UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of ~~August~~September 2025

Commission File Number 000-30902

COMPUGEN LTD.

(Translation of registrant’s name into English)

26 Harokmim Street Holon 5885849, Israel (Address of Principal Executive Offices)

Holon 5885849, Israel

(Address of Principal Executive Offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

Form 20-F ☒ Form 40-F ☐

Compugen Ltd.

On orSeptember ~~about August 6~~16, 2025, Compugen Ltd. (the “Company”) ~~took~~held ~~action~~its to2025 ~~distribute~~Annual ~~copies~~General Meeting of Shareholders ~~its~~(the ~~proxy~~“Meeting”). ~~statement~~The toCompany ~~its~~filed ~~shareholders~~the ~~and~~notice toof ~~mail~~the toMeeting, ~~its shareholders~~the ofproxy ~~record~~statement aand the proxy ~~statement~~card ~~for~~with anthe ~~annual~~Securities ~~general~~and ~~meeting~~Exchange ofCommission ~~shareholders~~as Exhibit 99.1 to bethe ~~held~~Company’s Report on ~~Tuesday,~~Form 6-K ~~September~~on 16August 6, 2025 (File No. 000-30902), which is incorporated herein by reference. All proposals brought before the shareholders at ~~6:00~~the PMMeeting ~~(Israel~~were ~~time)~~approved inby ~~Israel~~the requisite majority vote of the Company’s shareholders.

AThe ~~copy~~information ofcontained ~~the~~in ~~notice~~this ofReport ~~2025~~on ~~annual~~Form ~~general~~6-K ~~meeting~~is ofhereby ~~shareholders~~incorporated ofby reference into the Company,’s ~~proxy~~Registration ~~statement~~Statement ~~and~~on ~~proxy card are attached to this~~ Form 6 F-K3, as ~~Exhibit~~amended, 99File No.1 333-270985.

The information contained in this Form 6-K is hereby incorporated by reference into the Company’s Registration Statements on Form F-3, File No. 333-270985.

Exhibits

Exhibit Number 99.1 Description of Exhibit Notice of 2025 annual general meeting of shareholders of Compugen Ltd., proxy statement and proxy card.

Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	COMPUGEN LTD.
Date: August 6, 2025	By:	/s/ Eran Ben Dor
Date: September 17, 2025	By:	/s/ Eran Ben Dor
		Eran Ben Dor General Counsel

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