UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)

x	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended ~~June~~September 30, 2010.

o	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission file number: 0-21145

ENCORIUM GROUP, INC.

(Exact name of registrant as specified in its charter)


Delaware		56-1668867
(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification No.)

435 Devon Park Drive, Building 500, Wayne, Pennsylvania		19087
(Address of principal executive offices)		(Zip Code)

484-588-5400

(Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No o

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes o No o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definition of “large accelerated filer”, “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Act) Yes o No x

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date: As of ~~August~~April 1629, ~~2010~~2011, there were 35,~~408~~415,~~247~~500 shares of Encorium Group, Inc. common stock issued, par value $.001 per share, which excludes 38,765 shares in treasury.

ENCORIUM GROUP, INC.

INDEX

		~~Page~~	Page
PART I. FINANCIAL INFORMATION
ITEM 1.	Consolidated Condensed Financial Statements (unaudited)	2	2
	Consolidated Condensed Balance Sheets – June 30, 2010 and December 31, 2009	2
	Consolidated Condensed Balance Sheets – September 30, 2010 and December 31, 2009		2
	Consolidated Condensed Statements of Operations – Three and Six months ended June 30, 2010 and 2009	3
	Consolidated Condensed Statements of Operations–Three and Nine months ended September 30, 2010 and 2009 Consolidated Condensed 2009		3
	Consolidated Condensed Statements of Cash Flows – Six months ended June 30, 2010 and 2009	4
	Consolidated Condensed Statements of Cash Flows – Nine months ended September 30, 2010 and 2009		4
	Notes to Consolidated Condensed Financial Statements	5	5
ITEM 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	26	22
ITEM 4T.	Controls and Procedures	40	34
PART II. OTHER INFORMATION
ITEM 1A.	~~Risk Factors~~	41Risk Factors	35
ITEM 6.	~~Exhibits~~	51Exhibits	45
SIGNATURES		52	46

Table of Contents

PART I. FINANCIAL INFORMATION

ITEM 1.

FINANCIAL STATEMENTS

ENCORIUM GROUP, INC. CONSOLIDATED CONDENSED BALANCE SHEETS (UNAUDITED)

CONSOLIDATED CONDENSED BALANCE SHEETS

		September 30,			December 31,
		2010			2009
Assets		(UNAUDITED)
Current Assets
Cash and cash equivalents		$	187,566		$	196,583
Investigator advances			-			19,232
Accounts receivable, less allowance of $317,317 at
September 30, 2010 and $412,973 at December 31, 2009			2,975,099			3,454,173
Prepaid expenses and other			1,375,040			872,722
Costs and estimated earnings in excess of
related billings on uncompleted contracts			640,079			1,794,134
Debt issuance costs, current, net			75,400			75,400
Current assets of discontinued operations			-			28,832
	Total Current Assets		5,253,184			6,441,076

Property and Equipment, Net			429,918			307,552

Goodwill			2,449,822			1,389,045
Other intangibles, net			1,238,030			3,508,310
Debt issuance costs, long-term, net			94,250			150,800
Other assets			431,004			313,524
Total Assets		$	9,896,208		$	12,110,307

Liabilities and Stockholders' Equity
Current Liabilities
Accounts payable		$	3,283,129		$	1,756,678
Notes payable			317,340			334,413
Notes payable stockholder			1,782,223			-
Credit Lines			847,680			300,697
Accrued expenses			3,373,869			2,333,099
Deferred taxes			174,883			248,117
Obligations under capital leases			95,590			54,510
Billings in excess of related costs and
estimated earnings on uncompleted contracts			1,632,751			1,179,779
Customer advances			1,142,086			1,361,496
Current liabilities of discontinued operations			413,573			607,552
	Total Current Liabilities		13,063,124			8,176,341

Long Term Liabilities
Notes Payable			634,666			668,826
Obligations under capital leases			51,408			52,541
Accrued salaries			121,619			-
Deferred taxes			61,381			837,424
Other liabilities			280,246			104,624
Liability for warrants to purchase common stock			65,000			-
	Total Long Term Liabilities		1,214,320			1,663,415
Total Liabilities			14,277,444			9,839,756

Commitments and contingencies

Stockholders' Equity (Deficit)
Common stock, $.001 par value 35,000,000 shares authorized,
3,640,802 and 3,426,938 shares issued at September 30, 2010
and December 31, 2009, respectively			3,641			3,427
Additional paid-in capital			35,942,824			35,442,460
Accumulated deficit			(40,199,318	)		(33,607,123	)
Accumulated other comprehensive income			598,306			1,158,476
			(3,654,547	)		2,997,240
Less: Treasury stock, at cost, 38,765 shares			(726,689	)		(726,689	)
Total Stockholders’ Equity (Deficit)			(4,381,236	)		2,270,551

Total Liabilities and Stockholders’ Equity (Deficit)		$	9,896,208		$	12,110,307

	June 30,			December 31,
	2010			2009
Assets	(UNAUDITED)
Current Assets
Cash and cash equivalents	$	176,460		$	196,583
Investigator advances		12,544			19,232
Accounts receivable, less allowance of $316,576 at
June 30, 2010 and $412,973 at December 31, 2009		2,583,812			3,454,173
Prepaid expenses and other		1,017,327			872,722
Costs and estimated earnings in excess of
related billings on uncompleted contracts		1,421,783			1,794,134
Debt issuance costs, current		75,400			75,400
Current assets of discontinued operations		-			28,832
Total Current Assets		5,287,326			6,441,076
Property and Equipment, Net		305,003			307,552
Goodwill		1,183,188			1,389,045
Other intangibles, Net		2,865,956			3,508,310
Debt issuance costs, long-term		113,100			150,800
Other assets		268,050			313,524
Total Assets	$	10,022,623		$	12,110,307
Liabilities and Stockholders' Equity
Current Liabilities
Accounts payable	$	2,233,562		$	1,756,678
Notes payable		530,471			334,413
Credit Lines		790,897			300,697
Accrued expenses		2,390,956			2,333,099
Deferred taxes		220,530			248,117
Obligations under capital leases		44,873			54,510
Billings in excess of related costs and
estimated earnings on uncompleted contracts		1,043,579			1,179,779
Customer advances		1,370,907			1,361,496
Current liabilities of discontinued operations		503,753			607,552
Total Current Liabilities		9,129,528			8,176,341
Long Term Liabilities
Notes Payable		569,706			668,826
Obligations under capital leases		53,679			52,541
Deferred taxes		681,488			837,424
Other liabilities		98,885			104,624
Liability for warrants to purchase common stock		109,000			-
Total Long Term Liabilities		1,512,758			1,663,415
Total Liabilities		10,642,286			9,839,756
Commitments and contingencies
Stockholders' Equity (Deficit)
Common stock, $.001 par value 4,375,000
shares authorized, 3,447,002 and 3,426,938 shares issued at June 30, 2010
and December 31, 2009, and 3,408,237 and 3,388,173 shares outstanding
at June 30, 2010 and December 31, 2009, respectively		3,447			3,427
Additional paid-in capital		35,380,848			35,442,460
Accumulated deficit		(36,335,885	)		(33,607,123	)
Accumulated other comprehensive income		1,058,616			1,158,476
		107,026			2,997,240
Less: Treasury stock, at cost, 38,765 shares		(726,689	)		(726,689	)
Total Stockholders’ Equity (Deficit)		(619,663	)		2,270,551
Total Liabilities and Stockholders’ Equity (Deficit)	$	10,022,623		$	12,110,307

See accompanying notes to the consolidated condensed financial statements.

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ENCORIUM GROUP, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS
(UNAUDITED)
	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2010			2009			2010			2009
Revenue
Net revenue	$	3,775,262		$	4,483,263		$	6,776,622		$	9,021,436
Reimbursement revenue		613,238			799,315			1,169,403			1,915,366
Total Revenue		4,388,500			5,282,578			7,946,025			10,936,802
Operating Expenses
Direct		2,654,449			3,421,074			5,450,989			6,364,975
Reimbursement out-of-pocket expenses		613,238			799,315			1,169,403			1,915,366
Selling, general and administrative		1,800,114			2,238,561			3,810,830			4,320,868
Depreciation and amortization		95,959			92,877			190,541			183,375
Total Operating Expenses		5,163,760			6,551,827			10,621,763			12,784,584
Loss from Operations		(775,260	)		(1,269,249	)		(2,675,738	)		(1,847,782	)
Interest Income		-			1,064			-			10,107
Interest Expense		(60,691	)		(2,059	)		(74,976	)		(14,563	)
Net Interest (Expense)		(60,691	)		(995	)		(74,976	)		(4,456	)
Gain on Warrants		15,301			-			15,301			-
Net Loss from continuing operations before Income Taxes		(820,650	)		(1,270,244	)		(2,735,413	)		(1,852,238	)
Income Tax Expense (Benefit)		(15,493	)		11			(22,082	)		(7,927	)
Net Loss from continuing operations	$	(805,157	)	$	(1,270,255	)	$	(2,713,331	)	$	(1,844,311	)
Net Loss from discontinued operations		-			(674,416	)		(15,431	)		(295,580	)
Income Tax Expense (Benefit)		-			-			-			-
Net Loss	$	(805,157	)	$	(1,944,671	)	$	(2,728,762	)	$	(2,139,891	)
Weighted Average Common and Common Equivalent Shares Outstanding
Basic and diluted		3,404,048			2,565,485			3,396,154			2,565,485
Net Loss per Common Share
Continuing Operations	$	(0.24	)	$	(0.50	)	$	(0.80	)	$	(0.72	)
Discontinued Operations	$	-		$	(0.26	)	$	-		$	(0.11	)
Net Loss per Common Share	$	(0.24	)	$	(0.76	)	$	(0.80	)	$	(0.83	)

ENCORIUM GROUP, INC.
CONSOLIDATED CONDENSED STATEMENTS OF OPERATIONS
(UNAUDITED)

	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2010			2009			2010			2009
Revenue
Net revenue	$	2,793,625		$	4,446,606		$	9,570,247		$	13,468,042
Reimbursement revenue		948,479			661,176			2,117,882			2,576,542
Total Revenue		3,742,104			5,107,782			11,688,129			16,044,584

Operating Expenses
Direct		2,497,427			2,905,878			7,948,416			9,270,853
Reimbursement out-of-pocket expenses		948,479			661,176			2,117,882			2,576,542
Selling, general and administrative		1,953,116			2,058,878			5,763,946			6,379,746
Depreciation and amortization		141,180			98,563			331,721			281,938
Impairment loss		2,779,288			-			2,779,288			-
Total Operating Expenses		8,319,490			5,724,495			18,941,253			18,509,079

Loss from Operations		(4,577,386	)		(616,713	)		(7,253,124	)		(2,464,495	)

Interest Expense		(63,543	)		(26,676	)		(138,519	)		(31,132	)
Net Interest Expense		(63,543	)		(26,676	)		(138,519	)		(31,132	)

Gain on warrants		44,000			-			59,301			-

Net Loss from continuing operations before Income Taxes		(4,596,929	)		(643,389	)		(7,332,342	)		(2,495,627	)

Income Tax Expense (Benefit)		(733,496	)		98,826			(755,578	)		90,899

Net Loss from continuing operations	$	(3,863,433	)	$	(742,215	)	$	(6,576,764	)	$	(2,586,526	)

Net loss from discontinued operations		-			(258,436	)		(15,431	)		(554,016	)

Net Loss	$	(3,863,433	)	$	(1,000,651	)	$	(6,592,195	)	$	(3,140,542	)

Weighted Average Common and Common Equivalent Shares Outstanding

Basic and diluted		3,420,876			2,565,485			3,404,485			2,565,485

Net Loss per Common Share
Continuing Operations	$	(1.13	)	$	(0.29	)	$	(1.94	)	$	(1.00	)
Discontinued Operations	$	-		$	(0.10	)	$	-		$	(0.22	)

Net Loss per Common Share	$	(1.13	)	$	(0.39	)	$	(1.94	)	$	(1.22	)

See accompanying notes to the consolidated condensed financial statements.

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ENCORIUM GROUP, INC
CONSOLIDATED STATEMENTS OF CASH FLOWS
(UNAUDITED)
	Six Months Ended June 30,
	2010			2009
Net Cash Used By Operating Activities	$	(852,617	)	$	(4,713,471	)
Investing Activities:
Purchases of property and equipment		(75,983	)		(36,258	)
Net Cash Used By Investing Activities		(75,983	)		(36,258	)
Financing Activities:
Payments under capital leases		(23,805	)		(46,742	)
Net cash from short-term borrowings		850,530			275,567
Net Cash Provided By Financing Activities		826,725			228,825
Effect of Exchange Rate Changes on Cash and Cash Equivalents		81,752			(346,218	)
Net Decrease In Cash and Cash Equivalents		(20,123	)		(4,867,122	)
Cash and Cash Equivalents, Beginning of Period		196,583			5,705,818
Cash and Cash Equivalents, End of Period	$	176,460		$	838,696

ENCORIUM GROUP, INC.
CONSOLIDATED CONDENSED STATEMENTS OF CASH FLOWS
(UNAUDITED)

	Nine Months Ended September 30,
	2010			2009
Net Cash Used By Operating Activities	$	(801,035	)	$	(5,439,361	)

Investing Activities:
Progenitor acquisition, net of cash received		(1,269,949	)		-
Purchases of property and equipment		(114,377	)		(41,817	)
Net Cash Used By Investing Activities		(1,384,326	)		(41,817	)

Financing Activities:
Payments under capital leases		(11,096	)		(79,830	)
Net cash from borrowings - stockholder		1,694,756			-
Net cash from short-term borrowings		559,249			701,335
Net Cash Provided By Financing Activities		2,242,909			621,505

Effect of Exchange Rate Changes on Cash and Cash Equivalents		(66,565	)		(527,902	)

Net Decrease In Cash and Cash Equivalents		(9,017	)		(5,387,575	)

Cash and Cash Equivalents, Beginning of Period		196,583			5,705,818

Cash and Cash Equivalents, End of Period	$	187,566		$	318,243

See accompanying notes to the consolidated condensed financial statements.

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ENCORIUM GROUP, INC.

NOTES TO CONSOLIDATED CONDENSED FINANCIAL STATEMENTS

(UNAUDITED)

1. DESCRIPTION OF BUSINESS:

In this discussion, the terms, “Company”, “we”, “us”, and “our”, refer to Encorium Group, Inc. and subsidiaries (formerly known as, “Covalent Group, Inc.”), except where it is made clear otherwise.

We are a clinical research organization that engages in the design and management of complex clinical trials for the pharmaceutical, biotechnology and medical device industries. Our mission is to provide our clients with high quality, full-service support for their clinical trials. We offer therapeutic expertise, experienced team management and advanced technologies.

Our clients consist of many of the largest companies in the pharmaceutical, biotechnology and medical device industries. From protocol design and clinical program development, to proven patient recruitment, to managing the regulatory approval process, we have the resources to directly implement or manage Phase I through Phase IV clinical trials and to deliver clinical programs on time and within budget. We have clinical trial experience across a wide variety of therapeutic areas such as cardiovascular, endocrinology/metabolism, diabetes, neurology, oncology, immunology, vaccines, infectious diseases, gastroenterology, dermatology, hepatology, women’s health and respiratory medicine. We have the capacity and expertise to conduct clinical trials on a global basis.

We were initially incorporated in August 1998 in Nevada. In June 2002, we changed our state of incorporation to Delaware. In November 2006, we changed our name from Covalent Group, Inc. to Encorium Group, Inc. Prior to November 2006, the Company conducted the majority of its operations in the U.S. while utilizing strategic partnerships with foreign CROs for the provision of services internationally. On November 1, 2006, the Company acquired its wholly-owned subsidiary, Encorium Oy, a CRO founded in 1996 in Finland with offices in offices in Espoo, Turku, Tampere, Oulu and Seinäjoki (Finland), Copenhagen (Denmark), Tallinn (Estonia), Vilnius (Lithuania), Stockholm (Sweden), Bucharest (Romania), Warsaw (Poland), and Ankara (Turkey). Subsequent to the acquisition of Encorium Oy in 2006 the Company managed all of its North American and South American clinical trial studies from its headquarters in Wayne, Pennsylvania and its European and Asian clinical trial studies from Encorium Oy’s facilities in Espoo, Finland. As a result of declining revenues and increased expenses with respect to the Company’s U.S. line of business, on July 16, 2009 the Company sold substantially all of the assets relating to the Company’s US line of business to Pierrel Research USA, Inc., as a result of which the Company no longer has any employees or significant operations in the United States.

On July 19, 2010, the Company acquired Progenitor Holding AG, a corporation organized in Switzerland (“Progenitor Holding”) and its operating subsidiaries organized in Mexico, Panama, Argentina, Chile, Switzerland, India and Hong Kong (collectively referred to herein as “Progenitor”). Progenitor is a European headquartered emerging market clinical research organization providing international drug development services in emerging market regions. Pursuant to the terms of a Stock Purchase Agreement on July 19, 2010, the Company purchased from the shareholders of Progenitor Holding all of issued and outstanding shares of Progenitor Holding. ~~See Note 16, Subsequent Events.~~

On October 20, 2010, the Company received notification that the NASDAQ Qualifications Panel (the "Panel") determined to delist the Company's securities from The NASDAQ Stock Market, effective with the open of business on October 22, 2010, as a result of the Company's failure to regain compliance with the minimum $2.5 million stockholders' equity requirement. The Company’s common stock is currently quoted on the Pink Sheets. Investors can now view real time stock quotes for HLCS at http://www.otcmarkets.com.

On February 16, 2010, the Company effected a one-for-eight reverse split of its Common Stock effective at 5 PM Eastern Time on February 16, 2010. The Company implemented the reverse stock split under the authority granted to the Board of Directors by the Company's stockholders at the annual meeting of stockholders held on January 8, 2010, to affect a reverse stock split of the Company's Common Stock, par value $0.001 per share, at a ratio within a range of from one-for-three to one-for-ten shares. As a result of the reverse stock split, each eight shares of issued and outstanding shares of the Company Common Stock were combined and reconstituted as one share of Common Stock, par value $0.001 per share, of the Company. The reverse stock split reduced the number of outstanding shares of Common Stock from 27,105,383 shares to 3,388,173 shares. All fractional shares which would have otherwise resulted from the reverse stock split were rounded up to the nearest whole share in lieu of fractional shares. On the Company's balance sheet, the aggregate par value of the issued Common Stock was reduced by reclassifying the par value amount of the eliminated shares of Common Stock to additional paid-in capital. All per share amounts and outstanding shares, including all Common Stock equivalents, stock options, equity compensation plans, and warrants, have been retroactively restated in the Financial Statements and in the Notes to the Financial Statements for all period presented to reflect the reverse stock split.

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The Company is currently listed on The NASDAQ Capital Market. On August 25, 2009, the Company received a letter from The NASDAQ Stock Market notifying the Company that, based on its Form 10-Q for the period ended June 30, 2009, the Company’s stockholders’ equity did not comply with the minimum $2.5 million stockholders’ equity requirement for continued listing on The NASDAQ Capital Market. As provided in the NASDAQ Marketplace Rules, the Company submitted to NASDAQ a plan and timeline to achieve and sustain compliance. NASDAQ granted the Company an extension until December 8, 2009 to comply and notified Company that, if at the time of its periodic report for the year ending December 31, 2009, the Company did not evidence compliance; the Company’s common stock may be subject to delisting. As of December 31, 2009 the stockholders' equity of the Company was $2.3 million, which failed to meet the $2.5 million minimum stockholders equity requirement. The Company received a delisting action on April 22, 2010 from the NASDAQ Stock Market notifying the Company of its failure to comply with the requirement. In accordance with the terms of the Market Place Rules, the Company requested a hearing before the NASDAQ Listing Qualifications Panel. The Company met with the NASDAQ Listing Qualifications Panel on June 10, 2010 and presented its plan of compliance which was substantially based on its acquisition of Progenitor and the successful completion of a proposed rights offering pursuant to the terms of the Registration Statement on Form S-1 filed by the Company with the Securities and Exchange Commission on June 10, 2010. On July 9, 2010 the Listing Qualifications Panel granted the Company’s request for continued listing, subject to certain conditions, including that on or before October 19, 2010, the Company must disclose the closing of the proposed rights offering and the resulting stockholders’ equity which must be at least $2.5 million and provided that the Company is able to demonstrate compliance with all other requirements for continued listing on The Nasdaq Capital Market. There can be no assurances that the Company will be able to successfully complete the rights offering by October 19 or otherwise be able to demonstrate compliance with all other requirements for continued listing.

In the event the Company's stock is ultimately delisted, the Company anticipates that its common stock would be eligible to trade on the OTC Bulletin Board or in the "Pink Sheets." However, securities may become eligible for such trading only if a market maker makes application to register and quote the security in accordance with SEC Rule 15c2-11, and such application is cleared. Only a market maker may file such application. See “Risk Factors” for a discussion of some of the risks involved in investing in our shares of common stock.

The accompanying consolidated condensed financial statements have been prepared on the basis of the company continuing as a going concern.

We anticipate that will meet our cash requirements through September of 2011, assuming we are able to fully implement our current costs cutting initiatives, we are able to win additional contracts during ~~fiscal~~2011 ~~2010~~ and we are able to maintain our current customer contracts. In the event we are unable to do so, in order for the Company to continue as a going concern, we will be required to obtain additional capital or significantly reduce our operating costs, which may include the cessation of operations in some countries.

Our ability to obtain additional financing in the future will depend in part upon prevailing capital market conditions, as well as conditions in our business and our operating results; and those factors may affect our efforts to arrange additional financing on terms that are satisfactory to us or at all. Given the current levels of the trading price of the Company’s common stock, if the Company was to raise additional capital by issuing equity securities other than to existing stockholders, existing stockholders’ percentage ownership would be reduced and they would experience substantial dilution. If we were to raise additional funds by issuing debt securities, these debt securities would have rights, preferences, and privileges senior to those of our common stock, and the terms of the debt securities issued could impose significant restrictions on our operations. These factors have raised substantial doubt about our ability to continue as a going concern for the foreseeable future. If we are unable to obtain additional capital, we will scale back our operations until such capital is obtained. Our consolidated condensed financial statements do not include any adjustment to reflect the possible future effects on the recoverability or classification of assets or the amounts and classification of liabilities that may result from the outcome of our ability to continue as a going concern.

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2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES:

Basis of Presentation

The accompanying unaudited Consolidated Condensed Financial Statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“generally accepted accounting principles”) and with the instructions to Form 10-Q. Certain information and accounting policies and footnote disclosures normally included in financial statements prepared in conformity with accounting principles generally accepted in the United States of America have been condensed or omitted pursuant to such instructions, although ~~Encorium~~the Company believes that the included disclosures are adequate for a fair presentation. The information furnished reflects all adjustments (consisting of normal recurring adjustments), which are, in the opinion of management, necessary for a fair summary of the financial position, results of operations and cash flows for the interim periods presented. These Consolidated Condensed Financial Statements should be read in conjunction with the Consolidated Condensed Financial Statements and notes thereto filed with the Company’s Annual Report on Form 10-K for the year ended December 31, 2009.

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Use of Estimates

The preparation of consolidated financial statements in conformity with accounting principles generally accepted in the United States of America require management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the period. Actual results could differ from those estimates.

Consolidation

The consolidated condensed financial statements for the three and ~~six~~nine months ended ~~June~~September 30, 2010 and 2009 include our accounts and the accounts of our wholly-owned subsidiaries. Intercompany transactions and balances have been eliminated in consolidation.

Cash and Cash Equivalents

We consider all highly liquid debt instruments purchased with an original maturity of three months or less to be cash equivalents.

We maintain cash accounts at several institutions in Europe and one in the USU.S. Deposits in Europe are generally insured by individual states up to € 50,000 for each account (approximately $6168 thousand as of ~~June~~September 30, 2010). Accounts in the USU.S. are generally insured up to $250,000 for each account. As of ~~June~~September 30, 2010, our cash and cash equivalents were based primarily in Europe with two institutions. To date, the Company has not experienced any loss or lack of access to its invested cash or cash equivalents, however, there can be no assurance that access to invested balances will not be impacted by adverse conditions in the financial and credit markets.

Investigator Advances

We received advance payments from a small number of our clients as part of long-term contracts, which includes a separate cash account to be utilized for payment of investigator fees. As of ~~June~~September 30, 2010 and December 31, 2009, this cash amount was $120 ~~thousand~~ and $20 thousand, respectively. This amount is also included in customer advances within current liabilities in the accompanying balance sheets.

Revenue Recognition

The majority of our net revenue is recognized from fixed price contracts on a proportional performance method based on assumptions regarding the estimated completion of the project. This method is used because management considers total costs incurred to be the best available measure of progress on these contracts. Work is also performed under time and material contracts whereby we recognize revenue as hours are worked based on the hourly billing rate for each contract.

Each month costs are accumulated on each project and compared to total estimated cost to complete to determine the degree of completion for that particular project. This determines the percentage of completion for the project. This percentage of completion is multiplied by the contract value to determine the amount of revenue to be recognized. As the work progresses, original estimates may be adjusted due to revisions in the scope of work or other factors and a contract modification may be negotiated with the customer to cover additional costs. Our accounting policy for recognizing revenue for changes in scope is to recognize revenue when the Company has reached agreement with the client, the services pursuant to the change in scope have been performed, the price has been set forth in the change of scope document and collectibility is reasonably assured based on our course of dealings with the client. We bear the risk of cost overruns on work performed absent a signed contract modification. Because of the inherent uncertainties in estimating costs, it is reasonably possible that the cost estimates used will change in the near term and may have a material adverse impact on our financial performance.

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In the past, we have had to commit unanticipated resources to complete projects resulting in lower gross margins on those projects. We may experience similar situations in the future ~~although our current contracts in process are of a shorter duration and subject to less cost volatility~~. Should our estimated costs on fixed price contracts prove to be low in comparison to actual costs, future margins could be reduced, absent our ability to negotiate a contract modification.

There are no standard billing and payment provisions which are present in each contract. Each contract has separate and distinct billing and payment terms which are the result of negotiation between us and the client. Billings and the related payment terms from fixed price contracts are generally determined by provisions in the contract that may include certain payment schedules and the submission of required billing detail. The payment schedule in the contract reflects the value of services to be performed by us at the initiation of the contract. The payment schedule may include the value of certain interim service components as well as periodic payments which are reasonably assured at the start of the contract and which we expect to receive during the duration of the contract. Accordingly, cash receipts, including the receipt of upfront payments, periodic payments and payments related to the achievement of certain billing mechanisms, do not necessarily correspond to cost incurred and revenue recognized on contracts. A contract’s payment structure typically requires an upfront payment of 10% to 20% of the contract value at or shortly after the initiation of the contract, a series of periodic payments over the life of the contract and payments based upon the achievement of certain billing mechanisms. The upfront payments are deferred and recognized as revenues and services are performed under the proportional performance method. Periodic payments, including payments related to the achievement of certain billing mechanisms in the contract, are invoiced pursuant to the terms of the contract once the agreed upon services criteria have been achieved. Payments based upon interim billing mechanisms are included in the value of the contract because we expect to receive them during the term of the contract. All payments received pursuant to the contract are recognized in accordance with the proportional performance method. In a comprehensive full service drug development program, the client would not generally purchase certain service components separately but as an integrated, full service arrangement in connection with the development of the drug.

Clients generally may terminate a contract on short notice which might cause unplanned periods of excess capacity and reduced revenues and earnings. Client initiated delays or cancellations for ongoing clinical trials can come suddenly and may not be foreseeable. To offset the effects of early termination of significant contracts, we attempt to negotiate the payment of an early termination fee as part of the original contract. Generally, we have not been successful in negotiating such fees. Our contracts typically require payment to us of expenses incurred to wind down a study and fees earned to date. Therefore, revenue recognized prior to cancellation does not require a significant adjustment upon cancellation. If we determine that a loss will result from the performance of a fixed price contract, the entire amount of the estimated loss is charged against income in the period in which such determination is made.

Our accounting policy for recognizing revenue for terminated projects requires us to perform a reconciliation of study activities versus the activities set forth in the contract. We negotiate with the client, pursuant to the terms of the existing contract, regarding the wind up of existing study activities in order to clarify which services the client wants us to perform. Once we and the client agree on the reconciliation of study activities and the agreed upon services have been performed by us, we would record the additional revenue provided collectibility is reasonably assured.

Our operations have experienced, and may continue to experience, period-to-period fluctuations in net revenue and results from operations. Because we generate a large proportion of our revenues from services performed at hourly rates, our revenues in any period are directly related to the number of employees and the number of hours worked by those employees during that period. Our results of operations in any one quarter can fluctuate depending upon, among other things, the number of weeks in the quarter, the number and related contract value of ongoing client engagements, the commencement, postponement and termination of engagements in the quarter, the mix of revenue, the extent of cost overruns, employee hiring, vacation patterns, exchange rate fluctuations and other factors.

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Reimbursable Out-of-Pocket Expenses

On behalf of our clients, we pay fees to investigators and other out-of-pocket costs for which we are reimbursed at cost, without mark-up or profit. Out-of-pocket costs are included in Operating Expenses, while the reimbursements received are reported separately as Reimbursement Revenue in the Consolidated Condensed Statements of Operations.

As is customary in the industry, we will continue to exclude from revenue and expense in the Consolidated Condensed Statements of Operations fees paid to investigators and the associated reimbursement since we acts as an agent on behalf of the pharmaceutical company sponsors with regard to investigator payments. These investigator fees are not reflected in our Net Revenue, Reimbursement Revenue, Reimbursement Out-of-Pocket Expenses, and/or Direct Expenses. The amounts of these investigator fees were $~~164~~79 thousand and $~~491~~54 thousand for the three months ended ~~June~~September 30, 2010 and 2009, respectively. The amounts of these investigator fees were $~~518~~563 thousand and $~~983~~1.0 ~~thousand~~million for the ~~six~~nine months ended ~~June~~September 30, 2010 and 2009, respectively.

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Accounts Receivable

Accounts receivable and costs and estimated earnings in excess of related billings on completed contracts represent amounts due from our clients who are concentrated primarily in the pharmaceutical and biotechnology industries.

Concentration of Credit Risk

Our accounts receivable and costs and estimated earnings in excess of related billings on uncompleted contracts are concentrated with a small number of companies within the pharmaceutical and biotechnology industries. The significant majority of this exposure is to large, well established firms. Credit losses have historically been minimal. As of ~~June~~September 30, 2010 and December 31, 2009, the total of accounts receivable and costs and estimated earnings in excess of related billings on uncompleted contracts was $43.06 million and $5.2 million respectively. The following table sets forth the exposure to our top clients:

	June 30, 2010					December 31, 2009
	September 30, 2010					December 31, 2009
	Total of Accounts Receivable and cost and estimated earnings in excess of billings		Percentage			Total of Accounts Receivable and cost and estimated earnings in excess of billings		Percentage
Client A	$	1754,~~760,399~~350		4421	%	$	1571,~~716,077~~896		3311	%
Client B		~~598~~738,~~642~~537		1520	%		~~571,896~~-		11-	%
Client C		~~590~~391,~~495~~076		1511	%		~~611,497~~-		12-	%
Top Clients	$	2,949,536		74	%	$	2,899,470		56	%
Client D		202,533		6	%		1,716,077		33	%
Top Clients	$	2,086,496		58	%	$	2,287,973		44	%

10Several client contracts contain provisions that allow us to bill and receive advance payments to be utilized for investigator fees and reimbursable expenses. In some instances, the client requires that we maintain separate cash accounts to be utilized for investigator fees, which are included as Investigator Advances. Funds received as customer advances, excluding investigator advances for which separate cash accounts are required as part of our contract with the client, are included as part of Cash and Cash Equivalents. The balance of customer advances, including investigator advances of $0, was $1.1 million as of September 30, 2010. The balance of customer advances, including investigator advances of $19 thousand, was $1.4 million as of December 31, 2009. As of September 30, 2010 and December 31, 2009, there were no customer advances billed, but not received.

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Several client contracts contain provisions that allow us to bill and receive advance payments to be utilized for investigator fees and reimbursable expenses. In some instances, the client requires that we maintain separate cash accounts to be utilized for investigator fees, which are included as Investigator Advances. Funds received as customer advances, excluding investigator advances for which separate cash accounts are required as part of our contract with the client, are included as part of Cash and Cash Equivalents. The balance of customer advances, including investigator advances of $12 thousand, was $1.4 million as of June 30, 2010. The balance of customer advances, including investigator advances of $19 thousand was $1.4 million as of December 31, 2009. As of June 30, 2010 and December 31, 2009, there were no customer advances billed, but not received.

Financial Instruments

The fair value of cash and cash equivalents, restricted cash, accounts receivable, costs and estimated earnings in excess of related billings on uncompleted contracts, accounts payable, accrued expenses and billings in excess of related costs and estimated earnings on uncompleted contracts, notes payable, credit lines, and obligations under capital leases were not materially different than their carrying amounts as reported at ~~June~~September 30, 2010 and December 31, 2009.

As of ~~June~~ September 30, 2010, the Company was not a counter party to any forward foreign exchange contracts.

Property and Equipment

Property and equipment are recorded at cost. Depreciation is provided using the straight-line method over the estimated useful lives of the assets, which range from 3 to 8 years for equipment and furniture and fixtures and the remaining lease term for leasehold improvements and assets under capital lease. Depreciation and amortization, excluding the amortization of intangible assets, for the three months ended ~~June~~September 30, 2010 and 2009 was $3225 thousand and $2526 thousand, respectively. Depreciation and amortization, excluding the amortization of intangible assets, for the ~~six~~nine months ended ~~June~~September 30, 2010 and 2009 was $5782 thousand and $5077 thousand, respectively. Expenditures for maintenance and repairs are charged to expense as incurred. When assets are sold, retired, or fully depreciated the cost and accumulated depreciation are removed from the accounts, and any gain or loss on the sale of property and equipment is included in operations.

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Stock-Based Compensation

The Company accounts for stock based compensation in accordance with ASC 718 using the Modified Prospective Approach. ASC 718 requires the cost of all share-based payments to employees, including grants of employee stock options, to be recognized in the financial statements based on their fair values at grant date, or the date of later modification, over the requisite service period. In addition, ASC 718 requires unrecognized cost (based on the amounts previously disclosed in our pro forma footnote disclosure) related to options vesting after the date of initial adoption to be recognized in the financial statements over the remaining requisite service period. Accordingly, prior period amounts have not been restated.

Goodwill and Intangible Assets

Goodwill is carried at cost and is not amortized. We test goodwill for impairment on an annual basis on November 1st of each fiscal year, relying on a number of factors including operating results, business plans and anticipated future cash flows. Company management uses its judgment in assessing whether goodwill has become impaired between annual impairment tests. Recoverability of goodwill is evaluated using a two-step process. The first step involves a comparison of the fair value of a reporting unit with its carrying value. If the carrying amount of the reporting unit exceeds its fair value, then proceed to the second step of the process which involves a comparison of the implied fair value and carrying value of the goodwill of that reporting unit. If the carrying value of the goodwill of a reporting unit exceeds the fair value of that goodwill, an impairment loss is recognized in an amount equal to the excess. Definite-lived intangibles are amortized on a straight-line basis over their useful lives. We review our other intangible assets for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets may not be recoverable.

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Foreign Currency Translation

Assets and liabilities of the Company’s international operations are translated into U.S. dollars at exchange rates in effect on the balance sheet date and equity accounts are translated at historical exchange rates. Revenue and expense items are translated at average exchange rates in effect during the year. Gains or losses from translating foreign currency financial statements are recorded in other comprehensive income.

Income Taxes

The Company accounts for income taxes in accordance with the provisions of ASC 740, “Accounting for Income Taxes”, (“ASC 740”). ASC 740 requires recognition of deferred tax liabilities and assets for the future expected tax consequences of events that have been included in the financial statements or tax returns.

Under this method deferred tax liabilities and assets are determined based on the difference between the financial statement tax bases of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. At ~~June~~September 30, 2010, the Company recorded a full valuation allowance against its net deferred tax assets and net operating loss carry-forwards given that it is more likely than not that the deferred tax asset will not be realized.

The Company files its tax returns as prescribed by the tax laws of the jurisdiction in which it operates. None of the Company’s tax filings in these jurisdictions are currently under audit. The Company’s policy is to recognize interest and penalties in Other Expense.

Earnings (Loss) Per Share

Earnings (loss) per share is calculated in accordance with ASC 260, “Earnings Per Share”, (“ASC 260”). Basic earnings (loss) per share is computed by dividing net income (loss) for the period by the weighted average number of common shares outstanding during the period. Diluted earnings (loss) per share is computed by dividing net income (loss) by the weighted average number of common shares plus the dilutive effect of warrants and outstanding stock options under the Company’s equity incentive plans. For 2010 and 2009 diluted net loss per common share is the same as basic net loss per common share, since the effects of potentially dilutive securities are anti-dilutive.

Recently Issued Accounting Standards

In January 2010, the FASB issued ASU No. 2010-6, “Improving Disclosures About Fair Value Measurements”, which provides amendments to ASC 820 , “Fair Value Measurements and Disclosures” , including requiring reporting entities to make more robust disclosures about (1) the different classes of assets and liabilities measured at fair value, (2) the valuation techniques and inputs used, (3) the activity in Level 3 fair value measurements including information on purchases, sales, issuances, and settlements on a gross basis and (4) the transfers between Levels 1, 2, and 3. The standard is effective for annual reporting periods beginning after December 15, 2009, except for Level 3 reconciliation disclosures, which are effective for annual periods beginning after December 15, 2010. The Company adopted the standard for Levels 1 and 2 on January 1, 2010, and does not expect the adoption of the standard for Level 3, on January 1, 2011, to have a material impact on its consolidated financial statements.

In December 2009, the FASB issued ASU No. 2009-17, “Improvements to Financial Reporting by Enterprises Involved with Variable Interest Entities”, which amends ASC 810, “Consolidation” to address the elimination of the concept of a qualifying special purpose entity. The standard also replaces the quantitative-based risks and rewards calculation for determining which enterprise has a controlling financial interest in a variable interest entity with an approach focused on identifying which enterprise has the power to direct the activities of a variable interest entity and the obligation to absorb losses of the entity or the right to receive benefits from the entity. This standard also requires continuous reassessments of whether an enterprise is the primary beneficiary of a VIE whereas previous accounting guidance required reconsideration of whether an enterprise was the primary beneficiary of a VIE only when specific events had occurred. The standard provides more timely and useful information about an enterprise's involvement with a variable interest entity and became effective as of the beginning of interim and annual reporting periods that begin after November 15, 2009. The Company adopted the standard on January 1, 2010 and the adoption did not have a material impact on its consolidated financial statements.10

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~~The~~In December 2009, the FASB ~~updated~~issued ~~ASC~~ASU ~~Topic~~No. ~~810~~2009-17, “~~Consolidations”~~Improvements ~~(“ASC~~to ~~Topic~~Financial ~~810”),~~Reporting ~~and~~by ~~ASC~~Enterprises ~~Topic~~Involved ~~860,~~with “Variable ~~Transfers~~Interest ~~and~~Entities”, ~~Servicing~~which ”amends (“ASC ~~Topic 860~~810,“Consolidation”), to ~~which~~address ~~significantly~~the ~~changed~~elimination of the ~~accounting~~concept ~~for~~of ~~transfers~~a ofqualifying ~~financial~~special ~~assets~~purpose ~~and~~entity. ~~the~~The ~~criteria~~standard ~~for~~also ~~determining~~replaces ~~whether~~the toquantitative-based ~~consolidate~~risks aand ~~variable~~rewards ~~interest~~calculation ~~entity~~for ~~(VIE).~~determining ~~The~~which ~~update~~enterprise tohas ~~ASC~~a ~~Topic~~controlling ~~860~~financial ~~eliminates~~interest ~~the~~in ~~qualifying~~a ~~special~~variable ~~purpose~~interest entity ~~(QSPE)~~with ~~concept,~~an ~~establishes~~approach ~~conditions~~focused ~~for~~on ~~reporting~~identifying awhich ~~transfer~~enterprise ofhas athe ~~portion~~power ofto adirect ~~financial~~the ~~asset~~activities asof a ~~sale,~~variable ~~clarifies~~interest ~~the~~entity ~~financial~~and ~~asset~~the ~~de-recognition~~obligation ~~criteria,~~to ~~revises~~absorb ~~how~~losses ~~interests~~of ~~retained~~the byentity or the ~~transferor~~right into areceive ~~sale~~benefits offrom ~~financial~~the ~~assets~~entity. ~~initially~~This ~~are~~standard ~~measured,~~also ~~and~~requires ~~removes~~continuous ~~the~~reassessments ~~guaranteed~~of ~~mortgage~~whether ~~securitization~~an ~~re-characterization~~enterprise ~~provisions.~~is ~~The~~the ~~update~~primary tobeneficiary ~~ASC~~of ~~Topic~~a ~~810~~VIE ~~requires~~whereas ~~reporting~~previous ~~entities~~accounting toguidance ~~evaluate~~required ~~former~~reconsideration ~~QSPEs~~of ~~for~~whether ~~consolidation,~~an ~~changes~~enterprise was the ~~approach~~primary tobeneficiary ~~determining~~of a VIE's ~~primary~~only ~~beneficiary~~when ~~from~~specific aevents ~~mainly~~had ~~quantitative~~occurred. ~~assessment~~The tostandard anprovides ~~exclusively~~more ~~qualitative~~timely ~~assessment~~and ~~designed~~useful toinformation ~~identify~~about aan ~~controlling~~enterprise's ~~financial~~involvement with a variable interest, entity and ~~increases~~became ~~the~~effective ~~frequency~~as of ~~required~~the ~~reassessments~~beginning toof ~~determine~~interim ~~whether~~and aannual ~~company~~reporting isperiods ~~the~~that ~~primary~~begin ~~beneficiary~~after ofNovember a15, ~~VIE~~2009. The Company adopted the ~~provisions~~standard ofon ~~these staff positions effective~~ January 1, 2010. ~~The~~and the adoption ofdid ~~these~~not ~~staff~~have ~~positions~~a ~~could~~material impact ~~future~~on ~~transactions~~its ~~entered~~consolidated ~~into~~financial ~~by the Company~~statements.

~~New~~The ~~Accounting~~FASB ~~Pronouncements~~updated ~~Not~~ASC ~~Yet~~Topic ~~Effective~~810, “Consolidations” (“ASC Topic 810”), and ASC Topic 860, “Transfers and Servicing ” (ASC Topic 860), which significantly changed the accounting for transfers of financial assets and the criteria for determining whether to consolidate a variable interest entity (VIE). The update to ASC Topic 860 eliminates the qualifying special purpose entity (QSPE) concept, establishes conditions for reporting a transfer of a portion of a financial asset as a sale, clarifies the financial asset de-recognition criteria, revises how interests retained by the transferor in a sale of financial assets initially are measured, and removes the guaranteed mortgage securitization re-characterization provisions. The update to ASC Topic 810 requires reporting entities to evaluate former QSPEs for consolidation, changes the approach to determining a VIE's primary beneficiary from a mainly quantitative assessment to an exclusively qualitative assessment designed to identify a controlling financial interest, and increases the frequency of required reassessments to determine whether a company is the primary beneficiary of a VIE. The Company adopted the provisions of these staff positions effective January 1, 2010. The adoption of these staff positions could impact future transactions entered into by the Company.

In October 2009, the FASB issued ASU 2009-13, “Multiple-Deliverable Revenue Arrangements,” (amendments to ASC Topic 605, “Revenue Recognition” ) (“ASU 2009-13”) and ASU 2009-14, “ Certain Arrangements that Include Software Elements”, ( amendments to ASC Topic 985 , “Software”) (“ASU 2009-14”). ASU 2009-13 requires entities to allocate revenue in an arrangement using estimated selling prices of the delivered goods and services based on a selling price hierarchy. The amendments eliminate the residual method of revenue allocation and require revenue to be allocated using the relative selling price method. ASU 2009-14 removes tangible products from the scope of software revenue guidance and provides guidance on determining whether software deliverables in an arrangement that includes a tangible product are covered by the scope of the software revenue guidance. ASU 2009-13 and ASU 2009-14 should be applied on a prospective basis for revenue arrangements entered into or materially modified in fiscal years beginning on or after June 15, 2010, with early adoption permitted. The Company ishas ~~currently~~evaluated ~~evaluating~~ the impact of the adoption of these ASUs on its consolidated results of operations or financial condition~~. The~~, ~~Company~~and ~~will~~the ~~implement~~adoption ~~the~~did ~~standard~~not ~~effective~~have ~~January~~a 1,material ~~2011~~impact on its consolidated financial statements.

In April 2010, the FASB issued ASU 2010-13, Topic 718, “Compensation—Stock Compensation” (“ASU 2010-13”), which addresses the classification of an employee share-based payment award with an exercise price denominated in the currency of a market in which the underlying equity security trades. ASU 2010-13 specifies that a share-based payment awarded that contains a condition that is not a market, performance, or service condition is required to be classified as a liability unless it otherwise qualifies as equity. The amendment is effective for fiscal years, and interim period beginning on or after December 15, 2010. The Company ishas ~~currently~~evaluated ~~evaluating~~ the impact of the adoption of this ASU ~~2010-13~~ on its consolidated results of operations ofor financial condition., ~~The~~and ~~Company~~the ~~will~~adoption ~~implement~~did ~~the~~not ~~standard~~have ~~effective~~a ~~January~~material 1,impact ~~2011~~on its consolidated financial statements.

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3. DISCONTINUED OPERATIONS

On July 16, 2009 the Company sold substantially all of the assets relating to the Company’s U.S. line of business to Pierrel Research USA, Inc., as a result of which the Company no longer has any employees or significant operations in the United States. The purchase price was $2.6 million comprised of $80 thousand in cash and the assumption of liabilities in the amount of $2.5 million.

In accordance with ASC 360, the operational results and cash flows of the U.S. line of business are presented as discontinued operations. Net Revenues from discontinued operations for the three months ended ~~June~~September 30, 2010 and 2009 were $0 and $~~1.3~~20 ~~million~~thousand, respectively. Net Revenues from discontinued operations for the ~~six~~nine months ended ~~June~~September 30, 2010 and 2009 were $0 and $3.8 million, respectively. Loss from discontinued operations before taxes for the three months ended ~~June~~September 30, 2010 and ~~June~~September 30, 2009 was $0 and $~~674~~258 thousand, respectively. Loss from discontinued operations before taxes for the ~~six~~nine months ended ~~June~~September 30, 2010 and ~~June~~September 30, 2009 was $15 thousand and $~~296~~554 thousand, respectively. The operating results related to the USU.S. line of business are included in discontinued operations.

The assets and liabilities of discontinued operations at ~~June~~September 30, 2010 and December 31, 2009 were as follows:

	June 30,		December 31,
	September 30,		December 31,
	2010		2009
Accounts receivable, net	$	-	$	28,832
Current assets of discontinued operations	$	-	$	28,832
Accounts payable	$	~~397~~307,~~509~~329	$	485,203
Accrued expenses		42,409		58,514
Billings in excess of related costs and
estimated earnings on uncompleted contracts		53,368		53,368
Customer advances		10,467		10,467
Current liabilities of discontinued operations	$	~~503~~413,~~753~~573	$	607,552

4. ~~LINES OF CREDIT~~ACQUISITION

AsOn ofJuly ~~June 30~~19, 2010, the Company ~~had~~acquired ~~four~~100% ~~lines~~of the outstanding shares of ~~credit~~common stock of Progenitor Holding AG (“Progenitor”) in a transaction accounted for ~~its~~using ~~European~~the acquisition method of accounting. Accordingly, the results of operations ~~totaling~~are included in the Company’s consolidated financial statements from that date forward. Progenitor is a European headquartered emerging market clinical research organization providing drug development services in emerging market regions. The purchase price was $12.57 million including $1.42 million ~~with~~paid ~~interest~~in cash at closing and ~~outstanding~~193,800 ~~amounts~~shares asof common stock valued at $2.50 per share, or $485 thousand, plus working capital adjustment estimated to be $36 thousand and salary guarantees for key employees of Progenitor of $625 thousand. The purchase price was allocated to assets acquired and liabilities assumed based on their estimated fair value at the ~~following~~date ~~table:~~of acquisition. The excess purchase price over those fair values was recorded as goodwill. The fair value assigned to assets acquired and liabilities assumed are based on valuations using management’s estimates and assumptions as of July 19, 2010, the effective date of the acquisition. Transaction costs incurred by the Company in connection with acquisition consisted of consulting and legal fees totaling $54 thousand. All transaction costs associated with the acquisition were expensed as incurred.

Lender	Credit Line		Interest Rate	Effective rate at June 30, 2010			Amount outstdanding at June 30, 2010		Amount outstanding at December 31, 2009
Svenska Handelsbanken AB	$	610,400	Handelsbanken Avista plus 2.35%		2.55	%	$	541,904	$	459
Sampo Pankki Oyj		366,240	Sampo viitepaivaluottokorko plus 3.5%		5.00	%		157,458		300,238
Svenska Handelsbanken AB		64,078	Handelsbanken's base rate		6.35	%		61,436		-
Svenska Handelsbanken AB		81,946	Handelsbanken's base rate		6.15	%		30,098		-
Total	$	1,122,664					$	790,896	$	300,697

Unaudited pro forma results of operations resulting from the acquisition of Progenitor that would have been for the nine months ended September 30, 2010 as if the combination had occurred on January 1, 2010:

	Nine Months Ended September 30, 2010 (Unaudited)
Net Revenue (1)	9,967,692
Net Loss	6,334,595
Earnings (loss) per share - basic	(1.86)
Earnings (loss) per share – diluted	(1.86)

(1) Excludes reimbursement revenue

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~~The~~Comparative ~~lines~~data ofregarding ~~credit~~the ~~are~~pro ~~collateralized~~forma byresults ~~substantially~~of ~~all~~Progenitor ~~assets~~for of the ~~Company~~nine ~~and~~months aended ~~personal~~September ~~guarantee~~30, of2009 ~~our~~were ~~Chief~~not ~~Executive~~included ~~Officer~~ in the ~~amount~~table above due to the lack of ~~$122~~data ~~thousand~~available for the period.

5. NOTES PAYABLE

The total consideration provided by the Company to acquire Progenitor is summarized below:

Cash	$	1,421,200
Common stock		484,500
Working capital adjustment		36,378
Salary Guarantees		625,470
Total Consideration	$	2,567,548


The preliminary allocation of the purchase price is as follows:

Current assets	$	447,230
Property, plant and equipment		70,973
Other assets		125,682
Goodwill		1,131,722
Customer relationships		1,057,543
Current liabilities		(130,911	)
Non-current liabilities (1)		(134,691	)
	$	2,567,548

(1) Included in non-current liabilities is a related party note payable between Progenitor Holding AG, Switzerland and Progenitor Germany AG. Progenitor Germany AG, is a separate legal entity of Progenitor Research International that was not included as part of the Progenitor acquisition. However, the former shareholders of Progenitor Holding AG, who are also employees of the Company, remain the majority shareholders of Progenitor Germany AG.

5. LINES OF CREDIT

As of September 30, 2010, the Company had four lines of credit for its European operations totaling $1.25 million with interest and outstanding amounts as per the following table:

Lender	Credit Line		Interest Rate	Effective rate at September 30, 2010			Amount outstdanding at September 30, 2010		Amount outstanding at December 31, 2009

Svenska Handelsbanken AB	$	680,000	Handelsbanken Avista plus 2.35%		2.55	%	$	470,506	$	459
Sampo Pankki Oyj		408,000	Sampo viitepaivaluottokorko plus 3.5%		5.00	%		246,931		300,238
Svenska Handelsbanken AB		71,384	Handelsbanken's base rate		6.35	%		56,803		-
Svenska Handelsbanken AB		91,290	Handelsbanken's base rate		6.15	%		73,440		-

Total	$	1,250,674					$	847,680	$	300,697

Commitments by the lenders are valid indefinitely, subject to other terms and conditions of the underlying agreements. (Amounts were converted based on an exchange rate of 1.00 EUR ~ 1.36 USD and 1.00 EUR ~ 1.4332 USD for September 30, 2010 and December 31, 2009, respectively). The lines of credit are collateralized by substantially all assets of the Company and a personal guarantee of our Chief Executive Officer in the amount of $136 thousand. On January 12, 2011, Svenska Handelsbanken AB notified Encorium Oy that it would terminate its line of credit (the “Handelsbanken Line”) with Encorium Oy. See Subsequent Events Note for further information regarding the description, terms and conditions related to the line of credit with Svenska Handelsbanken AB.

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6. NOTES PAYABLE

Notes payable consist of the following:

	June 30,			December 31,
	September 30,			December 31,
	2010			2009
Promissory Note collateralized by substantially all assests of Encorium Oy and certain assets of
related parties payable in equal semi-annual installments of $142,426 plus interest. On June 28, 2010,
related parties payable in equal semi-annual installments of $158,667 plus interest. On December 16, 2010,
the original terms of the Note were modified to extend the note by 6 months and defer the initial
the terms of the Note were modified to extend the maturity date to December 16, 2013 and defer the
semi-annual installment to December of 2010.
initial semi-annual installment to June of 2011.
The Promissory Note bears interest at the six month euribor plus 2.35% (3.41% at June 30, 2010).	$	854,559		$	1,003,239
The Promissory Note bears interest at the six month euribor plus 2.35% (3.41% at September 30, 2010).	$	952,006		$	1,003,239
Unsecured promissory note due to shareholder. The Promissory Note bears interest at 5% for amounts		245,618			-
Less current portion		(317,340	)		(334,413	)
outstanding through August 31, 2010 and 7% for ammounts outstanding thereafter.
Total notes payable net of current portion	$	634,666		$	668,826
Less current portion		(530,471	)		(334,413	)
Accrued interest	$	8,116		$	16,754
Total notes payable net of current portion	$	569,706		$	668,826
Notes payable stockholder
Unsecured promissory note due to stockholder. The Promissory Note bears interest at 5% for amounts		273,556			-
outstanding through August 31, 2010 and 7% for amounts outstanding thereafter.
Unsecured promissory note due to stockholder. The Promissory Note bears interest at 5% for amounts
outstanding through October 31, 2010 and 7% for amounts outstanding thereafter.		1,508,667			-
Total notes payable stockholder	$	1,782,223		$	-
Accrued interest	$	14,230		$	-

(Amounts were converted based on an exchange rate at ~~June~~September 30, 2010 and December 31, 2009 of 1.00 EUR ~ 1.~~2208~~36 USD and ~ 1.00 EUR ~ 1.4332 USD, respectively). In connection with the Company’s rights offering which was completed on October 15, 2010, the Company exchanged the outstanding notes payable due to a stockholder for shares of common stock of the Company. See Subsequent Events Note for further information.

67. EARNINGS PER SHARE

Earnings (loss) per share is calculated in accordance with ASC 260. Basic earnings (loss) per share is computed by dividing net income (loss) for the period by the weighted average number of common shares outstanding during the period. Diluted earnings (loss) per share is computed by dividing net income (loss) by the weighted average number of common shares plus the dilutive effect of outstanding stock options under the Company’s equity incentive plans. For the three and ~~six~~nine months ended ~~June~~September 30, 2010 and 2009, diluted net loss per common share is the same as basic net loss per share, since the effects of potentially dilutive securities are ~~anitdilutive~~antidilutive. Stock options outstanding that are not included in the table below because of their anti-dilutive effect for the ~~six~~three and nine months ended ~~June~~September 30, 2010 and ~~June 30,~~ 2009 were ~~151~~148,~~458~~125 and 9794,~~500~~375, respectively. Warrants outstanding that are not included in the table below because of their anti-dilutive effect for the ~~six~~nine months ended ~~June~~September 30, 2010 and 2009 were 54,633 and 109,266, respectively.

The net loss and weighted average common and common equivalent shares outstanding for purposes of calculating net loss per common share were computed as follows:

	Three months ended June 30,						Six months ended June 30,
	Three months ended September 30,						Nine months ended Spetember 30,
	2010			2009			2010			2009
Net Loss	$	(~~805~~3,~~157~~863,433	)	$	(1,~~944~~000,~~660~~651	)	$	(26,~~728~~592,~~762~~195	)	$	(23,~~139~~140,~~891~~542	)
Weighted average number of common shares
outstanding used in computuing basic and diluted loss per share		3,404,048			2,565,448			3,396,154			2,565,448
outstanding used in computuing basic and
Basic and diluted loss per share	$	(0.24	)	$	(0.76	)	$	(0.80	)	$	(0.83	)
diluted loss per share		3,420,876			2,565,485			3,404,485			2,565,485
Basic and diluted loss per share	$	(1.13	)	$	(0.39	)	$	(1.94	)	$	(1.22	)

1514

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78. COMPREHENSIVE LOSS

A reconciliation of comprehensive loss is as follows:

	Three Months Ended						~~Six~~Nine Months Ended
	June 30,						June 30,
	September 30,						September 30,
	2010			2009			2010			2009
Net loss	$	(~~805~~3,~~157~~863,433	)	$	(1,~~944~~000,~~671~~651	)	$	(26,~~728~~592,~~762~~195	)	$	(23,~~139~~140,~~891~~542	)
Foreign currency
translation adjustment		11(460,~~609~~310	)		(1,~~121~~131,~~646~~037	)		99(560,~~860~~170	)		~~719~~(411,~~642~~395	)
Comprehensive (loss)	$	(793,548	)	$	(823,025	)	$	(2,628,902	)	$	(1,420,249	)
Comprehensive income (loss)	$	(4,323,743	)	$	(2,131,688	)	$	(7,152,365	)	$	(3,551,937	)

89. SEGMENT INFORMATION

The Company follows the provisions of ASC 280, “Disclosures About Segments of an Enterprise and Related Information” which establishes standards for reporting business segment information. The Company operates in one segment predominantly in the clinical research industry providing a broad range of clinical research services on a global basis to the pharmaceutical and biotechnology industries.

The following table summarizes the distribution of net revenue and contracts with significant clients:

	Three Months Ended June 30,				Six Months Ended June 30,
	Three Months Ended September 30,				Nine Months Ended September 30,
	2010		2009		2010		2009
	Percentage of Revenues	Number of Contracts	Percentage of Revenues	Number of Contracts	Percentage of Revenues	Number of Contracts	Percentage of Revenues	Number of Contracts
Client A	4218%	13	3731%	1113	3228%	13	3633%	13
Client B	1814%	711	1418%	84	1716%	811	68%	813
Top Clients	60%	20	51%	19	49%	21	42%	21
Client C	18%	2	0%	-	10%	2	0%	-
Client D	10%	1	0%	-	3%	1	0%	-
Top Clients	60%	27	49%	17	57%	27	41%	26

1610. STOCKHOLDERS EQUITY

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9. STOCKHOLDERS EQUITY

Treasury Stock

In October 2008 the Company approved a stock repurchase program in an amount of up to $250,000. There were no purchases of Common Stock ~~during~~for the nine months ended September 30, 2010. There were 38,765 common shares in treasury as of ~~June~~September 30, 2010. The shares are valued using the cost method of accounting for treasury stock.

1011. STOCK-BASED COMPENSATION

Employee Equity Incentive Plans

2006 Equity Incentive Plan

In November 2006, the Board of Directors approved the 2006 Equity Incentive Plan, which was approved by the ~~stockholders~~stockholdes in November 2006. Upon adoption, a total of 125,000 shares (as adjusted for the 8:1 reverse split which became effective February 16, 2010) were available for grant under this plan. The plan provides for the granting of incentive and non-qualified stock options for the purchase of shares of common stock to directors, officers, employees, advisors and consultants, as defined under the provisions of the plan. Options issued under the plan have typically been subject to a 3 year vesting period with a contractual term of 10 years.

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2002 Equity Incentive Plan

In March 2002, the Board of Directors approved the 2002 Equity Incentive Plan, which was approved by the ~~shareholders~~stockholders in June 2002. Upon adoption, a total of 125,000 shares (as adjusted for the 8:1 reverse split which became effective February 16, 2010) were available for grant under this plan. The plan provides for the granting of incentive and non-qualified stock options for the purchase of shares of common stock to directors, officers, employees, advisors and consultants, as defined under the provisions of the plan. Options issued under the plan have typically been subject to a 3 year vesting period with a contractual term of 5 years.

General Option Information

The Company has issued stock options to employees under share-based compensation plans. Stock options are issued at the current market price on the date of the grant, subject to a vesting period and contractual term associated with the plan the options were issued under. The fair value of each stock option is estimated on the date of grant using the Black-Scholes option pricing model that uses the assumptions noted in the following table. Expected volatility is based on historical volatility of our common stock. We use historical data on exercises of stock options and other factors to estimate the expected life of the share-based payments granted. For options granted under the 2002 Equity Incentive Plan, we determined the expected life to be 5 years for options granted prior to January 1, 2006 and 4 years for any options granted subsequent to January 1, 2006. We determined the expect life for options granted under the 2006 Equity Incentive Plan to be 7 years. The risk free rate is based on the U.S. Treasury bond rate commensurate with the expected life of the option.

	Three Months Ended June 30,		Six Months Ended June 30,
	Three Months Ended September 30,		Nine Months Ended September 30,
	2010	2009	2010	2009
Risk-free interest rate	—	—	3.15%	2.20%-2.55%
Expected dividend yield	—	—	—	—
Expected life	—	—	7 years	7 years
Expected volatility	—	—	117.46%	72.50%
Forfeiture rate	—	—	—	15.00%

17A summary of award activity under the stock option plans as of September 30, 2010 and changes during the nine month period is presented below:

					Weighted
				Range of	Average
				Exercise	Exercise
	Number of			Prices	Price per		Intrinsic
	Shares			per Share	Share		Value
Options outstanding at December 31, 2009		75,417		$1.92 - $48.64	$	5.93		-
Granted		81,250		$1.45		1.45	$	28,438
Exercised		-		-		-		-
Canceled		(1,667	)	$48.64		48.64		-
Options outstanding at March 31, 2010		155,000		$1.45 - 48.64	$	3.12		-
Granted		-		-		-		-
Exercised		-		-		-		-
Canceled		(3,542)		$1.92 - 15.20		5.83		-
Options outstanding at June 30, 2010		151,458		$1.45 - 48.64	$	3.06		-
Granted		-		-		-		-
Exercised		-		-		-		-
Canceled		(3,333)		$1.92 - 15.20		10.22		-
Options outstanding at September 30, 2010		148,125		$1.45 - $48.64	$	2.90		-

Vested options outstanding at:
September 30, 2010		28,752		$1.92 - $48.64	$	7.05		-
Non-vested options outstanding at:
September 30, 2010		119,373		$1.45 - $48.64	$	0.91	$	106,242

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AApproximately ~~summary~~82,167 ofoptions, ~~award~~net ~~activity~~of ~~under~~forfeitures, of the ~~stock~~119,373 ~~option~~non-vested ~~plans~~options as of ~~June~~September 30, 2010 ~~and~~will ~~changes~~vest ~~during~~within the ~~six~~next ~~month period is presented below:~~year.

					Weighted
				Range of	Average
				Exercise	Exercise
	Number of			Prices	Price per		Intrinsic
	Shares			per Share	Share		Value
Options outstanding at December 31, 2009		75,417		$1.92 - $48.64	$	5.93		-
Granted		81,250		$1.45		1.45	$	97,500
Exercised		-		-		-		-
Canceled		(1,667	)	$48.64		48.64		-
Options outstanding at March 31, 2010		155,000		$1.45 - $48.64	$	3.12		-
Granted		-		-		-		-
Exercised		-		-		-		-
Canceled		(3,542	)	$1.92 - $15.20		5.83		-
Options outstanding at June 30, 2010		151,458		$1.45 - $48.64	$	3.06		-
Vested options outstanding at:
June 30, 2010		32,085		$1.92 - $48.64	$	7.38		-
Non-vested options outstanding at:
June 30, 2010		119,373		$1.45 - $48.64	$	0.91	$	207,709

As of September 30, 2010, there was approximately $84 thousand of total unrecognized compensation cost related to unvested share-based compensation awards granted under the stock option plans. That cost is expected to be recognized over a weighted-average period of approximately 2.1 years.

~~Approximately~~Based ~~94,354~~upon ~~options~~the above assumptions, ~~net~~the ofweighted ~~forfeitures,~~average fair value of the ~~119,373~~stock ~~non-vested~~ options asgranted offor ~~June~~the nine months ended September 30, 2010 ~~will~~and ~~vest~~2009 ~~within~~was $1.29 and $0.20, respectively. There were no options granted for the ~~next~~three ~~year~~months ended September 30, 2010 and 2009, respectively.

As of June 30, 2010, there was approximately $109 thousand of total unrecognized compensation cost related to unvested share-based compensation awards granted under the stock option plans. That cost is expected to be recognized over a weighted-average period of approximately 2.4 years.

Based upon the above assumptions, the weighted average fair value of the stock options granted for the six months ended June 30, 2010 and 2009 was $1.29 and $1.60, respectively. There were no options granted for the three months ended June 30, 2010 and 2009, respectively.

The Company has a policy of issuing new shares to satisfy share option exercises.

18The following table summarizes information regarding stock options outstanding at September 30, 2010:

Options Outstanding
		Weighted	Weighted
		Average	Average
	Number	Remaining	Exercise
Range of	Outstanding at	Contractual	Price
Exercise	September 30,	Life in	per
Prices	2010	Years	Share
$1.00 - $1.50	81,250	9.46	$	1.45
1.51 - 2.00	25,000	8.18		1.94
2.01 - 2.50	9,375	8.34		2.32
2.51 - 3.00	5,625	8.10		2.88
3.01 - 3.50	21,875	9.13		3.28
12.51 - 13.00	2,500	7.66		12.80
48.51 - 49.00	2,500	6.32		48.64
	148,125	8.99	$	2.90

The following table summarizes information regarding exercisable stock options at September 30, 2010:

Options Exercisable
		Weighted	Weighted
	Number of	Average	Average
	Exercisable	Remaining	Exercise
Range of	Options at	Contractual	Price
Exercise	September 30,	Life in	Per
Prices	2010	Years	Share
1.51 - 2.00	18,751	8.18	$	1.95
2.01 - 2.50	3,126	8.34		2.32
2.51 - 3.00	1,875	8.10		2.88
12.51 - 13.00	2,500	7.66		12.80
48.51 - 49.00	2,500	6.32		48.64
	28,752	7.99	$	7.05

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The following table summarizes information regarding stock options outstanding at June 30, 2010:

Options Outstanding
			Weighted		Weighted
			Average		Average
	Number		Remaining		Exercise
Range of	Outstanding at		Contractual		Price
Exercise	June 30,		Life in		per
Prices	2010		Years		Share
$1.00 - $1.50		81,250		9.72	$	1.45
1.51 - 2.00		26,250		8.43		1.94
2.01 - 2.50		9,375		8.59		2.32
2.51 - 3.00		5,625		8.35		2.88
3.01 - 3.50		21,875		9.38		3.28
12.51 - 13.00		2,500		7.92		12.80
15.01 - 15.50		2,083		7.70		15.20
48.51 - 49.00		2,500		6.57		48.64
		151,458		9.22	$	3.06

The following table summarizes information regarding exercisable stock options at June 30, 2010:

Options Exercisable
			Weighted		Weighted
	Number of		Average		Average
	Exercisable		Remaining		Exercise
Range of	Options at		Contractual		Price
Exercise	June 30,		Life in		Per
Prices	2010		Years		Share
1.51 - 2.00		20,001		8.43	$	1.94
2.01 - 2.50		3,126		8.59		2.32
2.51 - 3.00		1,875		8.35		2.88
12.51 - 13.00		2,500		7.92		12.80
15.01 - 15.50		2,083		7.95		15.20
48.51 - 49.00		2,500		6.82		48.64
		32,085		8.21	$	7.38

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A summary of stock options expected to vest in the next twelve months is as follows:

Options Expected To Vest

Weighted

~~Weighted~~

Weighted

~~Weighted~~

Options

Average

~~Average~~

Average

~~Average~~

Expected

Remaining

~~Remaining~~

Exercise

~~Exercise~~

Range of

to Vest

Contractual

~~Contractual~~

Price

~~Price~~

Exercise

Net of

Life in

~~Life in~~

Per

~~Per~~

Prices

~~Fortietures~~Forfeitures

Years

~~Years~~

~~Share~~

$1.00 - $1.50

69,063

~~81,250~~

9.46

~~9.72~~

1.45

~~1.45~~

1.51 - 2.00

2,656

~~2,656~~

8.18

~~8.43~~

1.92

~~1.92~~

2.01 - 2.50

2,656

~~2,656~~

8.34

~~8.59~~

2.32

~~2.32~~

2.51 - 3.00

1,594

~~1,594~~

8.10

~~8.35~~

2.88

~~2.88~~

3.01 - 3.50

6,198

~~6,198~~

9.13

~~9.38~~

3.28

~~3.28~~

94,354

9.36

1.58

82,167

9.07

1.60

The estimated annual share-based compensation expense relating to ASC 718 for the twelve months ended December 31, 2010 is expected to be $113 thousand. The Company recognized stock-based compensation expense of $3225 thousand and $22221 thousand for the three months ended ~~June~~September 30, 2010 and 2009, respectively. The Company recognized stock-based compensation expense of $6388 thousand and $79300 thousand for the ~~six~~nine months ended ~~June~~September 30, 2010 and 2009, respectively.

11 12. SUPPLEMENTAL CASH FLOW INFORMATION

No income tax payments were required for the three ~~months~~ and ~~six~~nine months ended ~~June~~September 30, 2010 and 2009. Cash paid for interest for the ~~six~~nine months ended ~~June~~September 30, 2010 and 2009 was approximately $3654 and $1531 thousand, respectively. We entered into a new capital lease obligation during the ~~six~~three months ended ~~June~~September 30, 2010 for $3262 thousand. For the nine months ended September 30, 2010, we entered into two new capital lease obligations totaling $94 thousand. We did not enter into any capital lease obligations during the ~~six~~nine months ended ~~June~~September 30, 2009. We did not acquire any property and equipment through leasing arrangements during the ~~six~~nine months ended ~~June~~September 30, 2009.

For the ~~six~~nine months ended ~~June~~September 30, 2010, included in non-cash financing activities was $80 thousand related to the cash-less exercise of 54,633 warrants. Non-cash investing activities for the nine months ended September 30, 2010, included $485 thousand of the Company’s Common Stock that was issued to the former Shareholders of Progenitor Research International in connection with the acquisition and $36 thousand of accrued acquisition costs.

1213. GOODWILL AND OTHER INTANGIBLES

~~The~~Management ~~Company~~determined ~~followed~~that the ~~provisions~~Company ofhad ~~ASC~~two ~~805.~~reporting ~~The~~units ~~amount~~for ~~of goodwill that resulted from~~ the ~~Encorium~~ ~~Oy acquisition,~~purposes ~~including deferred taxes~~ of ~~$1,697,724,~~goodwill ~~was~~impairment ~~$15,388,299~~testing. Due Into ~~accordance~~impairment ~~with ASC 805~~triggers, ~~the~~ ~~amount of goodwill resulting from~~ the ~~Encorium~~ ~~Oy acquisition~~Company ~~was~~conducted ~~determined~~an asinterim ~~the excess of cost over the fair values of acquired net assets. Goodwill is carried at cost and is not amortized. We test~~ goodwill ~~for~~ impairment test on anEncorium ~~annual~~Oy’s ~~basis~~goodwill ~~as November 1st~~ of ~~each fiscal year~~$1, ~~relying on a number of factors including operating results~~318, ~~business plans and anticipated future cash flows~~100. ~~Company management uses its judgment in assessing whether goodwill has become impaired between annual impairment tests. Recoverability of goodwill is evaluated using a two-step process.~~ The ~~first step involves a comparison of the~~ fair value of aEncorium ~~reporting unit with its carrying value. If the carrying amount of the reporting unit exceeds its fair value~~Oy, ~~then~~as ~~the~~determined ~~second~~using ~~step of the process involves~~ a ~~comparison~~discounted ofcash ~~the~~flow ~~implied~~model, ~~fair~~was ~~value~~greater ~~and~~than ~~carrying~~its ~~value of the goodwill of that reporting unit. If the~~ carrying value ofat ~~the~~September ~~goodwill of a reporting unit exceeds the fair value of that goodwill~~30, ~~an impairment loss is recognized in an amount equal to the excess~~2010. As ~~Definite-lived intangibles are amortized on~~ a ~~straight-line~~result ~~basis~~no ~~over~~impairment ~~their~~was ~~useful lives~~recorded. WeAs ~~review~~of ~~our~~September ~~other~~30, ~~intangible~~2010, ~~assets~~no ~~for~~goodwill impairment ~~whenever~~test ~~events~~was orperformed ~~changes~~on inProgenitor’s ~~circumstances~~goodwill ~~indicate~~of ~~that~~$1,131,722, ~~the~~since ~~carrying~~Progenitor ~~amount~~was ofacquired ~~the~~on ~~assets~~July ~~may~~19, ~~not be recoverable~~2010.

20Determining the fair value of a reporting unit is a matter of judgment and involves the use of significant estimates and assumptions. The use of different assumptions could change the results of an impairment test. An erosion of future business could result in an impairment charge in future periods.

The Company’s intangible assets were acquired in business combinations. As of September 30, 2010, the Company’s intangible assets consisted customer relationships. Due to certain triggering events, the Company also conducted an interim impairment test of the intangible assets acquired in connection with the acquisition of Encorium Oy, as of September 30, 2010. The Company compared the carrying value of the customer relationships to the undiscounted cash flows resulting from those assets to determine recoverability. As a result, the Company determined that the intangible assets of Encorium Oy were not recoverable, impairment existed. The Company used the discounted future cash flows related to the customer relationships to determine the amount of impairment loss. As a result, the Company recognized a non-cash impairment loss of approximately $2.8 million. In addition, the Company reduced the carrying values of Encorium Oy’s intangible assets, and related deferred income tax liability. As of September 30, 2010, no impairment test was performed on Progenitor’s intangible assets, net of amortization, of $1,013,479, since Progenitor was acquired on July 19, 2010.

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~~The~~All ~~Company also acquired $6.5 million of unidentifiable~~ intangible assets in connection with the Encorium Oy acquisition. Of the $6.5 million of acquired intangible assets, $3.9 million was attributed to customer relationships, $2.6 million was attributable to backlog and $53 thousand was attributable to a non-compete agreement. All of these intangibles are subject to amortization ~~on a straight-line basis~~. Gross ~~The~~carrying ~~estimated useful lives for customer relationships~~amounts, ~~backlog~~accumulated ~~and non-compete agreement are 16 years~~amortization, ~~18 months~~ and 4net ~~years,~~carrying ~~respectively.~~value ~~Amortization expense~~ for the ~~three~~periods ~~months~~ending ~~ended~~September ~~June~~ 30, 2010 and ~~2009~~December ~~was $64 thousand and $68 thousand~~31, ~~respectively. Amortization expense for the six months ended June 30, 2010 and~~ 2009 ~~was $133 thousand, respectively. As of June 30, 2010, estimated amortization of intangibles~~ for ~~the~~intangible ~~five~~assets ~~fiscal~~are ~~years subsequent to June 30, 2010 is~~ as follows:

2010	$	120,287
September 30, 2010
2011		232,028
	Weighted Average Amortization Period in Years		Gross Carrying Amount		Accumulated Amortization		Impairment Losses		Net Carrying Value
2012		232,028
Customer relationships		5.0	$	8,035.703	$	4,018,385	$	2,779,288	$	1,238,030
2013		232,028
December 31, 2009
2014		232,028
	Weighted Average Amortization Period in Years		Gross Carrying Amount		Accumulated Amortization		Impairment Losses		Net Carrying Value
Customer relationships		10.1	$	7,353,749	$	3,845,439	$	-	$	3,508,310

13Amortization expense for the three months ended September 30, 2010 and 2009 was $116 thousand and $72 thousand, respectively. Amortization ~~INCOME~~expense ~~TAXES~~for the nine months ended September 30, 2010 and 2009 was $250 thousand and $205 thousand, respectively. As of September 30, 2010, estimated amortization of intangibles for the five fiscal years subsequent to September 30, 2010 and thereafter is as follows:

The Company accounts for income taxes in accordance with the provisions of FASB ASC 740, “Accounting for Income Taxes” (“ASC 740”). ASC 740 requires recognition of deferred tax liabilities and assets for the future expected tax consequences of events that have been included in the financial statements or tax returns. Under this method deferred tax liabilities and assets are determined based on the difference between the financial statement tax bases of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. At June 30, 2010, the Company recorded a full valuation allowance against its net deferred tax assets and net operating loss carry-forwards given that it is more likely than not that the deferred tax asset will not be realized.

2010	$	63,742
2011		254,971
2012		254,971
2013		254,971
2014		254,971
Thereafter		154,404
Total	$	1,238,030

The Company files its tax returns as prescribed by the tax laws of the jurisdiction in which it operates. The Company’s policy is to recognize interest and penalties in Other Expense.

14. FAIR VALUE MEASUREMENTS

The Company has adopted a single definition of fair value, a framework for measuring fair value, and expanded disclosures concerning fair value. In this valuation, the exchange price is the price in an orderly transaction between market participants to sell an asset or transfer a liability at the measurement date and fair value is a market-based measurement and not an entity-specific measurement.

The Company utilizes the following hierarchy in fair value measurements:

•

Level 1 – Inputs use quoted prices in active markets for identical assets or liabilities that the Company has the ability to access.

•

Level 2 – Inputs use other inputs that are observable, either directly or indirectly. These inputs include quoted prices for similar assets and liabilities in active markets as well as other inputs such as interest rates and yield curves that are observable at commonly quoted intervals.

•

Level 3 – Inputs are unobservable inputs, including inputs that are available in situations where there is little, if any, market activity for the related asset or liability.

In instances where inputs used to measure fair value fall into different levels in the above fair value hierarchy, fair value measurements in their entirety are categorized based on the lowest level input that is significant to the valuation. The Company’s assessment of the significance of particular inputs to these fair measurements requires judgment and considers factors specific to each asset or liability.

2119

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The Company has warrants classified as liabilities, which are measured at fair value on a recurring basis. The warrants are measured at fair value using the Black-Scholes valuation model with pricing inputs that are observable in the market or that can be derived principally from or corroborated by observable market data. In selecting the appropriate fair value technique the Company considers the nature of the instrument, the market risks that it embodies, and the expected means of settlement.

Recurring Fair Value Measurements: There were no recurring fair value measurements of liabilities at December 31, 2009. Liabilities measured at fair value on a recurring basis at ~~June~~September 30, 2010 are as follows:

Quoted Prices in Active Markets for Identical Liabilities (Level 1)

Significant Other Observable Inputs (Level 2)

Significant Unobservable Inputs (Level 3)

Balance at ~~June~~September 30, 2010

Liability for warrants to purchase common stock

—

~~109~~65,000

—

~~109~~65,000

Non-Recurring Fair Value Measurements: There were no non-recurring fair value measurements of assets at December 31, 2009. Assets measured at fair value on a non-recurring basis at September 30, 2010 are as follows:

	Quoted Prices in Active Markets for Identical Assets (Level 1)	Significant Other Observable Inputs (Level 2)	Significant Unobservable Inputs (Level 3)		Balance at September 30, 2010		Total Loss for the Period Ended September 30, 2010

Intangible assets	—	—	$	24,551	$	224,551	$	2,779,288

In accordance with the provisions of ASC 360-10, intangible assets with a carrying amount of $3.0 million were written down to their fair value of $0.2 million, resulting in an impairment charge of $2.8 million, which was included in the results of operations for the period.

See the Goodwill and Other Intangibles note for a discussion of the valuation techniques and a description of the information used to determine fair value.

15. COMMON STOCK AND WARRANTS

In May 2007, the Company sold 218,532 shares of its common stock, $0.001 par value in a private placement (the “Offering”) at a price of $22.88 per share and warrants to purchase an aggregate of 109,266 shares of the Company’s common stock, $0.001 par value, at an exercise price of $4.12 per share for a period of five years commencing six months from the date of issuance to certain investors (the “Investors”). The Offering resulted in aggregate gross proceeds to the Company of $5 million before deducting commissions, fees and expenses. The net proceeds of the transaction are expected to be used to fund organic expansion and, as opportunities arise, for complementary acquisitions, as well as for general corporate purposes and working capital.

In October 2009 the Company entered into Warrant Exchange Agreements (the “Exchange Agreements”) with the Investors pursuant to which the Company issued to the Investors (i) an aggregate of 233,000 shares of Common Stock (collectively, the “Exchange Shares”); and (ii) warrants to purchase an aggregate of 109,266 shares of Common Stock, exercisable for a period of five years from the issue date of October 16, 2009, at an exercise price of $3.20 per share (collectively, the “Exchange Warrants“). The Exchange Shares and Exchange Warrants were issued in exchange for warrants issued to the Investors in the Offering. Except as described above, the terms of the Exchange Warrants, including anti-dilution adjustments, are substantially similar to those of the Original Warrants. The Company obtained stockholder approval for the issuance of stock upon exercise of the Exchange Warrants at its Annual Meeting of stockholders held on January 8, 2010.

The Company evaluates the classification of warrants in accordance with ASC 815, "Derivatives and Hedging" ("ASC 815"). As of December 31, 2009, the warrants were not readily convertible to cash due to the number of shares to be exchanged as compared to the daily trading volume. As a result the warrants were classified as stockholders' equity since the net settlement provision was not met as defined by ASC 815.

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In accordance with ASC 815, an ongoing evaluation is performed to determine whether the warrants are readily convertible to cash. Beginning on March 31, 2010, due to the increase in daily trading volume, the warrants were readily convertible to cash. As a result, the warrants now meet the definition of a derivative and are recorded at fair value and classified as a liability on the balance sheet. The liability for warrants to purchase common stock are revalued at each balance sheet date and marked to fair value with the corresponding adjustment recognized as "gain or loss on warrants" in the statements of operations.

As of ~~June~~September 30, 2010, the fair value of the liability for warrants to purchase common stock was $~~109~~65 thousand. The assumptions used to value the liability at ~~June~~September 30, 2010 were: weighted average exercise price of $3.20, weighted average life of 4.30 years, volatility ~~113~~112%, and risk free interest rate of 21.5527%.

On April 19, 2010, 54,633 warrants were exercised in a cashless exercise resulting in 20,064 shares being issued to the exercising warrant holder. ~~The exercise of these warrants resulted in a gain on warrant of $15 thousand for the three and six months ended June 30, 2010.~~

AtGain ~~June~~on ~~30, 2010, the Company had 54,633~~ warrants ~~outstanding~~was to$44 ~~purchase~~thousand ~~its common stock at~~ and ~~exercise~~$59 ~~price~~thousand offor ~~$3.20~~the three and annine ~~expiration~~months ~~date~~ended ofSeptember ~~October 16~~30, ~~2014~~2010.

At September 30, 2010, the Company had 54,633 warrants outstanding to purchase its common stock at and exercise price of $3.20 and an expiration date of October 16, 2014.

At December 31, 2009, the Company had 109,266 warrants outstanding to purchase its common stock at an exercise price of $3.20 and an expiration date of October 16, 2014.

In October 2009, the Company sold 492,188 shares of its common stock, $0.001 par value in a private placement (the 2009 Offering) at a price of $3.20 per share to an individual investor. The 2009 Offering resulted in aggregate proceeds of $1,575,000 towhich bewas used for general corporate purposes and working capital.

In December 2009, the Company issued a Note to Finnvera plc. The current value of the note at ~~June~~September 30, 2010 was $~~854~~952,~~559~~000 (see Note 5). In connection with this Note, the investor in the 2009 Offering and the Company’s Chief Executive Officer (the “Guarantors”) issued personal guarantees as collateral with an aggregate value of $586 thousand. In consideration for the personal guarantees, the Company issued 97,500 shares of its common stock, par value $0.001 on a pro-rata basis to the Guarantors. The value of the shares has been recorded as debt issuance costs and will be amortized over the life of the Note. As of ~~June~~September 30, 2010 the total debt issuance costs and accumulated amortization ~~were~~on ~~$188~~debt ~~thousand~~issuance ~~and~~costs was $3857 thousand~~, respectively~~.

(Amounts were converted based on an exchange rate at ~~June~~September 30, 2010 of 1.00 EUR ~ 1.~~2208~~36 USD)

16. SUBSEQUENT EVENTS

On ~~July~~October 1915, 2010, the Company ~~acquired~~completed ~~Progenitor Holding AG,~~ a ~~corporation~~rights ~~organized~~offering inof ~~Switzerland~~its ~~(“Progenitor~~common ~~Holding”)~~stock. The ~~and~~rights ~~its~~offering ~~operating~~entitled ~~subsidiaries~~each ~~organized~~stockholder inof ~~Mexico,~~record ~~Panama,~~on ~~Argentina,~~August ~~Chile~~20, ~~Switzerland,~~2010 ~~India~~to ~~and~~purchase ~~Hong~~one ~~Kong~~share ~~(collectively~~of ~~referred~~common tostock ~~herein~~at as$1.75 ~~“Progenitor”)~~per share. ~~Progenitor~~Upon iscompletion aof ~~European~~the ~~headquartered~~rights ~~emerging~~offering, ~~market~~the ~~clinical~~company ~~research~~issued ~~organization~~641,002 ~~providing~~shares ~~international~~of ~~drug~~its ~~development~~common ~~services~~stock in ~~emerging~~exchange ~~market~~for ~~regions~~$1.1 ~~Pursuant to the terms of a Stock Purchase Agreement on July 19~~million. Additionally, ~~2010~~ the Company ~~purchased~~exchanged ~~from~~notes ~~the~~payable ~~shareholders~~ of ~~Progenitor~~$1.7 ~~Holding~~million ~~all~~due ofto ~~issued~~a ~~and~~significant ~~outstanding~~stockholder for 1,015,000 shares of ~~Progenitor~~common ~~Holding~~stock.

On October 20, 2010, the Company received notification that the NASDAQ Qualifications Panel (the "Panel") determined to delist the Company's securities from The ~~consideration~~NASDAQ ~~for~~Stock Market, effective with the ~~acquisition~~open ~~was~~of business on October 22, 2010, as a ~~combination~~result of ~~cash~~the ~~and~~Company's ~~stock~~failure ~~valued~~to atregain compliance with the minimum $2.05 million, ~~plus~~stockholders' ~~earn-out~~equity ~~consideration~~requirement. ofThe $1Company’s common stock is currently quoted on the Pink Sheets.8 ~~million~~Investors ~~payable~~can asnow ~~follows~~view real time stock quotes for HLCS at http://www.otcmarkets.com.

On ~~closing~~January of12, ~~the~~2011 ~~transaction~~Svenska Handelsbanken AB notified Encorium Oy, the Company’s ~~paid~~wholly-owned tosubsidiary, ~~the~~that ~~former~~it ~~shareholders~~would terminate its line of ~~Progenitor~~credit ~~Holding~~(the ~~$977~~“Handelsbanken ~~thousand~~Line”) with Encorium Oy. The Handlesbanken Line was entered into on February 9, 2005 between Encorium Oy and anSvenska ~~additional~~Handelsbanken AB and provided for up to EUR 500,000 of borrowings at a 1.25% interest rate. On February 15, 2011, Encorium Oy repaid $~~366~~203 thousand under the Handelsbanken Line and on ~~July~~March 2715, ~~2010. In~~2011 ~~addition,~~repaid the ~~former~~remaining ~~shareholders~~outstanding ofprincipal ~~Progenitor~~balance ~~Holding~~of ~~will~~$490 bethousand. The ~~entitled~~Company toreplaced the ~~additional~~Handelsbanken ~~compensation~~Line with a line from its significant stockholder, as ~~follows:~~described below.

~~· Sixty~~(Amounts ~~days~~were ~~after~~converted ~~July~~based ~~19,~~on ~~2010, the former shareholders of Progenitor are entitled to receive common stock of the Company having~~ an ~~aggregate~~exchange ~~value~~rate ofat ~~EURO~~February ~~375~~15,~~000,~~ ~~with~~2011 ~~each share being valued at the greater~~ of ~~(i) the average daily closing price of the Company’s common stock on the Nasdaq Capital Market for the 30 consecutive trading days after July 19, 2010 or (ii) $2~~1.~~50,~~00 ~~which~~EUR we~ ~~refer to as the “Closing Stock Consideration”~~1. ~~For~~35 ~~purposes of calculating the Closing Stock Consideration the~~ USD ~~share~~and ~~value~~an ~~shall~~exchange berate ~~translated~~at toMarch ~~EUROs~~15, ~~using~~2011 ~~the exchange rate~~ of ~~USD~~ 1.~~292~~00 :EUR ~~EURO~~~ 1.~~00.~~40 USD)

23Effective February 11, 2011, Encorium Oy entered into a Line of Credit Promissory Note with Ilari Koskelo, a current stockholder of the Company, to replace the Handelsbanken Line, as described above (the “Ilari Line”). Encorium Oy borrowed $685 thousand under the Ilari Line to repay the outstanding amounts on the Handelsbanken Line. The unpaid principal under the Ilari Line accrues and compounds interest monthly at the rate of ten percent (10.0%) per annum. Any principal amount borrowed under the Ilari Line is payable on demand on the twelve month anniversary of the date such principal amount was received by Encorium Oy or according to a separately agreed payment schedule. The interest on any principal amount borrowed under the Ilari Line is payable quarterly beginning on the sixth month anniversary of the date such principal amount was received by Encorium Oy. On the occurrence of any Event of Default (as defined in the Ilari Line), and upon five days written notice and cure period, all principal and other amounts owed under Ilari Line shall become immediately due and payable. In addition, upon a Change of Control (as defined in the Ilari Line) of the Company or Encorium Oy, a change in control fee equal to twenty percent of the then outstanding principal amount will be payable.

(Amounts were converted based on an exchange rate at February 11, 2011 of 1.00 EUR ~ 1.37 USD)

On March 25, 2011, Philip L. Calamia resigned from his position as Interim Chief Financial Officer of the Company to pursue other interests. The Company is in the process of finding a replacement for the vacant position of Chief Financial Officer. Until the position is filled, Niklas Tevajärvi, Chief Financial Officer of the Company’s Europe and Asia Operations, has assumed the role of Principle Accounting Officer, effective with the filing of this Quarterly Report.

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· On or prior to April 30, 2011 (or at a later date if the dispute resolution provisions of the transaction documentation are required to determine the 2010 earnout consideration) and subject to any amount due from the former shareholders of Progenitor Holding to the Company pursuant to transaction documentation, the shareholders will be entitled to receive an additional number of shares of the Company’s common stock, which we refer to as the “2010 earnout consideration,” based on Progenitor’s consolidated earnings before interest, taxes, depreciation and amortization for the fiscal year ending December 31, 2010, calculated under U.S. GAAP, which we refer to as “2010 EBITDA,” as follows:

o If 2010 EBITDA is equal to or greater than EURO 400,000, the 2010 earnout consideration shall be as follows: (A) a cash payment equal to 70% of the amount obtained by multiplying 2.2 by the 2010 EBITDA, and (B) the number of shares of common stock of the Company equal to 30% of the quotient obtained by dividing (1) the amount obtained by multiplying 2.2 by the 2010 EBITDA by (2) the greater of the average daily closing price of the Company’s common stock from December 1, 2010 to February 28, 2011 or $3.00. For purposes of calculating the 2010 earnout consideration, the USD share value shall be translated to EUROs using the average daily exchange rate for the period January 1, 2010 to December 31, 2010.

o If 2010 EBITDA is equal to or greater than EURO 200,000 but less than EURO 400,000, the 2010 earnout amount shall be as follows: (A) a cash payment equal to 70% of the amount obtained by multiplying 1.5 by the 2010 EBITDA, and (B) the number of shares of common stock of the Company equal to 30% of the quotient obtained by dividing (1) the amount obtained by multiplying 1.5 by the 2010 EBITDA by (2) the greater of the average daily closing price of the Company’s common stock from December 1, 2010 to February 28, 2011 or $3.00. For purposes of calculating the 2010 earnout consideration, the USD share value shall be translated to EUROs using the average daily exchange rate for the period January 1, 2010 to December 31, 2010.

o If 2010 EBITDA is less than EURO 200,000, the 2010 earnout consideration shall be zero.

· On or prior to February 28, 2012 (or at a later date if the dispute resolution provisions of the transaction documentation are required to determine the 2011 earnout consideration) and subject to any amount due from the former shareholders of Progenitor Holding to the Company pursuant to the transaction documentation, the former shareholders of Progenitor Holding will be entitled to receive an additional number of shares of our common stock, which we refer to as the “2011 earnout consideration,” based on Progenitor’s consolidated earnings before interest, taxes, depreciation and amortization for the fiscal year ending December 31, 2011, calculated under U.S. GAAP, which we refer to as “2011 EBITDA,” as follows:

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o if 2011 EBITDA is equal to or greater than EURO 450,000, the 2011 earnout consideration shall be as follows: (A) a cash payment equal to 70% of the amount obtained by multiplying 2.2 by the 2011 EBITDA, and (B) the number of shares of common stock of the Company equal to 30% of the quotient obtained by dividing (1) the amount obtained by multiplying 2.2 by the 2011 EBITDA by (2) the greater of the average daily closing price of the Company’s common stock from December 1, 2011 to February 28, 2012 or $3.00. For purposes of calculating the 2011 earnout consideration, the USD share value shall be translated to EUROs using the average daily exchange rate for the period January 1, 2011 to December 31, 2011.

o if 2011 EBITDA is equal to or greater than EURO 250,000 but less than EURO 450,000, the 2011 earnout consideration shall be as follows: (A) a cash payment equal to 70% of the amount obtained by multiplying 1.5 by the 2011 EBITDA, and (B) the number of shares of common stock of the Company equal to 30% of the quotient obtained by dividing (1) the amount obtained by multiplying 1.5 by the 2011 EBITDA by (2) the greater of the average daily closing price of the company’s common stock from December 1, 2011 to February 28, 2012 or $3.00. For purposes of calculating the 2011 earnout consideration, the USD share value shall be translated to EUROs using the average daily exchange rate for the period January 1, 2011 to December 31, 2011.

o If 2011 EBITDA is less than EURO 250,000, the 2011 earnout consideration shall be zero.

· subject to any amounts due from the former shareholders of Progenitor Holding to the Company, 18 months after July 19, 2010, the Company shall (i) pay, or cause to be paid to the former shareholders of Progenitor Holding, the sum of EURO 150,000 and (ii) issue to the former shareholders of Progenitor Holding common stock of the Company having an aggregate value of EURO 75,000, with each share being valued at the greater of (A) the average daily closing price of the Company’s common stock on the Nasdaq Capital Market for the thirty consecutive trading days after the date of Closing or (B) $2.50 (which we refer to herein as the “Holdback Amount”).

Under the terms of transaction documentation, the consideration payable to the former shareholders of Progenitor Holding described above is subject to the following post-closing adjustment:

• Within 60 days following July 19, 2010, the Company shall prepare and deliver to the former shareholders of Progenitor Holding an unaudited balance sheet of Progenitor Holding as of July 19, 2010, which shall include a statement of the working capital of Progenitor Holding (on a consolidated basis). In the event Progenitor Holding’s working capital is less than EURO 100,000 the deficiency shall be offset from the Holdback Amount. In the event Progenitor Holding’s working capital is greater than EURO 100,000, then the Company will pay the former shareholders of Progenitor Holding any surplus within 5 days of determination of the amount due.

The Company financed the cash component of the purchase consideration by issuing an unsecured note in the amount of $1.3 million to Ilari Koskelo, a significant stockholder of the Company. The note bears interest at 5% per year on the unpaid principal through October 31, 2010 and 7% per year on the unpaid principal after November 1, 2010. The principal is payable on demand after September 1, 2010.

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ITEM 2.

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

In this discussion, the terms “Company,” “we,” “us” and “our” refer to Encorium Group, Inc. and our consolidated subsidiaries, except where it is made clear otherwise.

Forward Looking Statements

When used in this Report on Form 10-Q and in other public statements, both oral and written, by the Company and Company officers, the words “estimate,” “project,” “expect,” “intend,” “believe,” “anticipate” and similar expressions are intended to identify forward-looking statements regarding events and trends that may affect our future operating results and financial position. Such statements are subject to risks and uncertainties that could cause our actual results and financial position to differ materially. Such factors include, among others: (i) the risk that we may not have sufficient funds to operate our business; (ii) our success in attracting new business and retaining existing clients and projects; (iii) the size, duration and timing of clinical trials we are currently managing may change unexpectedly; (iv) the termination, delay or cancellation of clinical trials we are currently managing could cause revenues and cash-on-hand to decline unexpectedly; (v) the timing difference between our receipt of contract milestone or scheduled payments and our incurring costs to manage these trials; (vi) outsourcing trends in the pharmaceutical, biotechnology and medical device industries; (vii) the ability to maintain profit margins in a competitive marketplace; (viii) our ability to attract and retain qualified personnel; (ix) the sensitivity of our business to general economic conditions; (x) other economic, competitive, governmental and technological factors affecting our operations, markets, products, services and prices; (xi) announced awards received from existing and potential customers are not definitive until fully negotiated contracts are executed by the parties; (xii) our backlog may not be indicative of future results and may not generate the revenues expected; and (xiii) uncertainties regarding the availability of additional capital ~~and continued listing of our common stock on Nasdaq~~. You should not place undue reliance on any forward-looking statement. We undertake no obligation to publicly release the result of any revision of these forward-looking statements to reflect events or circumstances after the date they are made or to reflect the occurrence of unanticipated events. Please refer to the section entitled “Risk Factors” beginning on page 4144 in this Quarterly Report on Form 10-Q for the period ended ~~June~~September 30, 2010 for a more complete discussion of factors which could cause our actual results and financial position to change.

Overview

We are a clinical research organization that engages in the design and management of complex clinical trials for the pharmaceutical, biotechnology and medical device industries. We were initially incorporated in August 1998 in Nevada. In June 2002, we changed our state of incorporation to Delaware. In November 2006, we expanded our international operations with the acquisition of our wholly-owned subsidiary, Encorium Oy, a CRO founded in 1996 in Finland, which offers clinical trial services to the pharmaceutical and medical device industries. Since 2006 we have conducted substantially all of our European operations through Encorium Oy and its wholly-owned subsidiaries located in Denmark, Estonia, Sweden, Lithuania, Romania, Germany and Poland. On July 16, 2009 the Company sold substantially all of the assets relating to the Company’s US line of business to Pierrel Research USA, Inc., the result of which the Company no longer has any employees or significant operations in the United States. Due to this sale, for the three and ~~six~~nine months ended ~~June~~September 30, 2010 and 2009, the results of the U.S. business have been presented as discontinued operations in the consolidated condensed financial statements.

The following discussion should be read in conjunction with the Company’s consolidated financial statements and notes thereto.

26On October 20, 2010, the Company received notification that the NASDAQ Qualifications Panel (the "Panel") determined to delist the Company's securities from The NASDAQ Stock Market, effective with the open of business on October 22, 2010, as a result of the Company's failure to regain compliance with the minimum $2.5 million stockholders' equity requirement. The Company’s common stock is currently quoted on the Pink Sheets. Investors can now view real time stock quotes for HLCS at http://www.otcmarkets.com.

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The consideration for the acquisition was a combination of cash and stock valued at $2.0 million, plus earn-out consideration of up to $1.8 million. The earn-out is subject to the achievement of certain targets as set forth in the purchase agreement and if achieved, will be payable during the first quarter of 2011 and 2012.22

Historically our net cash used in operations has been substantial. Our net cash used in operations for the six months ended June 30, 2010 was $853 thousand. Our cash and cash equivalents as of June 30, 2010 was $176 thousand. We anticipate that will meet our cash requirements at least into the third quarter of 2011, assuming we are able to fully implement our current costs cutting initiatives, we are able to win additional contracts during fiscal 2010 and we are able to maintain our current customer contracts. Our ability to obtain additional financing in the future will depend in part upon prevailing capital market conditions, as well as conditions in our business and our operating results; and those factors may affect our efforts to arrange additional financing on terms that are satisfactory to us or at all. If we are unable to secure additional financing on terms acceptable to us and on a timely basis, we may significantly reduce our operating costs, which may include the cessation of operations in some countries. Our consolidated condensed financial statements do not include any adjustment to reflect the possible future effects on the recoverability or classification of assets or the amounts and classification of liabilities that may result from the outcome of our ability to continue as a going concern.

The accompanying consolidated condensed financial statements have been prepared on the basis of the Company continuing as a going concern. However, the factors summarized above have raised substantial doubt about our ability to continue as a going concern for the foreseeable future.

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The consideration for the acquisition was a combination of cash and stock valued at $2.57 million, plus earn-out consideration of up to $1.8 million. The earn-out is subject to the achievement of certain targets as set forth in the purchase agreement and if achieved, will be payable during the first quarter of 2011 and 2012.

The Company financed the cash component of the purchase consideration by issuing an unsecured note in the amount of $1.5 million to Ilari Koskelo, a significant stockholder of the Company. The note bears interest at 5% per year on the unpaid principal through October 31, 2010 and 7% per year on the unpaid principal after November 1, 2010. The principal is payable on demand after September 1, 2010. In connection with the Company’s rights offering which was completed on October 15, 2010, the Company exchanged the outstanding note payable to stockholder for shares of common stock of the Company. See Subsequent Events Note for further information.

Historically our net cash used in operations has been substantial. Our net cash used in operations for the nine months ended September 30, 2010 was $801 thousand. Our cash and cash equivalents as of September 30, 2010 was $188 thousand. We anticipate that will meet our cash requirements at least into the third quarter of 2011, assuming we are able to fully implement our current costs cutting initiatives, we are able to win additional contracts during 2011 and we are able to maintain our current customer contracts. Our ability to obtain additional financing in the future will depend in part upon prevailing capital market conditions, as well as conditions in our business and our operating results; and those factors may affect our efforts to arrange additional financing on terms that are satisfactory to us or at all. If we are unable to secure additional financing on terms acceptable to us and on a timely basis, we may significantly reduce our operating costs, which may include the cessation of operations in some countries. Our consolidated condensed financial statements do not include any adjustment to reflect the possible future effects on the recoverability or classification of assets or the amounts and classification of liabilities that may result from the outcome of our ability to continue as a going concern.

Net revenue is derived principally from the design, management and monitoring of clinical research studies. Clinical research service contracts generally have terms ranging from several months to several years. A portion of the contract fee is generally payable upon execution of the contract, with the balance payable in installments over the life of the contract. Several of our older contracts contain payment schedules that are weighted towards the later stages of the contract. A significant portion of our net revenue is recognized from fixed price contracts on a proportional performance basis. To measure the performance, we compare actual direct costs incurred to estimated total contract direct costs, which we believe is the best indicator of the performance of the contract obligations as the costs relate to the labor hours incurred to perform the service.

Contracts generally may be terminated by clients immediately or with short notice. Clinical trials may be terminated or delayed for several reasons including, among others, unexpected results or adverse patient reactions to the drug, inadequate patient enrollment or investigator recruitment, manufacturing problems resulting in shortages of the drug, budget constraints of clients or decisions by the client to de-emphasize or terminate a particular trial, development efforts on a particular drug or our failure to properly perform our obligations. Depending on the size of the trial in question, a client’s decision to terminate or delay a trial in which we participate could have a material and adverse effect on our backlog, future revenue and results from operations.

General

The information set forth and discussed below for the three and ~~six~~nine months ended ~~June~~September 30, 2010 and 2009 is derived from the Consolidated Condensed Financial Statements included elsewhere herein. The financial information set forth and discussed below is unaudited but, in the opinion of management, reflects all adjustments (primarily consisting of normal recurring adjustments) necessary for a fair presentation of such information. The results of our operations for a particular quarter may not be indicative of results expected during the other quarters or for the entire year.

Our quarterly results can fluctuate as a result of a number of factors, including our success in attracting new business, the size and duration of clinical trials, the timing of client decisions to conduct new clinical trials or to cancel or delay ongoing trials, changes in cost estimates to complete ongoing trials, and other factors, many of which are beyond our control.

Net revenue is derived principally from the design, management and monitoring of clinical research studies. Clinical research service contracts generally have terms ranging from several months to several years. A portion of the contract fee is generally payable upon execution of the contract, with the balance payable in installments over the life of the contract. A significant portion of our net revenue is recognized from fixed-price contracts on a proportional performance basis. To measure the performance, we compare actual direct costs incurred to estimated total contract direct costs, which we believe is the best indicator of the performance of the contract obligations as the costs relate to the labor hours incurred to perform the service. Total direct costs are incurred for each contract and compared to estimated total direct costs for each contract to determine the percentage of the contract that is completed. This percentage is multiplied by the estimated total contract value to determine the amount of net revenue recognized.

Contracts generally may be terminated by clients immediately or with short notice. Clinical trials may be terminated or delayed for several reasons, including, among others, unexpected results or adverse patient reactions to the drug, inadequate patient enrollment or investigator recruitment, manufacturing problems resulting in shortages of the drug or decisions by the client to de-emphasize or terminate a particular trial or development efforts on a particular drug. Depending on the size of the trial in question, a client’s decision to terminate or delay a trial in which we participate could have a material and adverse effect on our backlog, future revenue and results from operations.23

Our backlog relative to continuing operations was approximately $16.6 million as of June 30, 2010 as compared to $19.6 million as of June 30, 2009. Our backlog consists of anticipated net revenue from signed contracts and letters of intent that either have not started but are anticipated to begin in the near future or are in process and have not yet been completed. Many of our studies and projects are performed over an extended period of time, which may be several years. Amounts included in backlog have not yet been recognized as net revenue in our Consolidated Statements of Operations. Once contracted work begins, net revenue is recognized over the life of the contract on a proportional performance basis. The recognition of net revenue and contract terminations, if any, reduces our backlog while the awarding of new business increases our backlog. For the six months ended June 30, 2010 we obtained approximately $9.1 million of new business awards as compared to approximately $4.8 million for the six months ended June 30, 2009.

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Our backlog relative to continuing operations was approximately $13.3 million as of September 30, 2010 as compared to $19.9 million as of September 30, 2009. Our backlog consists of anticipated net revenue from signed contracts and letters of intent that either have not started but are anticipated to begin in the near future or are in process and have not yet been completed. Many of our studies and projects are performed over an extended period of time, which may be several years. Amounts included in backlog have not yet been recognized as net revenue in our Consolidated Statements of Operations. Once contracted work begins, net revenue is recognized over the life of the contract on a proportional performance basis. The recognition of net revenue and contract terminations, if any, reduces our backlog while the awarding of new business increases our backlog. For the nine months ended September 30, 2010 we obtained approximately $11.2 million of new business awards as compared to approximately $8.3 million for the nine months ended September 30, 2009.

We believe that our backlog as of any date may not necessarily be a meaningful predictor of future results because backlog can be affected by a number of factors including the size and duration of contracts, many of which are performed over several years. Additionally, contracts relating to our clinical trial business may be subject to early termination by the client or delay for many reasons, as described above. Also, the scope of a contract can change during the course of a study. For these reasons, we might not be able to fully realize our entire backlog as net revenue.

The following table sets forth amounts for certain items in our consolidated statements of operations expressed as a percentage of net revenue. The following table excludes revenue and costs related to reimbursable out-of-pocket expenses because they are not generated by the services we provide, do not yield any gross profit to us, and do not have any impact on our net income. We believe this information is useful to our investors because it presents the net revenue and expenses that are directly attributable to the services we provide to our clients and provides a more accurate picture of our operating results and margins.

~~Percentage of net revenue, excluding reimbursable out-of-pocket expenses:~~24

	% of Net Revenue						% of Net Revenue
	Three Months Ended						Six Months Ended
	June 30,						June 30,
	2010			2009			2010			2009
Net revenue		100	%		100	%		100	%		100	%
Total Revenue		100	%		100	%		100	%		100	%
Operating Expenses
Direct		70.3	%		76.3	%		80.4	%		70.6	%
Reimbursement out-of-pocket expenses		16.2	%		17.8	%		17.3	%		21.2	%
Selling, general and administrative		47.7	%		49.9	%		56.2	%		47.9	%
Depreciation and amortization		2.5	%		2.1	%		2.8	%		2.0	%
Loss from Operations		(20.5	%)		(28.3	%)		(39.5	%)		(20.5	%)
Net Loss from continuing operations		(21.3	%)		(28.3	%)		(40.0	%)		(20.4	%)
Net Loss		(21.3	%)		(43.4	%)		(40.3	%)		(23.7	%)

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Percentage of net revenue, excluding reimbursable out-of-pocket expenses:

	% of Net Revenue						% of Net Revenue
	Three Months Ended						Nine Months Ended
	September 30,						September 30,
	2010			2009			2010			2009

Net revenue		100	%		100	%		100	%		100	%
Total Revenue		100	%		100	%		100	%		100	%

Operating Expenses
Direct		89	%		65	%		83	%		69	%
Selling, general and administrative		70	%		46	%		60	%		47	%
Depreciation and amortization		5	%		2	%		4	%		2	%
Impairment loss		100	%		0	%		29	%		0	%

Loss from Operations		(164	%)		(14	%)		(76	%)		(18	%)

Net Loss from continuing operations		(138	%)		(17	%)		(69	%)		(19	%)

Net Loss		(138	%)		(23	%)		(69	%)		(23	%)

Contractual Obligations and Commitments

We entered into two capital lease obligations during the nine months ended September 30, 2010 totaling $94 thousand for the acquisition of certain software applications. We entered into a $3262 thousand capital lease obligation during the ~~six~~three months ended ~~June~~September 30, 2010 ~~pursuant~~for to the acquisition of certain software applications. We did not enter into any capital lease obligations for the ~~six~~nine months ended ~~June~~September 30, 2009. We are committed under a number of non-cancelable operating leases, primarily related to office space and other office equipment.

Below is a summary of our future payment commitments by year under contractual obligations. Actual amounts paid under these agreements could be higher or lower than the amounts shown below as a result of changes in volume and other variables:

		Total				2010				2011				2012				2013
Operating leases		$	3,~~193~~390,~~564~~378			$	~~853~~665,~~647~~824			$	1,~~135~~348,~~550~~306			$	~~731~~838,~~833~~894			$	~~472~~537,~~534~~354

InFor the remainder of 2010, we anticipate capital expenditures of approximately $~~100~~25,000—$~~200~~85,000 for leasehold improvements, software applications, workstations, personal computer equipment and related assets.

Critical Accounting Policies and Estimates

The following discussion should be read in conjunction with the consolidated condensed financial statements and notes thereto.

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The accompanying unaudited Consolidated Condensed Financial Statements have been prepared in conformity with accounting principles generally accepted in the United States of America and with the instructions to Form 10-Q. Certain information and accounting policies and footnote disclosures normally included in financial statements prepared in conformity with accounting principles generally accepted in the United States of America have been condensed or omitted pursuant to such instructions, although Encorium believes that the included disclosures are adequate for a fair presentation. The information furnished reflects all adjustments (consisting of normal recurring adjustments), which are, in the opinion of management, necessary for a fair summary of the financial position, results of operations and cash flows for the interim periods presented. These Consolidated Condensed Financial Statements should be read in conjunction with the Consolidated Condensed Financial Statements and notes thereto filed with Form 10-K for the year ended December 31, 2009.

Use of Estimates

Consolidation

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Cash and Cash Equivalents

We consider all highly liquid debt instruments purchased with an original maturity of three months or less to be cash equivalents.

We maintain cash accounts at several institutions in Europe and one in the USU.S. Deposits in Europe are generally insured by individual states up to € 50,000 for each account (approximately $6168,000 as of ~~June~~September 30, 2010). Accounts in the USU.S. are generally insured up to $250,000 for each account. As of ~~June~~September 30, 2010 our cash and cash equivalents were based primarily in Europe with two institutions. To date, the Company has not experienced any loss or lack of access to its invested cash or cash equivalents, however, there can be no assurance that access to invested balances will not be impacted by adverse conditions in the financial and credit markets.

Investigator Advances

Revenue Recognition

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Reimbursable Out-of-Pocket Expenses

Accounts Receivable

33Several client contracts contain provisions that allow us to bill and receive advance payments to be utilized for investigator fees and reimbursable expenses. In some instances, the client requires that we maintain separate cash accounts to be utilized for investigator fees, which are included as Investigator Advances. Funds received as customer advances, excluding investigator advances for which separate cash accounts are required as part of our contract with the client, are included as part of Cash and Cash Equivalents. The balance of customer advances, including investigator advances of $0, was $1.1 million as of September 30, 2010. The balance of customer advances, including investigator advances of $19 thousand was $1.4 million as of December 31, 2009. As of September 30, 2010 and December 31, 2009, there were no customer advances billed, but not received.

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Financial Instruments

As of ~~June~~September 30, 2010, the Company was not a counter party to any forward foreign exchange contracts.

Property and Equipment

Property and equipment are recorded at cost. Depreciation is provided using the straight-line method over the estimated useful lives of the assets, which range from 3 to 8 years for equipment and furniture and fixtures and the remaining lease term for leasehold improvements and assets under capital lease. Depreciation and amortization, excluding the amortization of intangible assets, for the ~~six~~three months ended ~~June~~September 30, 2010 and 2009 was $5725 thousand and $5026 thousand, respectively. Depreciation and amortization, excluding the amortization of intangible assets, for the nine months ended September 30, 2010 and 2009 was $82 thousand and $77 thousand, respectively. Expenditures for maintenance and repairs are charged to expense as incurred. When assets are sold, retired, or fully depreciated the cost and accumulated depreciation are removed from the accounts, and any gain or loss on the sale of property and equipment is included in operations.

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Stock-Based Compensation

Goodwill and Intangible Assets

Goodwill is carried at cost and is not amortized. We test goodwill for impairment on an annual basis as November 1st of each fiscal year, relying on a number of factors including operating results, business plans and anticipated future cash flows. Company management uses its judgment in assessing whether goodwill has become impaired between annual impairment tests. Recoverability of goodwill is evaluated using a two-step process. The first step involves a comparison of the fair value of a reporting unit with its carrying value. In Ifthe event that the carrying amount of the reporting unit exceeds its fair value, ~~then~~goodwill ~~the~~is not recoverable, impairment exists. The second step of the process involves a comparison of the implied fair value and carrying value of the goodwill of that reporting unit. Ifto ~~the~~determine ~~carrying value of~~ the ~~goodwill~~amount of ~~a reporting unit exceeds the fair value of that goodwill, an~~ impairment loss ~~is recognized in an amount equal~~ to ~~the excess~~recognize. Definite-lived intangibles are amortized on a straight-line basis over their useful lives. We review our other intangible assets for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets may not be recoverable.

34Management determined that the Company had two reporting units for the purposes of goodwill impairment testing. Due to impairment triggers, the Company conducted an interim goodwill impairment test on Encorium Oy’s goodwill of $1,318,100. The fair value of Encorium Oy, as determined using a discounted cash flow model, was greater than its carrying value at September 30, 2010. As a result no impairment was recorded. As of September 30, 2010, no goodwill impairment test was performed on Progenitor’s goodwill of $1,131,722, since Progenitor was acquired on July 19, 2010.

~~Table~~Determining the fair value of ~~Contents~~a reporting unit is a matter of judgment and involves the use of significant estimates and assumptions. The use of different assumptions could change the results of an impairment test. An erosion of future business could result in an impairment charge in future periods.

Foreign Currency Translation

Income Taxes

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Under this method deferred tax liabilities and assets are determined based on the difference between the financial statement tax bases of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. At June 30, 2010, the Company recorded a full valuation allowance against its net deferred tax assets and net operating loss carry-forwards given that it is more likely than not that the deferred tax asset will not be realized.

Earnings (Loss) Per Share

Results of Operations

Three Months Ended ~~June~~September 30, 2010 Compared With Three Months Ended ~~June~~September 30, 2009

Continuing Operations:

Net revenue for the three months ended ~~June~~September 30, 2010 decreased by $~~700~~1.6 ~~thousand~~million to $32.8 million as compared to $4.54 million for the three months ended ~~June~~September 30, 2009. The decrease in net revenues was primarily attributable to reduced new business awards, contract cancelations ~~along with the performance of unexpected out of scope work for which revenue can not be recognized until corresponding change orders are executed with the client~~. Of the $~~700~~1.6 ~~thousand~~million decrease, approximately $~~325~~300 thousand was due to unfavorable foreign currency fluctuations. For the three months ended ~~June~~September 30, 2010, net revenue from our largest clients amounted to 6050% of our net revenue, with the largest clients representing 4218%, 18%, and 1814% of net revenue, respectively. For the three months ended ~~June~~ September 30, 2009, net revenue from these same clients also amounted to 5149% of our net revenue, representing 3731%, and 1418% of net revenue, respectively.

Reimbursement revenue consisted of reimbursable out-of-pocket expenses incurred on behalf of our clients. Reimbursements are made at cost, without mark-up or profit, and therefore have no impact on net income.

35Direct expenses included compensation and other expenses directly related to conducting clinical studies. These costs decreased by approximately $400 thousand to $2.5 million for the three months ended September 30, 2010 from $2.9 million for the three months ended September 30, 2009 primarily due to favorable foreign currency fluctuations. Direct expenses as a percentage of net revenue were approximately 89% and 65% for the three months ended September 30, 2010 and 2009, respectively.

Selling, general, and administrative expenses (“SG&A”) includes the salaries, wages and benefits of all administrative, financial and business development personnel and all other support expenses not directly related to specific contracts. These costs decreased approximately $100 thousand to $2.0 million for the three months ended September 30, 2010 from $2.1 million for the three months ended September 30, 2009. The decrease in SG&A expenses was primarily attributable to favorable foreign currency fluctuations. As a percentage of revenues, SG&A expenses increased to 70% for the three months ended September 30, 2010 compared with 46% the prior year period.

Depreciation and amortization expense was approximately $141 thousand and $98 thousand for the three months ended September 30, 2010 and 2009, respectively.

Due to impairment triggers, the Company conducted an interim impairment test of goodwill acquired in connect with the acquisition of Encorium Oy, as of September 30, 2010. Company determined that there was no impairment related to the amount of goodwill acquired in connection with the acquisition of Encorium Oy and no adjustment to the carrying value was necessary. As of September 30, 2010, the Company’s intangible assets consisted customer relationships. Due to certain triggering events, the Company also conducted an interim impairment test of the intangible assets acquired in connection with the acquisition of Encorium Oy, as of September 30, 2010. The Company compared the carrying value of the customer relationships to the undiscounted cash flows resulting from those assets to determine recoverability. As a result, the Company determined that the intangible assets of Encorium Oy were not recoverable, impairment existed. The Company used the discounted future cash flows related to the customer relationships to determine the amount of impairment loss. As a result, the Company recognized a non-cash impairment loss of approximately $2.8 million. In addition, the Company reduced the carrying values of intangible assets, and related deferred income tax liability. As of September 30, 2010, no goodwill impairment test was performed on Progenitor’s goodwill of $1,131,722 or Progenitor’s intangible assets, net of amortization, of $1,013,479, since Progenitor was acquired on July 19, 2010.

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~~Direct~~Loss ~~expenses~~from ~~included~~operations ~~compensation~~increased ~~and other expenses directly related to conducting clinical studies. These costs decreased~~ by ~~approximately~~ $~~800~~4.0 ~~thousand~~million to $24.6 million for the three months ended ~~June~~September 30, 2010 ~~from~~compared ~~$3.4 million for the three months ended June 30, 2009. The decrease in direct expenses was due~~ to ~~reductions~~a inloss ~~staff~~from ~~and~~operations ~~subcontractors~~of ~~utilized on active clinical studies being conducted. Approximately~~ $~~230~~617 thousand offrom ~~the~~operations ~~decrease was attributable to favorable foreign currency fluctuations. Direct expenses as a percentage of net revenue were approximately 70% and 76%~~ for the three months ended ~~June~~ September 30, ~~2010~~2009, ~~and~~primarily ~~June~~for ~~30,~~the ~~2009,~~reasons ~~respectively~~noted in the preceding paragraphs.

~~Selling,~~Net ~~general,~~interest ~~and~~expense ~~administrative~~for ~~expenses (“SG&A”) includes~~ the ~~salaries,~~three ~~wages~~months ~~and~~ended ~~benefits~~September ~~of all administrative~~30, ~~financial~~2010 ~~and~~was ~~business~~approximately ~~development~~$64 ~~personnel~~thousand ~~and~~compared ~~all other support expenses not directly related~~ to ~~specific~~net ~~contracts.~~interest ~~These~~expense ~~costs~~of ~~decreased approximately~~ $~~438~~27 thousand ~~to $1.8 million~~ for the three months ended ~~June~~ September 30, ~~2010. The~~2009 ~~decrease in SG&A is~~ primarily ~~due~~as toa ~~reductions~~result inof ~~staff~~an ~~and~~increase ~~other~~levels ~~costs. Approximately $100 thousand was attributable to favorable foreign currency fluctuations. As a percentage~~ of ~~revenues,~~borrowing ~~SG&A~~under ~~expenses~~our ~~decreased~~various tocredit ~~48%~~facilities ~~for~~during the three months ended ~~June~~September 30, 2010 compared ~~with~~to ~~50%~~ the same prior year period ~~as a result of the combination of cost decreases and favorable foreign currency fluctuations~~.

~~Depreciation~~Income ~~and~~tax ~~amortization~~benefit ~~expense~~for ~~was~~the ~~approximately~~three months ended September 30, 2010 was $96733 thousand ~~and~~compared to income tax expense of $9399 thousand for the three months ended ~~June~~September 30, ~~2010~~2009 ~~and~~primarily ~~2009,~~due ~~respectively~~to the income tax benefit associated with the $2.8 million non-cash impairment charge recorded in the third quarter of 2010.

~~Loss~~Net loss from continuing operations ~~decreased by $494 thousand to $775 thousand~~ for the three months ended ~~June~~ September 30, 2010 was $3.9 million, or $(1.13) per common share, as compared to a net loss from continuing operations of $1742 thousand, or $(0.329) ~~million~~per ~~from~~common ~~operations~~share for the three months ended ~~June~~ September 30, 2009~~, primarily for the reasons noted in the preceding paragraphs~~.

Net interest expense for the three months ended June 30, 2010 was approximately $60 thousand compared to net interest expense of $1 thousand for the three months ended June 30, 2009 primarily as a result of an increase level of borrowing under our credit facilities during the three months ended June 30, 2010 compared to the same prior year period.

Net loss from continuing operations for the three months ended June 30, 2010 was $805 thousand, or $(0.24) per common share, as compared to a net loss from continuing operations of $1.3 million, or $(0.50) per common share for the three months ended June 30, 2009.

Discontinued Operations, Net of Tax

The net after tax loss from discontinued operations for the three months ended ~~June~~September 30, 2010 amounted to $0 as compared to the net after tax ~~income~~loss of $~~674~~258 thousand from discontinued continued operations during the three months ended ~~June~~September 30, 2009.

~~Six~~Nine Months Ended ~~June~~September 30, 2010 Compared With ~~Six~~Nine Months Ended ~~June~~September 30, 2009

Continuing Operations:

Net revenue for the ~~six~~nine months ended ~~June~~September 30, 2010 decreased by approximately $23.29 million to $69.86 million as compared to $913.05 million for the ~~six~~nine months ended ~~June~~September 30, 2009. The decrease in net revenues was primarily attributable to reduced new business awards, and contract cancelations ~~along with the performance of unexpected out of scope work for which revenue can not be recognized until corresponding change orders are executed with the client~~. Approximately $~~159~~446 thousand of the decrease was attributable to unfavorable foreign currency fluctuations. For the ~~six~~nine months ended ~~June~~September 30, 2010, net revenue from our largest clients amounted to 4944% of our net revenue, with the largest clients representing 3228%, and 1716% of net revenue, respectively. For the ~~six~~nine months ended ~~June~~September 30, 2009, net revenue from these same clients also amounted to 4241% of our net revenue, representing 3633%, and 68% of net revenue, respectively.

Direct expenses included compensation and other expenses directly related to conducting clinical studies. These costs decreased by approximately $1.03 million to $58.40 million for the ~~six~~nine months ended ~~June~~September 30, 2010 from $69.43 million for the ~~six~~nine months ended ~~June~~ September 30, 2009. The decrease in direct expenses was due to reductions in staff and subcontractors utilized on active clinical studies being conducted. Approximately $67334 thousand of the decrease was attributable to favorable foreign currency fluctuations. Direct expenses as a percentage of net revenue were approximately 8083% and 7169% for the ~~six~~nine months ended ~~June~~September 30, 2010 and ~~June~~September 30, 2009, respectively.

Selling, general, and administrative expenses (“SG&A”) includes the salaries, wages and benefits of all administrative, financial and business development personnel and all other support expenses not directly related to specific contracts. These costs decreased approximately $~~510~~600 thousand to $35.8 million for the ~~six~~nine months ended ~~June~~September 30, 2010 from $6.4 million for the nine months ended September 30, 2009. Approximately $141 thousand of the decrease was attributable to favorable foreign currency fluctuations. The remaining decrease in SG&A expenses was due cost cutting measures implemented by management in response to the decreases in net revenue. As a percentage of revenues, SG&A expenses increased to 5660% for the ~~six~~nine months ended ~~June~~September 30, 2010 compared with 4847% the prior year period as a result of lower net revenues.

36Depreciation and amortization expense was approximately $332 thousand and $282 thousand for the nine months ended September 30, 2010 and 2009, respectively.

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~~Depreciation~~Due to impairment triggers, the Company conducted an interim impairment test of goodwill acquired in connect with the acquisition of Encorium Oy, as of September 30, 2010. Company determined that there was no impairment related to the amount of goodwill acquired in connection with the acquisition of Encorium Oy and ~~amortization~~no ~~expense~~adjustment to the carrying value was necessary. As of September 30, 2010, the Company’s intangible assets consisted customer relationships. Due to certain triggering events, the Company also conducted an interim impairment test of the intangible assets acquired in connection with the acquisition of Encorium Oy, as of September 30, 2010. The Company compared the carrying value of the customer relationships to the undiscounted cash flows resulting from those assets to determine recoverability. As a result, the Company determined that the intangible assets of Encorium Oy were not recoverable, impairment existed. The Company used the discounted future cash flows related to the customer relationships to determine the amount of impairment loss. As a result, the Company recognized a non-cash impairment loss of approximately $~~190~~2.8 ~~thousand~~million. In ~~and~~addition, ~~$183~~the ~~thousand~~Company ~~for~~reduced the ~~six~~carrying ~~months~~values ~~ended~~of ~~June~~intangible assets, and related deferred income tax liability. As of September 30, 2010, ~~and~~no ~~2009~~goodwill impairment test was performed on Progenitor’s goodwill of $1,131,722 ~~respectively~~or Progenitor’s intangible assets, net of amortization, of $1,013,479, since Progenitor was acquired on July 19, 2010.

Loss from operations increased by $~~900~~4.8 ~~thousand~~million to $2.7.3 million for the ~~six~~nine months ended ~~June~~September 30, 2010 compared to a loss from operations of $12.85 million from operations for the ~~six~~nine months ended ~~June~~September 30, 2009, primarily for the reasons noted in the preceding paragraphs.

Net interest expense for the ~~six~~nine months ended ~~June~~September 30, 2010 was approximately $75139 thousand compared to net interest expense of $431 thousand for the ~~six~~nine months ended ~~June~~September 30, 2009 primarily as a result of an increase level of borrowing under our credit facilities during the ~~six~~nine months ended ~~June~~September 30, 2010 compared to the same prior year period.

~~Net~~Income ~~loss~~tax ~~from~~benefit ~~continuing operations~~ for the ~~six~~nine months ended ~~June~~September 30, 2010 was $~~2.7~~756 ~~million,~~thousand orcompared to income tax expense of $~~(0.80)~~91 ~~per~~thousand ~~common~~for ~~share~~the three months ended September 30, as2009 ~~compared~~primarily due to athe ~~net~~income ~~loss~~tax ~~from~~benefit ~~continuing~~associated ~~operations~~with ofthe $12.8 million, ornon-cash ~~$(0.72)~~impairment ~~per~~charge ~~common~~recorded ~~share~~in ~~for~~ the ~~six~~third ~~months~~quarter ~~ended~~of ~~June 30, 2009~~2010.

Net loss from continuing operations for the nine months ended September 30, 2010 was $6.6 million, or $(1.94) per common share, as compared to a net loss from continuing operations of $2.6 million, or $(1.00) per common share for the nine months ended September 30, 2009.

Discontinued Operations, Net of Tax

The net after tax loss from discontinued operations for the ~~six~~nine months ended ~~June~~September 30, 2010 amounted to $15 thousand as compared to the net after tax ~~income~~loss of $~~296~~554 thousand from discontinued continued operations during the ~~six~~nine months ended ~~June~~September 30, 2009.

Liquidity and Capital Resources

On July 16, 2009, the Company sold substantially all of the assets relating to the Company’s US line of business to Pierrel Research USA, Inc., the result of which the Company no longer has any employees or significant operations in the United States. Due to this sale, for the three and ~~six~~nine months ended ~~June~~September 30, 2010 and 2009, the results of the U.S. business have been presented as discontinued operations in the consolidated financial statements.

On October 19, 2009, we announced that we had completed a private placement of 467,188 shares of its common stock with a private investor for an aggregate purchase price of $1,575,000 or $3.20 per share.

Historically our net cash used in operations has been substantial. Our net cash used in operations for the ~~six~~nine months ended ~~June~~September 30, 2010 was $~~853~~801 thousand. Our cash and cash equivalents as of ~~June~~ September 30, 2010 was $~~176~~188 thousand. We anticipate that will meet our cash requirements at least into the third quarter of 2011, assuming we are able to fully implement our current costs cutting initiatives, we are able to win additional contracts during fiscal 2010 and we are able to maintain our current customer contracts. Our ability to obtain additional financing in the future will depend in part upon prevailing capital market conditions, as well as conditions in our business and our operating results; and those factors may affect our efforts to arrange additional financing on terms that are satisfactory to us or at all. If we are unable to secure additional financing on terms acceptable to us and on a timely basis, we may significantly reduce our operating costs, which may include the cessation of operations in some countries. Our consolidated condensed financial statements do not include any adjustment to reflect the possible future effects on the recoverability or classification of assets or the amounts and classification of liabilities that may result from the outcome of our ability to continue as a going concern.

On July 19, 2010, the Company acquired Progenitor Holding AG, a corporation organized in Switzerland (“Progenitor Holding”) and its operating subsidiaries organized in Mexico, Panama, Argentina, Chile, Switzerland, India and Hong Kong (collectively referred to herein as “Progenitor”). Progenitor is a European headquartered emerging market clinical research organization providing international drug development services in emerging market regions. Pursuant to the terms of a Stock Purchase Agreement on July 19, 2010 the Company purchased from the shareholders of Progenitor Holding all of issued and outstanding shares of Progenitor Holding.

The consideration for the acquisition was a combination of cash and stock valued at $2.0 million, plus earn-out consideration of $1.8 million. The earn-out is subject to the achievement of certain targets as defined in the underlying agreements and will be payable, if these targets are met during the first quarter of 2011 and 2012.31

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The consideration for the acquisition was a combination of cash, common stock and salary guarantees valued at $2.5 million. The purchase agreement contains provisions for additional “earn-out” consideration. The earn-out is subject to the achievement of certain targets as defined in the underlying agreements and will be payable, if these targets are met during the first quarter of 2011 and 2012. Management has determined that these “earn out” targets will not likely be achieved.

The Company financed the cash component of the purchase consideration by issuing an unsecured note in the amount of $1.3 million to Ilari Koskelo, a significant Stockholder of the Company. The note bears interest at 5% per year on the unpaid principal through October 31, 2010 and 7% per year on the unpaid principal after November 1, 2010. The principal is payable on demand after September 1, 2010. In connection with the Company’s rights offering which was completed on October 15, 2010, the Company exchanged the outstanding notes payable to stockholder for shares of common stock of the Company. See Subsequent Events Note for further information.

Our contracts usually require a portion of the contract amount to be paid at the time the contract is initiated. Additional payments are generally made upon completion of negotiated performance milestones, or on a regularly scheduled basis, throughout the life of the contract. Accordingly, cash receipts do not necessarily correspond to costs incurred and revenue recognized. For terminated studies, our contracts frequently entitle us to receive the costs of winding down the terminated project, as well as all fees earned by us up to the time of termination.

Net revenue is recognized on a proportional performance basis. We typically receive a low volume of large-dollar receipts. As a result, the number of days net revenue outstanding in accounts receivable, costs and estimated earnings in excess of related billings, customer advances, and billings in excess of related costs will fluctuate due to the timing and size of billings and cash receipts. At ~~June~~September 30, 2010, the net days revenue outstanding ~~decreased~~increased by 1161 days to 2092 days compared to 31 days at December 31, 2009. Compared to December 31, 2009, accounts receivable decreased $~~870~~486 thousand to $2.69 million at ~~June~~September 30, 2010, primarily due the reduction in overall projects and the related billing schedules.

Costs and estimated earnings in excess of related billings on uncompleted contracts decreased by approximately $~~372~~1.2 ~~thousand~~million to $~~1.4~~640 ~~million~~thousand as of ~~June~~September 30, 2010 compared to $1.7 million as of December 31, 2009. The balance at ~~June~~September 30, 2010 primarily consisted of 32 clinical trials. The top two balances constituted 3554% and 2218% of the balance. This balance is mostly attributable to a delay in the timing of billings compared to when the work was performed.

Our net cash used by operating activities was approximately $~~853~~801 thousand for the ~~six~~nine months ended ~~June~~ September 30, 2010, compared to net cash used by operating activities of $45.74 million for the ~~six~~nine months ended ~~June~~September 30, 2009. The $34.86 million decrease iswas primarily related to ~~decreases~~the year over year change in accounts payable, billings in excess of related costs and estimated earnings on uncompleted contracts and customer advances for the ~~six~~nine months ended ~~June~~September 30, 2010 as compared to same prior year period. Net cash used by investing activities was $761.4 ~~thousand~~million for the ~~six~~nine months ended ~~June~~September 30, 2010, ~~and~~of ~~represented~~which ~~purchases~~$1.3 million was used for the acquisition of Progenitor, net of cash received and $114 thousand was used to purchase computer equipment and software applications. This compares to net cash used by investing activities of $3642 thousand for the ~~six~~nine months ended ~~June~~September 30, 2009, which was also used to purchase computer equipment and software applications. Net cash provided by financing activities was $~~827~~2.2 ~~thousand~~million for the ~~six~~nine months ended ~~June~~September 30, 2010, compared with net cash ~~used~~provided by financing activities of $~~229~~622 thousand for the ~~six~~nine months ended ~~June~~September 30, 2009. The primary difference related to $~~851~~559 thousand of short-term borrowings and $1.7 million borrowed from shareholders used to fund the acquisition of Progenitor and operations during the first ~~six~~nine months of 2010 as compared to $~~275~~701 thousand for the ~~six~~nine months ended ~~June~~September 30, 2009.

As a result of these cash flows, our cash and cash equivalents balance at ~~June~~September 30, 2010, was $~~176~~188 thousand as compared to $197 thousand at December 31, 2009.

We purchased approximately $~~108~~114 thousand of computer equipment and software applications ~~for~~during ~~six~~the nine months ended ~~June~~September 30, 2010. We anticipate capital expenditures of approximately $7525,000— - $~~125~~85,000 during the remainder of 2010, primarily for leasehold improvements, software applications, workstations, personal computer equipment and related assets.

Recently Issued Accounting Standards

In January 2010, the FASB issued ASU No. 2010-6, “Improving Disclosures About Fair Value Measurements”, which provides amendments to ASC 820 “Fair Value Measurements and Disclosures” , including requiring reporting entities to make more robust disclosures about (1) the different classes of assets and liabilities measured at fair value, (2) the valuation techniques and inputs used, (3) the activity in Level 3 fair value measurements including information on purchases, sales, issuances, and settlements on a gross basis and (4) the transfers between Levels 1, 2, and 3. The standard is effective for annual reporting periods beginning after December 15, 2009, except for Level 3 reconciliation disclosures, which are effective for annual periods beginning after December 15, 2010. The Company adopted the standard for Levels 1 and 2 on January 1, 2010, and does not expect the adoption of the standard for Level 3, on January 1, 2011, to have a material impact on its consolidated financial statements.

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~~The~~In December 2009, the FASB ~~updated~~issued ~~ASC~~ASU ~~Topic~~No. ~~810~~2009-17, “~~Consolidations”~~Improvements ~~(“ASC~~to ~~Topic~~Financial ~~810~~Reporting by Enterprises Involved with Variable Interest Entities”) , ~~and~~which amends ASC ~~Topic 860~~810, “Consolidation” to ~~Transfers~~address ~~and~~the ~~Servicing~~elimination ”of ~~(ASC~~the ~~Topic~~concept ~~860”),~~of ~~which~~a ~~significantly~~qualifying ~~changed~~special ~~the~~purpose ~~accounting~~entity. ~~for~~The ~~transfers~~standard ofalso ~~financial~~replaces ~~assets~~the quantitative-based risks and ~~the~~rewards ~~criteria~~calculation for determining ~~whether~~which toenterprise ~~consolidate~~has a ~~variable~~controlling financial interest ~~entity~~in ~~(VIE).~~a ~~The~~variable ~~update~~interest toentity ~~ASC~~with ~~Topic~~an ~~860~~approach ~~eliminates~~focused ~~the~~on ~~qualifying~~identifying ~~special~~which ~~purpose~~enterprise ~~entity~~has ~~(QSPE)~~the ~~concept,~~power ~~establishes~~to ~~conditions~~direct ~~for~~the ~~reporting~~activities ~~a transfer~~ of a ~~portion~~variable ofinterest aentity ~~financial~~and ~~asset~~the asobligation ato ~~sale,~~absorb ~~clarifies~~losses of the ~~financial~~entity ~~asset~~or ~~de-recognition~~the ~~criteria,~~right ~~revises~~to ~~how~~receive ~~interests~~benefits ~~retained~~from by the ~~transferor~~entity. inThis astandard ~~sale~~also ofrequires ~~financial~~continuous ~~assets~~reassessments ~~initially~~of ~~are~~whether ~~measured,~~an ~~and~~enterprise ~~removes~~is the ~~guaranteed~~primary ~~mortgage~~beneficiary ~~securitization~~of ~~re-characterization~~a ~~provisions.~~VIE ~~The~~whereas ~~update~~previous toaccounting ~~ASC~~guidance ~~Topic~~required ~~810~~reconsideration ~~requires~~of ~~reporting~~whether ~~entities~~an toenterprise ~~evaluate~~was ~~former~~the ~~QSPEs~~primary ~~for~~beneficiary ~~consolidation,~~of ~~changes~~a ~~the~~VIE ~~approach~~only towhen ~~determining~~specific aevents ~~VIE's~~had ~~primary~~occurred. ~~beneficiary~~The ~~from~~standard aprovides ~~mainly~~more ~~quantitative~~timely ~~assessment~~and touseful aninformation ~~exclusively~~about ~~qualitative~~an ~~assessment~~enterprise's ~~designed~~involvement towith ~~identify~~ a ~~controlling~~variable ~~financial~~ interest, entity and ~~increases~~became ~~the~~effective ~~frequency~~as of ~~required~~the ~~reassessments~~beginning toof ~~determine~~interim ~~whether~~and aannual ~~company~~reporting isperiods ~~the~~that ~~primary~~begin ~~beneficiary~~after ofNovember a15, ~~VIE~~2009. The Company adopted the ~~provisions~~standard ofon ~~these staff positions effective~~ January 1, 2010. ~~The~~and the adoption ofdid ~~these~~not ~~staff~~have ~~positions~~a ~~could~~material impact ~~future~~on ~~transactions~~its ~~entered~~consolidated ~~into~~financial ~~by the Company~~statements.

In October 2009, the FASB issued ASU 2009-13, “Multiple-Deliverable Revenue Arrangements,” (amendments to ASC Topic 605, “Revenue Recognition” ), (“ASU 2009-13”) and ASU 2009-14, “ Certain Arrangements that Include Software Elements”, ( amendments to ASC Topic 985 , “Software”) (“ASU 2009-14”). ASU 2009-13 requires entities to allocate revenue in an arrangement using estimated selling prices of the delivered goods and services based on a selling price hierarchy. The amendments eliminate the residual method of revenue allocation and require revenue to be allocated using the relative selling price method. ASU 2009-14 removes tangible products from the scope of software revenue guidance and provides guidance on determining whether software deliverables in an arrangement that includes a tangible product are covered by the scope of the software revenue guidance. ASU 2009-13 and ASU 2009-14 should be applied on a prospective basis for revenue arrangements entered into or materially modified in fiscal years beginning on or after June 15, 2010, with early adoption permitted. The Company ishas ~~currently~~evaluated ~~evaluating~~ the impact of the adoption of these ASUs on its consolidated results of operations or financial condition~~. The~~, ~~Company~~and ~~will~~the ~~implement~~adoption ~~the~~did ~~standard~~not ~~effective~~have ~~January~~a 1,material ~~2011~~impact on its consolidated financial statements.

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ITEM 4T.

CONTROLS AND PROCEDURES

A control system, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Further, the design of a control system must reflect the fact that there are resource constraints and the benefits of controls must be considered relative to costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within our company have been detected. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.

The Company’s principal executive officer and principal financial officer, with the participation of other members of the Company’s management, have evaluated the effectiveness of the Company’s disclosure controls and procedures (as defined in Rule 13a-15(e) under the Securities and Exchange Act of 1934, as amended) as of the end of the period covered by this report (the “Evaluation Date”) and, based on that evaluation, concluded that, as of the Evaluation Date, the Company’s disclosure controls and procedures were effective to ensure that information that is required to be disclosed in its reports under the Securities and Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to management, including the Company’s ~~principal~~Chief ~~executive~~Executive ~~officer~~Officer and ~~principal~~Principal ~~financial~~Accounting ~~officer~~Officer, as appropriate, to allow timely decisions regarding required disclosure.

~~Our~~Based ~~management,~~on ~~including~~this ~~our~~evaluation ~~principal executive~~ and ~~principal~~the ~~financial~~identification ~~officers,~~of ~~has~~the ~~evaluated~~material ~~any~~weakness ~~changes~~ in ~~our~~ internal control over financial reporting ~~that~~described ~~occurred~~below, the ~~during~~Chief ~~the~~Executive ~~quarter~~and ~~ended~~Principal ~~June 30,~~Accounting ~~2010~~Officers, ~~and~~have ~~has~~ concluded that ~~there~~for ~~was no change that occurred during~~ the quarter ended ~~June~~ September 30, 2010 ~~that has materially affected~~, orthe isCompany’s ~~reasonably~~disclosure ~~likely~~controls toand ~~materially~~procedures ~~affect,~~were ~~our~~not ~~internal control over financial reporting~~effective.

40Management determined that at September 30, 2010 the Company had a material weakness because it did not have a sufficient number of personnel with an appropriate level of knowledge and experience of generally accepted accounting principles in the United States of America (U.S. GAAP) that are commensurate with the Company’s financial reporting requirements. Contributing to this lack of sufficient resources was the unanticipated voluntary turnover of key personnel. Because of the material weakness, the Company took the following actions so that its consolidated financial statements as of, and for the quarter ended September 30, 2010, are presented in accordance with U.S. GAAP. These actions included (i) supplementing existing resources with technically qualified third party consultants and (ii) performing additional procedures and analyses.

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PART II. OTHER INFORMATION

ITEM 1A. RISK FACTORS

Risks Related to our Business

We may not be able to meet our cash requirements without implementing cost cutting initiatives, increasing revenues, and maintaining current customer contracts; failure to do so will result in the need to raise additional capital or significantly reduce our operating costs, which may include the cessation of operations in certain countries.

Historically, our net cash used in operations has been substantial. Our net cash used in operations for the ~~six~~nine months ended ~~June~~September 30, 2010 was $~~853~~801 thousand. Our cash and cash equivalents as of ~~June~~September 30, 2010 was $~~176~~188 thousand as compared to $197 thousand as of December 31, 2009. We anticipate that will meet our cash requirements at least into September of 2011, assuming we are able to fully implement our current costs cutting initiatives, we are able to win additional contracts and we are able to maintain our current customer contracts. In the event we are unable to do so, in order for the Company to continue as a going concern we will be required to obtain additional capital from external sources or significantly reduce our operating costs, which may include the cessation of operations in some countries.

Our ability to obtain additional financing in the future will depend in part upon prevailing capital market conditions, as well as conditions in our business and our operating results; and those factors may affect our efforts to arrange additional financing on terms that are satisfactory to us or at all. Given the current levels of the trading price of the Company’s common stock, if the Company were to raise additional capital by issuing equity securities other than to existing stockholders, existing stockholders’ percentage ownership would be reduced and they would experience substantial dilution. If we were to raise additional funds by issuing debt securities, these debt securities would have rights, preferences, and privileges senior to those of our common stock, and the terms of the debt securities issued could impose significant restrictions on our operations. If we are unable to obtain additional capital, we will scale back our operations until such capital is obtained or seek stockholder approval to wind down operations and liquidate the company.

The perception that we may not be able to continue as a going concern may adversely affect our business.

Any perception that we may not be able to continue as a going concern may cause others to choose not to deal with us due to concerns about our ability to meet our contractual obligations and may adversely affect our ability to win new contracts and/or raise additional capital.

WeOur ~~currently~~common ~~fail~~stock tohas ~~meet~~been ~~NASDAQ’s~~delisted ~~$2.5~~from ~~million~~The ~~minimum~~NASDAQ ~~stockholders’~~Capital ~~equity~~Market, ~~requirement~~which ~~for~~negatively ~~continued~~impacts ~~listing and may not be able to meet~~ the ~~other~~price ~~listing~~of ~~requirements~~our incommon ~~the~~stock ~~future,~~and ~~with the result being that~~ our ~~Common~~ability ~~Stock~~to ~~may~~access bethe ~~delisted~~capital ~~from NASDAQ~~markets.

~~The Company is currently listed on The NASDAQ Capital Market.~~ On ~~August 25~~October 20, ~~2009~~2010, the Company received anotification ~~letter~~that ~~from~~the ~~The~~ NASDAQ ~~Stock~~Qualifications ~~Market~~Panel ~~notifying~~ (the ~~Company~~"Panel") ~~that,~~determined ~~based~~to ondelist ~~its Form 10-Q for~~ the ~~period ended June 30, 2009, the~~ Company’'s ~~stockholders’~~securities ~~equity~~from ~~did not comply with the minimum $2.5 million stockholders’ equity requirement for continued listing on~~ The NASDAQ ~~Capital~~Stock Market~~. As provided in the NASDAQ Marketplace Rules~~, ~~the~~effective ~~Company~~with ~~submitted to NASDAQ a plan and timeline to achieve and sustain compliance. NASDAQ granted~~ the ~~Company~~open anof ~~extension~~business ~~until~~on ~~December~~October 822, ~~2009 to comply and notified Company that~~2010, ifas ata ~~the~~result ~~time~~ of ~~its periodic report for~~ the ~~year ending December 31, 2009, the~~ Company ~~did not evidence compliance; the Company’~~'s ~~common~~failure ~~stock may be subject~~ to ~~delisting. As~~regain ofcompliance ~~December~~with ~~31, 2009~~ the ~~stockholders'~~minimum ~~equity of the Company was~~ $2.~~3 million, which failed to meet the $2.~~5 million ~~minimum~~ stockholders' equity requirement. The Company’s ~~received~~common astock ~~delisting~~is ~~action~~currently quoted on ~~April 22, 2010 from~~ the ~~NASDAQ~~Pink ~~Stock Market notifying the Company of its failure to comply with the requirement~~Sheets. ~~In accordance with the terms of the Market Place Rules, the Company requested a hearing before the NASDAQ Listing Qualifications Panel.~~ The ~~Company~~delisting ~~met with the NASDAQ Listing Qualifications Panel on June 10, 2010 and presented its plan~~ of ~~compliance~~our ~~which~~common ~~was~~stock ~~substantially~~will ~~based~~significantly onaffect ~~its acquisition of Progenitor and~~ the ~~successful~~ability ~~completion~~ of ainvestors ~~proposed rights offering pursuant~~ to ~~the~~trade ~~terms~~our ofsecurities ~~the~~and ~~Registration~~will ~~Statement~~significantly onnegatively ~~Form~~affect ~~S-1 filed by~~ the ~~Company~~value ~~with the Securities~~ and ~~Exchange~~liquidity ~~Commission~~of onour ~~June~~common ~~10, 2010~~stock. On ~~July~~In 9addition, ~~2010~~ the ~~Listing~~delisting ~~Qualifications~~of ~~Panel~~our ~~granted~~common ~~the~~stock ~~Company’s~~will ~~request~~materially ~~for~~adversely ~~continued~~affect ~~listing,~~our ~~subject~~ability to ~~certain~~raise ~~conditions,~~capital ~~including that~~ on orterms ~~before~~acceptable ~~October~~to ~~19,~~us ~~2010,~~or ~~the Company must disclose the closing of the proposed rights offering and the resulting stockholders’ equity which must be~~ at ~~least $2~~all.5 ~~million~~Delisting ~~and~~from ~~provided that the Company is able to demonstrate compliance with all other requirements for continued listing on~~ The ~~Nasdaq~~NASDAQ Capital Market~~. There~~ ~~can~~will bealso nohave ~~assurances~~other ~~that~~negative ~~the~~results, ~~Company~~including ~~will~~the bepotential ~~able~~loss toof ~~successfully~~confidence ~~complete the rights offering~~ by ~~October~~suppliers 19and oremployees, ~~otherwise~~the beloss ~~able~~of toinstitutional ~~demonstrate~~investor ~~compliance~~interest ~~with~~and ~~all~~fewer ~~other~~business ~~requirements~~development ~~for continued listing~~opportunities.

If delisted, our common stock will likely be quoted in the over-the-counter market in the so-called “pink sheets” or quoted in the OTC Bulletin Board. In addition, our common stock would be subject to the rules promulgated under the Securities Exchange Act of 1934 relating to “penny stocks.” These rules require brokers who sell securities that are subject to the rules, and who sell to persons other than established customers and institutional accredited investors, to complete required documentation, make suitability inquiries of investors and provide investors with information concerning the risks of trading in the security. These requirements would make it more difficult to buy or sell our common stock in the open market. In addition, the delisting of our common stock could materially adversely affect our ability to raise capital on terms acceptable to us or at all. Delisting from NASDAQ could also have other negative results, including the potential loss of confidence by clients and employees, the loss of institutional investor interest and fewer business development opportunities.35

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Our common stock is subject to the penny stock regulations that impose restrictions on the marketability of our common stock. As a consequence, the ability of our stockholders to sell shares of our common stock could be impaired.

The Securities and Exchange Commission (the "Commission") has adopted regulations that generally define a "penny stock" to be an equity security that has a market price of less than $5.00 per share or an exercise price of less than $5.00 per share subject to certain exceptions that are not applicable to our Company at present. Our common stock is subject to the penny stock rules that impose additional sales practice requirements on broker-dealers who sell these securities to persons other than established customers and accredited investors. The regulations require that prior to any transaction involving a penny stock, a risk disclosure schedule must be delivered to the buyer explaining the penny stock market and its risks. For transactions covered by these rules, the broker-dealer must make a special suitability determination for the purchase, and must have received the purchaser's written consent to the transaction prior to sale. As such the market liquidity for the common stock will be limited to the ability of broker-dealers to sell it in compliance with the above-mentioned disclosure requirements.

You should be aware that, according to the Commission, the market for penny stocks has suffered in recent years from patterns of fraud and abuse. Such patterns include:

control of the market for the security by one or a few broker-dealers;

"boiler room" practices involving high-pressure sales tactics;

manipulation of prices through prearranged matching of purchases and sales;

the release of misleading information;

excessive and undisclosed bid-ask differentials and markups by selling broker-dealers; and

dumping of securities by broker-dealers after prices have been manipulated to a desired level, which hurts the price of the stock and causes investors to suffer loss.

We are aware of the abuses that have occurred in the penny stock market. Although we do not expect to be in a position to dictate the behavior of the market or of broker-dealers who participate in the market, we will strive within the confines of practical limitations to prevent such abuses with respect to our common stock.

Our backlog may not be indicative of future results.

Backlog is the amount of revenue that remains to be earned and recognized on written awards, signed contracts and letters of intent. We cannot be certain that the backlog we have reported will be indicative of our future results. A number of factors may affect our backlog, including: the ability of clients to reduce or expand the size and duration of the projects (some are performed over several years); the termination or delay of projects; and a change in the scope of work during the course of a project. In addition since our backlog is reported in U.S. Dollars, but substantially all of our contracts are denominated in currencies other than the U.S. Dollar, changes in the foreign currency exchange rates could reduce the amount of backlog reported.

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Also, if clients delay projects, the projects will remain in backlog, but will not generate revenue at the rate originally expected. Accordingly, historical indications of the relationship of backlog to revenues may not be indicative of future results and should not be relied upon.

Our inability to forecast our revenue pipeline or convert revenue pipeline into contracts could increase fluctuations in our revenue and financial results.

We use a “pipeline” system, a common industry practice, to forecast contract awards and trends in our business. Our management team monitors the status of all potential contract awards, including the potential dollar amount of each contract transaction. We aggregate these estimates periodically to generate a pipeline and then evaluate the pipeline to identify trends in our business. This pipeline analysis and related estimates of revenue may differ significantly from actual revenues in a particular reporting period. When customers delay contracts, reduce the amount of their contract or cancel contracts altogether, it will reduce the rate of conversion of the pipeline into contracts and our revenues will be harmed. Our inability to respond to a variation in the pipeline or in the conversion of the pipeline into contracts in a timely manner, or at all, could cause us to plan or budget inaccurately and thereby could adversely affect our results of operations and financial condition.

Our operating results can be expected to fluctuate from period to period.

Fluctuating operating results are usually due to the level of new business awards in a particular period and the timing of the initiation, progress or cancellation of significant projects. Even a short acceleration or delay in such projects could have a material effect on our results in a given reporting period. Varying periodic results could adversely affect the price of our common stock if investors react to our reporting operating results which are less favorable than in a prior period or lower than those anticipated by investors or the financial community generally.

Our stock price may continue to experience fluctuations.

The market prices of securities of thinly-traded companies such as ours generally are highly volatile. In this market environment, the sale of a substantial number of shares of our common stock in the public market or the perception that such a sale might occur would likely have a materially adverse effect on the market price of our common stock.

Any litigation brought against us as a result of this volatility could result in substantial costs and a diversion of our management’s attention and resources, which could negatively impact our financial condition, revenues, results of operations, and the price of our common stock.

If we raise additional capital by issuing equity securities in a fluctuating market, many or all of our existing stockholders may experience substantial dilution, and if we need to raise capital by issuing equity securities at a time when our stock price is down, we may have difficulty raising sufficient capital to meet our requirements.

We may incur additional impairment charges which may adversely affect our results of operations.

The Company follows the provisions ASC 805, “Business Combinations” and ASC 350, “Goodwill and Other Intangible Assets ,” applicable to business combinations. In accordance with these standards, goodwill acquired in connection with the ~~acquisition~~acquisitions of Encorium Oy ~~was~~and ~~not amortized. In addition, the any goodwill acquired in connection with the acquisition of~~ Progenitor ~~will~~were not be amortized. Under ASC 350, goodwill is subject to impairment testing annually or whenever events or changes in circumstances indicate that the carrying amount may not be fully recoverable. The Company performed ~~its~~interim ~~annual~~goodwill impairment testing as of ~~November 1~~September 30, ~~2009~~2010 and determined that ~~both~~ goodwill ~~and related intangible assets~~ acquired in connection with the acquisition of Encorium Oy ~~were~~was not impaired and that no adjustment to the carrying value was necessary. The Company also performed interim testing of the intangible assets acquired in connection with the acquisition of Encorium Oy, as of September 30, 2010. As a result, the company determined that ~~date~~intangible assets acquired in connection with the acquisition of Encorium Oy were impaired and recognized a non-cash impairment loss of approximately $2.8 million. The Company also reduced the carrying value of Encorium Oy’s intangible assets and related deferred tax liability. Impairment testing involves various estimates and assumptions, which could vary, and an analysis of relevant market data and market capitalization. If our stock price continues to decline or if economic conditions continue to deteriorate, we may incur additional impairment charges which may adversely impact our results of operations and financial condition.

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Failure to develop new business in our intensely competitive industry will cause our revenues to decline.

The market for clinical research services is highly competitive. We primarily compete against in-house departments of pharmaceutical, and biotechnology companies and other clinical research organizations. Competitors in our industry range from small, limited-service providers to full service, global clinical research organizations. Many of our competitors have an established global presence, including Quintiles Transnational Corp., Covance, Inc., Parexel International Corporation, Icon Clinical Research, and Kendle International, Inc. In addition, many of our competitors have substantially greater financial and other resources than we do. Significant factors in determining whether we will be able to compete successfully include: our consultative and clinical trials design capabilities; our reputation for on-time quality performance; our expertise and experience in specific therapeutic areas; the scope of our service offerings; our ability to recruit investigators and study subjects in a timely manner; our strength in various geographic markets; the price of our services; our ability to acquire, process, analyze and report data in a time-saving and accurate manner; our global data services capabilities; our ability to manage large-scale clinical trials both domestically and internationally; and our size.

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If our services are not competitive based on these or other factors and we are unable to develop an adequate level of new business, our business, backlog position, financial condition and results of operations will be materially and adversely affected. In addition, we may compete for fewer clients arising out of consolidation within the pharmaceutical industry and the growing tendency of drug companies to outsource to a smaller number of preferred clinical research organizations that have far greater resources and capabilities.

Our services may from time to time experience periods of increased price competition that could have a material adverse effect on our profitability and revenues. Additionally, the CRO industry is not highly capital-intensive, and the financial costs of entry into the industry are relatively low. Therefore, as a general matter, the industry has few barriers to entry. Newer, smaller entities with specialty focuses, such as those aligned to a specific disease or therapeutic area, may compete aggressively against us for clients.

We depend on a small number of industries and clients for our business, and the loss of one of our significant clients could cause revenues to drop quickly and unexpectedly.

Historically, projects in the fields of cardiovascular, oncology, immunology, vaccines, medical devices as well as clinical staff outsourcing have represented 50-75% of our European project work, although the mix of projects is subject to change from year to year.~~.Our~~ For the three months ended September 30, 2010, our net revenues from our top largest clients amounted to 60% of our net revenues representing 4218%, 18%, 14%, and 1810% of our net revenues, respectively, ~~for the three months ended June 30, 2010,~~ as compared to the three months ended ~~June~~September 30, 2009 in which net revenues from these clients amounted to 5149% of our revenues representing 3731%, and 14 18%. The Company expects that a relatively small number of clients will continue to represent a significant percentage of its net revenue. Contracts with these clients generally can be terminated on short notice. The loss of business from any one of these significant clients would have a material and adverse effect on its business and revenues.

Loss of key personnel, or failure to attract and retain additional personnel, may cause the success and growth of our business to suffer.

Our future success depends on the personal efforts and abilities of the principal members of our senior management and scientific team to provide strategic direction, develop business, provide service to our clients, manage our operations and finances, and maintain a cohesive and stable environment. The loss of their services might significantly delay or prevent the achievement of business development and strategic objectives. As a provider of complex clinical trial support services, our success depends on our ability to retain key employees and to attract additional qualified employees. Competition for qualified personnel is intense and we cannot assure you that we will be able to retain existing personnel or attract and retain additional highly qualified employees in the future. The loss of services of any of our key executives may have a material and adverse ~~affect~~effect on our business operations, results of operations and financial position.

Competition for our key executives and skilled personnel, particularly those with a medical degree, a Ph.D. or equivalent degrees, is intense. We compete with clinical research organizations, pharmaceutical and biotechnology companies, and academic and research institutions that have far greater financial resources to recruit skilled personnel. Our inability to attract and retain qualified executives and scientific staff could have a material and adverse ~~affect~~effect on our business plan, results of operations and financial condition. There can be no assurance that we will be able to continue to attract and retain qualified executives and scientific staff in the future.

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We may bear financial losses because our contracts may be delayed or terminated or reduced in scope for reasons beyond our control.

Our contracts generally may be terminated or reduced in scope either immediately or upon notice. Clients may terminate or delay their contracts for a variety of reasons, including, but not limited to, the failure of products to satisfy safety requirements, unexpected or undesired clinical results, merger or potential merger-related activities, the client’s budget constraints, the client’s decision to terminate the development of a particular product or to end a particular study, insufficient patient enrollment in a study, insufficient investigator recruitment, manufacturing problems resulting in shortages of the product, or our failure to perform our obligations under the contract. This risk of loss or delay of contracts potentially has greater effect as we pursue larger outsourcing arrangements with global pharmaceutical companies.

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Also, over the past several years we have observed that clients may be more willing to delay, cancel or reduce contracts more rapidly than in the past. In addition, companies may proceed with fewer clinical trials or conduct them without assistance of contract research organizations as a result of changing priorities or other internal considerations. These factors may cause such companies to cancel contracts with CROs, such as Encorium. The loss, reduction in scope or delay of a significant contract or the loss or delay of multiple contracts could materially and adversely affect our business, results of operations and financial condition.

The fixed price nature of our contracts could have a negative impact on our operating results.

A significant portion of our contracts are at fixed prices. As a result, we bear the risk of cost overruns. If we fail to adequately price our contracts, fail to effectively estimate the cost to complete fixed price contracts, or if we experience significant cost overruns, our business, results of operations and financial condition could be materially and adversely affected. In addition, contracts with our clients are subject to change orders, which occur when the scope of work performed by us needs to be modified from what was originally contemplated by our contract with the client. This can occur, for example, when there is a change in a key study assumption or parameter or a significant change in timing. Under U.S. generally accepted accounting principles, we cannot recognize additional revenue anticipated from change orders until appropriate documentation is received by us from the client authorizing the change made. However, if we incur additional expense in anticipation of receipt of that documentation, we must recognize the expense as incurred. Further, we may not be successful convincing our clients to approve change orders which change the scope of current contracts. Such under-pricing or significant cost overruns could have a material adverse effect on our business, results of operations, financial condition or cash flows.

Changes in outsourcing trends in the pharmaceutical and biotechnology industries could materially and adversely affect our operating results and growth rate.

Industry trends and economic factors that affect our clients in the pharmaceutical and biotechnology industries also affect our business. Our revenues depend greatly on the expenditures made by the pharmaceutical and biotechnology industries in research and development. The practice of many companies in these industries has been to hire outside organizations like us to conduct clinical research projects. This practice has grown significantly in the last decade, and we have benefited from this trend. However, if this trend were to change and companies in these industries were to reduce the number of research and development projects they outsource, our business could be materially and adversely affected. For example, over the past several years, mergers and other factors in the pharmaceutical industry appear to have slowed decision-making by pharmaceutical companies and delayed drug development projects. The continuation of or increase of these trends could have a negative ~~affect~~effect on our business.

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Additionally, numerous governments and managed care organizations have undertaken efforts to control growing healthcare costs through legislation, regulation and voluntary agreements with medical care providers and pharmaceutical companies. If future regulatory cost containment efforts limit the profits that can be derived on new drugs, our clients might reduce their research and development spending, which could reduce our business.

Failure to comply with existing regulations could harm our reputation and our operating results.

Any failure on our part to comply with applicable regulations could result in the termination of on-going clinical research or the disqualification of data for submission to regulatory authorities. For example, if we were to fail to verify that patient participants were fully informed and had fully consented to a particular clinical trial, the data collected from that trial could be disqualified. If this were to happen, we could be contractually required to repeat the trial at no further cost to our client, but at a substantial cost to us. The issuance of a notice from the FDA based upon a finding of a material violation by us of GCP requirements could result in contractual liability to our clients and/or the termination of ongoing studies which could materially and adversely affect our results of operations. Similar notices could be issued from the regulatory authorities in other countries where we conduct clinical studies. Furthermore, our reputation and prospects for future work could be materially and adversely diminished.

Changes in governmental regulation could reduce the need for the services we provide, which would negatively affect our future business opportunities.

In recent years the United States Congress, state legislatures and foreign governments have considered various types of health care reform in order to control growing health care costs. The United States Congress, state legislatures and foreign governments may again address health care reform in the future. We are unable to predict what legislative proposals will be adopted in the future, if any.

Implementation of health care reform legislation that results in additional costs to develop new drugs could limit the profits that can be made by our clients from the development of new products. This could adversely affect our clients’ research and development expenditures, which could in turn decrease the business opportunities available to us both in the United States and elsewhere. In addition, new laws or regulations may create a risk of liability, increase our costs or limit our service offerings. We cannot predict the likelihood of any of these events.

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Governmental agencies throughout the world, but particularly in the U.S., strictly regulate the drug development and approval process. Our business involves helping pharmaceutical and biotechnology companies navigate the regulatory drug approval process. Any changes in drug approval regulatory requirements such as the introduction of simplified drug approval procedures or an increase in regulatory requirements that we have difficulty satisfying, could eliminate or substantially reduce the need for our services. These and other changes in regulation could have an impact on the business opportunities available to us. As a result, our business, results of operations and financial condition may be materially and adversely affected.

Proposed and future laws and regulations, including laws and regulations relating to the confidentiality of patient information, might increase the cost of our business, increase our risks of liability or limit our service offerings.

Various governments might adopt healthcare legislation or regulations that are more burdensome than existing regulations. These changes could increase our expenses or limit our ability to offer some of our products or services. For example, the confidentiality of patient specific information and the circumstances under which it may be released for inclusion in our databases or used in other aspects of our business are subject to substantial government regulation. Additional legislation governing the possession, use and dissemination of medical record information and other personal health information has been proposed at both the state and national levels and is likely to be proposed in other countries. Proposed federal regulations governing patient specific health information might require us to implement new security measures that require substantial expenditures or limit our ability to offer some of our products and services. These regulations might also increase our costs by creating new privacy requirements and mandating additional privacy procedures for our business, thereby materially and adversely affecting our business, results of operations and financial condition.

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Adverse changes in general economic or political conditions in any of the major countries in which we do business could adversely affect our business, operating results and financial position.

Recently, general worldwide economic conditions have experienced a downturn due to slower economic activity, concerns about inflation and deflation, increased energy costs, decreased consumer confidence, reduced corporate profits and capital spending, adverse business conditions, the ongoing effects of the war in Iraq, recent international conflicts and terrorist and military activity, and the impact of natural disasters and public health emergencies. If economic growth in the global economy is further slowed, many customers may delay or reduce spending on our services, which would harm our business, results of operations and financial condition.

Our operations may be interrupted by the occurrence of a natural disaster or other catastrophic event.

We depend upon our clients, study sites and our facilities, as well as the ability to readily travel among these, for the continued operation of our business. We also depend upon the continuous, effective, reliable and secure operation of our computer hardware, software, networks, telecommunications networks, internet servers and related infrastructure. However, catastrophic events, including terrorist attacks, could still disrupt our operations, those of our clients or study sites, or our ability to travel among these locations, which would also affect us. Although we carry business interruption insurance, we might suffer losses as a result of business interruptions that exceed the coverage available under our insurance policies. Any natural disaster or catastrophic event affecting our facilities could have a material and adverse affect on our business and results of operations.

Our success depends on our ability to keep pace with rapid technological changes that could make our products and services less competitive or obsolete.

The clinical research aspects of the pharmaceutical and biotechnology industries are subject to increasingly rapid technological changes. Our competitors or others might develop technologies, products or services that are more effective or commercially attractive than our current or future technologies, products or services, or render our technologies, products or services less competitive or obsolete. If we cannot make enhancements to our technologies, products and services necessary for us to remain competitive, our competitive position, and in turn our business, results of operations and financial condition, would be materially and adversely affected.

We may have exposure to substantial personal injury claims and may not have adequate insurance to cover such claims.

Our business primarily involves the testing of experimental drugs and biologics or other regulated products on consenting human volunteers pursuant to a study protocol. These tests create a risk of liability for personal injury to or death of volunteers resulting from negative reactions to the drugs administered or from improper care provided by third-party investigators, particularly to volunteers with life-threatening illnesses. In connection with many clinical trials, we contract with physicians to serve as investigators in conducting clinical trials to test new drugs on human volunteers. We do not believe that we are legally accountable for the medical care rendered by third party investigators, and we seek to limit our liability with our clients, third party investigators and others. Although our contracts with clients generally include indemnity provisions and we have loss insurance, our financial condition and results of operations could be materially and adversely affected if we had to pay damages or incur defense costs in connection with a claim that is outside the scope of an indemnity or insurance coverage. Additionally, our financial condition could be materially and adversely affected if our liability exceeds the amount of our insurance.

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Contractual indemnification provisions generally do not protect us against liability arising from certain of our own actions, such as negligence. Our financial condition and results of operations could be materially and adversely affected if we were required to pay damages or bear the cost of defending any claim which is not covered by a contractual indemnification provision, in the event that a party who must indemnify us does not fulfill its indemnification obligations, or if the amount we are required to pay is beyond the level of our insurance coverage. In addition, we may not be able to continue to maintain adequate insurance coverage on terms acceptable to us.

If we are unable to attract suitable willing volunteers for the clinical trials of our clients, our results could be materially and adversely affected.

One of the factors on which we compete is the ability to recruit independent investigators who can identify volunteers for the clinical studies we manage on behalf of our clients. These clinical trials rely upon the ready accessibility and willing participation of volunteer subjects. These subjects generally include volunteers from the communities in which the studies are conducted, which to date have provided an adequate pool of potential subjects for research studies. Many of our contracts include payments for achieving specific targets directly tied to the recruitment of study subjects. The trials we manage and our operating results could be materially and adversely affected if we are unable to attract suitable and willing volunteers on a consistent basis.

If we are unable to safeguard our networks and clients’ data, our clients may not use our services and our business may be harmed.

Our networks may be vulnerable to unauthorized access, computer hacking, computer viruses and other security problems. An individual who circumvents security measures could misappropriate proprietary information or cause interruptions or malfunctions in our operations. We may be required to expend significant resources to protect against the threat of security breaches or to alleviate problems caused by any breaches. Security measures that we adopt from time to time may be inadequate.

We may have difficulty obtaining director and officer liability insurance in acceptable amounts for acceptable rates.

We cannot assure that we will be able to obtain in the future sufficient director and officer liability insurance coverage at acceptable rates and with acceptable deductibles and other limitations. Failure to obtain such insurance could materially harm our financial condition in the event that we are required to defend against and resolve any future securities class actions or other claims made against us or our management. Further, the inability to obtain such insurance in adequate amounts may impair our future ability to retain and recruit qualified officers and directors.

We do not intend to pay dividends.

We have never paid any cash dividends on our common stock and do not expect to declare or pay any cash or other dividends in the foreseeable future.

Failure to comply with Section 404 of the Sarbanes-Oxley Act could negatively impact the market price of our stock . Failure to maintain effective internal controls in accordance price.

If, in the future, we fail to maintain the adequacy of our internal controls, as such standards are modified, supplemented or amended from time to time, we may not be able to ensure that we can conclude on an ongoing basis that we have effective internal controls over financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act. Failure to achieve and maintain an effective internal control environment could negatively impact the market price of our common stock.

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Actions or inspections by regulatory authorities may cause clients not to award future contracts to us or to cancel existing contracts, which may have a material and adverse effect on our results of operations.

We may be subject to continuing inspections of our facilities and documentation in connection with studies we have conducted in support of marketing applications, or routine inspections of our facilities that have yet to be inspected by regulatory authorities. Regulatory authorities can have significant authority over the conduct of clinical trials, and they have the power to take regulatory and legal action in response to violations of clinical standards, subject protection and regulatory requirements in the form of civil and criminal fines, injunctions and other measures. Additionally, there is a risk that actions by regulatory authorities, if they result in significant inspectional observations or other measures, could cause clients not to award us future contracts or to cancel existing contracts. Depending upon the amount of revenue lost, the results could have a material and adverse affect on our results of operations.

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We might lose business opportunities as a result of healthcare reform.

Numerous governments have undertaken efforts to control healthcare costs through legislation, regulation and voluntary agreements with healthcare providers and drug companies. Healthcare reform could reduce the demand for our services and, as a result, our revenue. Any such legislation could cause our customers to spend less on research and development. If this were to occur, we could have fewer clinical trials for our business, which could reduce our earnings.

Our business is subject to international economic, political and other risks that could negatively affect our results of operations or financial position.

Since the sale of our U.S. Business on July 16, 2009, all of our operations are conducted outside the U.S. Our business is subject to substantial risks associated with doing business internationally, including:

	●	less stable political and economic environments and changes in a specific country’s or region’s political or economic conditions,

	●	potential negative consequences from changes in tax laws affecting our ability to repatriate profits,

	●	unfavorable labor regulations,

	●	greater difficulties in managing and staffing foreign operations,

	●	the need to ensure compliance with the numerous regulatory and legal requirements applicable to our business in each of these jurisdictions, and to maintain an effective compliance program to ensure compliance,

	●	changes in trade policies, regulatory requirements and other barriers,

	●	civil unrest or other catastrophic events, and

	●	longer payment cycles of foreign customers and difficulty collecting receivables in foreign jurisdictions.

These factors are beyond our control. The realization of any of these or other risks associated with operating in foreign countries could have a material adverse effect on our business, results of operations or financial condition.

We have substantial exposure to currency risks.

Since the sale of our U.S. Business on July 16, 2009, all of our operations are conducted outside the U.S. We operate in many foreign countries and are subject to exchange rate gains and losses for multiple currencies. We may also be subject to foreign currency transaction risk when our service contracts are denominated in a currency other than the currency in which we incur expenses or earn fees related to such contracts. Changes in the exchange rate foreign currencies and the U.S. dollar could materially affect the translation of our subsidiaries’ financial results into U.S. dollars for purposes of reporting our consolidated financial results.

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The Company depends on the biopharmaceutical industry for most of its revenue.

The Company’s revenues depend on the outsourcing trends, size of the drug-development pipeline and research and development expenditures of the biopharmaceutical industry. Economic factors and industry trends that affect companies in the industry affect its business. A slowdown in research and development spending or a reprioritization of the drug development pipelines or limited access to capital to fund projects in the biopharmaceutical industry could negatively affect our net service revenues and results of operations. Mergers and acquisitions in the biopharmaceutical industry and the related rationalization of the drug-development pipelines could result in delay or cancellation of certain existing projects.

The Company’s indebtedness could adversely affect its business and financial condition.

As of ~~June~~September 30, 2010, the Company’s consolidated indebtedness was approximately $23.0 6 million. The Company’s level of indebtedness will have several important effects on its future operations. For example, the Company will be required to use a portion of its cash flow from operations for the payment of principal and interest due on its outstanding indebtedness. In addition, the Company’s outstanding indebtedness and leverage could increase the impact of negative changes in general economic and industry conditions, as well as competitive pressures. Finally, the level of the Company’s outstanding indebtedness may affect its ability to obtain additional financing for working capital, capital expenditures or general corporate purposes.

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General economic conditions as well as conditions affecting the Company’s operations specifically, including, but not limited to, financial and business conditions, many of which are beyond its control, may affect its future performance. As a result, these and other factors may affect the Company’s ability to make principal and interest payments on its indebtedness. The Company’s business might not generate the cash flow necessary to service its indebtedness. If the Company cannot generate sufficient cash flow from operations in the future to service its indebtedness, it may, among other things:

	•	Seek additional financing in the debt or equity markets;

	•	Seek to refinance or restructure all or a portion of its indebtedness;

	•	Sell selected assets; and/or

	•	Reduce or delay planned capital expenditures.

These measures might not be sufficient to enable the Company to service its indebtedness in which event an event of default could potentially occur under one of the Companies loan facilities which would materially and adversely affect the Company’s financial condition and operations.

The Company may be exposed to risk from its various counterparties.

The current global economy has shown signs of weakening and continues to show signs of fragility; its impact may be far reaching. As a result, the Company may be exposed to risks related to defaults from its suppliers and customers. Key suppliers could fail to deliver agreed upon goods or services. Customers may not be able to obtain financing for their clinical trials with the Company, which may result in the delay or cancellation of these trials. Additionally, customers may not be able to pay or may pay receivables more slowly than in the past resulting in bad debt expenses or poor cash flow.

49We may be unable to quickly and effectively integrate operations of Progenitor which could materially adversely affect our combined business, financial condition and results of operations

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Risks Related to the Acquisition of Progenitor

We may be unable to quickly and effectively integrate operations which could materially adversely affect our combined business, financial condition and results of operations

In order to increase profitability and operating efficiencies, we will need to integrate and coordinate certain key elements, including:

	•	service offerings;

	•	marketing and business development efforts;

	•	management and other professional personnel; and

	•	operational systems of Encorium and Progenitor

We may not accomplish the integration smoothly, expeditiously or successfully. The difficulties of combining the companies’ operations include:

	•	coordinating the efforts and managing the operation, facilities and decision-making process;

	•	integrating organizations whose personnel have diverse business and cultural backgrounds; and

	•	combining different corporate cultures.

The process of integrating operations could cause an interruption of, or loss of momentum in, the activities of the combined company’s businesses and the loss of key personnel. We will need to dedicate management resources to the integration process which may distract attention from normal operations. Employee uncertainty and lack of focus during the integration process may also disrupt our businesses. If we fail to complete quickly and effectively the integration of our operations, there could be uncertainty in the marketplace or client concern regarding the impact of the business combination, which could materially adversely affect the financial condition and results of operations of the combined businesses.

~~The acquisition of Progenitor may affect our ability to hire, train and retain highly qualified professionals which may cause our business to suffer.~~43

Our success following the closing of the business combination will depend upon the retention of senior executives and other key employees from both Encorium and Progenitor who are critical to the continued advancement, development and support of our services, ongoing sales and marketing efforts. The loss for any reason of any key executive officer or of any significant group of our client-serving professionals could negatively affect our business and prospects. Employee uncertainty regarding the effects of the business combination could also cause increased turnover among our employees.

The market price of our common stock may decline as a result of the acquisition of Progenitor.

The market price of our common stock may decline as a result of the acquisition of Progenitor, including if:

• we do not achieve the perceived benefits of the acquisition as rapidly or to the extent anticipated by financial or industry analysts; • the effects of the acquisition on the businesses are not consistent with the expectations of financial or industry analysts; or

Our stockholders will suffer dilution to their equity and voting interests as a result of the acquisition of Progenitor.

In connection with the acquisition of Progenitor, we will issue additional shares to the former stockholders of Progenitor. If the combined company is unable to realize the strategic and financial benefits currently anticipated from the business combination, the Encorium stockholders will have experienced dilution of their ownership interest without receiving any commensurate benefit.

We could lose clients as a result of uncertainty regarding the acquisition

Uncertainty regarding the acquisition of Progenitor and the ability of Encorium and Progenitor to integrate effectively their operations without significant reduction in quality of service could lead some clients to select other vendors. The loss of business from significant clients could have a negative effect on our business following the closing.

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The market price of our common stock may decline as a result of the acquisition of Progenitor Holding.

The market price of our common stock may decline as a result of the acquisition of Progenitor Holding, including if:

	•	we do not achieve the perceived benefits of the acquisition as rapidly or to the extent anticipated by financial or industry analysts; or

	•	the effects of the acquisition on the businesses are not consistent with the expectations of financial or industry analysts; or

Our stockholders have suffered dilution to their equity and voting interests as a result of the acquisition of Progenitor Holding.

In connection with the acquisition of Progenitor, we have issued and may issue additional shares of the Company’s Common Stock in the future to the former stockholders of Progenitor Holding in connection with any earn out payments. If the combined company is unable to realize the strategic and financial benefits currently anticipated from the business combination, the Encorium stockholders will have experienced dilution of their ownership interest without receiving any commensurate benefit.

We could lose clients as a result of uncertainty regarding the acquisition of Progenitor Holding

Uncertainty regarding the acquisition of Progenitor Holding and the ability of Encorium and Progenitor Holding to integrate effectively their operations without significant reduction in quality of service could lead some clients to select other vendors. The loss of business from significant clients could have a negative effect on our business.

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ITEM 6. EXHIBITS

(a) Exhibits

31.1	Certification of Chief Executive Officer required by Rule 13a-14(a) or Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

31.2	Certification of Chief Financial Officer required by Rule 13a-14(a) or Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

32.1	Certification pursuant to 18 U.S.C. § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

32.2	Certification pursuant to 18 U.S.C. § 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	ENCORIUM GROUP, INC.	~~ENCORIUM GROUP, INC.~~
Dated: August 16, 2010		By:	/S/ KAI LINDEVALL, M.D. PH. D.
Dated: May 3, 2011
			Kai Lindevall, M.D. Ph. D.
	By:	/S/ KAI LINDEVALL, M.D. PH. D.
			Executive Chairman
		Kai Lindevall, M.D. Ph. D.
			(Principal Executive Officer)
		Executive Chairman
Dated: August 16, 2010		By:	/S/ PHILIP L. CALAMIA
		(Principal Executive Officer)
			Philip L. Calamia
Dated: May 3, 2011	By:	/S/ NIKLAS TEVAJARI
			Interim Chief Financial Officer
		Niklas Tevajärvi
			(Principal Accounting Officer)
		Principal Accounting Officer

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