Lewis William 4

4 · INSMED Inc · Filed Mar 5, 2026

Insider Transaction Report

Form 4

Period: 2026-03-05

INSMED IncINSM

Lewis William

DirectorChair and CEO

Transactions

Exercise/Conversion
Common Stock
[F1]
2026-03-05$30.46/sh+6,259$190,649→ 307,444 total
Exercise/Conversion
Common Stock
[F1]
2026-03-05$17.16/sh+4,440$76,190→ 311,884 total
Sale
Common Stock
[F1][F2]
2026-03-05$144.23/sh−2,083$300,431→ 309,801 total
Sale
Common Stock
[F1][F3]
2026-03-05$145.27/sh−2,589$376,104→ 307,212 total
Sale
Common Stock
[F1][F4]
2026-03-05$146.66/sh−3,899$571,827→ 303,313 total
Sale
Common Stock
[F1][F5][F6]
2026-03-05$147.54/sh−2,128$313,965→ 301,185 total
Exercise/Conversion
Stock Option (right to buy)
[F1][F7]
2026-03-05−6,259→ 56,332 total
Exercise: $30.46Exp: 2028-01-04→ Common Stock (6,259 underlying)
Exercise/Conversion
Stock Option (right to buy)
[F1][F7]
2026-03-05−4,440→ 39,960 total
Exercise: $17.16Exp: 2027-05-17→ Common Stock (4,440 underlying)

Holdings

Common Stock
(indirect: By Trust)
233,924

Footnotes (7)

[F1]This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.
[F2]This is the weighted average sales price representing 2,083 shares sold at prices ranging from $143.84 to $144.70 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.
[F3]This is the weighted average sales price representing 2,589 shares sold at prices ranging from $144.99 to $145.78 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.
[F4]This is the weighted average sales price representing 3,899 shares sold at prices ranging from $146.09 to $147.06 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.
[F5]This is the weighted average sales price representing 2,128 shares sold at prices ranging from $147.15 to $148.04 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.
[F6]The Reporting Person no longer has a reportable beneficial interest in the securities owned by the William Lewis Family Legacy Trust, which were included in the Reporting Person's prior ownership reports.
[F7]The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

Signature

/s/ William Lewis, by Michael A. Smith as Attorney-in-fact|2026-03-05

Documents

1 file

4
wk-form4_1772745408.xmlPrimary
FORM 4