Krishnan Krish S 4

4 · Krystal Biotech, Inc. · Filed Mar 3, 2026

Insider Transaction Report

Form 4

Period: 2026-02-27

Krystal Biotech, Inc.KRYS

Krishnan Krish S

DirectorPresident and CEO10% Owner

Transactions

Exercise/Conversion
Common Stock
[F1]
2026-02-27+8,750→ 1,486,806 total
Tax Payment
Common Stock
[F2][F3]
2026-02-27$275.64/sh−3,981$1,097,323→ 1,482,825 total
Exercise/Conversion
Common Stock
[F4]
2026-02-27+26,250→ 1,509,075 total
Tax Payment
Common Stock
[F5][F3]
2026-02-27$275.64/sh−11,942$3,291,693→ 1,497,133 total
Exercise/Conversion
Common Stock
[F6]
2026-02-27+5,725→ 1,502,858 total
Tax Payment
Common Stock
[F7][F3]
2026-02-27$275.64/sh−2,605$718,042→ 1,500,253 total
Exercise/Conversion
Common Stock
[F8][F9][F10]
2026-02-27+22,500→ 1,436,211 total(indirect: By Spouse)
Tax Payment
Common Stock
[F9][F11][F3][F10]
2026-02-27$275.64/sh−10,236$2,821,451→ 1,425,975 total(indirect: By Spouse)
Exercise/Conversion
Common Stock
[F9][F12][F10]
2026-02-27+4,000→ 1,429,975 total(indirect: By Spouse)
Tax Payment
Common Stock
[F9][F13][F3][F10]
2026-02-27$275.64/sh−1,820$501,665→ 1,428,155 total(indirect: By Spouse)
Exercise/Conversion
Restricted Stock Units
[F1]
2026-02-27−8,750→ 17,500 total
→ Common Stock (8,750 underlying)
Exercise/Conversion
Performance Stock Units
[F4]
2026-02-27−26,250→ 0 total
→ Common Stock (26,250 underlying)
Exercise/Conversion
Restricted Stock Units
[F6]
2026-02-27−5,725→ 17,175 total
→ Common Stock (5,725 underlying)
Award
Stock Option (Right to Buy)
[F15]
2026-02-27+45,249→ 45,249 total
Exercise: $275.64Exp: 2036-02-26→ Common Stock (45,249 underlying)
Award
Restricted Stock Units
[F16][F17][F18]
2026-02-27+18,140→ 18,140 total
→ Common Stock (18,140 underlying)

Holdings

Common Stock
(indirect: By Trust)
90,000
Common Stock
[F14]
(indirect: By Trust)
50,000

Footnotes (18)

[F1]35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period. 8,750 RSUs vested on February 27, 2026.
[F10]Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.
[F11]Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 22,500 PSUs on February 27, 2026.
[F12]16,000 restricted stock units ("RSUs") were granted on February 28, 2025 to the Reporting Person's spouse, Suma M. Krishnan. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 4,000 RSUs, vesting on February 27, 2026.
[F13]Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 4,000 RSUs on February 27, 2026.
[F14]Directly beneficially owned by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.
[F15]The stock options vests in four equal annual installments beginning on February 27, 2027.
[F16]Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.
[F17]The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates.
[F18]The RSUs vest in four equal annual installments with the first installment vesting on February 27, 2027.
[F2]Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 8,750 RSUs on February 27, 2026.
[F3]The closing price on February 27, 2026 of the Company's common stock on the Nasdaq Global Select Market.
[F4]52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 26,250 PSUs, vested on February 27, 2026.
[F5]Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 26,250 PSUs on February 27, 2026.
[F6]22,900 restricted stock units ("RSUs") were granted on February 28, 2025. Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 5,725 RSUs, vesting on February 27, 2026.
[F7]Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 5,725 RSUs on February 27, 2026.
[F8]45,000 performance stock units ("PSUs") were granted on February 29, 2024, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and the remaining one-half of the PSUs granted, or 22,500 PSUs, vested on February 27, 2026.
[F9]These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

Signature

/s/ Krish S. Krishnan|2026-03-03

Documents

1 file

4
wk-form4_1772580619.xmlPrimary
FORM 4