UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 4 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940 |_| Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). (Print of Type Responses) ________________________________________________________________________________ 1. Name and Address of Reporting Person* Esteve Antonio -------------------------------------------------------------------------------- (Last) (First) (Middle) 350 South Main Street, Suite 307 -------------------------------------------------------------------------------- (Street) Doylestown PA 18901 -------------------------------------------------------------------------------- (City) (State) (Zip) ________________________________________________________________________________ 2. Issuer Name and Ticker or Trading Symbol Discovery Laboratories, Inc. (Discovery) DSCO ________________________________________________________________________________ 3. I.R.S. Identification Number of Reporting Person, if an entity (voluntary) ________________________________________________________________________________ 4. Statement for Month/Day/Year November 4, 2002 ________________________________________________________________________________ 5. If Amendment, Date of Original (Month/Day/Year) ________________________________________________________________________________ 6. Relationship of Reporting Person(s) to Issuer (Check all applicable) |X| Director |_| 10% Owner |_| Officer (give title below) |_| Other (specify below) ____________________________________________________________________ ________________________________________________________________________________ 7. Individual or Joint/Group Filing (Check Applicable line) |X| Form Filed by One Reporting Person |_| Form Filed by More than One Reporting Person ________________________________________________________________________________ ================================================================================ Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned ================================================================================

5. Amount of 6. 4. 5.Securities Owner- Securities Acquired (A) or ~~Amount~~Beneficially of ship 2A. 3. Disposed of (D) ~~Securities~~Owned Form: 7. 2. Deemed Transaction (Instr. 3, 4 and 5) ~~Beneficially~~Following Direct Nature of 2.Trans- Execution Code ------------------------------- ~~Owned~~Reported ~~at End~~ (D) or Indirect 1. ~~Transaction~~action Date, if (Instr. 8) (A) ofTransaction(s) ~~Month~~ Indirect Beneficial Title of Security Date any ------------ ~~Amount~~ or ~~Price~~ (Instr. 3 & (I) Ownership (Instr. 3) (mm/dd/yy) (mm/dd/yy) Code V Amount (D) ~~and~~Price Instr.4) (Instr.4) (Instr. 4) ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 911/235/02 P ~~162~~340,~~973~~485 A $1.~~495~~94 ~~984~~1,~~835~~325,320 I Laboratorios del Dr. Esteve S.A. ------------------------------------------------------------------------------------------------------------------------------------ -- 317,164 I Laboratorios P.E.N.S.A. ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ====================================================================================================================================

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. * If the form is filed by more than one reporting person, see Instruction 4(b)(v). Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number FORM 4 (continued) Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) ================================================================================

109. 9Number 10. of Owner- ~~Number~~deriv- ship ofative Form 2. ~~Deriv~~Secur- of Conver- 5. 7. ~~ative~~ities Deriv- 11. sion Number of Title and Amount ~~Secur~~Bene- ative Nature or Derivative 6. of Underlying 8. ~~ities~~ficially Secur- of Exer- 3A. 4. Securities Date Securities Price ~~Bene-~~Owned ity: In- cise 3.Deemed Trans- Acquired (A) Exercisable and (Instr. 3 and 4) of ~~ficially~~Follow- Direct direct Price ~~Trans~~3. Execut- action or Disposed Expiration Date ---------------- Deriv- ~~Owned~~ing (D) or Bene- 1. of ~~action~~Trans- ion Code of(D) (Month/Day/Year) Amount ative atReported ~~End~~ In- ficial Title of Deriv- action Date if (Instr. (Instr. 3, ---------------- or Secur- ofTrans- direct Owner- Derivative ative ~~(Month/~~Date any 8) 4 and 5) Date Expira- Number ity ~~Month~~action(s) (I) ship Security Secur- ~~Day~~(mm/dd/ (mm/dd/ ------ ------------ Exer- tion of (Instr. (Instr. (Instr. (Instr. (Instr. 3) ity ~~Year~~yy) yy) Code V (A) (D) cisable Date Title Shares 5) 4) 4) 4) ------------------------------------------------------------------------------------------------------------------------------------ Class I $2.425 11/5/02 P A 2/5/03 11/5/07 Common 153,218 $0.125 153,218 I Labor- Warrants Stock atorios del Dr. Esteve ------------------------------------------------------------------------------------------------------------------------------------ Stock Options 20,000 D ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ====================================================================================================================================

Explanation of Responses: /s/ Antonio Esteve 11/6/02 --------------------------------------------- ----------------------- **Signature of Reporting Person Date ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Page 2

Filing Compare · WINDTREE THERAPEUTICS INC /DE/