UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of

of the Securities Exchange Act of 1934

Date of report (Date of earliest event reported): ~~February 28~~March 10, 2023

PROMETHEUS BIOSCIENCES, INC.

(Exact name of registrant as specified in its charter)

Delaware	001-40187	81-4282653
(State or other jurisdiction ofincorporation or organization)	(CommissionFile Number)	(I.R.S. EmployerIdentification No.)
(State or other jurisdiction of incorporation or organization)	(Commission File Number)	(I.R.S. Employer Identification No.)

3050 Science Park RoadSan Diego, California 92121(Address of principal executive offices) (Zip Code) 858-422-4300(Registrant’s telephone number, include area code) N/A(Former Name or Former Address, if Changed Since Last Report)Road

San Diego, California 92121

(Address of principal executive offices) (Zip Code)

(858) 422-4300

(Registrant’s telephone number, include area code)

N/A

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		TradingSymbol(s)		Name of each ~~exchangeon~~exchange on which registered
Common Stock, par value $0.0001 per share		RXDX		The Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 27.0201. ~~Results~~ ofRegulation ~~Operations~~FD ~~and Financial Condition~~Disclosure.

~~On February 28, 2023,~~ Prometheus Biosciences, Inc. ~~issued~~(“Prometheus”) ais ~~press~~aware ~~release~~that ~~announcing~~the ~~its~~Federal ~~financial~~Deposit ~~results~~Insurance ~~for~~Corp. ~~the~~(“FDIC”) ~~quarter~~has ~~and~~taken ~~year~~control ~~ended~~of ~~December~~Silicon ~~31,~~Valley ~~2022.~~Bank A(“SVB”) ~~copy~~due ofto ~~the~~liquidity ~~press~~concerns. ~~release~~Prometheus isdoes ~~attached~~not ~~hereto~~hold asany ~~Exhibit~~deposits ~~99.1~~at ~~and~~SVB isor ~~incorporated~~have ~~herein~~any byother ~~reference~~direct investments at SVB.

InThe ~~accordance~~information ~~with~~set ~~General~~forth ~~Instruction B.2 of Form 8-K, the information~~ in this ~~Current~~Item ~~Report~~7.01 onis ~~Form~~being ~~8-K,~~furnished ~~including~~pursuant ~~Exhibit~~to 99Item 7.1,01 and shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended ~~(the “Exchange Act”)~~, or otherwise subject to the liabilities of that section, ~~nor~~and it shall itnot be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or under the Exchange Act, whether made before or after the date hereof, except as expressly ~~set~~provided ~~forth~~ by specific reference in such a filing.

~~Item~~Forward-Looking ~~9.01. Financial~~ Statements ~~and Exhibits.~~

~~(d)~~Prometheus ~~Exhibits~~cautions you that statements included in this report that are not a description of historical facts are forward-looking statements. These forward-looking statements include statements regarding any liquidity concern. The inclusion of forward-looking statements should not be regarded as a representation by Prometheus that any of these results will be achieved. Actual results may differ from those set forth in this report due to the risks and uncertainties associated with liquidity concerns that may affect other banking institutions, as well as risks and uncertainties inherent in Prometheus’ business, including those described in Prometheus’ other filings with the Securities Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and Prometheus undertakes no obligation to revise or update this report to reflect events or circumstances after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

Exhibit No.		Description
99.1		Press Release issued on February 28, 2023
104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	~~PROMETHEUS BIOSCIENCES, INC.~~	PROMETHEUS BIOSCIENCES, INC.
Date: February 28, 2023	By:	/s/ Timothy K. Andrews
Date: March 10, 2023		By:	/s/ Timothy K. Andrews
		~~Timothy K. Andrews~~	Timothy K. Andrews
		~~General Counsel and Secretary~~	General Counsel and Secretary

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