)
Other, net	(89		)	69			(54		)	69
Total other income (expense), net	(~~532~~40		)	(81,~~335~~097		)	(1,~~618~~658		)	(1011,~~823~~920		)
Net loss	$	(1137,~~362~~494	)	$	(3422,~~053~~851	)	$	(3673,~~173~~667	)	$	(7294,~~047~~898	)
Change in unrealized gain (loss) on marketable securities	~~203~~274			(~~634~~81		)	~~352~~626			(~~600~~681		)
Comprehensive loss	$	(1137,~~159~~220	)	$	(3422,~~687~~932	)	$	(3573,~~821~~041	)	$	(7295,~~647~~579	)
Weighted average shares outstanding – basic	~~215~~219,~~872~~913			~~199~~208,~~852~~994			~~214~~215,~~032~~964			~~187~~194,~~312~~434
Weighted average shares outstanding – diluted	~~215~~219,~~872~~913			~~199~~208,~~852~~994			~~214~~215,~~032~~964			~~187~~194,~~312~~434
Net loss per share – basic	$	(0.0517	)	$	(0.1711	)	$	(0.1734	)	$	(0.3849	)
Net loss per share – diluted	$	(0.0517	)	$	(0.1711	)	$	(0.1734	)	$	(0.3849	)
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Table of Contents

ARRAY BIOPHARMA INC.

Condensed Consolidated Statement of Stockholders' Equity

(In thousands)

(Unaudited)

Three months ended December 31, 2018
Three months ended March 31, 2019
				Additional Paid-in Capital		Accumulated Other Comprehensive Income (Loss)			Accumulated Deficit			Total
	Common Stock
	Shares	Amounts
Balance as of September 30, 2018	213,027	$	213	$	1,309,985	$	(312	)	$	(1,090,818	)	$	219,068
Shares issued for cash under employee share plans	414	1		63		—			—			64
Share-based compensation expense	—	—		5,530		—			—			5,530
Issuance of common stock, net of offering costs / At-the-market offering	4,419	4		71,844		—			—			71,848
Change in unrealized loss on marketable securities	—	—		—		203			—			203
Net loss	—	—		—		—			(11,362		)	(11,362		)
Balance as of December 31, 2018	217,860	$	218	$	1,387,422	$	(109	)	$	(1,102,180	)	$	285,351
Six months ended December 31, 2018
Shares issued for cash under employee share plans	2,091	1		11,413		—			—			11,414
				Additional Paid-in Capital		Accumulated Other Comprehensive Loss			Accumulated Deficit			Total
Share-based compensation expense	—	—		8,321		—			—			8,321
Issuance of common stock, net of offering costs / At-the-market offering	1,597	2		33,757		—			—			33,759
Change in unrealized loss on marketable securities	—	—		—		274			—			274
Net loss	—	—		—		—			(37,494		)	(37,494		)
Balance as of March 31, 2019	221,548	$	221	$	1,440,913	$	165		$	(1,139,674	)	$	301,625
Nine months ended March 31, 2019
				Additional Paid-in Capital		Accumulated Other Comprehensive Income (Loss)			Accumulated Deficit			Total
	Common Stock
	Shares	Amounts
Balance as of June 30, 2018	211,290	$	211	$	1,286,000	$	(461	)	$	(1,066,007	)	$	219,743
Shares issued for cash under employee share plans	~~917~~3,008	23		213,~~318~~731		—			—			213,~~320~~734
Share-based compensation expense	—	—		1018,~~342~~663		—			—			1018,~~342~~663
Issuance of common stock, net of offering costs / At-the-market offering	57,~~653~~250	57		88122,~~762~~519		—			—			88122,~~767~~526
Change in unrealized loss on marketable securities	—	—		—		~~352~~626			—			~~352~~626
Net loss	—	—		—		—			(3673,~~173~~667		)	(3673,~~173~~667		)
Balance as of December 31, 2018	217,860	$	218	$	1,387,422	$	(109	)	$	(1,102,180	)	$	285,351
Balance as of March 31, 2019	221,548	$	221	$	1,440,913	$	165		$	(1,139,674	)	$	301,625
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Table of Contents

ARRAY BIOPHARMA INC.

Condensed Consolidated Statement of Stockholders' Equity

(In thousands)

(Unaudited)

Three Months Ended December 31, 2017
Three Months Ended March 31, 2018
				Additional Paid-in Capital			Accumulated Other Comprehensive Loss			Accumulated Deficit			Total
	Common Stock
	Shares	Amounts
Balance as of September 30, 2017	196,126	$	196	$	1,183,122		$	(42	)	$	(956,655	)	$	226,621
Shares issued for cash under employee share plans	2,463	2		13,178			—			—			13,180
Share-based compensation expense	—	—		3,236			—			—			3,236
Extinguishment of 2020 Notes	7,956	8		(15,705		)	—			—			(15,697		)
Conversion of 2020 Notes	913	1		5,418			—			—			5,419
Issuance of 2024 Notes	—	—		44,110			—			—			44,110
Change in unrealized loss on marketable securities	—	—		—			(634		)	—			(634		)
Net loss	—	—		—			—			(34,053		)	(34,053		)
Balance as of December 31, 2017	207,458	$	207	$	1,233,359		$	(676	)	$	(990,708	)	$	242,182
Six Months Ended December 31, 2017
Shares issued for cash under employee share plans	816	1		3,670			—			—			3,671
Share-based compensation expense	—	—		4,719			—			—			4,719
Issuance of common stock, net of offering costs / At-the-market offering	2,230	2		37,508			—			—			37,510
Change in unrealized loss on marketable securities	—	—		—			(81		)	—			(81		)
Net loss	—	—		—			—			(22,851		)	(22,851		)
Balance as of March 31, 2018	210,504	$	210	$	1,279,256		$	(757	)	$	(1,013,559	)	$	265,150
Nine Months Ended March 31, 2018
				Additional Paid-in Capital			Accumulated Other Comprehensive Loss			Accumulated Deficit			Total
	Common Stock
	Shares	Amounts
Balance as of June 30, 2017	171,308	$	171	$	930,293		$	(76	)	$	(918,661	)	$	11,727
Shares issued for cash under employee share plans	23,~~887~~703	23		1418,~~601~~271			—			—			1418,~~603~~274
Share-based compensation expense	—	—		813,~~819~~538			—			—			813,~~819~~538
Issuance of common stock, net of offering costs / At-the-market offering	~~324~~2,554	13		240,~~829~~337			—			—			240,~~830~~340
Issuance of common stock, net of offering costs / Public offering	24,070	24		242,994			—			—			243,018
Extinguishment of 2020 Notes	7,956	8		(15,705		)	—			—			(15,697		)
Conversion of 2020 Notes	913	1		5,418			—			—			5,419
Issuance of 2024 Notes	—	—		44,110			—			—			44,110
Change in unrealized loss on marketable securities	—	—		—			(~~600~~681		)	—			(~~600~~681		)
Net loss	—	—		—			—			(7294,~~047~~898		)	(7294,~~047~~898		)
Balance as of December 31, 2017	207,458	$	207	$	1,233,359		$	(676	)	$	(990,708	)	$	242,182
Balance as of March 31, 2018	210,504	$	210	$	1,279,256		$	(757	)	$	(1,013,559	)	$	265,150
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Table of Contents

ARRAY BIOPHARMA INC.

Condensed Consolidated Statements of Cash Flows

(In thousands)

(Unaudited)

	Six Months Ended
	Nine Months Ended
	December 31,
	March 31,
	2018			2017
	2019			2018
Cash flows from operating activities
Net loss	$	(3673,~~173~~667	)	$	(7294,~~047~~898	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	1,~~069~~606			1,~~138~~700
Non-cash interest expense	34,~~002~~593			34,~~640~~931
Share-based compensation expense	1018,~~342~~663			813,~~819~~538
Loss on extinguishment and conversion of Notes	—			6,457
Realized gain from investments, net	(35		)	—
Realized gain or loss on investments, net	(36		)	—
Change in fair value of notes payable	65			~~100~~200
Changes in operating assets and liabilities:
Accounts receivable	~~9,839~~424			1(12,~~309~~879		)
Prepaid expenses and other assets	(3341,~~916~~525		)	(~~673~~1,098		)
Accounts payable and other accrued expenses	(~~1,832~~447		)	24,~~539~~291
Accrued outsourcing costs	97,~~682~~506			(42,~~087~~946		)
Accrued compensation and benefits	~~(1,457~~882		)	~~(3,400~~173		)
Deferred rent	(~~328~~305		)	99134
Deferred revenue	(34,~~828~~881		)	(1417,~~241~~117		)
Other non-current liabilities	~~132~~(304		)	~~171~~468
Net cash used in operating activities	(4387,~~438~~426		)	(7091,~~176~~154		)
Cash flows from investing activities
Purchases of property and equipment	(~~843~~1,455		)	(~~212~~1,122		)
Proceeds from investment	35			—
Purchases of marketable securities	(~~234~~390,~~099~~146		)	(~~338~~395,~~060~~369		)
Proceeds from sales and maturities of marketable securities	~~201~~306,~~961~~978			91138,~~421~~241
Net cash used in investing activities	(3284,~~946~~588		)	(~~246~~258,~~851~~250		)
Cash flows from financing activities
Proceeds from issuance of common stock / Public offering	—			258,750
Offering costs for issuance of common stock / Public offering	—			(15,732		)
Proceeds from issuance of common stock / At-the-market offering	90125,~~629~~043			241,~~917~~216
Offering costs for the issuance of common stock / At-the-market offering	(12,~~862~~517		)	(87876		)
Net proceeds from employee stock purchases and options exercised	112,~~187~~600			1418,~~603~~274
Payment of note payable	(15,000		)	—
Proceeds from the modification of long-term debt, net	33,776			—
Payment for debt issuance costs	—			(4,306		)
Net cash provided by financing activities	~~108~~153,~~730~~902			~~256~~297,~~145~~326
Net increase in cash and cash equivalents	32,346			(60,882		)
Net decrease in cash and cash equivalents	(18,112		)	(52,078		)
Cash and cash equivalents at beginning of period	114,748			125,933
Cash and cash equivalents at end of period	$	~~147~~96,~~094~~636		$	6573,~~051~~855
Supplemental disclosure of cash flow information
Cash paid for interest	$	3,~~213~~650		$	2,~~161~~260
Change in unrealized loss on marketable securities	$	~~352~~626		$	(~~600~~681	)

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

Table of Contents

ARRAY BIOPHARMA INC.

Notes to the Unaudited Condensed Consolidated Financial Statements

NOTE 1 – OVERVIEW, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Organization

Array BioPharma Inc. ("Array", "we", "us", "our" or "the Company") is a fully- integrated, biopharmaceutical company focused on the discovery, development and commercialization of transformative and well-tolerated targeted small molecule drugs to treat patients afflicted with cancer and other high-burden diseases. We were incorporated in the State of Delaware in 1998. Since our founding, we have progressed two drugs through clinical development and received regulatory approval. BRAFTOVI® ~~and~~+ MEKTOVI® were approved by the Food and Drug Administration ("FDA") for commercial sales in the United States ("U.S.") in June 2018 and by the European Commission for commercial sales in the European Union through our partner, Pierre Fabre Medicamente SAS ("Pierre Fabre"), in September 2018.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared pursuant to the rules and regulations of the Securities and Exchange Commission ("SEC") for interim reporting and, as permitted under those rules, do not include all of the disclosures required by U.S. generally accepted accounting principles ("U.S. GAAP") for complete financial statements. The unaudited condensed consolidated financial statements reflect all normal and recurring adjustments that, in the opinion of management, are necessary to present fairly our financial position, results of operations and cash flows for the interim periods presented. Operating results for an interim period are not necessarily indicative of the results that may be expected for a full year. Our management performed an evaluation of our activities through the date of filing of this Quarterly Report on Form 10-Q.

These unaudited condensed consolidated financial statements should be read in conjunction with our audited financial statements and the notes thereto for the fiscal year ended June 30, 2018 included in our Annual Report on Form 10-K from which we derived our balance sheet data as of June 30, 2018.

We operate in one reportable segment and, accordingly, no segment disclosures have been presented herein. All of our equipment, leasehold improvements and other fixed assets are physically located within the U.S., and the vast majority of our agreements with partners are denominated in U.S. dollars.

Reclassifications

Certain prior period amounts in our unaudited condensed consolidated financial statements have been reclassified to conform to the current period presentation. Inventory in the amount of $0.1 million was previously presented within prepaid expenses and other current assets on our consolidated balance sheet dated June 30, 2018.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with U.S. GAAP requires our management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue and expenses, and related disclosure of contingent assets and liabilities. We base our estimates on our historical experience and on various other assumptions that we believe are reasonable under the circumstances. Our actual results could differ significantly from these estimates under different assumptions or conditions.

On an ongoing basis, we evaluate our estimates, including our most significant estimates related to revenue recognition, gross-to-net product sales adjustments, and estimating accrued outsourcing costs for clinical trials and preclinical testing.

~~Liquidity~~9

As of December 31, 2018 and June 30, 2018, we held cash, cash equivalents and marketable securities totaling $478.2 million and $413.4 million, respectively. With the exception of fiscal year 2015, we have incurred operating losses and an accumulated deficit as a result of ongoing research and development spending since inception. As of December 31, 2018, we had an accumulated deficit of $1.1 billion. Our results of operations were net losses of $11.4 million and $36.2 million for the three and six months ended December 31, 2018, respectively, and $147.3 million, $116.8 million and $92.8 million for the fiscal years ended June 30, 2018, 2017 and 2016, respectively.

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We have historically funded our operations from upfront fees, proceeds from research and development reimbursement arrangements, license and milestone payments received under our drug collaborations and license agreements, and proceeds from the sale of equity securities and debt provided by convertible debt and other credit facilities. We believe that our cash, cash equivalents and marketable securities as of December 31, 2018 will enable us to continue to fund operations in the normal course of business for more than a twelve-month period from the date of filing this Quarterly Report on Form 10-Q. Until we can generate sufficient levels of cash from operations, which we do not expect to achieve in at least the next two years, and because sufficient funds may not be available to us when needed from existing collaborations, we expect that we will be required to continue to fund our operations in part through the sale of debt or equity securities, or through licensing select programs or partial economic rights that include upfront, royalty and/or milestone payments.Liquidity

As of March 31, 2019 and June 30, 2018, we held cash, cash equivalents and marketable securities totaling $479.1 million and $413.4 million, respectively. With the exception of fiscal year 2015, we have incurred operating losses and have generated an accumulated deficit as a result of ongoing research and development spending since inception. As of March 31, 2019, we had an accumulated deficit of $1.1 billion. Our results of operations were net losses of $37.5 million and $73.7 million for the three and nine months ended March 31, 2019, respectively, and $147.3 million, $116.8 million and $92.8 million for the fiscal years ended June 30, 2018, 2017 and 2016, respectively.

We have historically funded our operations from upfront fees, proceeds from research and development reimbursement arrangements, license and milestone payments received under our drug collaborations and license agreements, and proceeds from the sale of equity securities and debt provided by convertible debt and other credit facilities. Beginning in fiscal year 2019, we also receive cash payments for commercial sales of our marketed drugs. We believe that our cash, cash equivalents and marketable securities as of March 31, 2019 will enable us to continue to fund operations in the normal course of business for more than a twelve-month period from the date of filing this Quarterly Report on Form 10-Q. Until we can generate sufficient levels of cash from operations, which we do not expect to achieve in at least the next two years, and because sufficient funds may not be available to us when needed from existing collaborations, we expect that we will be required to continue to fund our operations in part through the sale of debt or equity securities, or through licensing select programs or partial economic rights that include upfront, royalty and/or milestone payments.

Our assessment of our future need for funding and our ability to continue to fund our operations are forward-looking statements that are based on assumptions that may prove to be wrong and that involve substantial risks and uncertainties. Our actual future capital requirements could vary as a result of a number of factors.

Concentration of Business Risks

The following counterparties contributed greater than 10% of our total revenue during at least one of the periods set forth below. The revenue from these counterparties as a percentage of total revenue was as follows:

	Three Months Ended				~~Six~~Nine Months Ended
	December 31,				December 31,
	March 31,				March 31,
	2018		2017		2018		2017
	2019		2018		2019		2018
Loxo Oncology	~~48.5~~—	%	53.76	%	3322.37	%	85.09	%
Pierre Fabre	719.90	%	109.52	%	2019.39	%	1110.86	%
Novartis Pharmaceutical	1014.82	%	5337.13	%	14.97	%	5647.42	%
Asahi Kasei	—	%	23.0	%	—	%	14.9	%
ASLAN	—	%	34.7	%	—	%	16.6	%
Total	6733.2	%	9284.38	%	6857.53	%	9180.13	%

The loss of one or more of our significant partners or collaborators could have a material adverse effect on our business, operating results or financial condition. Although we are impacted by economic conditions in the biotechnology and pharmaceutical sectors, management does not believe significant credit risk exists as of ~~December~~March 31, ~~2018~~2019.

Geographic Information

The following table details revenue by geographic area based on the country in which our partners, Customers or license holders are located (in thousands):

	Three Months Ended				~~Six~~Nine Months Ended
	December 31,				December 31,
	March 31,				March 31,
	2018		2017		2018		2017
	2019		2018		2019		2018
North America	$	6537,~~945~~877	$	4,~~662~~682	$	88126,~~225~~102	$	1014,~~163~~845
Europe	1521,~~446~~461		2633,~~852~~744		4970,~~135~~596		4982,~~148~~892
Asia Pacific	1,158		10,704		2,099		12,653
Asia Pacific and Other	5,339		27,941		7,438		40,594
Total	$	8264,~~549~~677	$	4266,~~218~~367	$	~~139~~204,~~459~~136	$	71138,~~964~~331

~~Accounts Receivable~~10

Novartis Pharmaceutical Ltd. and Novartis Pharma AG (collectively, "Novartis") accounted for 41% and 52% of our total accounts receivable balance as of December 31, 2018 and June 30, 2018, respectively. Loxo Oncology ("Loxo") accounted for 0% and 14% of our total accounts receivable balance as of December 31, 2018 and June 30, 2018, respectively. Pierre Fabre accounted for 13% and 13% of our total accounts receivable balance as of December 31, 2018 and June 30, 2018, respectively.

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Accounts Receivable

Novartis Pharmaceutical Ltd. and Novartis Pharma AG (collectively, "Novartis") accounted for 30% and 52% of our total accounts receivable balance as of March 31, 2019 and June 30, 2018, respectively. Pierre Fabre accounted for 14% and 13% of our total accounts receivable balance as of March 31, 2019 and June 30, 2018, respectively. McKesson Corporation accounted for 11% and 0% of our total accounts receivable balance as of March 31, 2019. Loxo Oncology ("Loxo") accounted for 0% and 14% of our total accounts receivable balance as of March 31, 2019 and June 30, 2018, respectively.

Summary of Significant Accounting Policies

Our significant accounting policies are described in Note 1 to our audited financial statements for the fiscal year ended June 30, 2018, included in our Annual Report on Form 10-K. Our significant accounting policies for the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 also included the policies discussed below related to revenue and cost of goods sold for commercial product sales. With the exception of those noted below, there have been no material changes in our significant accounting policies as previously disclosed in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018.

Product Sales, Net

We received approval from the FDA on June 27, 2018 to market BRAFTOVI + MEKTOVI in the U.S. for the treatment of patients with unresectable or metastatic melanoma with a BRAFV600E or BRAFV600K mutation. We began selling BRAFTOVI + MEKTOVI in the U.S. in July 2018. We distribute our products principally through a limited number of specialty distributor and specialty pharmacy providers (collectively, our "Customers"). Our Customers subsequently sell our products to patients and health care providers. Separately, we enter into arrangements with third parties that provide for government-mandated and privately-negotiated rebates, chargebacks and discounts. Revenue from product sales is recognized when ~~the~~our ~~Customer~~performance ~~obtains~~obligations are satisfied, which is when Customers obtain control of our product, ~~typically~~and occurs upon delivery ~~to the Customer~~.

Revenue from product sales are recognized when our performance obligations are satisfied, which is when Customers obtain control of our product and occurs at a point in time, typically upon delivery.

Reserves for Variable Consideration

Revenues from product sales are recorded at the net sales price (transaction price), which includes estimates of variable consideration, including rebates, chargebacks, discounts, patient assistance programs, estimated product returns and other allowances that are offered within contracts between us and our Customers. These estimates are based on the amounts earned or to be claimed for related sales and are classified as reductions of accounts receivable if the amount is payable to our Customers or a current liability if the amount is payable to a party other than a Customer. Where appropriate, these estimates take into consideration a range of possible outcomes which are probability-weighted for relevant factors such as industry data and forecasted customer buying and payment patterns, our historical experience, current contractual and statutory requirements, specific known market events and trends. Overall, these reductions to gross sales reflect our best estimates of the amount of consideration to which we are entitled based on the terms of the contract. Variable consideration is included in the transaction price only to the extent that it is probable that a significant reversal in the amount of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is subsequently resolved. Actual amounts of consideration ultimately received may differ from our estimates. If actual results in the future vary from our estimates, we adjust these estimates, which would affect product revenue and earnings in the period such variances become known.

Rebates: Rebates include mandated discounts under the Medicaid Drug Rebate Program ("Medicaid") and the Medicare Coverage Gap Program ("Medicare"). Rebates are amounts owed after the final dispensing of products to a benefit plan participant and are based upon contractual agreements or legal requirements with the public-sector benefit providers. These estimates for rebates are recorded in the same period the related gross revenue is recognized, resulting in a reduction of product revenue and the establishment of a current liability which is included in accrued expenses on the consolidated balance sheet. We estimate our Medicaid and Medicare rebates based upon a range of possible outcomes that are probability-weighted for the estimated payor mix. The accrual for rebates is based on statutory discount rates and known sales to specialty pharmacy patients or expected utilization for specialty distributor sales to healthcare providers. As we gain more historical experience, estimates will be based on the expected utilization from historical data we have accumulated since the BRAFTOVI + MEKTOVI product launch. Rebates are generally invoiced and paid quarterly in arrears.

Chargebacks: Chargebacks are discounts that occur when contracted purchasers purchase directly from our specialty distributors at a discounted price. The specialty distributor, in turn, charges back the difference between the price initially paid to us by the specialty distributor and the discounted price paid to the specialty distributor by the contracted purchaser. Amounts for estimated chargebacks are established in the same period that the related gross revenue is recognized, resulting in a reduction of product revenue and accounts receivable. The accrual for specialty distributor chargebacks is estimated based on known chargeback rates, known sales to specialty distributors, and estimated utilization by types of contracted purchasers.11

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Discounts and Fees: Our payment terms are generally 45 days. Specialty distributors and specialty pharmacies are offered various forms of consideration, including service fees and prompt pay discounts for payment within a specified period. We expect these Customers will earn prompt pay discounts and therefore, we deduct the full amount of these discounts and service fees from product sales when revenue is recognized, resulting in a reduction of product revenue and accounts receivable.

Other Reserves: Patients who have commercial insurance and meet certain eligibility requirements may receive co-pay assistance. We estimate the amount of co-pay assistance provided to eligible patients based on the terms of the program when product is dispensed by specialty pharmacies to patients. These estimates are based on redemption information provided by third-party claims processing organizations and are recorded in accounts payable, accrued expenses and other liabilities on the unaudited condensed consolidated balance sheet.

We are offering a quick start program in the form of vouchers to eligible patients. We record amounts for estimated voucher redemptions in the same period that the related gross revenue is recognized, resulting in a reduction of product revenue, and these amounts are recorded in accounts payable, accrued expenses and other liabilities on the unaudited condensed consolidated balance sheet. Our accrual for voucher redemptions is estimated based on observed voucher redemption rates.

Cost of Goods Sold

Cost of goods sold consists of the cost of goods sold to Customers, international partners under product supply agreements, and royalty expense based on net sales of BRAFTOVI. We capitalize inventory costs associated with the production of our products after regulatory approval or when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized. Otherwise, such costs are expensed as research and development. A portion of the costs of BRAFTOVI +and MEKTOVI units recognized as revenue during the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 were expensed prior to FDA approval on June 27, 2018. We believe our cost of goods sold for the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 would have been $0.3.9 million and $04.76 million higher, respectively, if we had not previously expensed certain material and production costs with respect to the units sold. As of ~~December~~March 31, ~~2018~~2019, we had approximately $1511.43 million of inventory on hand that was previously expensed as research and development expense and will not be reported as cost of goods sold in future periods when sales of BRAFTOVI +and MEKTOVI are recognized as revenue.

Recently Adopted Accounting Standards

In May 2014, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2014-09, "Revenue from Contracts with Customers (Topic 606)" ("ASU 2014-09") and has subsequently issued a number of amendments to ASU 2014-09 (collectively, "ASC 606"). The new standard, as amended, requires entities to recognize revenue from the transfer of promised goods or services to customers based on the amount of the consideration to which the entity expects to be entitled to receive in exchange for those goods or services.

The new standard was effective for us on July 1, 2018, prior to our first commercial product sale, and we elected to adopt it using a modified retrospective transition method applied only to contracts that were not completed as of July 1, 2018. Our adoption of ASU 2014-09 did not require any cumulative effect adjustment to opening ~~retained~~accumulated ~~earnings~~deficit as of July 1, 2018 and did not have a material impact on our unaudited condensed consolidated financial statements.

We have examined our revenue recognition policies and contracts related to our collaboration, co-development and product revenue streams to determine the impact of the new standard using the five-step process prescribed by ASC 606 and recognize revenue for our categories of revenue as follows:

Product sales: Revenue from product sales is recognized when our performance obligations are satisfied, which is when customers obtain control of our product and occurs at a point in time, typically upon delivery.12

Licenses of intellectual property: If the license granted to our intellectual property is determined to be a discrete performance obligation from the other performance obligations identified in the arrangement, we recognize revenue from non-refundable, upfront fees allocated to the license when the license is transferred to the licensee and the recipient of the license is able to use and benefit from the license. For licenses that are determined to not be distinct from other performance obligations, such as development activities, we recognize revenue over time, using an input method as the related performance obligations are satisfied.

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~~Upfront~~Product ~~payments~~sales: ~~are~~Revenue ~~recorded~~from asproduct ~~deferred~~sales ~~revenue~~is ~~upon~~recognized ~~receipt~~when ~~and~~our performance obligations are ~~recognized~~satisfied, aswhich ~~revenue~~is ~~during~~when ~~subsequent~~customers ~~periods~~obtain ascontrol of our ~~performance~~product ~~obligations~~and ~~are~~occurs ~~met.~~at a point in time, typically upon delivery.

Milestone payments: Developmental and regulatory milestone payments generally relate to performance obligations that have been completed in the past and are recognized as revenue in the period in which the milestone is achieved and material risk of reversal of revenue has passed. Due to the uncertainty of drug development and the high historical failure rates generally associated with drug development, we may not receive any additional milestone payments under our agreements. We reevaluate the likelihood of achieving future milestones at the end of each reporting period. If the risk of significant reversal is resolved, future milestone revenue from an arrangement will be recognized as revenue in the period the risk is relieved. Adoption of ASC 606 has the effect of accelerating recognition of revenue for certain commercial milestone payments as compared to the legacy accounting guidance.

Product royalty and commercial milestone ~~revenues~~revenue: We have entered into arrangements that include sales-based royalties or commercial milestone payments for which the license is deemed to be the predominant item to which the royalties or milestones relate. We recognize revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty was allocated has been satisfied (or partially satisfied).

In August 2016, the FASB issued ASU No. 2016-15, "Statement of Cash Flows (Topic 230)" ("ASU 2016-15"). This amendment provides guidance on the presentation and classification of specific cash flow items to improve consistency within the statement of cash flows. ASU 2016-15 is effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2017, with early adoption permitted. We adopted the new standard on July 1, 2018 and did not have a material impact on our consolidated financial statements.

In May 2017, the FASB issued ASU 2017-09, "Compensation - Stock Compensation (Topic 718): Scope of Modification Accounting" ("ASU 2017-09"), which clarifies when to account for a change to the terms or conditions of a share-based payment award as a modification. Under the new guidance, modification accounting is required only if the fair value, the vesting conditions, or the classification of the award (as equity or liability) changes as a result of the change in terms or conditions. ASU 2017-19 is effective prospectively for the annual period ending June 30, 2019 and interim periods within that annual period. Early adoption is permitted. We adopted the new standard on July 1, 2018 and did not have a material impact on our consolidated financial statements.

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Recently Issued Accounting Standards

In February 2016, the FASB issued ASU No. 2016-02, "Leases (Topic 842)" ("ASU 2016-02") which supersedes FASB ASC Topic 840, Leases (Topic 840) and provides principles for the recognition, measurement, presentation and disclosure of leases for both lessees and lessors. In July 2018, the FASB issued ASU 2018-11, “Leases (Topic 842): Targeted Improvements” and ASU 2018-10, “Codification Improvements to Topic 842, Leases.” ASU 2016-02 and the subsequent modifications are identified as “ASC 842.” The new standard requires lessees to apply a dual approach, classifying leases as either finance or operating leases based on the principle of whether or not the lease is effectively a financed purchase by the lessee. This classification will determine whether lease expense is recognized based on an effective interest method or on a straight-line basis over the term of the lease, respectively. A lessee is also required to record a right-of-use asset and a lease liability for all leases with a term of greater than twelve months regardless of classification. Leases with a term of twelve months or less will be accounted for similar to existing guidance for operating leases. The standard is effective for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2018, with early adoption permitted upon issuance. We are currently evaluating the impact that ASU 2016-02 will have on our unaudited condensed consolidated financial statements and related disclosures and plan to adopt the new standard on July 1, 2019. We expect to record new right of use assets and lease liabilities, but do not expect the new standard to have a material impact on our consolidated financial statements.

In November 2018, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update No. 2018-18, “Collaborative Arrangements (Topic 808): Clarifying the Interaction between Topic 808 and Topic 606” (“ASU 2018-18”). The standard provides guidance on the interaction between Revenue Recognition (Topic 606) and Collaborative Arrangements (Topic 808) by aligning the unit of account guidance between the two topics and clarifying whether certain transactions between collaborative participants should be accounted for as revenue under Topic 606. ASU 2018-18 is effective for fiscal years beginning after December 15, 2019, and interim periods within those fiscal years. We are currently evaluating the impact ASU 2018-18 will have on our unaudited condensed consolidated financial statements and related disclosures, but do not expect it to have a material impact on our consolidated financial statements.

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NOTE 2 – MARKETABLE SECURITIES

Marketable securities consisted of the following as of ~~December~~March 31, ~~2018~~2019 and June 30, 2018 (in thousands):

	December 31, 2018
	March 31, 2019
			Gross		Gross
	Amortized		Unrealized		Unrealized			Fair
	Cost		Gains		Losses			Value
Short-term available-for-sale securities:
U.S. treasury securities	$	~~198~~123,~~762~~149	$	—	$	(983	)	$	~~198~~123,~~664~~146
Commercial paper	~~101~~110,~~533~~478		—		—			~~101~~110,~~533~~478
Corporate bonds	1961,~~913~~713		—60		~~(16~~—		)	1961,~~897~~773
Asset-backed securities	930,~~648~~727		532		—			930,~~653~~759
Mutual fund securities	~~217~~296		—		—			~~217~~296
	330,073		5		(114		)	329,964
	326,363		92		(3		)	326,452
Long-term available-for-sale securities:
Mutual fund securities	1,095		—		—			1,095
Corporate bonds	32,421		44		—			32,465
	1,095		—		—			1,095
Asset-backed securities	22,721		32		—			22,753
Total	$	331,168	$	5	$	(114	)	$	331,059
Mutual fund securities	790		—		—			790
	55,932		76		—			56,008
Total	$	382,295	$	168	$	(3	)	$	382,460

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	June 30, 2018
			Gross		Gross
	Amortized		Unrealized		Unrealized			Fair
	Cost		Gains		Losses			Value
Short-term available-for-sale securities:
U.S. treasury securities	$	297,965	$	—	$	(461	)	$	297,504
Mutual fund securities	235		—		—			235
	298,200		—		(461		)	297,739
Long-term available-for-sale securities:
Mutual fund securities	919		—		—			919
	919		—		—			919
Total	$	299,119	$	—	$	(461	)	$	298,658

The mutual fund securities shown in the above tables are securities held under the Array BioPharma Inc. Deferred Compensation Plan.

As of ~~December~~March 31, ~~2018~~2019, the amortized cost and estimated fair value of available-for-sale debt securities by contractual maturity were as follows (in thousands):

	Amortized		Fair
	Cost		Value
Due in one year or less	$	~~329~~326,~~856~~067	$	~~329~~326,~~747~~156
Due in one to three years	55,142		55,218
Total	$	381,209	$	381,374

NOTE 3 – PRODUCT REVENUE

Our commercial stage products include BRAFTOVI ~~and~~+ MEKTOVI, which received FDA approval on June 27, 2018 as a combination therapy for the treatment of patients with unresectable or metastatic melanoma with BRAFV600E or BRAFV600K mutation, as detected by an FDA-approved test.

We record gross-to-net sales accruals for rebates, chargebacks, discounts, estimated product returns and other allowances that are offered within contracts between us and our Customers and other indirect customers relating to the sales of our products.

Our provisions for discounts, early payments, rebates, sales returns, distributor service fees and chargebacks, and other incentives are under terms that are customary in the industry and are provided for in the same period in which the related sales are recorded.

13Net product revenue by product for the three and nine months ended March 31, 2019 was as follows (in thousands):



	Three Months Ended March 31, 2019		Nine Months Ended March 31, 2019
BRAFTOVI	$	17,351	$	35,737
MEKTOVI	17,727		36,047
Total net product sales	$	35,078	$	71,784

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~~Net~~Gross-to-net ~~product~~sales ~~revenues~~accruals byand ~~product~~the ~~for~~balance in the ~~three~~related ~~and~~allowance ~~six~~accounts for the nine months ended ~~December~~March 31, ~~2018~~2019 ~~was~~were as follows (in thousands):

	Three Months Ended December 31, 2018				Six Months Ended December 31, 2018
	Returns			Other			Total
BRAFTOVI	$	11,371			$	18,386
Balance as of June 30, 2018	$	—		$	—		$	—
MEKTOVI	11,342				18,320
Allowances for sales during prior periods	—			—			—
Total net product sales	$	22,713			$	36,706
Allowances for sales during the current period	129			14,592			14,721
Credits/deductions issued for prior year sales	—			—			—
Credits/deductions issued for sales during the current period	(26		)	(9,507		)	(9,533		)
Balance as of March 31, 2019	$	103		$	5,085		$	5,188

~~Gross~~There were no product sales or gross-to-net ~~sales~~ accruals ~~and~~during the ~~balance~~three inand ~~the~~nine ~~related allowance accounts for the six~~ months ended ~~December~~March 31, 2018 ~~were as follows (in thousands):~~ .

	Returns			Other			Total
Balance as of June 30, 2018	$	—		$	—		$	—
Allowances for sales during prior periods	—			—			—
Allowances for sales during the current period	67			7,950			8,017
Credits/deductions issued for prior year sales	—			—			—
Credits/deductions issued for sales during the current period	(26		)	(5,155		)	(5,181		)
Balance as of December 31, 2018	$	41		$	2,795		$	2,836

There were no product sales or gross-to-net accruals during the three and six months ended December 31, 2017.

NOTE 4 – COLLABORATION AND OTHER AGREEMENTS

The following table summarizes total revenue recognized for the periods indicated (in thousands):

	Three Months Ended				~~Six~~Nine Months Ended
	December 31,				December 31,
	March 31,				March 31,
	2018		2017		2018		2017
	2019		2018		2019		2018
Product royalties
Pierre Fabre	$	835	$	—	$	1,159	$	—
Ono	102		—		102		—
Total product royalties	$	937	$	—	$	1,261	$	—
Collaboration and other revenue
Pierre Fabre	$	510,~~427~~704	$	35,~~674~~347	$	1122,~~456~~160	$	712,~~023~~370
Loxo	—		2,395		2,403		4,653
Mirati	1,500		1,376		3,710		4,187
Mirati	1,216		1,422		2,210		2,811
Loxo	—		2,416		2,403		7,069
Other partners	~~1,806~~561		~~1,017~~974		23,~~490~~050		23,~~029~~003
Total collaboration and other revenue	812,~~449~~765		810,~~508~~113		1831,~~559~~323		1626,~~516~~629
License and milestone revenue
Loxo	~~40,000~~—		—		44,000		1,107
Pierre Fabre	~~1,074~~750		750		1617,~~824~~250		12,~~500~~250
Ono	~~918~~4,596		~~919~~4,665		16,~~836~~433		16,~~837~~502
Asahi Kasei	—		9,437		—		10,000
ASLAN	—		23,000		—		23,000
Other partners	482		209		732		417
Asahi Kasei	—		—		—		10,000
Total license and milestone revenue	42,474		11,315		63,392		14,861
Other partners	1,382		3,088		2,115		3,505
Total collaboration and license revenue	$	50,924	$	19,823	$	81,952	$	31,377
Total license and milestone revenue	6,728		31,503		69,798		46,364
Total collaboration and license revenue	$	19,493	$	41,616	$	101,121	$	72,993
Reimbursement revenue
Novartis	$	89,~~912~~169	$	2224,~~395~~751	$	2029,~~801~~970	$	4065,~~587~~338

14Product royalties

Product royalties consists of royalty revenue based on international sales of BRAFTOVI and MEKTOVI, which are marketed by Array in the U.S. We have granted Pierre Fabre and Ono Pharmaceutical Co. Ltd. (“Ono”) exclusive rights to commercialize both products in their respective territories outside of the United States and we receive royalty payments based on those sales. The Pierre Fabre and Ono agreements, including our royalty rights are described below.

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Collaboration and License Revenue

Collaboration and license revenue consists of revenue related to our drug discovery and development activities in collaboration with partners, which includes reimbursement for research and development of drug candidates that we out-license, up-front and milestone fees and ongoing royalty revenue based on sales by license holders of products which we have wholly out-licensed and are not marketed by Array. Currently approved and marketed products that we have out-licensed and have royalty rights to include Vitrakvi and Ganovo. To date, royalties earned based on sales of Vitrakvi and Ganovo have not been material.

The terms of our collaboration and license agreements include substantial ongoing collaboration and cost-sharing activities between the companies and may require us to perform future development and commercialization activities. In accordance with the revenue recognition criteria under ASC 606, Revenue from Contracts with Customers, we identified the following performance obligations in each of the following collaboration agreements, excluding Loxo: (1) the license rights and (2) clinical development and other services. For each agreement, we determined that the license rights are not distinct from the clinical development and other activities, and as such, are combined with certain other activities to form a performance obligation. Accordingly, any non-refundable upfront payments received under the agreements have been recorded as deferred revenue and are being recognized over the period during which management expects that substantial development activities will be performed.

We re-evaluate the likelihood of achieving future milestones at the end of each reporting period. Any remaining future milestone payments discussed in this Quarterly Report on Form 10-Q are related to performance obligations that have been not yet been satisfied. If the risk of significant reversal for a milestone becomes resolved in the future, then the revenue associated with the respective milestone will be recognized in the ~~the~~ period the risk is removed.

Pierre Fabre

On November 10, 2015, we entered into an agreement with Pierre Fabre (the "PF Agreement") pursuant to which we granted Pierre Fabre rights to commercialize encorafenib and binimetinib in all countries except for the U.S., Canada, Japan, Korea and Israel, where we retain our ownership rights (subject to rights granted to Ono Pharmaceutical Co., Ltd. ("Ono") under the agreement with Ono) and to Medison Pharma Ltd. The PF Agreement closed in December 2015.

The PF Agreement closed in December 2015 (the "Effective Date"). All clinical trials involving encorafenib and binimetinib that were ongoing or planned at the Effective Date, including the COLUMBUS trial and other then-ongoing Novartis sponsored and investigator sponsored clinical studies, continued to be conducted pursuant to the terms of the Novartis Agreements. Further worldwide development activities are governed by a Global Development Plan ("GDP") with Pierre Fabre. Pierre Fabre will jointly fund worldwide development costs under the GDP, with Array covering 60% and Pierre Fabre covering 40% of such costs.

In connection with the PF Agreement, we received a $30.0 million upfront payment during the year ended June 30, 2016 which has been recorded as deferred revenue and is being recognized through 2025, which is the period through which management expects that substantial development activities will be performed. In September 2018, we earned a $15.0 million milestone under the PF Agreement upon regulatory approval in the European Union, which was fully recognized as collaboration and license revenue during the period.

The PF Agreement contains additional substantive potential milestone payments of up to $390.0 million for achievement of seven commercialization milestones if certain net sales amounts are achieved for any licensed indications. We are further eligible for multiple tiered double-digit royalties on annual net sales of encorafenib and binimetinib in the PF territory, starting at 20% for annual net sales under €50.0 million and increasing to 35% for annual net sales in excess of €100.0 million subject to certain adjustments of up to $15.0 million cumulative for costs incurred to achieve or maintain the Marketing Authorization Application ("MAA") in Europe which can reduce royalties due to us by up to 50%.

Ono Pharmaceutical Co., Ltd.

Effective May 31, 2017, we entered into a License, Development and Commercialization Agreement (the “Ono Agreement”) with Ono, pursuant to which we granted Ono exclusive rights to commercialize encorafenib and binimetinib in Japan and the Republic of Korea (the “Ono Territory”), along with the right to develop these products in the Ono Territory. We retain all rights outside the Ono Territory, as well as the right to conduct development and manufacturing activities in the Ono Territory, except rights we have granted to Pierre Fabre under the PF Agreement and to Medison Pharma Ltd.

~~All~~Under ~~ongoing clinical trials involving encorafenib and binimetinib, including~~ the ~~BEACON~~terms ~~CRC and COLUMBUS trials, continued as planned as~~ of the ~~effective date of the~~ Ono Agreement, ~~and~~we ~~Ono~~received isa ~~entitled~~non-refundable toupfront ~~the~~cash ~~data~~payment ~~derived~~of ~~from such studies~~¥3.5 Asbillion, ~~part~~or of$31.2 ~~the Ono Agreement~~million, ~~Ono~~and ~~obtained~~we ~~the~~retain ~~right~~all rights to ~~participate~~conduct, ineither ~~any~~on ~~future~~our ~~global~~own ~~development~~or ofthrough ~~encorafenib~~third ~~and~~parties, ~~binimetinib~~all byclinical ~~contributing~~studies ~~12%~~and offile ~~those~~related ~~future~~regulatory ~~costs.~~filings ~~Ono~~with isrespect ~~responsible~~to ~~for seeking, and for any development of~~ encorafenib and binimetinib ~~specifically~~and ~~necessary~~ to ~~obtain~~develop, ~~regulatory~~manufacture and ~~marketing~~commercialize ~~approvals~~encorafenib ~~for~~and ~~products~~binimetinib inoutside the Ono Territory. We(subject ~~will furnish clinical supplies of drug substance~~ to ~~Ono~~rights ~~for~~we ~~use in Ono’s development efforts, and Ono may elect to~~ have usgranted ~~provide commercial supplies of drug product~~ to ~~Ono~~Pierre ~~pursuant~~Fabre ~~to a commercial supply agreement to be entered into between Ono and us,~~ in ~~each~~certain ~~case the costs of which will be borne by Ono.~~

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countries). The upfront payment has been recorded as deferred revenue and is being recognized through 2025 which is the period through which management expects that substantial development activities will be performed. We ~~have~~are ~~also~~entitled ~~agreed~~to receive potential milestone payments of up to ~~discuss~~¥500.0 ~~and~~million ~~agree~~for onthe aachievement ~~strategy~~of ~~with~~one ~~Ono~~remaining development milestone, ¥5.0 billion for the achievement of eight regulatory milestones relating to ~~ensure~~certain Marketing Authorization Application filings and approval in Japan for two specified indications, and ¥10.5 billion for the ~~supply~~achievement of five commercialization milestones if certain annual net sales targets are achieved. A portion of these milestones is related to ~~Ono~~the advancement of ~~companion~~the ~~diagnostics~~Phase 3 BEACON CRC trial in the Ono Territory. We are further eligible for ~~use~~tiered ~~with~~double-digit royalties on annual net sales of encorafenib and binimetinib in ~~certain~~the ~~indications~~Ono Territory, starting at 22% for annual net sales under ¥10.0 billion and increasing to 25% for annual net sales in excess of ¥10.0 billion subject to certain adjustments. As of March 31, 2019, ¥1.0 billion was the ~~Ono~~equivalent ~~Territory~~of approximately $9.0 million.

Under the terms of the Ono Agreement, we received a non-refundable upfront cash payment of ¥3.5 billion, or $31.2 million, and we retain all rights to conduct, either on our own or through third parties, all clinical studies and file related regulatory filings with respect to encorafenib and binimetinib and to develop, manufacture and commercialize encorafenib and binimetinib outside the Ono Territory (subject to rights we have granted to Pierre Fabre in certain countries). The upfront payment has been recorded as deferred revenue and is being recognized through 2025 which is the period through which management expects that substantial development activities will be performed. We are entitled to receive potential milestone payments of up to ¥900.0 million for the achievement of two remaining development milestones, ¥5.0 billion for the achievement of eight regulatory milestones relating to certain Marketing Authorization Application filings and approval in Japan for two specified indications, and ¥10.5 billion for the achievement of five commercialization milestones if certain annual net sales targets are achieved. A portion of these milestones is related to the advancement of the Phase 3 BEACON CRC trial in the Ono Territory. We are further eligible for tiered double-digit royalties on annual net sales of encorafenib and binimetinib in the Ono Territory, starting at 22% for annual net sales under ¥10.0 billion and increasing to 25% for annual net sales in excess of ¥10.0 billion subject to certain adjustments. As of December 31, 2018, ¥1.0 billion was the equivalent of approximately $9.1 million.

Loxo

We are party to a Drug Discovery Collaboration Agreement, as amended, with Loxo (the “Loxo Agreement”). Under the terms of the Loxo Agreement, Loxo funded discovery and preclinical programs conducted by us, including LOXO-101, which is currently marketed as Vitrakvi, LOXO-195, a next generation selective TRK inhibitor, LOXO-292, a RET inhibitor, and FGFR programs (the "Loxo Programs"). The research phase concluded in September 2018. Loxo is responsible for all additional preclinical and clinical development and commercialization. In connection with Eli Lilly's February 2019 acquisition of Loxo, Bayer secured exclusive licensing rights for the global development and commercialization of Vitrakvi and LOXO-195. The licensing agreement between Array and Loxo remains in effect, and Array remains entitled to royalties on sales of Vitrakvi.

We identified the following performance obligations: (1) the conduct of the research activities under the discovery program, including related technology transfer (the "research services deliverable"), (2) an exclusive worldwide license granted to Loxo to certain of our technology and our interest in collaboration technology, as well as exclusive worldwide marketing rights (the "license deliverable") and (3) participation on the Joint Research Committee ("JRC"). The Loxo Agreement provides for no general right of return for any non-contingent performance obligation. All the identified non-contingent performance obligations were considered distinct; therefore they are treated as separate performance obligations. Delivery of the research services and JRC participation obligations were completed throughout the research discovery program term. The license deliverable was complete as of September 30, 2013.

~~During~~In ~~the~~August ~~three months ended September 30,~~ 2018, we earned a $4.0 million milestone under the Loxo Agreement for the initiation of a registration enabling study for LOXO-292, which was fully recognized as collaboration and license revenue during the period. ~~During~~In ~~the three months ended~~ December ~~31,~~ 2018, we recognized milestone revenue of $40.0 million related to the first commercial sale of Vitrakvi by Loxo. We received a $20.0 million cash payment ~~during~~in ~~the three months ended~~ December ~~31,~~ 2018 and will receive two additional payments of $10.0 million on each of the one year and two year anniversaries of the first commercial sale. In accordance with ASC 606, we recognized the entire $40.0 million asin ~~revenue during the three months ended~~ December ~~31,~~ 2018 as our performance obligations have been satisfied, payment is contingent upon only the passage of time, and we determined that it is not probable that a significant reversal of revenue would occur. The $20.0 million of additional payments are reflected as $10.0 million in other current assets and $10.0 million in other non-current assets in our unaudited condensed consolidated balance ~~sheet~~sheets as of ~~December~~March 31, ~~2018~~2019.

The Drug Discovery Collaboration Agreement with Loxo contains substantive potential milestone payments of up to $7.0 million for two remaining development milestones and up to $595.0 million for the achievement of twenty commercialization milestones if certain net sales amounts are achieved for any licensed drug candidates in the U.S., the European Union and Japan plus mid-to-high single digit royalties on sales of any resulting drugs subject to certain adjustments.

Mirati

We are party to agreements with Mirati Therapeutics, Inc. ("Mirati" and the "Mirati Agreements"). During April 2018, Mirati elected to exercise an option to take an exclusive, worldwide license to an active compound under one such agreement for which we received $2.0 million and we continue to receive additional fees as reimbursement for research and development services. The option exercise fee, received in the three months ended June 30, 2018, was recorded

16Mirati is developing MRTX849, a small molecule inhibitor of KRAS G12C, invented by Array and Mirati Therapeutics. Mirati is evaluating MRTX849 in a Phase 1/2 clinical trial in patients with advanced solid tumors that harbor KRAS G12C mutations. Array and Mirati are also collaborating on a KRAS G12D inhibitor preclinical program. Array has freedom to operate on all other forms of Ras proteins.

In April 2018, Mirati elected to exercise an option to take an exclusive, worldwide license to an active compound under one such agreement for which we received $2.0 million and we continue to receive additional fees as reimbursement for research and development services. The option exercise fee, received in the three months ended

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June 30, 2018, was recorded as deferred revenue and is being recognized as revenue over two years, the period during which we expect that substantial development activities will be performed.

The Mirati Agreements contain substantive potential milestone payments of up to $1817.3 million for ~~seven~~six remaining developmental milestones and up to $674.0 million for the achievement of fourteen commercialization milestones if certain net sales amounts are achieved in the U.S., the European Union and Japan, plus royalties in the high single digits to mid-teens on sales.

Dr. Charles Baum, a current member of our Board of Directors, is the President and Chief Executive Officer of Mirati.

Other Collaboration Arrangements

In addition to the collaboration arrangements described above, we have entered into a number of other collaborative arrangements that include the potential for us to receive future milestone payments of up to $48.5 million for development milestones, up to $73.0 million for regulatory milestones, up to $159.5 million for sales milestones over a period of several years in addition to royalties on potential future product sales. Our ability to receive payments under these collaborations is contingent upon our collaboration partners' continued involvement in the programs and the lack of any adverse events which could cause the discontinuance of the programs.

Deferred Revenue

Deferred revenue balances were as follows for the dates indicated (in thousands):

	December 31,			June 30,
	March 31,			June 30,
	2018			2018
	2019			2018
Ono	$	2524,~~718~~799		$	27,555
Pierre Fabre (1)	2526,~~982~~098			22,394
Mirati	1,~~292~~042			2,468
Loxo	—			2,403
Other	—			2,000
Total deferred revenue	5251,~~992~~939			56,820
Less: Current portion	(1213,~~761~~627		)	(12,350		)
Deferred revenue, long-term portion	$	40,231		$	44,470
Deferred revenue, non-current portion	$	38,312		$	44,470

(1) Balance as of March 31, 2019 includes a $6.0 million prepayment for commercial drug supply of BRAFTOVI + MEKTOVI

Reimbursement Revenue

On March 2, 2015 ~~(the "Effective Date")~~, we regained development and commercialization rights to binimetinib under the Termination and Asset Transfer Agreement with Novartis and to encorafenib under the Asset Transfer Agreement with Novartis (which we collectively refer to as the “Novartis Agreements”). Along with global ownership of both assets, the Novartis Agreements transferred to us a 2% royalty obligation offset by certain expenses, which is payable based on net sales of encorafenib and is expensed as costs of goods sold as incurred.

Amounts provided by Novartis related to the development and commercialization of binimetinib and encorafenib are reported as reimbursement revenue on our unaudited condensed consolidated statements of operations. See Note 3 of Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018 for additional details related to our agreements with Novartis related to encorafenib and binimetinib.

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NOTE 5 – DEBT

Outstanding debt consists of the following (in thousands):

	December 31,			June 30,
	March 31,			June 30,
	2018			2018
	2019			2018
Notes payable at fair value	$	—		$	15,899
2024 convertible senior notes	$	126,060		$	126,060
Silicon Valley Bank term loan (1)	53,500			16,200
Long-term debt, gross	179,560			142,260
Less: Unamortized debt discount and fees	(4645,~~906~~315		)	(46,384		)
Long-term debt, net	~~132~~134,~~654~~245			95,876
Less: Current portion	—			(2,500		)
Long-term debt, non-current portion	$	~~132~~134,~~654~~245		$	93,376

(1) Outstanding debt owed to Silicon Valley Bank includes a final payment fee of $3.5 million and $1.2 million as of ~~December~~March 31, ~~2018~~2019 and June 30, 2018, respectively.

Redmile Notes Payable

On August 6, 2018, the Subordinated Convertible Promissory Notes (the "Redmile Notes Payable") held by Redmile Capital Offshore Fund II, Ltd. and Redmile Biopharma Investments I, L.P. (collectively, “Redmile”) matured and became payable pursuant to the Note Purchase Agreement dated September 2, 2016, as amended. On that date, we repaid $16.0 million to the Note holders, which included the $10.0 million principal, a $5.0 million exit fee and approximately $1.0 million accrued interest. Following the repayment of the Redmile Notes Payable, we had no notes payable recorded at fair value.

Silicon Valley Bank Term Loan

On August 10, 2018 (the “Amended Effective Date”), we entered into an Amended and Restated Loan and Security Agreement (the “Amended Loan Agreement”) with Silicon Valley Bank ("SVB") providing for a term loan in the original principal amount of $50.0 million and maintaining our existing letters of credit with SVB. The Amended Loan Agreement amends and restates our prior Loan and Security Agreement (the "Loan Agreement") with SVB. We utilized the proceeds from the term loan for repayment in full of all outstanding obligations under ~~our~~the ~~prior~~ Loan Agreement with SVB, repayment in full of our obligations under the Redmile Notes Payable, and as working capital to fund general business requirements. The entire term loan amount was borrowed on the Amended Effective Date.

The outstanding principal amount under the term loan bears interest at a floating per annum rate equal to the Prime Rate minus 2.0% (but not less than 0.0%) and was 3.5% as of ~~December~~March 31, ~~2018~~2019. We must make monthly payments of interest under the term loan commencing with the first month after the Amended Effective Date until maturity and, commencing on September 1, 2020 and monthly thereafter, we must make payments of principal under the term loan based on a thirty-six-month amortization schedule. A final payment of principal, accrued interest on the term loan and on any outstanding advances, as well as the final payment fee associated with the Amended Loan Agreement of $3.5 million are due on the maturity date of August 1, 2023. The resulting debt discount is being recognized using the effective interest method over the term of the loan. In accordance with ASC 470-50, we accounted for the exchange as a debt modification and the issuance costs paid to SVB associated with the Amended Loan Agreement were recorded as debt discount and were added to the remaining unamortized debt discount associated with prior Loan Agreement.

We granted SVB a first priority security interest in all of our assets other than our intellectual property, provided that accounts and proceeds of our intellectual property constitutes collateral and we have agreed not to encumber our intellectual property without SVB’s consent. The Amended Loan Agreement contains customary covenants, including restrictions on changes in control of Array, the incurrence of additional indebtedness, future encumbrances on our assets, the payment of dividends or distributions on our common stock and the sale, lease, transfer or disposition of encorafenib and binimetinib outside of certain markets if our cash and cash equivalents maintained with SVB fall below certain levels. In addition, we must maintain a liquidity ratio, defined as (i) our unrestricted cash and cash equivalents divided by (ii) all of our outstanding obligations owed to SVB, of at least 2.00 to 1.00, measured monthly.19

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2.625% Convertible Senior Notes Due 2024

On December 1, 2017, we issued and sold $126.1 million aggregate principal amount of 2.625% convertible senior notes due 2024 (the "2024 Notes") in exchange for our now -retired 2020 Notes. The 2024 Notes are our direct unsecured obligations and rank equal in right of payment with all of our other existing and future unsecured and unsubordinated indebtedness. The 2024 Notes are effectively subordinated to any of our existing and future secured indebtedness, including our indebtedness under the Amended Loan Agreement with SVB, to the extent of the value of our assets that secure such indebtedness.

The 2024 Notes will mature on December 1, 2024 and bear interest at a rate of 2.625%, payable semiannually in arrears on June 1 and December 1 of each year, beginning on June 1, 2018.

In accordance with ASC 470-20, we used an effective interest rate of 9.75% to determine the liability component of the 2024 Notes. This resulted in the recognition of $80.4 million as the liability component of the 2024 Notes and the recognition of the residual $45.7 million as the debt discount with a corresponding increase to additional paid-in capital for the equity component of the 2024 Notes. The underwriting discount and estimated offering expenses of $4.3 million were allocated between the debt and equity issuance costs in proportion to the allocation of the liability and equity components of the 2024 Notes. Equity issuance costs of $1.6 million were recorded as an offset to additional paid-in capital. Total debt issuance costs of $2.7 million were recorded on the issuance date and are reflected in our unaudited condensed consolidated balance sheets for all periods presented on a consistent basis with the debt discount, or as a direct deduction from the carrying value of the associated debt liability. The debt discount and debt issuance costs will be amortized as non-cash interest expense through December 1, 2024. The balance of unamortized debt issuance costs was $2.4 million and $2.6 million as of ~~December~~March 31, ~~2018~~2019 and June 30, 2018, respectively.

The fair value of the 2024 Notes was approximately $~~152~~216.96 million and $169.0 million at ~~December~~March 31, ~~2018~~2019 and June 30, 2018, respectively, and was determined using Level 2 inputs based on their quoted market values.

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Summary of Interest Expense

The following table shows the details of our interest expense for all of our debt arrangements outstanding during the periods presented, including contractual interest, and amortization of debt discount, debt issuance costs and loan transaction fees that were charged to interest expense (in thousands):

	Three Months Ended				~~Six~~Nine Months Ended
	December 31,				December 31,
	March 31,				March 31,
	2018		2017		2018		2017
	2019		2018		2019		2018
Silicon Valley Bank Term Loan
Simple interest	~~402~~431		87100		$	~~685~~1,115	$	~~180~~280
Amortization of prepaid fees for line of credit	~~260~~—		4414		~~430~~29		8599
Amortization of debt discount	14257		8180		29688		~~162~~242
Total interest expense on the Silicon Valley Bank term loan	676		212		1,144		427
Total interest expense on Silicon Valley Bank term loan	688		194		1,832		621
Convertible Senior Notes (1)
Contractual interest	835		~~896~~835		12,~~670~~505		12,~~889~~723
Amortization of debt discount	1,~~227~~257		1,~~512~~141		23,~~425~~682		34,~~291~~432
Amortization of debt issuance costs	7476		8769		~~147~~223		~~187~~257
Total interest expense on convertible senior notes	2,~~136~~168		2,~~495~~045		46,~~242~~410		57,~~367~~412
Other Debt
Simple interest	$7	6	$122	~~126~~	1219		~~252~~374
Total interest expense on other debt	67		~~126~~122		1219		~~252~~374
Total interest expense	$	2,~~818~~863	$	2,~~833~~361	$	58,~~398~~261	$	68,~~046~~407

(1) Includes the 2024 Notes and 2020 Notes (retired)

1921

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NOTE 6 – FAIR VALUE MEASUREMENTS

We use the following three-level hierarchy that maximizes the use of observable inputs and minimizes the use of unobservable inputs to value our financial instruments:


•	Level 1: Observable inputs such as unadjusted quoted prices in active markets for identical instruments.


•	Level 2: Quoted prices for similar instruments that are directly or indirectly observable in the marketplace.


•	Level 3: Significant unobservable inputs which are supported by little or no market activity and that are financial instruments whose values are determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires significant judgment or estimation.

Financial instruments measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. Our assessment of the significance of a particular input to the fair value measurement in its entirety requires us to make judgments and consider factors specific to the asset or liability. The use of different assumptions and/or estimation methodologies may have a material effect on estimated fair values. Accordingly, the fair value estimates disclosed or initial amounts recorded may not be indicative of the amount that we or holders of the instruments could realize in a current market exchange.

The following tables show the fair value of our financial instruments classified into the fair value hierarchy and measured on a recurring basis on the unaudited condensed consolidated balance sheets as of ~~December~~March 31, ~~2018~~2019 and June 30, 2018 (in thousands):

	Fair Value Measurement as of December 31, 2018
	Fair Value Measurement as of March 31, 2019
	Level 1		Level 2		Level 3		Total
Assets
Current Assets
U.S. treasury securities	$	—	$	~~198~~123,~~664~~146	$	—	$	~~198~~123,~~664~~146
Commercial paper	—		~~101~~110,~~533~~478		—		~~101~~110,~~533~~478
Corporate bonds	—		1961,~~897~~773		—		1961,~~897~~773
Asset-backed securities	—		930,~~653~~759		—		930,~~653~~759
Mutual fund securities	~~217~~296		—		—		~~217~~296
Long-term Assets
Non-current Assets
Mutual fund securities	1,095		—		—		1,095
Corporate bonds	—		32,465		—		32,465
Total assets	$	1,312	$	329,747	$	—	$	331,059
Asset-back securities	—		22,753		—		22,753
Mutual fund securities	790		—		—		790
Total assets	$	1,086	$	381,374	$	—	$	382,460

	Fair Value Measurement as of June 30, 2018
	Level 1		Level 2		Level 3		Total
Assets
Current Assets
U.S. treasury securities	$	297,504	$	—	$	—	$	297,504
Mutual fund securities	235				—		235
Long-term Assets
Non-current Assets
Mutual fund securities	919		—		—		919
Total assets	$	298,658	$	—	$	—	$	298,658
Liabilities
Notes payable, at fair value	$	—	$	—	$	15,899	$	15,899

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Our debt-based marketable securities are classified as level 2 within the valuation hierarchy. We estimate the fair values of these marketable securities by taking into consideration valuations obtained from third-party pricing sources. These pricing sources utilize industry standard valuation models, including both income and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. During the three months ended December 31, 2018, we diversified our investment portfolio and are classifying our investments in debt securities, including U.S. treasury securities, as Level 2 securities.

The table below provides a rollforward of the changes in fair value of Level 3 financial instruments for the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019, comprised of the Redmile Notes (in thousands):

	Three Months EndedDecember 31,				Six Months EndedDecember 31,
	Three Months Ended March 31, 2019				Nine Months Ended March 31, 2019
	2018		2017		2018			2017
	2019		2018		2019			2018
Beginning balance	$	—	$	12,~~400~~700	$	15,899		$	12,600
Change in fair value	—		~~300~~100		65			~~100~~200
Settlement upon maturity	—				(15,964		)	—
Ending balance	$	—	$	12,~~700~~800	$	—		$	12,~~700~~800

NOTE 7 – STOCKHOLDERS’ EQUITY

Common Stock Offering

On September 19, 2017, the Company closed an underwritten public offering of 24.1 million shares of its common stock, which included 3.1 million shares of common stock issued upon the exercise in full of the option to purchase additional shares granted to the underwriters in the offering. The shares were sold to the public at an offering price of $10.75 per share. The total net proceeds from the offering were $243.0 million, after underwriting discounts and commissions and offering expenses of approximately $15.7 million. The Company expects to continue to use the net proceeds from this offering to fund research and development efforts, including clinical trials for ~~its~~our proprietary candidates, build and scale its commercial capabilities, and for general working capital and corporate purposes.

At-the-Market Equity Offering

We entered into a sales agreement with Cantor Fitzgerald & Co. ("Cantor") dated March 27, 2013, which has been subsequently amended to permit Cantor, acting as our sales agent, to sell shares of our common stock from time to time in an at-the-market offering ("ATM Offering"). All sales of shares have been made pursuant to an effective shelf registration statement on Form S-3 filed with the SEC.

On May 9, 2018, we entered into ~~our~~a ~~current~~subsequent sales agreement with Cantor (the "Sales Agreement"), pursuant to which we may, from time to time, sell up to $125.0 million in shares of our common stock through Cantor, acting as our sales agent and/or principal, in an ATM Offering. We ~~are~~were not required to sell shares under the Sales Agreement. We ~~will~~paid ~~pay~~ Cantor a commission of up to 3% of the aggregate gross proceeds we ~~receive~~received from all sales of our common stock under the Sales Agreement. ~~Unless otherwise terminated, the Sales Agreement continues until the earlier of selling all shares available under the Sales Agreement or May 9, 2021.~~ We received net proceeds on sales under the Sales Agreement of approximately $88122.85 million at a weighted average price of $1617.0324 (excluding commissions) during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019, which resulted in the full utilization of the $125.0 million available sales under the Sales Agreement. We received net proceeds on sales under our prior sales agreement with Cantor of approximately $240.83 million at a weighted average price of $916.0214 during the ~~six~~nine months ended ~~December~~March 31, ~~2017~~2018.

21Effective May 7, 2019, we entered into a sales agreement with Jefferies LLC (the “Jefferies Sales Agreement”), pursuant to which we may, from time to time, sell up to $150.0 million in shares of our common stock through Jefferies LLC, acting as our sales agent and/or principal, in an at-the-market offering. We are not required to sell shares under the Jefferies Sales Agreement. We will pay Jefferies LLC a commission of up to 3% of the aggregate gross proceeds we receive from all sales of our common stock under the Jefferies Sales Agreement. Unless otherwise terminated, the Sales Agreement continues until the earlier of selling all shares available under the Jefferies Sales Agreement or May 7, 2022. No sales have been made under the Jefferies Sales Agreement.

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NOTE 8 – SHARE-BASED COMPENSATION

Share-based compensation expense for all equity awards issued pursuant to the Array BioPharma Amended and Restated Stock Option and Incentive Plan (the "Option and Incentive Plan") and for estimated shares to be issued under the Employee Stock Purchase Plan ("ESPP") for the current purchase period was approximately $58.53 million and $34.27 million for the three months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018, respectively, and $1018.37 million and $813.85 million for the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018, respectively.

We use the Black-Scholes option pricing model to estimate the fair value of our share-based awards. In applying this model, we use the following assumptions:


•	Risk-free interest rate - We determine the risk-free interest rate by using a weighted average assumption equivalent to the expected term based on the U.S. Treasury constant maturity rate.


•	Expected term - We estimate the expected term of our options based upon historical exercises and post-vesting termination behavior.


•	Expected volatility - We estimate expected volatility using daily historical trading data of our common stock.


•	Dividend yield - We have never paid dividends and currently have no plans to do so; therefore, no dividend yield is applied.

Option Awards

The fair values of our employee option awards were estimated using the assumptions below, which yielded the following weighted average grant date fair values for the periods presented:

	Six Months Ended December 31, 2018
	Nine Months Ended March 31, 2019
	2018	2017
	2019	2018
Risk-free interest rate	2.75% - 3.0%	1.6% - 2.04%
Expected option term in years	3.8 - 5.1	3.98 - 4.1
Expected volatility	63.5% - 67.0%	66.1% - 67.03%
Dividend yield	0%	0%
Weighted average grant date fair value	$89.9507	$5.3781

The following table summarizes our stock option activity under the Option and Incentive Plan for the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019:

	Number ofOptions		WeightedAverageExercisePrice		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value (in thousands)
Outstanding balance at June 30, 2018	15,326,350		$	7.68
Granted	4,~~358~~576,163		$	1516.9115
Exercised	(~~702~~2,~~102~~717,053	)	$	5.1428
Forfeited	(~~309~~885,~~347~~692	)	$	910.7788
Expired	(6,000	)	$	6.22
Outstanding balance at December 31, 2018	18,667,064		$	9.66	7.9	$	94,649
Outstanding balance at March 31, 2019	16,293,768		$	10.29	7.8	$	229,659
Vested and expected to vest at December 31, 2018	18,644,842		$	9.66	7.9	$	94,477
Exercisable at March 31, 2019	5,686,232		$	6.87	6.1	$	99,541
Exercisable at December 31, 2018	7,153,673		$	6.08	6.2	$	58,480

The aggregate intrinsic value in the above table is calculated as the difference between the closing price of our common stock at ~~December~~March 31, ~~2018,~~2019 of $1424.2538 per share and the exercise price of the stock options that had strike prices below the closing price. The total intrinsic value of all options exercised was $738.65 million during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019. The total intrinsic value of all options exercised during the ~~six~~nine months ended ~~December~~March 31, ~~2017~~2018 was $1424.84 million. The grant date fair value of options that vested during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018 was $912.37 million and $67.10 million, respectively.

22As of March 31, 2019, we had approximately $60.7 million of total unrecognized compensation expense related to the unvested stock options shown in the table above, which is expected to be recognized over a weighted average period of 3.1 years.

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As of December 31, 2018, we had approximately $68.3 million of total unrecognized compensation expense related to the unvested stock options shown in the table above, which is expected to be recognized over a weighted average period of 3.3 years.

Restricted Stock Units

The Option and Incentive Plan provides for the issuance of restricted stock units ("RSUs") that each represent the right to receive one share of our common stock, cash or a combination of cash and stock, typically following achievement of time- or performance-based vesting conditions. Our RSU grants that vest subject to continued service over a defined period of time, will typically vest between one to four years, with a percentage vesting on each anniversary date of the grant, or they may be vested in full on the date of grant. Vested RSUs will be settled in shares of common stock upon the vesting date, upon a predetermined delivery date, upon a change in control of Array, or upon the employee leaving Array. All outstanding RSUs may only be settled through the issuance of common stock to recipients, and we intend to continue to grant RSUs that may only be settled in stock. RSUs are assigned the value of our common stock at date of grant, and the grant date fair value is amortized over the applicable vesting period.

The following table summarizes the status of our unvested RSUs under the Option and Incentive Plan as of ~~December~~March 31, ~~2018~~2019 and changes during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019:

	Number of RSUs		WeightedAverageGrant Date Fair Value
Unvested at June 30, 2018	959,730		$	9.28
Granted	617,518		15.87
Vested	(~~224~~252,~~294~~108	)	910.9846
Forfeited	(2164,~~084~~845	)	912.5120
Unvested at December 31, 2018	1,331,870		$	12.21
Unvested at March 31, 2019	1,260,295		$	12.12

As of ~~December~~March 31, ~~2018~~2019, we had $1513.1 million of total unrecognized compensation cost related to unvested RSUs granted under the Option and Incentive Plan. The cost is expected to be recognized over a weighted-average period of approximately 3.31 years. The fair market value for RSUs that vested during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018 was $2.26 million and $1.8 million, respectively. RSUs granted during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018 had a fair value of $9.8 million and $5.38 million, respectively.

Employee Stock Purchase Plan

The ESPP allows qualified employees (as defined in the ESPP) to purchase shares of our common stock at a price equal to 85% of the lower of (i) the closing price at the beginning of the offering period or (ii) the closing price at the end of the offering period. Effective each January 1, a new 12-month offering period begins that will end on December 31 of that year. However, if the closing stock price on July 1 is lower than the closing stock price on the preceding January 1, then the original 12-month offering period terminates, and the purchase rights under the original offering period roll forward into a new six-month offering period that begins July 1 and ends on December 31. As of ~~December~~March 31, ~~2018~~2019, we had 0.97 million shares available for issuance under the ESPP,. ofThe ~~which~~Company issued 0.2 million shares ~~were~~under ~~subsequently~~the ~~issued~~ESPP induring ~~January~~each ~~2019~~of infiscal ~~accordance~~2019 ~~with~~and ~~the~~ 2018 ~~ESPP purchase~~.

NOTE 9 - RELATED PARTY TRANSACTIONS

We are party to Drug Discovery Collaboration Option Agreements, as amended, with Mirati pursuant to which we provide certain drug discovery and research activities to Mirati ~~from~~pursuant to which we have received upfront payments, license fees, milestone payments and reimbursement for research and development services and under which we are entitled to receive additional milestone payments based on achievement of certain milestones, as described in Note 4 - Collaboration and Other Agreements. Dr. Charles Baum, a current member of our Board of Directors, is the President and Chief Executive Officer of Mirati.

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We are also a party to a Master Collaboration Agreement with ArcherDX for project-specific collaborations in the field of development and commercialization of in vitro diagnostics and companion diagnostics for Array Compounds. Pursuant to this agreement, we will make future payments to ArcherDX for contract milestones, ongoing costs and pass-through expenses for project work plans. Kyle Lefkoff, a current member of our Board of Directors, is also a Director of ArcherDX. We have not yet made any payments to ArcherDX.

NOTE 10 - NET LOSS PER SHARE

Basic and diluted loss per common share are computed by dividing net loss by the weighted average number of common shares outstanding during the period. Diluted loss per share includes the determinants of basic net income per share and, in addition, gives effect to the potential dilution that would occur if securities or other contracts to issue common stock were exercised, vested or converted into common stock, unless they are anti-dilutive.

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The following table summarizes the net loss per share calculation (in thousands, except per share amount):

	Three Months Ended						~~Six~~Nine Months Ended
	December 31,						December 31,
	March 31,						March 31,
	2018			2017			2018			2017
	2019			2018			2019			2018
Net loss - basic and diluted	$	(1137,~~362~~494	)	$	(3422,~~053~~851	)	$	(3673,~~173~~667	)	$	(7294,~~047~~898	)
Weighted average shares outstanding - basic and diluted	~~215~~219,~~872~~913			~~199~~208,~~852~~994			~~214~~215,~~032~~964			~~187~~194,~~312~~434
Per share data:
Basic and diluted	$	(0.0517	)	$	(0.1711	)	$	(0.1734	)	$	(0.3849	)

For the periods presented, all common stock equivalents are excluded from the computation of diluted loss per share, as the result would be anti-dilutive~~. Common stock equivalents are not included in the calculations of diluted loss per share because to do so would have been anti-dilutive~~, which include the following (~~amounts~~ in thousands):

	December 31,
	March 31,
	2018	2017
	2019	2018
2.625% convertible senior notes	8,156	8,156
Stock options	1816,~~667~~294	1415,~~910~~722
Unvested RSUs	1,~~332~~260	1,~~245~~275
Total anti-dilutive common stock equivalents excluded from diluted loss per share calculation	2825,~~155~~710	2425,~~311~~153

ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Management’s Discussion and Analysis of Financial Condition and Results of Operations contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In some cases, forward-looking statements can be identified by the use of terms such as "may", "will", "expects", "intends", "plans", "anticipates", "estimates", "potential", or "continue", or the negative thereof or other comparable terms. These statements are based on current expectations, projections and assumptions made by management and are not guarantees of future performance. Although we believe that the expectations reflected in the forward-looking statements contained herein are reasonable, these expectations or any of the forward-looking statements could prove to be incorrect and actual results could differ materially from those projected or assumed in the forward-looking statements. Our future financial condition, as well as any forward-looking statements, are subject to significant risks and uncertainties including, but not limited to, the factors set forth under the heading “Item 1A." Risk Factors” under Part II of this Quarterly Report on Form 10-Q and under "Forward Looking Statements" and "Item 1A. Risk Factors" under Part I of our Annual Report on Form 10-K for the fiscal year ended June 30, 2018, and in other reports we file with the SEC. All forward-looking statements are made as of the date of this report and, unless required by law, we undertake no obligation to update any forward-looking statements.

24The following discussion of our financial condition and results of operations should be read in conjunction with our unaudited condensed consolidated financial statements and related notes to those statements included elsewhere in this Quarterly Report on Form 10-Q, our audited consolidated financial statements and related notes to those statements included in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018, and the information under the heading "Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations" in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018. The terms “we”, “us”, “our”, "the Company", or "Array" refer to Array BioPharma Inc.

~~Table~~Our offiscal ~~Contents~~year ends on June 30. When we refer to a fiscal year or quarter, we are referring to the year in which the fiscal year ends and the quarters during that fiscal year. Therefore, fiscal 2019 refers to the fiscal year ending June 30, 2019, and the third or current quarter refers to the three months ended March 31, 2019.

The following discussion of our financial condition and results of operations should be read in conjunction with our unaudited condensed consolidated financial statements and related notes to those statements included elsewhere in this Quarterly Report on Form 10-Q, our audited consolidated financial statements and related notes to those statements included in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018, and with the information under the heading "Item 7. Management's Discussion and Analysis of Financial Condition and Results of Operations" in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018. The terms “we”, “us”, “our”, "the Company", or "Array" refer to Array BioPharma Inc.

Our fiscal year ends on June 30. When we refer to a fiscal year or quarter, we are referring to the year in which the fiscal year ends and the quarters during that fiscal year. Therefore, fiscal 2019 refers to the fiscal year ending June 30, 2019, and the second or current quarter refers to the three months ended December 31, 2018.

Overview

We are a fully-integrated, biopharmaceutical company focused on the discovery, development and commercialization of transformative and well-tolerated targeted small molecule drugs to treat patients afflicted with cancer and other high-burden diseases. We market BRAFTOVI® (encorafenib) capsules in combination with MEKTOVI® (binimetinib) tablets for the treatment of patients with unresectable or metastatic melanoma with a BRAFV600E or BRAFV600K mutation in the United States ("US") and with partners in other major worldwide markets. Our lead clinical programs, encorafenib and binimetinib, are being investigated in over 30 clinical trials across a number of solid tumor indications, including a Phase 3 trial in BRAF-mutant metastatic colorectal cancer ("CRC"). Our pipeline includes several additional programs being advanced by us or current license-holders, including the following programs currently in registration trials: selumetinib (partnered with AstraZeneca), LOXO-292 (partnered with Loxo Oncology), ipatasertib (partnered with Genentech), tucatinib (partnered with Seattle Genetics) and ARRY-797. Vitrakvi® (larotrectinib, partnered with Loxo Oncology) is approved in the United States and Ganovo® (danoprevir, partnered with Roche and licensed by Roche to Ascletis Pharmaceuticals Co., Ltd. in China) is approved in China . 26

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We are a fully integrated biopharmaceutical company focused on the discovery, development and commercialization of transformative and well-tolerated targeted small molecule drugs to treat patients afflicted with cancer and other high-burden diseases. We market BRAFTOVI^® (encorafenib) capsules in combination with MEKTOVI^®(binimetinib)tablets for the treatment of patients with unresectable or metastatic melanoma with a BRAF^V600E or BRAF^V600K mutation in the United States ("U.S.") and with partners in other major worldwide markets. Our lead clinical programs, encorafenib and binimetinib, are being investigated in over 30 clinical trials across a number of solid tumor indications, including a Phase 3 trial in BRAF-mutant metastatic colorectal cancer ("CRC"). Our pipeline includes several additional programs being advanced by us or current license-holders, including the following programs currently in registration trials: selumetinib (partnered with AstraZeneca), LOXO-292 (partnered with Eli Lilly), ipatasertib (partnered with Genentech), tucatinib (partnered with Seattle Genetics) and ARRY-797. Vitrakvi^® (larotrectinib, partnered with Bayer AG) is approved in the United States, and Ganovo^® (danoprevir, partnered with Roche and licensed by Roche to Ascletis Pharmaceuticals Co., Ltd. in China) is approved in China.

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Our most significant approved and clinical stage drugs include:

Drug Candidate	Target/Disease State	Partner	Clinical Status
BRAFTOVI + MEKTOVI	BRAF and MEK inhibitors for advanced BRAF-mutant melanoma	Pierre Fabre Medicament SAS and Ono Pharmaceutical Co., Ltd.	Approved
Encorafenib	BRAF inhibitor for BRAF-mutant CRC	Pierre Fabre Medicament SAS and Ono Pharmaceutical Co., Ltd.	Phase 3
Binimetinib	MEK inhibitor for BRAF-mutant CRC and other cancers	Pierre Fabre Medicament SAS and Ono Pharmaceutical Co., Ltd.	Phase 3
Vitrakvi / Larotrectinib (1)(2)	PanTrk inhibitor for cancer	~~Loxo~~Bayer ~~Oncology, Inc.~~AG	Approved
Ganovo / Danoprevir (1)	Protease inhibitor for Hepatitis C virus	Roche Holding AG	Approved (3)
Selumetinib (1)	MEK inhibitor for NF1 (4)	AstraZeneca, PLC	Phase 2 / Registration Trial
Tucatinib / ONT-380 (1)	HER2 inhibitor for breast cancer	Seattle Genetics, Inc.	Phase 2 / Registration Trial
Ipatasertib / GDC-0068 (1)	AKT inhibitor for cancer	Genentech, Inc.	Phase 3
Varlitinib / ASLAN001 (1)	Pan-HER2 inhibitor for cancer	ASLAN Pharmaceuticals Pte Ltd.	Phase 2 / 3
ARRY-797	p38 inhibitor for Lamin A/C-related dilated cardiomyopathy	Wholly-owned by Array	Phase 3
LOXO-292 (1)	Ret inhibitor for cancer	~~Loxo~~Eli ~~Oncology,~~Lilly ~~Inc.~~and Company	Phase 2 / Registration Trial
ARRY-382	CSF1R inhibitor for cancer	Wholly-owned by Array	Phase 2
Motolimod / VTX-2337 (1)	Toll-like receptor for cancer	Celgene Corp. / VentiRx Pharmaceuticals, Inc.	Phase 2
Prexasertib / LY2606368 (1)	CHK-1 inhibitor for cancer	Eli Lilly and Company	Phase 2
LOXO-195 (1)	Trk inhibitor for cancer	Bayer AG	Phase 1 / 2
LOXO-195 (1)	Trk inhibitor for cancer	Loxo Oncology, Inc.	Phase 1 / 2
AK-1830 (1)	TrkA selective inhibitor for inflammation and pain	Asahi Kasei Pharma Corporation	Phase 1
MRTX849 (1)	KRAS G12C inhibitor for cancer	Mirati Therapeutics, Inc.	Phase 1 / 2

(1) Compound is being advanced by the current license holder. We are entitled to receive future potential milestone and/or potential royalty payments contingent upon successful development and commercialization.

(2) Vitrakvi^® is a registered trademark of Bayer AG. All trademarks are properties of their respective owners.

(3) Approved in China.

(4) As we have previously disclosed, we have informed AstraZeneca of our position that the NF1 development program is outside of the permitted field for this license.

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BRAFTOVI and MEKTOVI

In the U.S., BRAFTOVI capsules in combination with MEKTOVI tablets are approved for the treatment of patients with unresectable or metastatic melanoma with a BRAF^V600E or BRAF^V600K mutation, as detected by an FDA-approved test. BRAFTOVI is not indicated for the treatment of patients with wild-type BRAF melanoma.

BRAFTOVI + MEKTOVI were available for sale beginning on July 2, 2018, and patients began receiving the combination therapy that same week.

Net product sales for the ~~second~~third quarter were $2235.71 million. Array continues to see strong demand for BRAFTOVI + MEKTOVI and to receive positive feedback from healthcare providers, payers and the melanoma community regarding the combination.

We have exclusive rights to BRAFTOVI and MEKTOVI in the U.S. and Canada. Array has granted Ono Pharmaceutical Co., Ltd. exclusive rights to commercialize both products in Japan and South Korea, Medison Pharma Ltd. exclusive rights to commercialize both products in Israel and Pierre Fabre exclusive rights to commercialize both products in all other countries, including those in Europe, Latin America and Asia (excluding Japan and South Korea).

BRAFTOVI + MEKTOVI have received regulatory approval in the United States, the European Union, Australia and Japan. The Swiss Medicines Agency (Swissmedic) is currently reviewing the Marketing Authorization Applications for BRAFTOVI and MEKTOVI submitted by Pierre Fabre.

BRAFTOVI^® and MEKTOVI^®are registered trademarks of Array BioPharma Inc. in the U.S. and various other countries.

Encorafenib and Binimetinib

On March 2, 2015 ~~(the "Effective Date")~~, we regained development and commercialization rights to binimetinib under the Termination and Asset Transfer Agreement with Novartis Pharmaceutical Ltd. and Novartis Pharma AG (collectively, "Novartis") and to encorafenib under the Asset Transfer Agreement with Novartis Pharma AG (which we collectively refer to as the “Novartis Agreements”). Along with global ownership of both assets, the Novartis Agreements transferred to Array a low -single -digit royalty obligation payable based on net sales of encorafenib and we received an upfront payment of $85.0 million from Novartis. We believe these programs present significant opportunity to Array in the area of oncology.

Novartis continues to fund ongoing trials with encorafenib and binimetinib that were active or planned as of the close of the Novartis Agreements in 2015. AsThe ~~of December 31, 2018, the~~ level of spend associated with these studies continues to decrease as the studies progress through their later life cycle. As patients have continued to receive treatment under certain trials for longer than initially anticipated, we have reached certain reimbursement limits for select trials, including the COLUMBUS Phase 3 trial. Reimbursement revenue from Novartis was approximately $6145.26 million for the 12 months ended ~~December~~March 31, ~~2018~~2019, of which $8.9.2 million was recorded in the three months ended ~~December~~March 31, ~~2018~~2019.

PIERRE FABRE AGREEMENT

We entered into a Development and Commercialization Agreement (the "PF Agreement") with Pierre Fabre in 2015 pursuant to which we granted Pierre Fabre rights to commercialize encorafenib and binimetinib in all countries except for the U.S., Canada, Japan, the Republic of Korea and Israel. The PF Agreement satisfied our commitment to secure a development and commercialization partner for the European market for both encorafenib and binimetinib acceptable to European Commission regulatory agencies made in connection with the Novartis Agreements.

The PF Agreement closed in December 2015. All clinical trials involving encorafenib and binimetinib that were ongoing or planned at the ~~Effective~~effective ~~Date~~date of the PF Agreement, including the COLUMBUS trial and other then active Novartis sponsored and investigator sponsored clinical studies, continue to be conducted pursuant to the terms of the Novartis Agreements. Additional worldwide development activities of encorafenib and binimetinib will be governed by a Global

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~~Additional worldwide development activities of encorafenib and binimetinib will be governed by a Global~~ Development Plan ("GDP") with Pierre Fabre. Pierre Fabre and Array jointly fund worldwide development costs under the GDP, with Array covering 60% and Pierre Fabre covering 40% of such costs. The initial GDP includes multiple trials, including the BEACON CRC trial. We and Pierre Fabre have agreed to commit at least €100 million in combined funds for these studies in CRC and melanoma.

Pierre Fabre is responsible for seeking regulatory and pricing and reimbursement approvals in the European Economic Area and its other licensed territories. We have also entered into a Clinical Supply Agreement and a Commercial Supply Agreement with Pierre Fabre pursuant to which we will supply or procure the supply of clinical and commercial supplies of drug substance and drug product for Pierre Fabre, the costs of which will be borne by Pierre Fabre. We have also agreed to cooperate with Pierre Fabre to ensure the supply of companion diagnostics for use with encorafenib and binimetinib in indications as needed.

Each party has agreed not to distribute, sell or promote competing products in each party’s respective markets during a period of exclusivity. Each party has also agreed to indemnify the other party from certain liabilities specified in the Agreement and to Medison Pharma Ltd.

In connection with the PF Agreement, we received $30.0 million as a non-refundable up-front payment during the year ended June 30, 2016 and we earned a $15.0 million milestone during the three months ended September 30, 2018, which was recognized at that time as collaboration and license revenue. The PF Agreement contains future substantive potential milestone payments of up to $390.0 million for achievement of seven commercialization milestones if certain net sales amounts are achieved for any licensed indications. We are also entitled to double-digit royalties based on net sales under the agreement, subject to certain adjustments of up to $15.0 million cumulative for costs incurred to achieve or maintain the Marketing Authorization Application ("MAA") in Europe which can reduce royalties due to us by up to 50%.

ONO AGREEMENT

Effective May 31, 2017, we entered into a License, Development and Commercialization Agreement (the “Ono Agreement”) with Ono, a company duly organized and existing under the laws of Japan, pursuant to which we granted Ono exclusive rights to commercialize encorafenib and binimetinib in Japan and the Republic of Korea (the “Ono Territory”), along with the right to develop these products in the Ono Territory. We retain all rights outside the Ono Territory as well as the right to conduct development and manufacturing activities in the Ono Territory, except for rights we have granted to Pierre Fabre under the PF Agreement.

Under the terms of the Ono Agreement, we received a non-refundable upfront cash payment of ¥3.5 billion, or $31.2 million. We are entitled to receive potential milestone payments of up to ¥~~900~~500.0 million for the achievement of ~~two~~one remaining development ~~milestones~~milestone, ¥5.0 billion for the achievement of eight regulatory milestones and ¥10.5 billion for the achievement of five commercialization milestones if certain annual net sales targets are achieved. A portion of these milestones is related to the advancement of the Phase 3 BEACON CRC trial in the Ono Territory. We are further eligible for tiered double-digit royalties on annual net sales of encorafenib and binimetinib in the Ono Territory, starting at 22.0% for annual net sales under ¥10.0 billion and increasing to 25.0% for annual net sales in excess of ¥10.0 billion, subject to certain adjustments. As of ~~December~~March 31, ~~2018~~2019, ¥1.0 billion was the equivalent of approximately $9.10 million.

All ongoing clinical trials involving encorafenib and binimetinib, including the BEACON CRC and COLUMBUS trials, continued as planned as of the effective date of the Ono Agreement, and Ono is entitled to the data derived from such studies. As part of the Ono Agreement, Ono obtained the right to participate in any future global development of encorafenib and binimetinib by contributing 12.0% of the future costs of such development. Ono is responsible for seeking regulatory and marketing approvals for products in the Ono Territory and for any development of encorafenib and binimetinib specifically necessary to obtain such approvals. We will furnish clinical supplies of drug substance to Ono for use in Ono’s development efforts, and Ono may elect to have us provide commercial supplies of drug product to Ono pursuant to a commercial supply agreement ~~to be entered into by us and Ono~~, in each case the costs of which will be borne by Ono. We have also agreed to discuss and agree with Ono on a strategy to ensure the supply of companion diagnostics to Ono for use with encorafenib and binimetinib in certain indications in the Ono Territory. Each party has agreed not to distribute, sell or promote competing MEK or RAF products in the Ono Territory during the term of the Ono Agreement.

The Ono Agreement will continue in effect on a product-by-product, country-by-country basis for a period that expires ten years after the later of expiration of patent protection or marketing exclusivity for the applicable product. The Ono ~~Agreement may be terminated by either party for breach of the Agreement by the other party, in the event of the~~

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Agreement may be terminated by either party for breach of the Agreement by the other party, in the event of the insolvency or bankruptcy of the other party, by Ono with 180 days’ prior notice after the fifth year after first commercial sale of either encorafenib or binimetinib in the Ono Territory, or by Ono on a product-by-product basis for certain safety reasons.

COLUMBUS PHASE 3 TRIAL

The COLUMBUS trial is a two-part, international, randomized, open-label Phase 3 trial evaluating the efficacy and safety of BRAFTOVI in combination with MEKTOVI compared to vemurafenib and encorafenib monotherapy in 921 patients with locally advanced, unresectable or metastatic melanoma with BRAF^V600 mutation. The primary endpoint of the trial was progression free survival; all secondary efficacy analyses, including overall survival ("OS"), are descriptive in nature. Over 200 sites across North America, Europe, South America, Africa, Asia and Australia participated in the trial.

BEACON CRC PHASE 3 TRIAL

BEACON CRC is a randomized, open-label, global trial evaluating the efficacy and safety of BRAFTOVI, MEKTOVI and cetuximab in patients with BRAF^V600E-mutant metastatic CRC whose disease has progressed after one or two prior regimens. BEACON CRC is the first and only Phase 3 trial designed to test a BRAF/MEK combo targeted therapy in BRAF^V600E-mutant advanced CRC. Thirty patients were treated in the safety lead-in and received the triplet combination (BRAFTOVI 300 mg daily, MEKTOVI 45 mg twice daily and ERBITUX^® (cetuximab), an anti-EGFR antibody, per label). Of the 30 patients, 29 had a BRAF^V600E mutation. MSI-H, resulting from defective DNA mismatch repair, was detected in only one patient.

~~Updated~~On ~~safety~~March ~~and efficacy results~~18, ~~including mature OS~~2019, ~~from~~we ~~the~~announced ~~safety~~that ~~lead-in of~~ the ~~BEACON~~National ~~CRC~~Comprehensive ~~trial~~Cancer ~~evaluating the triplet combination of BRAFTOVI, MEKTOVI and ERBITUX, in patients with BRAFV600E-mutant metastatic colorectal cancer~~ Network® ("~~mCRC~~NCCN®") ~~showed~~updated ~~that~~their ~~mature~~Clinical ~~median~~Practice OSGuidelines ~~was~~in ~~15.3~~Oncology ~~months (95% CI, 9.6-not reached)~~ for ~~patients~~Colon ~~treated with the triplet. Updated median progression-free survival ("mPFS")~~ and ~~updated~~Rectal ~~confirmed~~Cancer ~~ORR~~to ~~results~~include ~~for~~BRAFTOVI® ~~patients~~in ~~treated~~combination with ~~the~~MEKTOVI® and cetuximab ~~triplet~~or inpanitumumab ~~the safety lead-in remain the same,~~ as ~~previously~~a ~~reported,~~Category ~~with~~2A 8treatment ~~months~~option ~~mPFS~~for ~~(95%~~patients ~~CI, 5.6~~with BRAFV600E-~~9.3)~~mutant ~~and~~metastatic acolorectal ~~48%~~cancer ~~ORR~~ (~~95% CI~~"mCRC"), ~~29.4-67.5).Overall~~after ~~response~~failure ~~rate~~of byone ~~central~~or ~~assessment,~~two ~~41%~~prior ~~(95%~~lines CIof ~~24%-61%),~~therapy ~~was~~for ~~consistent~~metastatic ~~with local assessment~~disease. ~~Among~~ The ~~the~~NCCN based 17their ~~patients~~recommendation ~~who~~on ~~received~~data ~~only~~from ~~one~~the ~~prior~~safety ~~line~~lead-in of ~~therapy,~~ the ~~ORR~~BEACON ~~was~~CRC ~~62%.~~trial Asevaluating ~~previously disclosed,~~ the triplet combination ~~was~~of ~~generally~~BRAFTOVI in ~~well-tolerated~~combination with noMEKTOVI ~~unexpected~~and ~~toxicities~~ERBITUX® (cetuximab), ~~supporting~~in ~~initiation~~29 ofpatients ~~the~~with BRAFV600E-mutant ~~randomized portion of the trial~~mCRC.

Updated safety and efficacy results, including mature OS, from the safety lead-in of the BEACON CRC trial evaluating the triplet combination of BRAFTOVI, MEKTOVI and ERBITUX, in patients with BRAF^V600E-mutant mCRC showed that mature median OS was 15.3 months (95% CI, 9.6-not reached) for patients treated with the triplet. Updated median progression-free survival ("mPFS") and updated confirmed ORR results for patients treated with the triplet in the safety lead-in remain the same, as previously reported, with 8 months mPFS (95% CI, 5.6-9.3) and a 48% ORR (95% CI, 29.4-67.5). Overall response rate by central assessment, 41% (95% CI 24%-61%), was consistent with local assessment. Among the 17 patients who received only one prior line of therapy, the ORR was 62%. As previously disclosed, the triplet combination was generally well-tolerated with no unexpected toxicities, supporting initiation of the randomized portion of the trial.

The randomized portion of the BEACON CRC trial is designed to assess the efficacy of BRAFTOVI in combination with ERBITUX with or without MEKTOVI compared to ERBITUX and irinotecan-based therapy. Approximately 615 patients are expected to be randomized 1:1:1 to receive triplet combination, doublet combination (BRAFTOVI and ERBITUX) or the control arm (irinotecan-based therapy and cetuximab). The study has been amended to include an interim analysis of endpoints including ORR. The primary overall survival endpoint is a comparison of the triplet combination to the control arm. Other secondary endpoints include PFS ("progression free survival"), duration of response, safety and tolerability. Health related quality of life data will also be assessed. The trial is being conducted at over 200 investigational sites in North America, South America, Europe and the Asia Pacific region. The BEACON CRC trial is being conducted with support outside of North America from Ono Pharmaceutical Co., Pierre Fabre and Merck KGaA, Darmstadt, Germany. The BEACON CRC trial has completed enrollment.

The FDA has granted Breakthrough Therapy Designation to BRAFTOVI in combination with MEKTOVI and cetuximab for the treatment of patients with BRAF^V600E-mutant metastatic CRC as detected by an FDA-approved test, after failure of one to two prior lines of therapy for metastatic disease. BRAF^V600E-mutant mCRC patients have a mortality risk more than double that of mCRC patients without the mutation, and currently there are no therapies specifically approved for this high unmet need population.

Following consultation with the FDA and EMA, we have initiated an amendment to the BEACON CRC protocol to allow for an interim analysis of trial endpoints. Should a planned analysis based primarily on confirmed ORR and durability of response be supportive, we plan to use it to seek accelerated approval in the U.S. The interim analysis may also support regulatory submissions in other regions. We anticipate topline results from this analysis in the first half of 2019. This timing allows for thesubset of patients required for the interim analysis of ORR to achieve a response and for the durability of responses to be appropriately evaluated. 31

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~~Worldwide,~~Following ~~colorectal~~consultation ~~cancer~~with is the ~~third~~FDA ~~most common type of cancer in men~~ and ~~the second most common in women~~EMA, ~~with~~we ~~approximately~~have ~~1.4~~initiated ~~million~~an ~~new~~amendment ~~diagnoses~~to inthe ~~2012.~~BEACON ~~Globally~~CRC inprotocol ~~2012, approximately 694,000 deaths were attributed~~ to ~~colorectal~~allow ~~cancer.~~for ~~In the U.S. alone,~~ an ~~estimated~~interim ~~140,250~~analysis ~~patients~~of ~~will~~trial beendpoints. ~~diagnosed~~Should ~~with~~a ~~cancer~~planned ofanalysis ~~the~~based ~~colon~~primarily oron ~~rectum~~confirmed inORR ~~2018,~~ and ~~approximately~~durability ~~50,000 are estimated to die~~ of ~~their~~response ~~disease.~~be ~~BRAF~~supportive, ~~mutations~~we ~~are~~plan ~~estimated~~ to ~~occur~~use init up to ~~15%~~seek ofaccelerated ~~patients~~approval ~~with~~in ~~mCRC~~the ~~and represent a poor prognosis for these patients~~U.S. The ~~V600~~interim ~~mutation~~analysis ismay ~~the~~also ~~most~~support ~~common~~regulatory ~~BRAF~~submissions ~~mutation and the risk of mortality~~ in ~~CRC~~other ~~patients~~regions. ~~with~~We ~~the BRAFV600E mutation~~anticipate istopline ~~more~~results ~~than~~from ~~two~~this ~~times~~analysis ~~higher~~in ~~than~~the ~~for~~first ~~those~~half ~~with~~of ~~wild-type BRAF~~2019. ~~Several~~ ~~irinotecan~~This ~~and~~timing ~~cetuximab-containing~~allows ~~regimens,~~for ~~similar to~~ the ~~BEACON~~subset ~~CRC~~of ~~control arm, have established observed historical published benchmarks in BRAFV600E-mutant mCRC~~ patients, ~~whose~~required ~~disease~~for ~~has~~the ~~progressed~~interim ~~after~~analysis ~~one or two prior lines~~ of ~~therapy. These benchmarks include~~ ORR ~~of 4%~~ to ~~8%,~~achieve ~~mPFS~~a ofresponse ~~2 to 3 months~~ and ~~median~~for OSthe durability of 4responses to 6be ~~months.~~appropriately BRAF V600E-mutant mCRC is an area of high unmet need as there are currently no FDA-approved therapies specifically indicated for patients with BRAF-mutant mCRC, and these patients derive limited benefit from available chemotherapy regimensevaluated.

Worldwide, colorectal cancer is the third most common type of cancer in men and the second most common in women, with approximately 1.4 million new diagnoses in 2012. Globally in 2012, approximately 694,000 deaths were attributed to colorectal cancer. In the U.S. alone, an estimated 140,250 patients were diagnosed with cancer of the colon or rectum in 2018, and approximately 50,000 are estimated to die of the disease each year. BRAF mutations are estimated to occur in up to 15% of patients with mCRC and represent a poor prognosis for these patients. The V600 mutation is the most common BRAF mutation and the risk of mortality in CRC patients with the BRAF^V600E mutation is more than two times higher than for those with wild-type BRAF. Several irinotecan and cetuximab-containing regimens, similar to the BEACON CRC control arm, have established observed historical published benchmarks in BRAF^V600E-mutant mCRC patients, whose disease has progressed after one or two prior lines of therapy. These benchmarks include ORR of 4% to 8%, mPFS of 2 to 3 months and median OS of 4 to 6 months. BRAF^V600E-mutant mCRC is an area of high unmet need as there are currently no FDA-approved therapies specifically indicated for patients with BRAF-mutant mCRC, and these patients derive limited benefit from available chemotherapy regimens.

ANCHOR CRC TRIAL

ANCHOR CRC, an international trial designed to assess the efficacy and safety of the combination of encorafenib, binimetinib and cetuximab in patients with BRAF^V600E-mutant mCRC in the first-line setting, is advancing. The trial was designed in partnership with top global key opinion leaders to assess the combination therapy in the first-line setting. The ANCHOR CRC trial is being conducted in collaboration with Pierre Fabre and Ono Pharmaceutical Co., Ltd., and with support from Merck KGaA, Darmstadt, Germany (support is for sites outside of North America).

The triplet combination of BRAFTOVI, MEKTOVI and ERBITUX for the treatment of patients with BRAF^V600E-mutant mCRC is investigational and not approved by the FDA.

BRAFTOVI + MEKTOVI LIFE-CYCLE TRIALS

POLARIS (NCT03911869), an open-label Phase 2 trial designed to assess the efficacy and safety of the combination of BRAFTOVI + MEKTOVI in patients with BRAF^V600-mutant brain metastasis, has been active since April 2019.

In April 2019, PHAROS (NCT03915951), an open-label Phase 2 trial designed to assess the efficacy and safety of the combination of BRAFTOVI + MEKTOVI in patients with BRAF^V600E-mutant non-small cell lung cancer, has been active since April 2019 .

IMMUNO-ONCOLOGY COLLABORATIONS WITH BRISTOL-MYERS SQUIBB, MERCK AND PFIZER

We are also developing binimetinib in combination with PD-1/PD-L1 checkpoint inhibitors and previously announced separate, strategic collaborations with Bristol-Myers Squibb, Merck and Pfizer. Each collaboration is pursuing a different rationally designed clinical approach.

BRISTOL-MYERS SQUIBB COLLABORATION

The clinical trial has completed enrollment. It is designed to investigate the safety, tolerability and efficacy of binimetinib in combination with nivolumab (anti-PD-1 therapy), with and without ipilimumab (CTLA-4 antibody), in patients with advanced metastatic microsatellite stable (MSS) CRC and the presence of a RAS mutation who have received one or two prior regimens. The trial is jointly supported by Array and Bristol-Myers Squibb and sponsored by Array.

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MERCK COLLABORATION

The clinical trial continues to advance and is designed to investigate the safety, tolerability and efficacy of binimetinib in combination with pembrolizumab (anti-PD-1 therapy), with and without FOLFOX or FOLFIRI (chemotherapy), in first or second-line patients with CRC whose tumors are not microsatellite instability-high (MSI-H). The trial is sponsored and funded by Merck, with Array providing binimetinib supply.

PFIZER COLLABORATION

The clinical trial continues to advance and is designed to investigate the safety, tolerability and efficacy of several novel anti-cancer combinations, including binimetinib, avelumab (anti-PD-L1 therapy) and talazoparib (PARP inhibitor) across various tumor types and is expected to begin during the third quarter of 2018. Initially, the focus will be on non-small cell lung cancer and pancreatic cancer, with additional indications being explored at a later stage. The trial is sponsored and funded by Pfizer, with Array providing binimetinib supply.

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ARRY-382

ARRY-382 is a wholly-owned, highly selective and potent, small molecule inhibitor of CSF1R kinase activity. We are advancing a Phase 2 trial of ARRY-382 in combination with pembrolizumab, an anti-PD-1 therapy, in patients with advanced solid tumors. The trial includes three cohorts: patients with pancreatic cancer with one prior line of therapy and no prior treatment with immune checkpoint inhibitors, patients with ovarian cancer who are platinum refractory and no prior treatment with immune checkpoint inhibitors, and patients with solid tumors who have progressed on prior PD1/PD-L1 inhibitors.

ARRY-797

ARRY-797 is an oral, selective p38 MAPK inhibitor that is currently advancing in a Phase 3 trial in patients with LMNA-related DCM, a rare, degenerative cardiovascular disease caused by mutations in the LMNA gene and characterized by poor prognosis.

Business Development and Partner Concentrations

We currently license or partner certain of our compounds and/or programs and enter into collaborations directly with pharmaceutical and biotechnology companies through opportunities identified by our business development group, senior management, scientists and customer referrals. In general, our partners may terminate their agreements with us with 60 to 180 days' prior notice. Specifics regarding termination provisions under our material collaboration or partnering agreements can be found in Note 4 – Collaboration and Other Agreements to our audited financial statements included in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018.

Additional information related to the concentration of revenue among our partners is reported in Note 1 – Overview, Basis of Presentation and Summary of Significant Accounting Policies – Concentration of Business Risks to our unaudited consolidated condensed financial statements included elsewhere in this Quarterly Report on Form 10-Q.

All of our collaboration and license agreements are denominated in U.S. dollars, except our agreement with Ono, which is denominated in Japanese Yen.

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Results of Operations

Revenue

Below is a summary of our total revenue (~~dollars~~ in thousands):

	Three Months Ended				Change					~~Six~~Nine Months Ended				Change
	December 31,				2018 vs. 2017					December 31,				2018 vs. 2017
	March 31,				2019 vs. 2018					March 31,				2019 vs. 2018
	2018		2017		$			%		2018		2017		$			%
	2019		2018		$			%		2019		2018		$			%
Product sales, net	$	2235,~~713~~078	$	—	$	2235,~~713~~078		(a)		$	3671,~~706~~784	$	—	$	3671,~~706~~784		(a)
Collaboration and license revenue	50,924		19,823		31,101			157	%	81,952		31,377		50,575			161	%
Product royalties	937		—		$	937		(a)		1,261		—		$	1,261		(a)
Reimbursement revenue	8,912		22,395		(13,483		)	(60	)%	20,801		40,587		(19,786		)	(49	)%
Collaboration and license revenue	19,493		41,616		(22,123		)	(53	)%	101,121		72,993		28,128			39	%
Total revenue	$	82,549	$	42,218	$	40,331		96	%	$	139,459	$	71,964	$	67,495		94	%
Reimbursement revenue	9,169		24,751		(15,582		)	(63	)%	29,970		65,338		(35,368		)	(54	)%
Total revenue	$	64,677	$	66,367	$	(1,690	)	(3	)%	$	204,136	$	138,331	$	65,805		48	%

(a) There were no product sales or product royalties during the prior year period.

Product Sales, net

Product sales, net consists of commercial revenue from sales of BRAFTOVI + MEKTOVI which commenced during the three months ended September 30, 2018. See Note 3 of the Notes to the unaudited condensed consolidated financial statements contained elsewhere in this report for additional details related to product sales, net.

31Product Royalties

~~Table~~Product royalties consists of ~~Contents~~royalty revenue based on international sales BRAFTOVI + MEKTOVI, which are marketed by Array in the U.S. We have granted Pierre Fabre and Ono Pharmaceutical Co. Ltd. (“Ono”) exclusive rights to commercialize both products in their respective territories outside of the United States and we receive royalty payments based on those sales. See Note 4 of the Notes to the unaudited condensed consolidated financial statements contained elsewhere in this report for additional details related to product royalties.

Collaboration and License Revenue

Collaboration and license revenue consists of revenue ~~for~~related to our ~~performance of~~ drug discovery and development activities in collaboration with partners, which includes reimbursement for research and development of ~~proprietary~~ drug candidates that we out-license, ~~as well as~~ up-front and milestone fees and ongoing ~~milestone~~royalty ~~payments~~revenue ~~from~~based ~~partners~~on sales by license holders of products which we have wholly out-licensed and ~~collaborators~~are not marketed by Array. Currently approved and marketed products that we have out-licensed and have royalty rights to include Vitrakvi and Ganovo. To date, royalties earned based on sales of Vitrakvi and Ganovo have not been material.

~~The~~In ~~increase~~January 2017, we earned a $23.0 million upfront license fee from ASLAN Pharmaceuticals which was fully recognized as revenue at that time, resulting in decreased collaboration and license revenue during the three months ended March 31, 2019 as compared to the same period in the prior year. The increase in collaboration and ~~six~~license revenue during the nine months ended ~~December~~March 31, ~~2018~~2019 compared with the same periods in the prior year was primarily due to milestones from Loxo and Pierre Fabre. ~~During~~In ~~the three months ended~~ December ~~31,~~ 2018, we recognized revenue for three milestones totaling $40.0 million related to commercial sales of Vitrakvi by Loxo. In addition, the European marketing approval of commercial sales of BRAFTOVI + MEKTOVI in September 2018 resulted in a milestone payment in the amount of $15.0 million to us from Pierre Fabre, which was recognized as revenue ~~during~~at ~~the~~that ~~three months ended September 30, 2018~~time. See Note 4 of the Notes to the unaudited condensed consolidated financial statements contained elsewhere in this report for additional details related to milestones from Loxo and Pierre Fabre. Partially offsetting the increased revenue from these milestones from Loxo and Pierre Fabre was revenue from the upfront payment from ASLAN as well as $10.0 million license revenue from Asahi Kasei that was earned and fully recognized during the nine months ended March 31, 2018.

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Reimbursement Revenue

Reimbursement revenue consists of amounts received for reimbursement of costs we incur under the Novartis Agreements where we act as a principal, control the research and development activities, bear credit risk and may perform a portion of the required services.

As discussed in Note 4 - Collaboration and Other Agreements to our consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q, we regained all development and commercialization rights to binimetinib, and obtained all development and commercialization rights to encorafenib from Novartis on March 2, 2015. In connection with the closing of these transactions, we and Novartis entered into two Transition Agreements dated March 2, 2015, one associated with binimetinib and the other associated with encorafenib. Novartis provides financial support to us under the Transition Agreements for clinical trials involving encorafenib and binimetinib in the form of reimbursement to Array for associated out-of-pocket costs and for one-half of our fully-burdened full-time equivalent ("FTE") employee costs based on an annual FTE rate, with certain activities subject to a maximum reimbursement limit. As of June 30, 2016, Novartis had transitioned responsibility for all previously Novartis-conducted trials and will provide this continuing financial support to Array for completing the trials. Novartis continues to fund ongoing trials with encorafenib and binimetinib that were active or planned as of the close of the Novartis Agreements in 2015. As of ~~December~~March 31, ~~2018~~2019, the level of spend associated with these studies continues to decrease as the studies progress through their later life cycle. As patients have continued to receive treatment under certain trials for longer than initially anticipated, we have reached certain reimbursement limits for select trials, including the COLUMBUS Phase 3 trial.

The decrease in reimbursement revenue for the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 compared with the same period in the prior year is attributable to the certain categories of expenses having reached reimbursement limits and the advancement of the transitioned studies, some of which have begun to wind down, resulting in lower reimbursable expenses.

Operating Expenses

Below is a summary of our total operating expenses (~~dollars~~ in thousands):

	Three Months Ended				Change					~~Six~~Nine Months Ended				Change
	December 31,				2018 vs. 2017					December 31,				2018 vs. 2017
	March 31,				2019 vs. 2018					March 31,				2019 vs. 2018
	2018		2017		$			%		2018		2017		$		%
	2019		2018		$			%		2019		2018		$		%
Cost of goods sold	$	~~786~~1,042	$	—	$	~~786~~1,042		(a)		$	~~981~~2,023	$	—	$	~~981~~2,023	(a)
Research and development	6265,~~120~~541		5671,~~329~~348		(5,~~791~~807		)	10(8	)%	~~117~~183,~~670~~211		~~109~~180,~~533~~881		82,~~137~~330		71	%
Selling, general and administrative	3035,~~473~~548		1116,~~607~~773		18,~~866~~775			~~163~~112	%	5590,~~363~~911		2340,~~655~~428		3150,~~708~~483		~~134~~125	%
Total operating expenses	$	93102,~~379~~131	$	6788,~~936~~121	$	2514,~~443~~010		3716	%	$	~~174~~276,~~014~~145	$	~~133~~221,~~188~~309	$	4054,~~826~~836	3125	%

(a) There were no product sales during the prior year period.

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Cost of Goods Sold

Cost of goods sold consists of product sold to Customers, international partners under product supply agreements, and royalty expense based on net sales of BRAFTOVI. A portion of the costs of BRAFTOVI + MEKTOVI units recognized as revenue during the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 were expensed prior to the June 27, 2018 FDA approval. We believe our cost of goods sold for the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 would have been $0.3.9 million and $04.76 million higher, respectively, if we had not previously expensed certain material and production costs with respect to the units sold. As of ~~December~~March 31, ~~2018~~2019, we had approximately $1511.43 million of inventory on hand that was previously expensed as research and development expense and will not be reported as cost of goods sold in future periods when sales of BRAFTOVI + MEKTOVI are recognized as revenue.

~~Cost of goods sold for the three and six months ended December 31, 2018 and 2017 consisted of the following (in thousands):~~35

	Three Months Ended				Six Months Ended
	December 31,				December 31,
	2018		2017		2018		2017
Cost of goods sold to Customers	$	587	$	—	$	716	$	—
Cost of goods sold to international partners under product supply agreements	75		—		77		—
Royalty expense	124		—		188		—
Total cost of goods sold	$	786	$	—	$	981	$	—

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Cost of goods sold for the three and nine months ended March 31, 2019 and 2018 consisted of the following (in thousands):



	Three Months Ended				Nine Months Ended
	March 31,				March 31,
	2019		2018		2019		2018
Cost of goods sold to Customers	$	828	$	—	$	1,544	$	—
Cost of goods sold to international partners under product supply agreements	4		—		81		—
Royalty expense	210		—		398		—
Total cost of goods sold	$	1,042	$	—	$	2,023	$	—

Research and Development Expense

Research and development expense includes costs associated with our proprietary and partnered drug programs, which primarily consist of personnel related expenses, payments made to third party contract research organizations for preclinical and clinical studies, investigative sites for clinical trials and consultants, manufacturing materials for use in clinical trials, costs of producing BRAFTOVI ~~and~~+ MEKTOVI prior to approval, costs associated with regulatory filings and patents, and other costs to support our research and development operations. We manage our programs based on scientific data and achievement of research plan goals. As many of our activities and costs benefit multiple projects, the allocation of costs to specific projects is not meaningful. As a result, we do not report costs on a program basis.

Research and development expense increased during the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 compared with the same periods in the prior year primarily due to increased costs to advance BEACON and other proprietary programs to later stages of development. This increase was partially offset by Novartis transitioned studies as the underlying activity and associated outsourced services and consulting costs continued to decline.

Outsourced services and consulting costs represent the most significant portion of our research and development expense, ranging from approximately 74% to 80% of total research and development expense during the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018.

During the three months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018, reimbursed expenses for the Novartis transitioned studies were $8.9.2 million and $2224.48 million, respectively, which represented approximately 14% and 4035% of total research and development during each respective period. During the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 and ~~2017~~2018, reimbursed expenses for the Novartis transitioned studies were $2030.80 million and $4065.63 million, respectively, which represented approximately 1816% and 3736% of total research and development expense during each respective period.

Selling, General and Administrative Expense

Selling, general and administrative expenses consist mainly of expenses associated with our sales, marketing, finance, legal and administrative organizations, including personnel costs, costs associated with the commercialization of BRAFTOVI ~~and~~+ MEKTOVI, patent filing and prosecution, consulting and professional services, ~~facilities, depreciation~~ and other office expenses.

33The increase in selling, general and administrative expense during the periods presented are primarily driven by costs associated with our marketing and sales activities in support of BRAFTOVI + MEKTOVI commercialization and legal expenses. We began hiring our sales force during the three months ended March 31, 2018 and completed that process in our fourth fiscal quarter of 2018. The nine months ended March 31, 2019 include expenses for fully staffed sales and marketing teams.

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The increase in selling, general and administrative expense during the periods presented are primarily driven by costs associated with our marketing and sales activities in support of BRAFTOVI + MEKTOVI commercialization and legal expenses.

Other Income (Expense), Net

Other income (expense), net is summarized in the following table (~~dollars~~ in thousands):

	Three Months Ended						Change					~~Six~~Nine Months Ended						Change
	December 31,						2018 vs. 2017					December 31,						2018 vs. 2017
	March 31,						2019 vs. 2018					March 31,						2019 vs. 2018
	2018			2017			$			%		2018			2017			$			%
	2019			2018			$			%		2019			2018			$			%
Loss on extinguishment and conversion of Notes	$	—		$	(6,457	)	$	6,457		(100	)%	$	—		$	(6,457	)	$	6,457		(100	)%
Interest income	$	2,912		$	1,295		$	1,617		125	%	$	6,722		$	3,075		$	3,647		119	%
Realized gain on investments	—			—			—			(a)		35			—			35			(a)
Interest expense	(2,863		)	(2,361		)	(502		)	21	%	(8,261		)	(8,407		)	146			(2	)%
Change in fair value of notes payable	—			(300		)	300			(100	)%	(65		)	(100		)	35			(35	)%
Loss on extinguishment and conversion of notes	—			—			—			(a)		—			(6,457		)	6,457			(a)
Interest income	2,286			1,255			1,031			82	%	3,810			1,780			2,030			114	%
Change in fair value of notes payable	—			(100		)	100			(100	)%	(65		)	(200		)	135			(68	)%
Interest expense	(2,818		)	(2,833		)	15			(1	)%	(5,398		)	(6,046		)	648			(11	)%
Other, net	(89		)	69			(158		)	(229	)%	(54		)	69			(123		)	(178	)%
Total other income (expense), net	$	(~~532~~40	)	$	(81,~~335~~097	)	$	71,~~803~~057		(9496	)%	$	(1,~~618~~658	)	$	(1011,~~823~~920	)	$	910,~~205~~262		(8586	)%

(a) Percentage change is not meaningful.

We incurred a loss of approximately $6.5 million in the three months ended December 31, 2017 for the extinguishment and conversion of the 2020 Notes and the 2024 Notes.

Interest income is earned from our investments in available-for-sale marketable securities, which has increased significantly from the previous year due to a higher balance of marketable securities.

Interest expense is primarily related to our 3.00% and 2.625% convertible senior notes but also includes interest expense related to Convertible Promissory Notes we issued to Redmile and interest on our term loan with Silicon Valley Bank. The ~~decrease~~increase in interest expense for the three months ended ~~December~~March 31, ~~2018~~2019 as compared to the prior year is primarily the result of amending our Silicon Valley Bank term loan which increased the outstanding principal by $35.0 million. The increased interest expense on the Silicon Valley Bank term loan is largely offset by exchanging the 2020 Notes which bore interest at 3.00% for the 2024 Notes which bear interest at 2.625%. Details of our interest expense for all of our debt arrangements outstanding during the periods presented, including actual interest paid and amortization of debt and loan transaction fees, are presented in Note 5 – Debt to our unaudited condensed financial statements included elsewhere in this Quarterly Report on Form 10-Q.

Liquidity and Capital Resources

As of ~~December~~March 31, ~~2018~~2019 and June 30, 2018, we held cash, cash equivalents and marketable securities totaling $~~478~~479.21 million and $413.4 million, respectively. With the exception of fiscal year 2015, we have incurred operating losses and have generated an accumulated deficit as a result of ongoing research and development spending since inception. As of ~~December~~March 31, ~~2018~~2019, we had an accumulated deficit of approximately $1.1 billion. Our results of operations were net losses of $1137.45 million and $3673.27 million for the three and ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019, respectively, and of $147.3 million, $116.8 million and $92.8 million for the fiscal years ended June 30, 2018, 2017 and 2016, respectively.

We have historically funded our operations from upfront fees, proceeds from research and development reimbursement arrangements, license and milestone payments received under our drug collaborations and license agreements, and proceeds from the sale of equity securities and debt provided by convertible debt and other credit facilities. Beginning in fiscal year 2019, we also receive cash payments for commercial sales of our marketed drugs. We believe that our cash, cash equivalents and marketable securities as of ~~December~~March 31, ~~2018~~2019 will enable us to continue to fund operations in the normal course of business for more than a twelve-month period from the date of filing this Quarterly Report on Form 10-Q. Until we can generate sufficient levels of cash from operations, which we do not expect to achieve in at least the next two years, and because sufficient funds may not be available to us when needed from existing collaborations, we expect that we will be required to continue to fund our operations in part through the sale of debt or equity securities, or through licensing select programs or partial economic rights that include upfront, royalty and/or milestone payments.

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that include upfront, royalty and/or milestone payments.

Our ability to successfully raise sufficient funds through the sale of debt or equity securities or from debt financing from lenders when needed is subject to many risks and uncertainties and, even if we were successful, future equity issuances would result in dilution to our existing stockholders and any future debt or debt securities may contain covenants that limit our operations or ability to enter into certain transactions. We also may not successfully consummate new collaboration and license agreements that provide for upfront fees or milestone payments, we may not earn milestone payments or such payments on favorable terms to us, or we may not earn milestone payments under such agreements when anticipated, or at all. Our ability to realize milestone or royalty payments under existing agreements and to enter into new arrangements that generate additional revenue through upfront fees and milestone or royalty payments is subject to a number of risks, many of which are beyond our control.

If we are unable to generate enough revenue from sales of commercial product or through existing or new collaboration and license agreements when needed or to secure additional sources of funding and receive related full and timely collections of amounts due, it may be necessary to significantly reduce the current rate of spending through reductions in staff and delaying, scaling back, or stopping certain research and development programs, including more costly late phase clinical trials on its wholly-owned or co-development programs as these programs progress into later stage development. Insufficient liquidity may also require us to relinquish greater rights to product candidates at an earlier stage of development or on less favorable terms to us and our stockholders than we would otherwise choose in order to obtain upfront license fees needed to fund operations.

Cash, Cash Equivalents, Marketable Securities

Cash equivalents are short-term, highly-liquid financial instruments that are readily convertible to cash and have maturities of 90 days or less from the date of purchase.

Marketable securities ~~- current~~ consist mainly of U.S. government agency obligations, commercial paper, corporate bonds and asset-backed securities with maturities of greater than 90 days when purchased. ~~Marketable securities - non-current are primarily securities held under our deferred compensation plan.~~

Below is a summary of our cash, cash equivalents and marketable securities (in thousands):

	December 31, 2018		June 30, 2018		$ Change
	March 31, 2019		June 30, 2018		$ Change
Cash and cash equivalents	$	~~147~~96,~~094~~636	$	114,748	$	32(18,~~346~~112	)
Marketable securities – current	~~329~~326,~~964~~452		297,739		3228,~~225~~713
Marketable securities – non-current	156,~~095~~008		919		~~176~~55,089
Total	$	~~478~~479,~~153~~096	$	413,406	$	6465,~~747~~690

The ~~increase~~decrease in cash and cash equivalents is primarily due to $33122.85 million net proceeds ~~from~~for ~~the~~shares ~~exchange~~ of ~~the~~our ~~Silicon~~common ~~Valley~~stock ~~Bank~~sold ~~term~~under ~~loans~~an at-the-market offering ("ATM") and $8833.8 million net proceeds ~~for~~from ~~shares~~the exchange of ~~our~~the ~~common~~Silicon ~~stock~~Valley ~~sold~~Bank ~~under~~term ~~the ATM~~loans, which were partially offset by $16.0 million paid to settle the Redmile notes with interest upon maturity, cash used in operations as well as the timing of our investment in marketable securities. The increases in marketable securities are also the result of the timing of investing cash and cash equivalents in marketable securities.

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Cash Flow Activities

Below is a summary of our cash flow activities (in thousands):

	Six Months EndedDecember 31,
	Nine Months EndedMarch 31,
	2018			2017			$ Change
	2019			2018			$ Change
Cash flows provided by (used in):
Operating activities	$	(4387,~~438~~426	)	$	(7091,~~176~~154	)	$	263,~~738~~728
Investing activities	(3284,~~946~~588		)	(~~246~~258,~~851~~250		)	~~213~~173,~~905~~662
Financing activities	~~108~~153,~~730~~902			~~256~~297,~~145~~326			(~~147~~143,~~415~~424		)
Total	$	32(18,~~346~~112	)	$	(6052,~~882~~078	)	$	9333,~~228~~966

~~The~~Net ~~decrease in net~~ cash used in operating activities ~~was~~decreased mainly due to ~~our~~the ~~lower~~decrease in net loss of approximately $21.2 million during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 as compared to the same period in the prior fiscal year, asoffset ~~well~~by asa ~~the~~change ~~$6.5~~in ~~million~~working ~~loss~~capital onitems ~~extinguishment~~ of ~~our~~approximately $15.6 ~~notes~~million ~~payable~~and ~~that~~increased ~~did~~non-cash ~~not~~adjustments ~~recur~~of $1.9 ~~in the current fiscal year, partly offset by increases in other assets and prepayments for inventory~~million.

Net cash used in investing activities decreased primarily due to net purchases of marketable securities of $3283.12 million during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 compared with net purchases of marketable securities of $~~246~~257.61 million following our public offering of shares of common stock during the ~~six~~nine months ended ~~December~~March 31, ~~2017~~2018.

Net cash provided by financing activities during the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019 consisted primarily of $88122.85 million net proceeds for shares of our common stock sold under the ATM and $33.8 million net proceeds from the exchange of the Silicon Valley Bank term loans, which were partially offset by $15.0 million paid to settle the Redmile notes upon maturity. Net cash provided by financing activities during the ~~six~~nine months ended ~~December~~March 31, ~~2017~~2018 primarily related to $243.0 million in net proceeds from a follow-on offering of our common stock in September 2017 and $40.3 million net proceeds for shares of our common stock sold under the ATM.

Recent Accounting Pronouncements

Our discussion of recently adopted accounting pronouncements and other recent accounting pronouncements is set forth in Note 1 - Overview, Basis of Presentation and Summary of Significant Accounting Policies to the accompanying unaudited condensed consolidated financial statements included elsewhere in this Quarterly Report on Form 10-Q.

Critical Accounting Policies and Estimates

Management's discussion and analysis of our financial condition and results of operations are based upon our accompanying unaudited condensed financial statements, which have been prepared in conformity with U.S. generally accepted accounting principles, or U.S. GAAP, and which requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue and expenses, and related disclosure of contingent assets and liabilities. We base our estimates on historical experience and on various other assumptions that we believe are reasonable under the circumstances. These estimates are the basis for our judgments about the carrying values of assets and liabilities, which in turn may impact our reported revenue and expenses. Our actual results could differ significantly from these estimates under different assumptions or conditions.

An accounting policy is deemed to be critical if it requires an accounting estimate to be made based on assumptions about matters that are highly uncertain at the time the estimate is made, and if different estimates that reasonably could have been used, or changes in the accounting estimate that are reasonably likely to occur periodically, could materially impact the unaudited condensed consolidated financial statements. Our critical accounting estimates are disclosed in the Management’s Discussion and Analysis of Financial Condition and Results of Operations section of our Annual Report on Form 10-K for the fiscal ~~period~~year ended June 30, 2018. During the ~~six~~nine months ended ~~December~~March 31, ~~2018~~2019, we began selling commercial product and consider reserves for variable consideration related to product sales to be a critical accounting estimate. See Note 1 of the notes to our unaudited condensed consolidated financial statements contained elsewhere in ~~this report for a description of our accounting policies and estimates for reserves for variable consideration related to product sales.~~

36 this report for a description of our accounting policies and estimates for reserves for variable consideration related to product sales.

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ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Market risk represents the risk of loss that may impact our financial position, results of operations or cash flows due to adverse changes in financial and commodity market prices and fluctuations in interest rates. All of our collaboration and other agreements and nearly all purchase orders are denominated in U.S. dollars, except our agreement with Ono Pharmaceuticals entered into in May 2017, which is denominated in Japanese Yen. Future payments from Ono will be due on payment terms of net 30 days and will not represent a significant component of our overall cash balance. As a result, historically and as of ~~December~~March 31, ~~2018~~2019, we have had little or no exposure to market risk from changes in foreign currency or exchange rates and a 10% hypothetical change in foreign exchange rates during the periods presented would not have had a material effect on our financial results.

Our investment portfolio is comprised primarily of readily marketable, high-quality securities that are diversified and structured to minimize market risks. We target an average portfolio maturity of eighteen months or less. Our exposure to market risk for changes in interest rates relates primarily to our investments in marketable securities. A significant change in market interest rates could have a material impact on interest income earned from our investment portfolio. We model interest rate exposure by a sensitivity analysis that assumes a theoretical 100 basis point (1%) change in interest rates. If the yield curve were to change by 100 basis points (1%) from the level that existed at ~~December~~March 31, ~~2018~~2019, we would expect future interest income to increase or decrease by approximately $3.38 million over the next 12 months based on the balance as of ~~December~~March 31, ~~2018~~2019 of $~~329~~381.74 million of investments in ~~debt~~U.S. treasury securities, commercial paper, corporate bonds and asset-backed securities. Changes in interest rates may affect the fair value of our investment portfolio; however, we will not recognize such gains or losses in our consolidated condensed statement of operations and comprehensive income (loss) unless the investments are sold.

Our term loan with Silicon Valley Bank of $50.0 million is our only variable rate debt. Assuming constant debt levels, a theoretical change of 100 basis points (1%) on our current interest rate of 3.5% on the Silicon Valley Bank debt as of ~~December~~March 31, ~~2018~~2019 would result in a change in our annual interest expense of $0.5 million.

Historically, and as of ~~December~~March 31, ~~2018~~2019, we have not used foreign currency derivative instruments or engaged in hedging activities.

ITEM 4. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

Under the supervision and with the participation of our Chief Executive Officer, Chief Financial Officer and other senior management personnel, we evaluated the effectiveness of the design and operation of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934) as of the end of the period covered by this Quarterly Report on Form 10-Q. Based on this evaluation, our Chief Executive Officer and our Chief Financial Officer have concluded that our disclosure controls and procedures were effective as of ~~December~~March 31, ~~2018~~2019 to provide a reasonable level of assurance that the information we are required to disclose in reports that we submit or file under the Securities Exchange Act of 1934: (i) is recorded, processed, summarized and reported within the time periods specified in the SEC rules and forms; and (ii) is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. Our disclosure controls and procedures are designed to provide reasonable assurance that such information is accumulated and communicated to management. Management’s assessment of the effectiveness of our disclosure controls and procedures is expressed at a reasonable level of assurance because an internal control system, no matter how well designed and operated, can provide only reasonable, but not absolute, assurance that the internal control system’s objectives will be met.

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to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. Our disclosure controls and procedures are designed to provide reasonable assurance that such information is accumulated and communicated to management. Management’s assessment of the effectiveness of our disclosure controls and procedures is expressed at a reasonable level of assurance because an internal control system, no matter how well designed and operated, can provide only reasonable, but not absolute, assurance that the internal control system’s objectives will be met.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting during the quarter ended ~~December~~March 31, ~~2018~~2019, that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

On November 20, 2017, we were notified that a complaint was filed against us and our Chief Executive Officer, former interim Chief Financial Officer, and current Chief Financial Officer in their capacities as officers of Array, in the United States District Court for the District of Colorado by Wendell Rose, individually and on behalf of all others similarly situated (the "Rose Action"). A second complaint was filed on November 28, 2017 also in the United States District Court for the District of Colorado by Robert Nauman, individually and on behalf of all others similarly situated (the "Nauman Action"). The complaints in both actions contain substantially similar allegations of violations of the federal securities laws by us and the defendant executive officers in connection with certain disclosures made, or omitted, by us regarding our NRAS-mutant melanoma program and seek to establish a class of investors who purchased our common stock between December 16, 2015 and March 17, 2017, inclusive, affected by the allegations in the complaints. The complaints seek unspecified remedies under the Securities Exchange Act of 1934. On March 12, 2018, the Court granted Peter Voulgaris's motion seeking appointment as lead plaintiff and their respective law firm. The Court also consolidated the Rose Action and the Nauman Action into one proceeding. Array filed a Motion to Dismiss the complaint on June 11, 2018. We will continue to evaluate the allegations set forth in the Complaint and intend to vigorously defend against all such allegations.

On July 28, 2017, AstraZeneca and Merck announced that they entered into an agreement to share the development and commercialization costs for selumetinib monotherapy and non-PD-L1/PD-1 combination therapy opportunities. Array remains eligible to receive from AstraZeneca milestones and royalties on all future selumetinib sales and now expects to receive a portion of certain consideration paid by Merck to AstraZeneca under this agreement. Array has informed AstraZeneca, however, that it is disputing the consideration that AstraZeneca has paid Array related to both upfront and potential future milestones under AstraZeneca's agreement with Merck. Array commenced legal proceedings against AstraZeneca on December 7, 2017, naming AstraZeneca as the defendant in New York ~~State~~state ~~Court~~court in Manhattan regarding this dispute. On February 1, 2018, we filed a second action against AstraZeneca's subsidiary AstraZeneca AB in New York ~~State~~state ~~Court~~court. The two cases have now been consolidated into one case. We are seeking damages and a declaratory judgment in ~~both~~that ~~actions~~consolidated case. AstraZeneca has filed a motion to dismiss the case which is currently scheduled to be argued on June 11, 2019.

ITEM 1A. RISK FACTORS

Investing in our common stock is subject to a number of risks and uncertainties. You should carefully consider the risk factors described under the heading “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018, and in other reports we file with the SEC. There have been no changes to the risk factors disclosed in our Annual Report on Form 10-K for the fiscal year ended June 30, 2018 that we believe are material. Additional risks and uncertainties not presently known to us or that we currently believe are immaterial also may negatively impact our business.

ITEM 5. OTHER INFORMATION

Effective May 7, 2019, we entered into a sales agreement with Jefferies LLC (the “Jefferies Sales Agreement”), pursuant to which we may, from time to time, sell up to $150.0 million in shares of our common stock through Jefferies LLC, acting as our sales agent and/or principal, in an at-the-market offering (the “ATM Offering”). We are not required

to sell shares under the Sales Agreement. We will pay Jefferies LLC a commission of up to 3% of the aggregate gross proceeds we receive from all sales of our common stock under the Sales Agreement. Unless otherwise terminated, the Sales Agreement continues until the earlier of selling all shares available under the Sales Agreement or May 7, 2022. No sales have been made under the Sales Agreement.

The ATM Offering is being made under a prospectus supplement filed on May 7, 2019, and related prospectus filed with the Securities and Exchange Commission pursuant to our automatically effective shelf registration statement on Form S-3 (Registration No. 333-220443).

A copy of the Sales Agreement is attached as Exhibit 10.2 to this Quarterly Report. The foregoing description of the Sales Agreement does not purport to be complete and is qualified in its entirety by reference to Exhibit 10.2. A copy of the opinion of Skadden, Arps, Slate, Meagher & Flom LLP relating to the validity of the securities issued in the ATM Offering is filed as Exhibit 5.1 to this Quarterly Report.

ITEM 6. EXHIBITS

(a) Exhibits

The following exhibits are filed or incorporated by reference as part of this Quarterly Report on Form 10-Q.

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EXHIBITS

		Incorporated by Reference
Exhibit Number	Description of Exhibit	Form	File No.	Date Filed
3.1	Amended and Restated Certificate of Incorporation of Array BioPharma Inc., as amended	10-Q	001-16633	10/30/18
3.2	Bylaws of Array Biopharma Inc., as amended and restated on February 1, 2018	10-Q	001-16633	2/6/2018
4.1	Specimen certificate representing the common stock	S-1/A	333-45922	10/27/2000
4.2	Indenture, dated as of December 1, 2017, by and between registrant and The Bank of New York Mellon Trust Company, N.A.	8-K	001-16633	12/4/2017
4.3	Form of 2.625% Convertible Senior Notes due 2024	8-K	001-16633	12/4/2017
5.1	Legal Opinion of Skadden, Arps, Slate, Meagher & Flom LLP	Filed herewith
10.1	Separation Agreement, dated March 19, 2019, between registrant and Curtis Oltmans*	Filed herewith
10.2	Sales Agreement between Array BioPharma Inc. and Jefferies LLC dated May 7, 2019	Filed herewith
31.1	Certification of Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended	Filed herewith
31.2	Certification of Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a) of the Securities Exchange Act of 1934, as amended	Filed herewith
32.1	Certifications of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002	Furnished herewith
101.INS	XBRL Instance Document	Filed herewith
101.SCH	XBRL Taxonomy Extension Schema Document	Filed herewith
101.CAL	XBRL Taxonomy Extension Calculation Linkbase Document	Filed herewith
101.LAB	XBRL Taxonomy Extension Label Linkbase Document	Filed herewith
101.PRE	XBRL Taxonomy Extension Presentation Linkbase Document	Filed herewith
101.DEF	XBRL Taxonomy Extension Definition Linkbase Document	Filed herewith

* Management contract or compensatory plan.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Boulder, State of Colorado, on this ~~5th~~7th day of ~~February~~May 2019.

ARRAY BIOPHARMA INC.



By:	/s/ RON SQUARER
	Ron Squarer
	Chief Executive Officer


By:	/s/ JASON HADDOCK
	Jason Haddock
	Chief Financial Officer
	(Principal Financial and Accounting Officer)

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