4 1 NASD 0001184429 Officer Neose Technologies, Inc. 0000877902 13-3549286 02/20/03 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 4 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 1. Name and Address of Reporting Person(s) Zopf, David A. 102 Witmer Road Horsham, PA 19044 2. Issuer Name and Ticker or Trading Symbol Neose Technologies, Inc. (NTEC) 3. I.R.S. Identification Number of Reporting Person, if an entity (Voluntary) 4. Statement for Month/Day/Year 2/20/2003 5. If Amendment, Date of Original (Month/Day/Year) 6. Relationship of Reporting Person(s) to Issuer (Check all applicable) [ ] Director [ ] 10% Owner [X] Officer (give title below) [ ] Other (specify below) (1) 7. Individual or Joint/Group Filing (Check Applicable Line) [X] Form filed by One Reporting Person [ ] Form filed by More than One Reporting Person

Table I Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Security 2)Trans- 3.Trans- 4.Securities Acquired(A) 5)Amount of 6) 7)Nature of action action or Disposed of (D) Securities Indirect Date Code A Beneficially D Beneficial (Month/ or Owned at or Ownership Day/Year) Code V Amount D Price End of Month I ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 02/18/03 S 1,000 D $6.2600 D Direct Common Stock 02/19/03 S 1,000 D $6.6500 D Direct Common Stock 02/19/03 S 3,000 D $6.5600 D Direct Common Stock 02/19/03 S 1,499 D $6.3800 D Direct Common Stock 02/20/03 S 3,500 D $6.2500 D Direct Common Stock 02/20/03 S 1,500 D $6.4800 11,306 D Direct Table II (PART 1) Derivative Securities Acquired, Disposed of, or Beneficially Owned (Columns 1 through 6) ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 2)Conversion 3)Trans- 4)Trans- 5)Number of Derivative 6)Date Exercisable and Security or Exercise action action Securities Acquired (A) Expiration Date Price of Date Code or Disposed of (D) Derivative Security Code V A D Exercisable Expiration ------------------------------------------------------------------------------------------------------------------------------------ ~~Incentive Stock Option (right $7.4500 02/12/03 A 11,483 (2) 02/12/13 to buy) Non-Qualified Stock Option $7.4500 02/12/03 A 23,517 (3) 02/12/13 (right to buy)~~ Table II (PART 2) Derivative Securities Acquired, Disposed of, or Beneficially Owned (Columns 1,3 and 7 through 11) ------------------------------------------------------------------------------------------------------------------------------------ 1)Title of Derivative 3)Trans- 7)Title and Amount 8)Price 9)Number of 10) 11)Nature of Security action of Underlying of Deri- Derivative Indirect Date Securities vative Securities D Beneficial Amount or Security Beneficially or Ownership Number of Owned at I - Title Shares End of Month ------------------------------------------------------------------------------------------------------------------------------------ ~~Incentive Stock Option (right 02/12/03 Common Stock 11,483 11,483 D Direct to buy) Non-Qualified Stock Option 02/12/03 Common Stock 23,517 23,517 D Direct (right to buy)~~ Explanation of Responses: (1) Executive Vice President (2) The option becomes exercisable as to 1 share on February 12, 2004, 1 share on February 12, 2005, 2,731 shares shares on February 12, 2006, and 8,750 shares on February 12, 2007. (3) The option becomes exercisable as to 8,749 shares on February 12, 2004, 8,749 shares on February 12, 2005, and 6,019 shares on Febru ary 12, 2006.

SIGNATURE OF REPORTING PERSON /S/ Zopf, David A. DATE 02/20/03

Filing Compare · ZOPF DAVID A MD