Shaikhly Samira 4

4 · Septerna, Inc. · Filed Mar 4, 2026

Insider Transaction Report

Form 4

Period: 2026-03-02

Septerna, Inc.SEPN

Shaikhly Samira

Chief People Officer

Transactions

Exercise/Conversion
Common Stock
[F1]
2026-03-02$1.55/sh+53,714$83,257→ 54,507 total
Exercise/Conversion
Common Stock
2026-03-02$2.76/sh+11,638$32,121→ 66,145 total
Exercise/Conversion
Common Stock
2026-03-02$2.76/sh+5,101$14,079→ 71,246 total
Sale
Common Stock
[F2][F3]
2026-03-02$27.51/sh−4,090$112,496→ 67,156 total
Sale
Common Stock
[F2][F4]
2026-03-02$28.14/sh−66,363$1,867,342→ 793 total
Exercise/Conversion
Stock Option (Right to Buy)
[F5]
2026-03-02−53,714→ 15,969 total
Exercise: $1.55Exp: 2033-03-30→ Common Stock (53,714 underlying)
Exercise/Conversion
Stock Option (Right to Buy)
[F5]
2026-03-02−11,638→ 3,460 total
Exercise: $2.76Exp: 2033-11-11→ Common Stock (11,638 underlying)
Exercise/Conversion
Stock Option (Right to Buy)
[F6]
2026-03-02−5,101→ 5,101 total
Exercise: $2.76Exp: 2034-03-19→ Common Stock (5,101 underlying)

Footnotes (6)

[F1]Includes 793 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in a transaction that was exempt under Rule 16b-3(c).
[F2]This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.
[F3]The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $26.90 to $27.89. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.
[F4]The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $27.90 to $28.70. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.
[F5]25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date.
[F6]1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

Signature

/s/ Mark A. Wilson, Attorney-in-Fact|2026-03-04

Documents

1 file

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ownership.xmlPrimary
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