Gheuens Sarah 4

4 · AGIOS PHARMACEUTICALS, INC. · Filed Mar 3, 2026

Insider Transaction Report

Form 4

Period: 2026-03-01

AGIOS PHARMACEUTICALS, INC.AGIO

Gheuens Sarah

Chief Medical Officer

Transactions

Exercise/Conversion
Common stock
2026-03-02+4,000→ 68,795 total
Sale
Common stock
[F1]
2026-03-02$28.96/sh−1,187$34,376→ 67,608 total
Exercise/Conversion
Common stock
2026-03-02+5,666→ 73,274 total
Sale
Common stock
[F2]
2026-03-02$28.96/sh−1,681$48,682→ 71,593 total
Exercise/Conversion
Common stock
2026-03-02+4,000→ 75,593 total
Sale
Common stock
[F3]
2026-03-02$28.96/sh−1,187$34,376→ 74,406 total
Award
Restricted stock units
[F4][F5]
2026-03-01+14,000→ 14,000 total
→ Common stock (14,000 underlying)
Award
Restricted stock units
[F4][F5]
2026-03-01+22,000→ 22,000 total
→ Common stock (22,000 underlying)
Award
Stock options (right to buy)
[F6]
2026-03-01+52,000→ 52,000 total
Exercise: $30.23Exp: 2036-03-01→ Common stock (52,000 underlying)
Exercise/Conversion
Restricted stock units
[F4][F7]
2026-03-02−4,000→ 0 total
→ Common stock (4,000 underlying)
Exercise/Conversion
Restricted stock units
[F4][F8]
2026-03-02−5,666→ 5,667 total
→ Common stock (5,666 underlying)
Exercise/Conversion
Restricted stock units
[F4][F9]
2026-03-02−4,000→ 8,000 total
→ Common stock (4,000 underlying)

Footnotes (9)

[F1]Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2023.
[F2]Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2024.
[F3]Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's performance share units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated March 1, 2025.
[F4]Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.
[F5]The restricted stock units were granted on March 1, 2026. Beginning on March 1, 2027, the shares underlying the restricted stock units will vest in three equal annual installments.
[F6]This option was granted on March 1, 2026. The shares underlying this option vest as to 25% of the underlying shares on March 1, 2027, with the remaining 75% vesting in 36 equal monthly installments thereafter.
[F7]The restricted stock units were granted on March 1, 2023. Beginning on March 1, 2024, the shares underlying the restricted stock units will vest in three equal annual installments.
[F8]The restricted stock units were granted on March 1, 2024. Beginning on March 1, 2025, the shares underlying the restricted stock units will vest in three equal annual installments.
[F9]The restricted stock units were granted on March 1, 2025. Beginning on March 1, 2026, the shares underlying the restricted stock units will vest in three equal annual installments.

Signature

/s/ William Cook, as attorney-in-fact for Sarah Gheuens|2026-03-03

Documents

1 file

4
wk-form4_1772572555.xmlPrimary
FORM 4