RA Capital Healthcare Fund LP 4

4 · Septerna, Inc. · Filed Jun 30, 2026

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Updated Jun 30, 2026

Septerna (SEPN) Director Dr. Jake Simson Receives 15,000-Share Option Award

What Happened

Dr. Jake Simson, a Partner at RA Capital Management and a Septerna (SEPN) director, is reported as the beneficiary of a derivative award: an option covering 15,000 Septerna shares. The grant was reported as acquired on 2026-06-26 at $0.00 (i.e., an option award rather than a cash purchase). This was not an exercise/sale — it is an award of an option that vests in the future.

Key Details

Transaction date: 2026-06-26; filing date: 2026-06-30.
Transaction type: Grant/Award of a derivative (option) for 15,000 shares at $0.00.
Vesting: The option vests in full upon the earlier of (i) June 26, 2027 or (ii) the issuer’s next annual meeting of stockholders, subject to continued service.
Ownership after transaction: Not specified in the filing.
Beneficial ownership disclaimers: RA Capital Management, L.P. (the Adviser) and related entities disclaim beneficial ownership except to the extent of pecuniary interest. Dr. Simson holds the option for the benefit of RA Capital funds and is obligated to turn over any net cash or stock received upon exercise to the Adviser to offset advisory fees.
Timeliness: Filing occurred four days after the transaction date; Form 4s are generally due within two business days of the transaction — consider checking the filing’s timeliness status if that matters to you.

Context

This is an option award (derivative grant), not a market purchase or sale; the shares are not immediately issued and were not sold. Such awards are commonly used for compensation or as part of governance/board arrangements.
The reporting entity is a 10% institutional owner and investment adviser; the filing reflects the adviser/funds’ economic arrangement rather than a straightforward personal buy or sell by an independent insider.

Form 4

Period: 2026-06-26

Director10% Owner

Transactions

Award
Stock Option (Right to Buy)
[F1][F2][F3]
2026-06-26+15,000→ 15,000 total(indirect: See Footnotes)
Exercise: $37.34Exp: 2036-06-25→ Common Stock (15,000 underlying)

Footnotes (3)

[F1]The shares underlying the stock option vest in full upon the earlier of (i) June 26, 2027 or (ii) the date of the Issuer's next annual meeting of stockholders, subject to Dr. Simson's continued service to the Issuer through such vesting date.
[F2]RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund III, L.P. (the "Nexus Fund III"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund III, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.
[F3]Under Dr. Simson's arrangement with the Adviser, Dr. Simson holds the option for the benefit of the Fund and the Nexus Fund III. Dr. Simson is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund III to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock.

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