UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 10-Q

[X]

QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For The Quarterly Period Ended ~~June~~September 30, 2017

[ ]

TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO .

Commission File Number 001-33523

COMBIMATRIX CORPORATION

(Exact Name of Registrant as Specified in Its Charter)

Delaware	47-0899439
(State or Other Jurisdiction of	(I.R.S. Employer
Incorporation or Organization)	Identification No.)

310 Goddard, Suite 150,
Irvine, CA	92618
(Address of Principal Executive Offices)	(Zip Code)

Registrant’s telephone number, including area code: (949) 753-0624

N/A

(Former name, former address and former fiscal year, if changed since last report.)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to filing requirements for the past 90 days. Yes [X] No [ ]

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes [X] No [ ]

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated
filer [ ]

Accelerated filer [ ]

Non-accelerated filer [ ]
(Do not check if a smaller
reporting company)

Smaller reporting
company [X]

Emerging growth
company [ ]

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. [ ]

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes [ ] No [X]

As of ~~August~~November 73, 2017, 2,~~918~~943,~~726~~892 shares of CombiMatrix Corporation common stock, $0.001 par value were issued and outstanding.

COMBIMATRIX CORPORATION

Table of Contents

Part I. Financial Information
Item 1.	Financial Statements (Unaudited)
	Consolidated Balance Sheets as of June 30, 2017 and December 31, 2016	3
	Consolidated Balance Sheets as of September 30, 2017 and December 31, 2016	3
	Consolidated Statements of Operations for the Three and Six Months Ended June 30, 2017 and 2016	4
	Consolidated Statements of Operations for the Three and Nine months Ended September 30, 2017 and 2016	4
	Consolidated Statements of Comprehensive Loss for the Three and Six Months Ended June 30, 2017 and 2016	5
	Consolidated Statements of Comprehensive Loss for the Three and Nine months Ended September 30, 2017 and 2016	5
	Consolidated Statements of Cash Flows for the Six Months Ended June 30, 2017 and 2016	6
	Consolidated Statements of Cash Flows for the Nine months Ended September 30, 2017 and 2016	6
	Notes to Consolidated Financial Statements	7
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	1817
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	23
Item 4.	Controls and Procedures	23
Part II. Other Information
Item 1.	Legal Proceedings	2423
Item 1A.	Risk Factors	2423
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	2629
Item 3.	Defaults Upon Senior Securities	2629
Item 4.	Mine Safety Disclosures	2629
Item 5.	Other Information	2629
Item 6.	Exhibits	2629
Signatures		2731
Exhibit Index		28

Part I. Financial Information

Item 1. Financial Statements (Unaudited)

COMBIMATRIX CORPORATION

CONSOLIDATED BALANCE SHEETS

(In thousands, except share amounts)

	June 30,			December 31,
	September 30,			December 31,
	2017			2016
	(unaudited)	~~(unaudited)~~
ASSETS
Current assets:
Cash and cash equivalents	$	32,~~022~~382		$	2,727
Short-term investments		-			1,000
Accounts receivable, net of allowance for doubtful accounts of $227 and $232		4,006			3,351
Accounts receivable, net of allowance for doubtful accounts of $234 and $232		4,177			3,351
Supplies		~~368~~443			599
Prepaid expenses and other assets		170			174
Total current assets		7,~~566~~172			7,851
Property and equipment, net		~~523~~537			597
Other assets		30			30
Total assets	$	87,~~119~~739		$	8,478
LIABILITIES AND STOCKHOLDERS' EQUITY
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable, accrued expenses and other	$	1,920		$	1,689
Accounts payable	$	884		$	542
Current portion, long-term debt		49			100
Accrued liabilities		1,281			1,147
Total current liabilities		1,969			1,789
Current portion, long-term debt		63			100
Capital lease obligations, net of current portion		72			50
Total current liabilities		2,228			1,789
Deferred rent		126			145
Capital lease obligations, net of current portion		122			50
Total liabilities		2,167			1,984
Deferred rent		115			145
Commitments and contingencies (Note 6)
Total liabilities		2,465			1,984
Stockholders' equity:
Commitments and contingencies (Notes 6 and 7)
Convertible preferred stock; $0.001 par value; 5,000,000 shares authorized; Series F - 8,000 shares authorized; 92 and 969 issued and outstanding		-			-
Stockholders’ equity:
Common stock; $0.001 par value; 50,000,000 shares authorized; 2,918,726 and 2,673,756 shares issued and outstanding		15			15
Convertible preferred stock; $0.001 par value; 5,000,000 shares authorized; Series F - 8,000 shares authorized; 14 and 969 issued and outstanding		-			-
Additional paid-in capital		109,471			109,068
Common stock; $0.001 par value; 50,000,000 shares authorized; 2,938,992 and 2,673,756 shares issued and outstanding		15			15
Additional paid-in capital		109,403			109,068
Accumulated other comprehensive loss		-			-
Accumulated deficit		(~~103~~104,~~534~~144	)		(102,589	)
Total stockholders' equity		5,952			6,494
Total stockholders’ equity		5,274			6,494
Total liabilities and stockholders' equity	$	8,119		$	8,478
Total liabilities and stockholders’ equity	$	7,739		$	8,478

The accompanying notes are an integral part of these consolidated financial statements.

COMBIMATRIX CORPORATION

CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except share and per share information)

(Unaudited)

	Three Months Ended						~~Six~~Nine Months Ended
	June 30,						June 30,
	September 30,						September 30,
	2017			2016			2017			2016
Revenues:
Diagnostic services	$	43,~~214~~977		$	3,~~049~~211		$	711,~~972~~949		$	59,~~979~~190
Royalties		2735			5837			5691			~~100~~137
Total revenues		4,~~241~~012			3,~~107~~248			812,~~028~~040			69,~~079~~327
Operating expenses:
Cost of services		1,~~632~~614			1,~~432~~476			34,~~140~~754			24,~~851~~327
Research and development		8590			~~149~~88			~~170~~260			~~292~~380
Sales and marketing		~~1,016~~967			1,~~141~~055			23,~~038~~005			23,~~477~~532
General and administrative		1,~~855~~930			1,~~586~~450			35,~~519~~449			34,~~112~~562
Patent amortization and royalties		25			25			5075			5075
Total operating expenses		4,~~613~~626			4,~~333~~094			813,~~917~~543			812,~~782~~876
Operating loss		(~~372~~614	)		(~~1,226~~846	)		(~~889~~1,503	)		(23,~~703~~549	)
Other income (expense):
Interest income		57			87			1118			1219
Interest expense		(3	)		(17	)		(1013	)		(3552	)
Total other income (expense)		24			(910	)		15			(2333	)
Net loss	$	(~~370~~610	)	$	(~~1,235~~856	)	$	(~~888~~1,498	)	$	(23,~~726~~582	)
Deemed dividend from issuing Series F convertible preferred stock and warrants	$	-		$	-		$	-		$	(1,877	)
Deemed dividend paid for right to repurchase Series E convertible preferred stock		-			-			-			(656	)
Deemed dividend from issuing and modifying Series E convertible preferred stock and warrants		-			-			-			890
Net loss attributable to common stockholders	$	(~~370~~610	)	$	(~~1,235~~856	)	$	(~~888~~1,498	)	$	(45,~~369~~225	)
Basic and diluted net loss per share	$	(0.1321	)	$	(0.8938	)	$	(0.3152	)	$	(2.4338	)
Deemed dividend from issuing Series F convertible preferred stock		-			-			-			(1.6725	)
Deemed dividend paid for right to repurchase Series E convertible preferred stock		-			-			-			(0.5844	)
Deemed dividend from issuing and modifying Series E convertible preferred stock		-			-			-			0.7959
Basic and diluted net loss per share attributable to common stockholders	$	(0.1321	)	$	(0.8938	)	$	(0.3152	)	$	(3.8948	)
Basic and diluted weighted average common shares outstanding		2,~~915~~925,~~303~~580			12,~~382~~253,~~019~~834			2,~~838~~867,~~521~~860			1,~~122~~502,~~975~~680

The accompanying notes are an integral part of these consolidated financial statements.

COMBIMATRIX CORPORATION

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(In thousands, except share and per share information)

(Unaudited)

	Three Months Ended						~~Six~~Nine Months Ended
	June 30,						June 30,
	September 30,						September 30,
	2017			2016			2017			2016
Net loss	$	(~~370~~610	)	$	(~~1,235~~856	)	$	(~~888~~1,498	)	$	(23,~~726~~582	)
Unrealized gain on available-for-sale investments		-			-			-			2
Total comprehensive loss	$	(~~370~~610	)	$	(~~1,235~~856	)	$	(~~888~~1,498	)	$	(23,~~724~~580	)

The accompanying notes are an integral part of these consolidated financial statements.

COMBIMATRIX CORPORATION

CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

(Unaudited)

	Six Months Ended
	Nine Months Ended
	June 30,
	September 30,
	2017			2016
Operating activities:
Net loss	$	(~~888~~1,498	)	$	(23,~~726~~582	)
Adjustments to reconcile net loss to net cash flows from operating activities:
Depreciation and amortization		~~122~~181			~~130~~195
Non-cash stock compensation		~~346~~508			~~405~~591
Provision for bad debts		~~301~~509			~~205~~302
Changes in assets and liabilities:
Accounts receivable		(~~956~~1,335	)		(~~687~~855	)
Supplies, prepaid expenses and other assets		~~235~~160			(2235	)
Accounts payable, accrued expenses and other		~~233~~480			~~151~~23
Net cash flows from operating activities		(~~607~~995	)		(23,~~544~~361	)
Investing activities:
Purchases of property and equipment		(2330	)		(~~147~~148	)
Proceeds from sale of property and equipment		19			-
Purchase of available-for-sale investments		(1,499	)		(4,998	)
Sale of available-for-sale investments		2,499			78,~~748~~248
Net cash flows from investing activities		~~996~~989			23,~~603~~102
Financing activities:
Repurchase of certain Series A, B, C and E common stock warrants		(230	)		-
Proceeds from issuance of Series F convertible preferred stock and common stock warrants		-			8,000
Costs from issuance of Series F convertible preferred stock and common stock warrants		-			(1,~~048~~064	)
Repurchase of Series E convertible prefered stock and dividends		-			(2,842	)
Repayments of long-term debt		(94109	)		(95143	)
Net cash flows from financing activities		(94339	)		43,~~015~~951
Change in cash and cash equivalents		~~295~~(345	)		43,~~074~~692
Cash and cash equivalents, beginning		2,727			653
Cash and cash equivalents, ending	$	32,~~022~~382		$	4,~~727~~345
Non-cash financing activities:
Property and equipment purchased under capital lease	$	63142		$	623
Adjustments to paid-in capital and retained earnings from change in accounting principle	$	57		$	-
Deemed dividends from issuing Series E convertible preferred stock	$	-		$	(890	)
Deemed dividends from issuing Series F convertible preferred stock	$	-		$	1,877
Accrued public offering costs	$	-		$	10
Accrued property and equipment	$	-		$	9
Accrued property, plant and equipment	$	-		$	20

The accompanying notes are an integral part of these consolidated financial statements.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(Unaudited)

1. OVERVIEW AND BACKGROUND

CombiMatrix Corporation (the “Company,” “we,” “us” and “our”) was originally incorporated in October 1995 as a California corporation and later reincorporated as a Delaware corporation in September 2000. In December 2002, we merged with, and became a wholly owned subsidiary of Acacia Research Corporation (“Acacia”). In August 2007, we split-off from Acacia and became publicly traded on The NASDAQ Stock Market. As a result of the split-off, we ceased to be a subsidiary of, or affiliated with, Acacia.

Description of the Company

We are a family health-focused clinical molecular diagnostic laboratory specializing in pre-implantation genetic screening, prenatal diagnosis, miscarriage analysis, and pediatric developmental disorders. We strive to provide best-in-class clinical laboratory support to healthcare professionals, allowing them to maximize the clinical utility of their patients’ test results and to optimize patient care. Our testing focuses on advanced technologies, including single nucleotide polymorphism, or (“SNP~~, chromosomal~~”) chromosomal microarray analysis, next generation sequencing, fluorescent in situ hybridization and high resolution karyotyping. Our approach to testing is to offer sophisticated technology along with high-quality clinical support to our ordering physicians and their patients. Our laboratory facilities and corporate headquarters are located in Irvine, California.

We also own a one-third minority interest in Leuchemix, Inc. (“Leuchemix”), a private drug development company focused on developing a series of compounds to address a number of oncology-related diseases.

Basis of Presentation

The accompanying consolidated financial statements have been prepared in accordance with generally accepted accounting principles for interim financial information and with the instructions to Form 10-Q and Rule 8-03 of Regulation S-X. Accordingly, certain information and notes required by generally accepted accounting principles in annual financial statements have been omitted or condensed. These interim consolidated financial statements should be read in conjunction with the consolidated financial statements and notes thereto for the year ended December 31, 2016, as reported by us in our Annual Report on Form 10-K filed with the Securities and Exchange Commission (the “SEC”) on March 3, 2017. The year-end consolidated balance sheet data was derived from audited financial statements but does not include all disclosures required by accounting principles generally accepted in the United States of America. The consolidated financial statements include all adjustments of a normal recurring nature which, in the opinion of management, are necessary for a fair statement of our financial position as of ~~June~~September 30, 2017, and results of operations and cash flows for the interim periods presented. The results of operations for the three and ~~six~~nine months ended September ~~June~~ 30, 2017 are not necessarily indicative of the results to be expected for the entire year.

Going Concern Analysis

We have a history of incurring net losses and net operating cash flow deficits. We ~~are~~ also incur expenses from deploying new technologies and ~~continue~~ from continuing to develop new and ~~improve~~improving existing commercial diagnostic testing services and related technologies. As a result, these conditions raise substantial doubt regarding our ability to continue as a going concern beyond twelve months from the date of this filing. ~~However,~~ asAs of ~~June~~September 30, 2017, we had cash, cash equivalents and short-term investments of $32.04 million. Also, the combination of continued revenue and cash reimbursement growth we have experienced over the past several quarters, coupled with improved gross margins and cost containment of expenses leads management to believe that it is probable that our cash resources will be sufficient to meet our cash requirements for current operations through and beyond the ~~fourth~~first quarter of ~~2017~~2018, when we anticipate achieving cash flow break-even status (excluding merger-related expenses). If necessary, management also believes that it is probable that external sources of debt and/or equity financing could be obtained based on management’s history of being able to raise capital coupled with current favorable market conditions. As a result of both management’s plans and current favorable trends in improving cash flow, we believe the initial conditions which raised substantial doubt regarding our ability to continue as a going concern have been alleviated. Therefore, the accompanying consolidated financial statements have been prepared assuming that we will continue as a going concern. However, there can be no assurance that our operations will become profitable or that external sources of financing, including the issuance of debt and/or equity securities, will be available at times and on terms acceptable to us, or at all.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

The consolidated financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from the matters discussed herein. While we believe in the viability of our strategy to generate sufficient revenue and cash reimbursement, control costs and our ability to raise additional funds if necessary, there can be no assurances to that effect. Our ability to continue as a going concern is dependent upon our ability to further implement our business plan, generate sufficient revenues and cash reimbursement and to control operating expenses.

Risks

Our business operations are also subject to certain risks and uncertainties, including:

	●	market acceptance of our services;

	●	technological advances that may make our services obsolete or less competitive;

	●	increases in operating costs, including costs for supplies, personnel and equipment;

	●	variability in third-party reimbursement of our tests;

	●	the availability and cost of capital; and

	●	governmental regulation that may restrict our business.

Our services are concentrated in a highly competitive market that is characterized by rapid technological advances, frequent changes in customer requirements and evolving regulatory requirements and industry standards. Failure to anticipate or respond adequately to technological advances, changes in customer requirements, changes in regulatory requirements or industry standards, or any significant delays in the development or introduction of planned services, could have a material adverse effect on our business and operating results.

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Use of Estimates. The preparation of financial statements in conformity with generally accepted accounting principles (“GAAP”) in the United States of America requires management to make estimates and assumptions that affect the reported amount of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from these estimates.

Principles of Consolidation. The accompanying consolidated financial statements include the accounts of the Company and our wholly owned and majority-owned subsidiaries. Investments for which we possess the power to direct or cause the direction of the management and policies, either through majority ownership or other means, are accounted for under the consolidation method. Material intercompany transactions and balances have been eliminated in consolidation. Investments in companies in which we maintain an ownership interest of 20% to 50% or exercise significant influence over operating and financial policies are accounted for under the equity method. The cost method is used where we maintain ownership interests of less than 20% and do not exercise significant influence over the investee.

Revenue Recognition. We recognize revenue when (i) persuasive evidence of an arrangement exists, (ii) delivery has occurred or services have been performed, (iii) amounts are fixed or determinable and (iv) collectability of amounts is reasonably assured.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

Service revenues from providing diagnostic tests are recognized when the testing process is complete and test results are reported to the ordering physician or clinic. These diagnostic services are billed to various payors, including third-party commercial insurance companies, healthcare institutions, government payors including various state Medicaid programs, and individuals. We report revenues from contracted payors based on a contractual rate, or in the case of state Medicaid contracts, published fee schedules for our tests. We report revenues from non-contracted payors based on the amounts expected to be collected. The differences between the amounts billed and the amounts expected to be collected from non-contracted payors are recorded as contractual allowances to arrive at net recognized revenues. The expected revenues from non-contracted payors are based on the historical collection experience of each payor or payor group, as appropriate, and also take into account recent collection trends. In each reporting period, we review our historical collection experience for non-contracted payors and adjust our expected revenues for current and subsequent periods accordingly. We also recognize additional revenue from actual cash payments that exceed amounts initially recognized, in the period the payments are received. Because a substantial portion of our revenues is from non-contracted third-party payors, it is likely that we will be required to make adjustments to accounting estimates with respect to contractual allowances in the future, which may positively or adversely affect our results of operations. In all cases described above, we report revenues net of any applicable statutory taxes collected from customers, as applicable. No single customer exceeded 10% of revenues for any of the periods presented.

Cash Equivalents and Short-Term Investments. We consider all highly liquid investments purchased with original maturities of three months or less when purchased to be cash equivalents. Short-term investments consist of fixed income investments with maturities between three and 12 months and other highly liquid investments that can be readily purchased or sold using established markets. These investments are classified as available-for-sale and are reported at fair value on ~~the~~our ~~Company’s~~ consolidated balance sheet. Unrealized holding gains and losses are reported within comprehensive loss in the consolidated statements of comprehensive loss. Fair value is based on available market information including quoted market prices, broker or dealer quotations or other observable inputs. If a decline in the fair value of a short-term investment below our cost basis is determined to be other than temporary, such investment is written down to its estimated fair value as a new cost basis and the amount of the write-down is included in earnings as an impairment charge. To-date, no permanent impairment charges have been realized or recorded.

Fair Value Measurements. We measure fair value as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that is determined based on assumptions that market participants would use in pricing an asset or liability. We utilize a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:

●	Level 1:	Observable market inputs such as quoted prices in active markets;

●	Level 2:	Observable market inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and

●	Level 3:	Unobservable inputs where there is little or no market data, which require the reporting entity to develop its own assumptions.

We classify our cash equivalents within the fair value hierarchy as Level 1 as these assets are valued using quoted prices in active markets for identical assets at the measurement date. We classify short-term investments within the fair value hierarchy as Level 2, primarily utilizing broker quotes in a non-active market for valuation of these investments. Financial instruments that contain valuation inputs that are not readily determinable from active markets or from similar securities trading in active markets, such as derivative financial instruments, are classified within the fair value hierarchy as Level 3.

Impairment of Long-Lived Assets. Long-lived assets and intangible assets are reviewed for potential impairment when events or changes in circumstances indicate the carrying amount of an asset may not be recoverable. In the event the sum of the expected undiscounted future cash flows resulting from the use of the asset is less than the carrying amount of the asset, an impairment loss equal to the excess of the asset’s carrying value over its fair value is recorded. If an asset is determined to be impaired, the loss is measured based on quoted market prices in active markets, if available. If quoted market prices are not available, the estimate of fair value is based on various valuation techniques, including a discounted value of estimated future cash flows.

Derivative Financial Instruments. We evaluate financial instruments for freestanding or embedded derivatives. Derivative instruments that do not qualify for permanent equity classification are recorded as liabilities at fair value, with changes in value recognized as other income (expense) in the consolidated statements of operations in the period of change. Derivative liabilities are categorized as either short-term or long-term based upon management’s estimates as to when the derivative instrument may be realized or based upon the holder’s ability to realize the instrument.

Concentration of Credit Risks. Cash and cash equivalents are invested in deposits with certain financial institutions and may, at times, exceed federally insured limits. We have not experienced any significant losses on our deposits of cash and cash equivalents. We do not believe that we are exposed to significant credit risk on cash and cash equivalents or on our short-term investments. Accounts receivable from Insurance Carrier A of $602,000 exceeded 10% of our total accounts receivable balance as of June 30, 2017. Accounts receivable from Insurance Carrier B of $441,000 exceeded 10% of our total accounts receivable balance as of December 31, 2016.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

Concentration of Credit Risks. Cash and cash equivalents are invested in deposits with certain financial institutions and may, at times, exceed federally insured limits. We have not experienced any significant losses on our deposits of cash and cash equivalents. We do not believe that we are exposed to significant credit risk on cash and cash equivalents or on our short-term investments. Accounts receivable from Insurance Carrier A of $601,000, Carrier B of $497,000 and Carrier C of $459,000 each exceeded 10% of our total accounts receivable balance as of September 30, 2017. Accounts receivable from Insurance Carrier B of $441,000 exceeded 10% of our total accounts receivable balance as of December 31, 2016.

Substantially all of the components and raw materials used in providing our testing services, including array slides and reagents, are currently provided to us from a limited number of sources or in some cases from a single source. Although we believe that alternative sources for those components and raw materials are available, any supply interruption in a sole-sourced component or raw material might result in up to a several-month production delay and materially harm our ability to provide testing services until a new source of supply, if any, could be located and qualified.

Accounts Receivable and Allowance for Doubtful Accounts. For our contracted third-party payors, governmental payors or direct-bill customers, accounts receivable are stated at principal amounts and are primarily comprised of amounts contractually due from customers for services performed. For our non-contracted customers, accounts receivable are stated at amounts expected to be collected based on historical collection experience with the third-party payor. The payment realization cycle for certain governmental and commercial insurance payors can be lengthy, involving denial, appeal and adjudication processes, and is subject to periodic adjustments that may be significant. Accounts receivable are periodically written off when identified as uncollectible after appropriate collection efforts have been exhausted. Such write-offs increase the contractual allowances (which reduce revenues) for those accounts in the period of adjustment. Collection of governmental, private health insurer, and client receivables are generally a function of providing complete and correct billing information to the insurers and clients within the filing deadlines required by each payor.

Collection of receivables due from patients and private-pay clients is generally subject to increased credit risk due to credit-worthiness or inability to pay. For these customers, an allowance for doubtful accounts is recorded for estimated uncollectible amounts, and involves significant assumptions and judgments. Specifically, the allowance for doubtful accounts is adjusted periodically and is principally based upon specific identification of past due or disputed accounts. We also review the age of receivables to assess our allowance at each period end. Additions to the allowance for doubtful accounts are charged to bad debt expense as a component of general and administrative expenses in the consolidated statements of operations.

Stock-Based Compensation. The compensation cost for all employee stock-based awards is measured at the grant date, based on the fair value of the award, and is recognized as an expense, on a straight-line basis, over the employee’s requisite service period (generally the vesting period of the equity award) which is generally four years. The fair value of each stock option award is estimated on the date of grant using a Black-Scholes option valuation model. The fair value of each restricted stock unit (“RSU”) award is based on the number of shares granted and the closing price of our common stock as reported on The NASDAQ Capital Market on the date of grant.

In March 2016, the Financial Accounting Standards Board (“FASB”) issued guidance regarding employee share-based payment accounting. The guidance is intended to simplify several areas of accounting for share-based compensation arrangements, including the income tax impact, classification on the statement of cash flows and provides the choice for companies to estimate forfeitures during the vesting period of an award or recognize forfeitures at the time an award is canceled and forfeited. The standard became effective ~~for~~and was implemented by us on January 1, 2017. We elected to change our policy regarding forfeitures to recognize ~~if and~~ when an award is canceled and forfeited rather than estimating forfeitures up front. The impact from implementing this policy ~~change~~ was to ~~reduce~~ reduce retained earnings and increase additional paid-in capital by $57,000.

Stock-based compensation expense for all periods presented attributable to our functional expense categories from stock option and RSU awards vesting during the periods presented were as follows (in thousands):

	Three Months Ended				~~Six~~Nine Months Ended
	June 30,				June 30,
	September 30,				September 30,
	2017		2016		2017		2016
Cost of services	$	9	$	414	$	1827	$	2034
Research and development		-		-		-		-
Sales and marketing		16		1719		3450		4463
General and administrative		~~128~~137		~~169~~153		~~294~~431		~~341~~494
Total non-cash stock compensation	$	~~153~~162	$	~~190~~186	$	~~346~~508	$	~~405~~591

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

Net Loss Per Share. Basic and diluted net loss per share has been computed by dividing the net loss by the weighted average number of common shares issued and outstanding during the periods presented. Options and warrants to purchase common stock as well as preferred stock convertible into shares of common stock are anti-dilutive and therefore are not included in the determination of the diluted net loss per share. The following table reflects the excluded dilutive securities:

Three Months Ended

~~Six~~Nine Months Ended

June 30,

September 30,

2017

2016

2017

2016

Common stock options

6462,~~326~~697

7166,~~749~~687

6462,~~326~~697

7166,~~749~~687

Restricted stock units

98,049

59,000

98,049

59,000

Common stock warrants

2,~~701~~578,~~647~~455

2,701,~~747~~754

2,~~701~~578,~~647~~455

2,701,~~747~~754

Series F preferred stock convertible into common stock

233,~~738~~582

1436,~~247,530~~662

233,~~738~~582

1436,~~247,530~~662

Excluded potentially dilutive securities

2,~~887~~742,~~760~~783

43,~~080~~264,~~026~~103

2,~~887~~742,~~760~~783

43,~~080~~264,~~026~~103

Segments. We have determined that we operate in one segment for financial reporting purposes.

Recent Accounting Pronouncements. In July 2017, the FASB issued an accounting standards update regarding earnings per share, distinguishing liabilities from equity and derivatives and hedging. Part 1 of the update addresses the complexity of accounting for certain financial instruments with down-round features, such as anti-dilution provisions of common stock warrant contracts that can require liability classification and subsequent mark-to-market accounting for these securities. As a result of this update, a down-round feature no longer precludes equity classification when assessing whether the instrument is indexed to an entity’s own stock, which means that derivative accounting treatment and liability classification are no longer required. The amendment requires the effect of a down round feature to be treated as a dividend and as a reduction of income available to common shareholders when computing basic earnings per share when the feature is triggered. In addition, convertible instruments with embedded conversion options that have down-round features are now subject to the specialized guidance for contingent beneficial conversion features, including related EPS guidance. Part II of the update addresses certain content that is pending or deferred and has no accounting effect. The amendments in Part I of the update are effective for all public entities for the first interim and annual reporting periods beginning after December 15, 2018, with early adoption permitted. We ~~are~~do ~~currently analyzing the details of the update and have~~ not ~~yet~~expect ~~determined what impact, if any,~~ the adoption of this update ~~may~~to have a material impact on our consolidated financial statements.

In May 2017, the FASB issued an accounting standards update regarding stock-based compensation. The purpose of the update is to provide clarity regarding when an entity should apply modification accounting from changes that an entity makes to the terms or conditions of share-based payment awards. The update is effective for all entities for the first interim and annual reporting periods beginning after December 15, 2017, with early adoption permitted. We do not expect the adoption of this update to have a material impact on our consolidated financial statements.

In January 2017, the FASB issued a new accounting standard that eliminates Step 2 of the goodwill impairment test currently required under GAAP. Instead, an entity should perform its annual or interim goodwill impairment test by comparing the fair value of a reporting unit with its carrying amount. An entity should recognize an impairment charge for the amount by which the carrying amount exceeds the reporting unit’s fair value; however, the loss recognized should not exceed the total amount of goodwill that had been allocated to that reporting unit. An entity still has the option to perform the qualitative assessment for a reporting unit to determine if the quantitative impairment test is necessary. This standard is effective for public business entities for the first interim and annual reporting periods beginning after January 1, 2020, with early adoption permitted for interim or annual goodwill impairment tests performed on testing dates after January 1, 2017. We do not expect the adoption of this standard to have a material impact on our consolidated financial statements.

Also in January 2017, the FASB issued a new accounting standard that changes the definition of a business to assist entities with evaluating when a set of transferred assets and activities is deemed to be a business. This update is effective on January 1, 2018, with early adoption permitted. We do not expect the adoption of this standard to have a material impact on our consolidated financial statements.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

In November 2016, the FASB issued new accounting guidance governing restricted cash, which requires entities to show the changes in the total of cash, cash equivalents, restricted cash and restricted cash equivalents in the statement of cash flows. As a result, entities will no longer present transfers between cash and cash equivalents and restricted cash and restricted cash equivalents in the statement of cash flows. The amendments in this guidance should be applied using a retrospective transition method to each period presented. This guidance is effective for annual periods beginning after December 15, 2017, and interim periods within those fiscal years with early adoption permitted, including adoption in an interim period. We do not expect the adoption of this guidance to have a material impact on our consolidated statements of cash flows.

In August 2016, the FASB issued new accounting guidance aimed at reducing the existing diversity in GAAP regarding how certain cash receipts and cash payments are classified in the statement of cash flows. The new guidance is effective for fiscal years beginning after December 15, 2017, and interim periods within those fiscal years. Early adoption is also permitted. We do not expect the adoption of this guidance to have a material impact on our consolidated statements of cash flows.

In February 2016, the FASB issued a new accounting standard regarding leases, which requires lessees to recognize on their balance sheets a right-of-use asset, representing their right to use the underlying asset for the lease term, and a lease liability for all leases with terms greater than 12 months. The standard also requires qualitative and quantitative disclosures designed to assess the amount, timing and uncertainty of cash flows arising from leases. The standard requires the use of a modified retrospective transition approach, which includes a number of optional practical expedients that entities may elect to apply. The standard is effective for us beginning January 1, 2019, and we are currently evaluating the impact that this standard will have on our consolidated financial statements.

In January 2016, the FASB issued accounting guidance regarding recognition and measurement of financial assets and financial liabilities. This guidance enhances the reporting model for financial instruments, which includes amendments to address aspects of recognition, measurement, presentation and disclosure. The guidance is effective for annual reporting periods beginning after December 15, 2017, and interim periods within those annual periods. We do not expect the adoption of this guidance to have a significant impact on our consolidated financial statements.

In May 2014, the FASB issued new accounting guidance regarding revenue recognition from contracts with customers, which when effective will supersede existing revenue recognition requirements and will eliminate most industry-specific guidance from GAAP. The core principle of the new guidance is to require an entity to recognize as revenue the amount that reflects the consideration to which it expects to be entitled in exchange for goods or services as it transfers control to its customers. The new guidance requires additional qualitative and quantitative disclosures about the nature, amount, timing and uncertainty of revenue and cash flows arising from contracts with customers. An entity can apply the new guidance retrospectively to each prior reporting period presented (i.e., the full retrospective method) or retrospectively with the cumulative effect of initially applying the standard recognized at the date of initial application in retained earnings. As originally issued, the new revenue recognition standard would be effective for us beginning January 1, 2017. However, in 2015, the FASB voted to defer the effective date of the new guidance for one year. We have nearly completed our detailed assessment of the impact that this guidance will have on our consolidated financial statements, with additional analysis currently ongoing. Based on our current assessment, we expect the majority of the amounts that have historically been recognized as bad debt expense, primarily related to patient responsibility, will be reflected as a reduction of the transaction price originally recognized and therefore as a reduction in revenue. We will adopt the new guidance beginning January 2018.

~~Reclassifications. Certain prior period amounts have been reclassified to conform to the current period presentation.~~11

3. CASH AND SHORT-TERM INVESTMENTS

As of June 30, 2017, we held $3.0 million in cash, cash equivalents and short-term investments, which are reported at fair value. Cash, cash equivalents and short-term investments consisted of the following as of June 30, 2017 and December 31, 2016 (in thousands):

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

	As of June 30, 2017								As of December 31, 2016
			Unrealized				Fair				Unrealized				Fair
	Cost		Gains		Losses		Value		Cost		Gains		Losses		Value
Cash and money market securities	$	1,772	$	-	$	-	$	1,772	$	2,727	$	-	$	-	$	2,727
Commercial paper		500		-		-		500		500		-		-		500
Certificates of deposit		750		-		-		750		500		-		-		500
	$	3,022	$	-	$	-	$	3,022	$	3,727	$	-	$	-	$	3,727

3. CASH AND SHORT-TERM INVESTMENTS

~~There~~As ~~were~~of noSeptember ~~realized~~30, ~~gains~~2017, orwe ~~losses~~held ~~for~~$2.4 million in cash, cash equivalents and short-term investments, which are reported at fair value. Cash, cash equivalents and short-term investments consisted of the ~~periods~~following ~~ended~~as ~~June~~of September 30, 2017 orand December 31, 2016. (in thousands):

	As of September 30, 2017								As of December 31, 2016
			Unrealized				Fair				Unrealized				Fair
	Cost		Gains		Losses		Value		Cost		Gains		Losses		Value

Cash and money market securities	$	2,382	$	-	$	-	$	2,382	$	2,727	$	-	$	-	$	2,727
Commercial paper		-		-		-		-		500		-		-		500
Certificates of deposit		-		-		-		-		500		-		-		500
	$	2,382	$	-	$	-	$	2,382	$	3,727	$	-	$	-	$	3,727

There were no realized gains or losses for the periods ended September 30, 2017 or 2016.

4. FAIR VALUE MEASUREMENTS

The following table summarizes, for each major category of financial assets measured on a recurring basis, the respective fair value at ~~June~~September 30, 2017 and December 31, 2016 and the classification by level of input within the fair value hierarchy defined above (in thousands):

Fair Value Measurements

June 30, 2017

Total

Level 1

Level 2

Level 3

September 30, 2017

Total

Level 1

Level 2

Level 3

Assets:

Cash equivalents

21,~~092~~346

~~842~~1,346

~~1,250~~-

Short-term investments

Cash equivalents

21,~~092~~346

~~842~~1,346

~~1,250~~-

			Fair Value Measurements
December 31, 2016	Total		Level 1		Level 2		Level 3
Assets:
Cash equivalents	$	1,735	$	1,735	$	-	$	-
Short-term investments		1,000		-		1,000		-
Cash equivalents	$	2,735	$	1,735	$	1,000	$	-

The carrying amounts of accounts receivable, accounts payable, accrued expenses, capital leases and the secured promissory note approximate fair value due primarily to the short-term nature of these financial instruments.

5. STOCKHOLDERS’ EQUITY

Series A through E Convertible Preferred Stock and Warrant Financings

Between 2012 and 2015, we executed several financing transactions whereby we issued convertible preferred stock and warrants to purchase common stock to investors. As of December 31, 2016, none of the Series A through E convertible preferred stock remained outstanding. For as long as the Series A warrants remain unexercised through their expiration date, except under certain permitted circumstances, we may not issue, or enter into any agreement to issue, common stock or common stock equivalents at a price per share below the $73.65 exercise price of the Series A warrants, unless waivers from the Series A investors are obtained. Until the time that less than 7.5% of the Series B, C and E warrants remain unexercised through their expiration date, except under certain permitted circumstances, we may not issue, or enter into any agreement to issue, common stock or common stock equivalents at prices per share below the $29.55, $29.55 and $32.51 exercise prices of the Series B, C and E warrants, respectively, unless waivers from the Series B, C and E investors are obtained. In addition, until there are no longer Series A, C and E warrants outstanding, we may not sell any variable rate securities except for certain exempt issuances.

1312

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

Series E Modifications

On February 4, 2016, we entered into a Series E 6% Convertible Preferred Stock Repurchase Agreement (the “Repurchase Agreement”) with the Series E Investors. Pursuant to the terms of the Repurchase Agreement, we agreed to pay each Series E Investor $300 per share of Series E Preferred Stock, or approximately $656,000, in consideration for the right to repurchase the Series E Investor’s Series E Preferred Stock at a price per share of $1,000 (the “Repurchase Price”), which was the original price per share paid by the Series E Investors for their Series E Preferred Stock in February 2015. We recognized the $656,000 payment as a deemed dividend paid to the Series E investors.

Immediately following the closing of our Series F public offering discussed below, we paid $2.2 million to the Series E Investors to repurchase all of the outstanding Series E Preferred Stock, in accordance with the terms of the Repurchase Agreement. Since almost none of the Series E Preferred Stock had converted by the time we repurchased the Series E Preferred Stock, the original $890,000 beneficial conversion feature that we recognized as a deemed dividend in 2015 was reversed as a return of capital from the Series E Preferred stockholders to the common stockholders.

Series F Convertible Preferred Stock and Warrants Financing

On March 24, 2016 (the “Series F Closing”), we closed an underwritten public offering (the “Series F Offering”) and issued 8,000 immediately separable units of securities to investors, with each unit consisting of: (i) one share of Series F convertible preferred stock (“Series F Preferred Stock”) convertible into shares of our common stock equal to 1,000 divided by the conversion price of $3.87, which was 75% of the consolidated closing bid price of our common stock on The NASDAQ Capital Market on March 18, 2016, the date we executed the underwriting agreement (“UA date”); and (ii) 258.397875 warrants, each to purchase one share of our common stock at an exercise price per share equal to $5.17 (“Series F Warrants”), which was 100% of the consolidated closing bid price of our common stock on The NASDAQ Capital Market on the UA date. The Series F Preferred Stock, the Series F Warrants, and the shares of common stock underlying the Series F Preferred Stock and Series F Warrants were registered on Form S-1, which was declared effective by the SEC on March 18, 2016. The Series F Preferred Stock was immediately convertible and the Series F Warrants were immediately exercisable for shares of common stock and have a term of five years. The Series F Warrants are exercisable for cash or, solely in the absence of an effective registration statement or prospectus, by cashless exercise. In total, there were 2,067,183 shares of common stock issuable upon conversion of the Series F Preferred Stock and up to 2,067,183 shares of common stock issuable upon exercise of the Series F Warrants. The units were sold for a purchase price equal to $1,000 per unit, resulting in gross proceeds received by us of $8.0 million. Total offering-related costs paid through December 31, 2016 were $1.1 million, resulting in net proceeds recognized of $6.9 million. Given that the effective conversion price of the Series F Preferred Stock was below the closing market price of our common stock at the time of the Series F Closing, we recognized a beneficial conversion feature in the amount of $1.9 million. Since the Series F Preferred Stock was immediately convertible into common stock, the beneficial conversion feature was treated as a deemed dividend charged to retained earnings at closing. Also, from the time of the Series F Closing through ~~June~~September 30, 2017, 7,~~908~~986 shares of the Series F Preferred Stock have converted into 2,~~043~~063,~~445~~601 shares of common stock, leaving 9214 shares of Series F Preferred Stock (representing 233,~~738~~582 shares of common stock) unconverted.

The Series F Preferred Stock is non-voting (except to the extent required by law and except for certain consent rights relating to amending the certificate of incorporation or bylaws, and the like), but ranks senior to our common stock with respect to distributions upon our dissolution, liquidation or winding-up. Until the volume weighted average price of our common stock on NASDAQ exceeds 200% of the conversion price of the Series F Preferred Stock for any 20 of 30 consecutive trading days, and the daily dollar trading volume during such period exceeds $200,000 per trading day, the Series F Preferred Stock is subject to full ratchet price based anti-dilution protection, subject to certain limitations. Also, the Company can force holders of Series F Preferred Stock to convert into our common stock if the volume-weighted average price of our common stock exceeds 200% of the Series F Preferred Stock conversion price for any 20 of 30 consecutive trading days, and the daily dollar trading volume during such period exceeds $200,000 per trading day, subject to certain other conditions. The Series F investors have agreed to be subject to a blocker that would prevent each of their respective common stock ownership at any given time from exceeding 4.99% of our outstanding common stock (which may be increased on 61 days’ notice, but not above 9.99%).

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

The Series F Warrants have a 5-year term and have a cashless exercise provision in the event there is no effective registration statement covering the common stock issuable upon exercise of the Series F Warrants. The Series F Warrants are not subject to price based anti-dilution protection. The Series F Warrants are listed on The NASDAQ Capital Market under the trading symbol “CBMXW.” For the nine months ended September 30, 2017, 210 Series F Warrants have been exercised, generating gross proceeds to the Company of $1,086. Subsequent to September 30, 2017 through November 3, 2017, 4,900 Series F Warrants were exercised, generating gross proceeds of $25,333.

Depending on the circumstances, upon a change in control constituting a “Fundamental Transaction” (as defined in the Series F Warrants), the holders of Series F Preferred Stock may be entitled to a 30% premium and the holders of Series F Warrants may have the right to require either that the Company purchase the Series F Warrants for an amount in cash that is determined in accordance with a formula set forth in the Series F Warrants or that the successor assumes and replaces the Series F Warrants with substantially equivalent warrants of the successor.

Common Stock Purchase Warrants Repurchase Agreement

On July 11, 2016, we entered into a Common Stock Purchase Warrants Repurchase Agreement (the “Warrants Repurchase Agreement”) with the holders (the “Holders”) of our outstanding common stock purchase warrants issued in October 2012, March 2013, May 2013, June 2013, June 2014, February 2015 and April 2015 (collectively, the “Warrants”) in connection with our Series A, Series B, Series C and Series E financings. Pursuant to the terms of the Warrants Repurchase Agreement, we have agreed to repurchase such Warrants from each Holder upon execution of a “Fundamental Transaction” (as defined in such Warrants) at various negotiated prices per Warrant share as set forth in the Warrants Repurchase Agreement. The Warrants Repurchase Agreement obligates us to repurchase half of such Warrants upon the announcement of a Fundamental Transaction. On July 31, 2017, we announced that we entered into an Agreement and Plan of Merger and Reorganization (the “Merger Agreement”) with Invitae Corporation (“Invitae”) and Coronado Merger Sub, Inc., a wholly owned subsidiary of Invitae (“Merger Sub”), pursuant to which Invitae plans to acquire us in an all-stock transaction in which Merger Sub will merge with and into us (the “Merger”). The Merger is considered a Fundamental Transaction under the Warrants Repurchase Agreement and, as a result of entering into and announcing the Merger Agreement, and pursuant to the terms of the Warrants Repurchase Agreement, we repurchased one -half of such outstanding Warrants on August 3, 2017, for approximately $230,000 of cash consideration. Under the terms of the Warrants Repurchase Agreement, we will be obligated to repurchase the remaining one-half of such Warrants for an additional $230,000 within three business days of any closing of the Merger. ~~In addition~~However, ~~upon~~under ~~any~~the ~~closing~~terms of the Merger Agreement, ~~all~~we ~~Securities~~are ~~Purchase~~required ~~Agreements~~to ~~and~~repurchase ~~Registration Rights Agreements~~the ~~associated~~remaining ~~with~~one-half ~~the original issuances~~ of such Warrants ~~will~~at beor ~~terminated~~prior ~~and~~to the ~~various~~closing ~~restrictions set forth therein will no longer be~~ of ~~any~~the ~~force or effect~~Merger. In ~~connection~~addition, ~~with~~upon ~~entering~~any ~~into~~closing of the ~~Warrants Repurchase Agreement~~Merger, weall Securities ~~were~~Purchase ~~granted~~Agreements ~~certain consents~~ and ~~waivers~~Registration ~~relating~~Rights toAgreements ~~the~~associated ~~Merger.~~with If the ~~Merger~~original isissuances ~~consummated,~~of wesuch ~~will~~Warrants will be ~~obligated~~terminated toand ~~repurchase~~ the ~~remaining~~various ~~outstanding Warrants~~restrictions ~~for~~set ~~approximately~~forth ~~$230,000~~therein ~~which~~ will beno ~~due~~longer ~~within~~be ~~three business days~~ of ~~closing~~any ~~the~~force ~~Merger~~or effect. In the event that we do not close the Merger or any other Fundamental Transaction, for whatever reason, then the remaining one-half of such Warrants will remain issued and outstanding. See Note 7 below.

~~Warrants~~14

Outstanding warrants to purchase common stock are as follows:

	Shares of Common Stock Issuable from Warrants Outstanding as of
	June 30,		December 31,		Exercise
	2017		2016		Price		Expiration
Equity-classified warrants:
March 2016		2,067,076		2,067,176	$	5.17		March 2021
April 2015		100,847		100,847	$	16.50		August 2020
April 2015		1,831		1,831	$	32.51		August 2020
February 2015		46,676		46,676	$	16.50		August 2020
June 2014		1,690		1,690	$	30.90		April 2018
December 2013		388,365		388,365	$	46.80		December 2018
June 2013		32,788		32,788	$	29.55		June 2019
May 2013		32,788		32,788	$	29.55		May 2019
March 2013		18,334		18,334	$	29.55		March 2019
October 2012		11,252		11,252	$	29.55		September 2018
Total		2,701,647		2,701,747

The number of warrants set forth in the table above are as of June 30, 2017 and December 31, 2016 and do not reflect the repurchase of half of the Warrants we completed on August 3, 2017.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

Warrants

Outstanding warrants to purchase common stock are as follows:

	Shares of Common Stock Issuable from Warrants Outstanding as of
	September 30,		December 31,		Exercise
	2017		2016		Price		Expiration
Equity-classified warrants:
March 2016		2,066,966		2,067,176	$	5.17		March 2021
April 2015		50,430		100,847	$	16.50		August 2020
April 2015		920		1,831	$	32.51		August 2020
February 2015		23,342		46,676	$	16.50		August 2020
June 2014		847		1,690	$	30.90		April 2018
December 2013		388,365		388,365	$	46.80		December 2018
June 2013		16,395		32,788	$	29.55		June 2019
May 2013		16,395		32,788	$	29.55		May 2019
March 2013		9,167		18,334	$	29.55		March 2019
October 2012		5,628		11,252	$	29.55		September 2018
Total		2,578,455		2,701,747

6. COMMITMENTS AND CONTINGENCIES

Executive Severance

We provide certain severance benefits such that if any of our executive officers is terminated for other than cause, death or disability, the executive will receive payments equal to three months’ base salary plus medical and dental benefits. In addition, we have implemented a Restated Executive Change of Control Severance Plan (as amended, the “Severance Plan”) that affects certain of our senior management-level employees who are classified as “Section 16 Officers” of the Company. Pursuant to the Severance Plan, if a participating employee is involuntarily terminated (other than for death, disability or for cause) or resigns for “good reason” (as defined in the Severance Plan) during the two-year period following a “change of control” (as defined in the Severance Plan) of the Company, then, subject to execution of a release of claims against the Company, the employee will be entitled to receive: (i) one-half times annual base salary (one times annual base salary for the Chief Executive Officer); (ii) immediate vesting of outstanding compensatory equity awards; and (iii) payment of COBRA premiums for the participating employee and eligible dependents for a pre-determined period of time. Payment of benefits under the Severance Plan will be limited by provisions contained in Section 409A of the U.S. Internal Revenue Code. The Severance Plan is administered by a plan administrator, which initially is the Compensation Committee of the Board of Directors. In order to participate in the Severance Plan, an eligible employee must waive any prior retention or severance agreements. The Severance Plan automatically renews annually unless terminated upon 12 months prior written notice. We expect that our Chief Executive Officer and Chief Financial Officer will receive benefits under the Severance Plan as a result of any consummation of the Merger.

Also, our Board of Directors and Compensation Committee have adopted a Transaction Bonus Plan (the “Transaction Bonus Plan”), which provides for certain bonus payments to be made, upon any consummation of a qualifying change of control transaction ~~such~~(as defined in the Transaction Bonus Plan) such as the Merger, to certain participants as shall be determined from time to time by the Compensation Committee of our Board of Directors. The aggregate value of the bonuses payable under the Transaction Bonus Plan shall be the greater of (i) $1,000,000 or (ii) ten percent of the net proceeds received in connection with a qualifying change of control transaction such as the Merger, and the percentage of such bonus pool awarded to each eligible participant shall be determined from time to time by our Compensation Committee.

Litigation

In 2002, we entered into a settlement agreement with Nanogen, Inc. (“Nanogen”) to settle all pending litigation between the parties. Pursuant to the terms of the settlement agreement, we agreed to make quarterly payments to Nanogen equal to 12.5% of total sales of products developed by us and our affiliates based on the patents that had been in dispute in the litigation, up to an annual maximum amount of $1.5 million. The minimum quarterly payments under the settlement agreement are $25,000 per quarter until the patents expire in 2018. Royalty expenses recognized under the agreement were $25,000 and $5075,000 for both of the three and ~~six~~nine months ended ~~June~~September 30, 2017 and 2016, respectively, and are included in patent amortization and royalties in in the accompanying consolidated statements of operations.

COMBIMATRIX CORPORATION

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)

(Unaudited)

From time to time, we are subject to other claims and legal actions that arise in the ordinary course of business. We believe that the ultimate liability with respect to these claims and legal actions, if any, will not have a material effect on our financial position, results of operations or cash flows. Any legal costs resulting from claims or legal actions are expensed as incurred.

7. ~~SUBSEQUENT~~PROPOSED ~~EVENTS~~MERGER WITH INVITAE CORPORATION

On July 31, 2017, we entered into the Merger Agreement with Invitae, pursuant to which Invitae plans to acquire us through an all-stock Merger. The Merger is subject to certain closing conditions, as set forth in the Merger Agreement, including, among others, obtaining certain regulatory approvals, approval from our stockholders, ~~Invitae’s~~and ~~registration~~at ofleast ~~common~~90% ~~stock~~participation toin bea ~~used~~Series toF ~~acquire us,~~Warrant ~~and~~exchange atoffer being ~~least~~conducted ~~90%~~by ~~participation~~Invitae in aconnection with the Merger. Any Series F ~~Warrants~~warrants that are exercised prior to expiration of the warrant exchange offer ~~that~~(including exercises contingent solely upon closing of the Merger) will be ~~conducted~~counted by Invitae intowards ~~connection with~~ the 90% ~~Merger~~threshold of participation.

16The Merger Agreement contains certain termination rights for both us and Invitae, including, among others, if the Merger is not consummated on or before January 31, 2018 (unless due to the terminating party’s action or failure to act or SEC delay) or if the approval of our stockholders is not obtained. If the Merger Agreement is terminated by either us or Invitae as a result of a breach by the other party of any of such other party’s representations, warranties or covenants, or because the occurrence of a material adverse effect applicable to such other party was the sole failed condition to closing, or if the Merger Agreement is terminated by Invitae as a result of the failure of our stockholders to approve the Merger Agreement or as a result of an adverse change in the recommendation of our board of directors, then the defaulting party will be obligated to reimburse the other party’s third party expenses up to a maximum of $400,000. The Merger Agreement further provides that, upon termination of the Merger Agreement under specified circumstances, including, among others, termination of the Merger Agreement as a result of an adverse change in the recommendation of our board of directors after receiving a bona fide alternative acquisition proposal or termination of the Merger Agreement as a result of our stockholders not approving the Merger Agreement following disclosure of a bona fide acquisition proposal after which we are sold within 12 months, we may be required to pay to Invitae a termination fee of up to $1.4 million (net of any expense reimbursement previously paid).

The Merger Agreement contains certain termination rights for both us and Invitae, including, among others, if the Merger is not consummated on or before January 31, 2018 (unless due to the terminating party’s action or failure to act or SEC delay) or if the approval of our stockholders is not obtained. If the Merger Agreement is terminated by either us or Invitae as a result of a breach by the other party of any of such other party’s representations, warranties or covenants, or because the occurrence of a material adverse effect applicable to such party was the sole failed condition to closing, or if the Merger Agreement is terminated by Invitae as a result of the failure of our stockholders to approve the Merger Agreement or as a result of an adverse change in the recommendation of our board of directors, then the defaulting party will be obligated to reimburse the other party’s third party expenses up to a maximum of $400,000. The Merger Agreement further provides that, upon termination of the Merger Agreement under specified circumstances, including, among others, termination of the Merger Agreement as a result of an adverse change in the recommendation of our board of directors after receiving a bona fide alternative acquisition proposal or termination of the Merger Agreement as a result of our stockholders not approving the Merger Agreement following disclosure of a bona fide acquisition proposal after which we are sold within 12 months, we may be required to pay to Invitae a termination fee of up to $1.4 million.

The foregoing description of the Merger Agreement is not a complete description of all of the parties’ rights and obligations under the Merger Agreement and is qualified in its entirety by reference to the Merger Agreement, which was filed as Exhibit 2.1 to our Current Report on Form 8-K filed with the SEC on July 31, 2017.

AsOn aSeptember ~~result~~13, of2017, ~~entering~~Invitae ~~into~~filed ~~and~~certain ~~announcing~~registration statements with the ~~Merger~~SEC ~~Agreement,~~in ~~and~~order ~~pursuant~~to register securities to be issued in the ~~terms~~Merger ofand the ~~Warrants~~Series ~~Repurchase~~F ~~Agreement~~Warrant exchange offer, as amended on September 28, 2017. These registration statements were declared effective by the SEC on October 5, 2017. On ~~August~~October 323, 2017, we ~~repurchased~~filed ~~one-half~~a ofproxy statement and solicitation materials regarding the ~~outstanding~~Special ~~Warrants~~Meeting ~~for~~of ~~approximately~~CombiMatrix ~~$230~~Stockholders to be held on November 10,~~000~~ 2017 at 1:00 PM Pacific time in Newport Beach, California. The primary purpose of ~~cash~~this ~~consideration~~meeting is for our stockholders to vote on the approval of the Merger and related proposals. The ~~remaining~~Series ~~half~~F Warrant exchange offer by Invitae is currently ongoing and will beexpire ~~due~~at ~~within~~12:00 ~~three~~midnight, ~~business~~New ~~days~~York City time, on November 13, 2017 (one minute after 11:59 p.m., New York City time, on November 13, 2017) unless extended. Assuming that our stockholders representing a majority of ~~any~~our issued and outstanding common stock as of September 26, 2017 vote in favor of the Merger and assuming other closing conditions are met, we anticipate closing of the Merger to occur during the fourth quarter of 2017.

1716

Item 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

Cautionary Statement

You should read the following discussion and analysis in conjunction with the consolidated financial statements and related notes thereto contained in Part I, Item 1 of this report. The information contained in this Quarterly Report on Form 10-Q is not a complete description of our businesses or the risks associated with an investment in our common stock. We urge you to carefully review and consider the various disclosures made by us in this report and in our other reports filed with the ~~U.S. Securities and Exchange Commission, or “~~SEC,” including our Annual Report on Form 10-K for the year ended December 31, 2016, filed with the SEC on March 3, 2017.

This report contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical fact included in this report, are forward-looking statements. Reference is made in particular to the description of our plans and objectives for future operations, assumptions underlying such plans and objectives, and other forward-looking statements included in this report. Such statements may be identified by the use of forward-looking terminology such as “may,” “will,” “should,” “would,” “could,” “expect,” “believe,” “estimate,” “anticipate,” “intend,” “plan,” “predict,” “seek,” “potential,” “more likely to,” “with a view to,” “our future success depends,” “continue,” “focus,” “ongoing,” or similar terms, variations of such terms or the negative of such terms, and include, but are not limited to, statements regarding projected results of operations, capital expenditures, earnings, management’s future strategic plans, development of new technologies and services, litigation, regulatory matters, market acceptance and performance of our services, the success and effectiveness of our technologies and services, our ability to retain and hire key personnel, the competitive nature of and anticipated growth in our markets, market size, market position of our services, marketing efforts and partnerships, liquidity and capital resources, our accounting estimates, and our assumptions and judgments. Such statements are based on management’s current expectations, estimates and projections about our industry, management’s beliefs, and certain assumptions made by us, all of which are subject to change. These forward looking statements are not guarantees of future results and are subject to a number of risks, uncertainties and assumptions that are difficult to predict and that could cause actual results to differ materially and adversely from those described in the forward-looking statements. The risks and uncertainties referred to above include, but are not limited to, the risk that holders of less than 90% of our Series F Warrants tender or exercise their securities or our ~~stockholders~~ stockholders fail to approve the Merger and the Merger Agreement is terminated due to these reasons; the occurrence of any event, change or other circumstances that could give rise to the termination of the Merger Agreement; the possibility that the proposed ~~Merger~~ Merger is delayed; the inability to complete the Merger due to the failure to satisfy any of the conditions to completion of the Merger; the impact of the announcement or the completion of the Merger on the market price of our or Invitae’s common stock, or or on our or Invitae’s relationships with employees, existing customers and suppliers or potential future customers and ~~suppliers~~ suppliers and on our or Invitae’s operating results and businesses generally; the ability of Invitae to successfully integrate ~~our~~ our operations and employees; the ability to realize anticipated synergies and costs savings of the proposed Merger; the risk ~~that~~ that if the Merger is terminated and we have to pay termination fees and transaction expenses, we may not have sufficient funds to to make such payments; our ability to grow revenue and improve gross margin; delays in achieving cash flow-positive operating results; the risk that operating expenses are not reduced or increase; the risk that test volumes and reimbursements level off or decline; the risk that payors decide to not cover our tests or to reduce the amounts they are willing to pay for our tests; the risk that we will not be able to grow our business as quickly as we need to; our ability to successfully increase the volume of our existing tests, expand the number of tests offered by our laboratory, increase the number of customers and partners and improve reimbursement for our testing; market acceptance of chromosomal microarray analysis, or CMA, as a preferred method over karyotyping; the rate of transition to CMA from karyotyping; changes in consumer demand; third-party reimbursement of CMA; our ability to attract and retain a qualified sales force and key technical personnel; our ability to successfully develop and introduce new technologies and services; rapid technological change in our markets; supply availability; our ability to bill and obtain reimbursement for highly specialized tests; the rate of growth of the in vitro fertilization, or IVF, diagnostic testing market; our ability to comply with regulations to which our business is subject, including changes in coding and reimbursement methods; legislative, regulatory and competitive developments in markets in which we and our subsidiaries operate; our limited market capitalization; our ability to obtain additional financing for working capital on acceptable terms and in a timely manner; future economic conditions; other circumstances affecting anticipated revenues and costs; and other factors as more fully disclosed in our discussion of risk factors in Item 1A of Part II of this report and in the “Risk Factors” described in our Annual Report on Form 10-K for the year ended December 31, 2016, filed with the SEC on March 3, 2017. These forward-looking statements speak only as of the date of this report and we expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations with regard thereto or any change in events, conditions, or circumstances on which any such statement is based, except as otherwise required by law.

1817

General

We are a family health-focused clinical molecular diagnostic laboratory specializing in pre-implantation genetic screening, prenatal diagnosis, miscarriage analysis, and pediatric developmental disorders. We strive to provide best-in-class clinical laboratory support to healthcare professionals, allowing them to maximize the clinical utility of their patients’ test results and to optimize patient care. Our testing focuses on advanced technologies, including single nucleotide polymorphism chromosomal microarray analysis, next generation sequencing, fluorescent in situ hybridization and high resolution karyotyping. Our approach to testing is to offer sophisticated technology along with high quality clinical support to our ordering physicians and their patients. Our laboratory facilities and corporate headquarters are located in Irvine, California.

We also own a one-third minority interest in Leuchemix, Inc., a private drug development company focused on developing a series of compounds to address a number of oncology-related diseases.

Overview of Recent Developments and Business Activities

For the three and ~~six~~nine months ended ~~June~~September 30, 2017, our business activities were driven primarily by continued commercialization ~~efforts~~ efforts for our suite of molecular diagnostic tests and expansion of our executive oversight and leadership. For the three and nine ~~six~~ months ended ~~June~~September 30, 2017, our operating activities included the recognition of $4.20 million and $812.0 million of total revenues, respectively, which increased by $~~1.1~~764,000 ~~million~~ and $12.97 million, respectively, from the comparable 2016 periods. These increases were due primarily to increased testing volumes and improved pricing and reimbursement of our microarray diagnostic tests, particularly in the reproductive health testing market (defined as testing volumes from prenatal, miscarriage analysis and pre-implantation genetic screening, or PGS diagnostic tests). Revenues from our reproductive health testing services increased by 4430% and 3835% during the three and ~~six~~ nine months ended ~~June~~September 30, 2017, respectively, compared to the comparable periods in 2016. Total ~~diagnostic~~ testing revenues ~~during~~ during the three and ~~six~~nine months ended ~~June~~September 30, 2017 increased by 3824% and 3329%, respectively, over the comparable periods in 2016. For the three and ~~six~~nine months ended ~~June~~September 30, 2017, our net loss decreased by $~~865~~246,000 and $12.81 million, respectively, compared to the comparable 2016 periods, due to increased revenues, and improved gross margins, partially offset by higher general and ~~relatively~~administrative ~~flat~~costs ~~operating~~due to increased merger-related expenses for all periods presented.

In January 2017, we appointed Dr. James W. Wheless to our Scientific Advisory Board. Dr. Wheless is a Diplomat of the American Board of Pediatrics and the American Board of Psychiatry and Neurology with special qualifications in child neurology, clinical neurophysiology and epilepsy. He is a fellow of the American Academy of Pediatrics and the American Academy of Neurology.

In February 2017, we appointed Dirk van den Boom, Ph.D., to our Board of Directors. Dr. van den Boom most recently served as President, Chief Executive Officer and Director of publicly traded molecular diagnostics company Sequenom, Inc., prior to that company’s acquisition by Laboratory Corporation of America in September 2016. Dr. van den Boom has co-authored more than 95 articles published in peer-reviewed journals and is inventor on more than 80 patents and patent applications.

In July 2017, we entered into a merger agreement (the “Merger Agreement”) with Invitae, Corporation (“Invitae”), pursuant to which Invitae plans to acquire us through an all-stock merger (the “Merger”). The Merger is subject to certain closing conditions, as set forth in the Merger Agreement, including, among others, obtaining certain regulatory approvals, approval from our stockholders, ~~Invitae’s~~and ~~registration~~at ofleast ~~common~~90% ~~stock~~participation toin bea ~~used~~Series toF ~~acquire us,~~Warrant ~~and~~exchange atoffer ~~least~~being ~~90%~~conducted ~~participation~~by Invitae in aconnection with the Merger (however, any Series F ~~Warrants~~warrants that are exercised prior to expiration of the warrant exchange offer (including ~~that~~exercises contingent solely upon closing of the Merger) will be ~~conducted~~counted by Invitae intowards ~~connection with~~ the ~~Merger.~~90% threshold of participation). We expect to incur significant expenses in connection with the Merger. While we have assumed that a certain level of expenses will be incurred, there are many factors that could affect the total amount or the timing of the Merger expenses, and many of the expenses that will be incurred are, by their nature, difficult to estimate. The ultimate amount and timing of such charges are uncertain at the present time.

The Merger Agreement contains certain termination rights for both us and Invitae, including, among others, if the Merger is not consummated on or before January 31, 2018 (unless due to the terminating party’s action or failure to act or SEC delay) or if the approval of our stockholders is not obtained. If the Merger Agreement is terminated by either us or Invitae as a result of a breach by the other party of any of such other party’s representations, warranties or covenants, or because the occurrence of a material adverse effect applicable to such other party was the sole failed condition to closing, or if the Merger Agreement is terminated by by Invitae as a result of the failure of our stockholders to approve the Merger Agreement or as a result of an adverse change in in the recommendation of our board of directors, then the defaulting party will be obligated to reimburse the other party’s third party expenses up to a maximum of $400,000. The Merger Agreement further provides that, upon termination of the Merger Agreement under specified circumstances, including, among others, termination of the Merger Agreement as a result of an adverse change in the recommendation of our board of directors after receiving a bona fide alternative acquisition proposal or termination of the Merger Agreement as a result of our stockholders not approving the Merger Agreement following disclosure of a bona fide acquisition proposal after which we are sold within 12 months, we may be required to pay to Invitae a termination fee of up to $1.4 million (net of any expense reimbursement previously paid).

1918

As a result of entering into and announcing the Merger Agreement, and pursuant to the terms of the Warrants Repurchase Agreement, on August 3, 2017, we repurchased one -half of the outstanding Warrants for approximately $230,000 of cash consideration. ~~The remaining~~Under ~~half~~the terms of the Warrants Repurchase Agreement, we will be ~~due~~obligated to repurchase the remaining one-half of such Warrants for an additional $230,000 within three business days of any closing of the Merger. However, under the terms of the Merger Agreement, we are required to repurchase the remaining one-half of such Warrants at or prior to the closing of the Merger.

On September 13, 2017, Invitae filed certain registration statements with the SEC in order to register securities issued in the Merger and the Series F Warrant exchange offer, as amended on September 28, 2017. These registration statements were declared effective on October 5, 2017. On October 23, 2017, we filed a proxy statement and solicitation materials regarding the Special Meeting of CombiMatrix Stockholders to be held on November 10, 2017 at 1:00 PM Pacific time in Newport Beach, California. The primary purpose of this meeting is for our stockholders to vote on the approval of the Merger and related proposals. The Series F Warrant exchange offer by Invitae is currently ongoing and will expire at 12:00 midnight, New York City time, on November 13, 2017 (one minute after 11:59 p.m., New York City time, on November 13, 2017) unless extended. Assuming that our stockholders representing a majority of our issued and outstanding common stock as of September 26, 2017 vote in favor of the Merger and assuming other closing conditions are met, we anticipate closing of the Merger to occur during the fourth quarter of 2017.

Critical Accounting Estimates

Our unaudited interim financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America. Preparation of these statements requires management to make judgments and estimates. Some accounting policies have a significant impact on amounts reported in these financial statements. A summary of significant accounting policies and a description of accounting policies that are considered critical may be found in our Annual Report on Form 10-K for the year ended December 31, 2016, filed with the SEC on March 3, 2017, in the Notes to the Consolidated Financial Statements and the Critical Accounting Estimates sections. In addition, refer to Note 2 to the consolidated interim financial statements included in Part I, Item 1 of this report.

Comparison of the Results of Operations for the Three and ~~Six~~Nine ~~Months~~months Ended ~~June~~September 30, 2017 and 2016

Revenues and Cost of Services (dollars in thousands):

	Three Months Ended												~~Six~~Nine Months Ended
	June 30,						Change						June 30,						Change
	September 30,						Change						September 30,						Change
	2017			2016			$			%			2017			2016			$			%
Diagnostic services revenues	$	43,~~214~~977		$	3,~~049~~211		$	~~1,165~~766			~~38%~~24	%	$	711,~~972~~949		$	59,~~979~~190		$	12,~~993~~759			~~33%~~30	%
Royalty revenues		2735			5837			(312	)		(~~53%~~5	%)		5691			~~100~~137			(4446	)		(~~44%~~34	%)
Cost of services		(1,~~632~~614	)		(1,~~432~~476	)		(~~200~~138	)		~~(14%~~9	)%		(34,~~140~~754	)		(24,~~851~~327	)		(~~289~~427	)		(10%	)%

Diagnostic Services Revenues. Diagnostic services revenues are generated from providing DNA-based genomic testing services primarily in the areas of PGS, miscarriage analysis, prenatal diagnostics (collectively referred to as “reproductive health” testing) and postnatal development disorders in children. The key drivers and metrics relating to the change in diagnostic services revenues were as follows:

	Three Months Ended								Six Months Ended
	June 30,				Change				June 30,				Change
	2017		2016		#		%		2017		2016		#		%
Total billable tests		3,087		2,780		307		11%		6,025		5,428		597		11%
Total reproductive health microarray tests (1)		1,748		1,403		345		25%		3,390		2,829		561		20%
Reproductive health percentage of total billable tests		56.6%		50.5%						56.3%		52.1%
Revenue per test - total billable tests	$	1,365	$	1,097	$	268		24%	$	1,323	$	1,102	$	221		20%
Revenue per test - total reproductive health microarray tests (1)	$	1,795	$	1,555	$	240		15%	$	1,768	$	1,536	$	232		15%

	Three Months Ended											Nine Months Ended
	September 30,						Change					September 30,						Change
	2017			2016			#		%			2017			2016			#		%

Total billable tests		2,952			2,835			117		4	%		8,977			8,263			714		9	%
Total reproductive health tests(1)		1,764			1,483			281		19	%		5,154			4,312			842		20	%
Reproductive health percentage of total billable tests		59.8	%		52.3	%							57.4	%		52.2	%

Revenue per test - total billable tests	$	1,347		$	1,133		$	214		19	%	$	1,331		$	1,112		$	219		20	%
Revenue per test - total reproductive health tests(1)	$	1,709		$	1,562		$	147		9	%	$	1,748		$	1,545		$	203		13	%

(1) includes PGS, PGD, prenatal and miscarriage analysis microarray tests

For the three months ended ~~June~~September 30, 2017, total billable tests and total diagnostic services revenues increased by 114% and 3824%, respectively, compared to the three months ended ~~June~~September 30, 2016. For the ~~six~~nine months ended ~~June~~September 30, 2017, total billable tests and total diagnostic services revenues increased by 119% and 3330%, respectively, compared to the ~~six~~nine months ended ~~June~~ September 30, 2016. Driving the increase in total billable tests and diagnostic services revenues for all periods presented were the increases in reproductive health testing volumes, which increased by 2519% and 20% for the three and ~~six~~nine months ended ~~June~~September 30, 2017 compared to the comparable 2016 periods, respectively. We believe this reflects the commercialization strategies and focus of our sales force, which have emphasized reproductive health microarray diagnostics testing over traditional genomics testing. In addition, improved reimbursement from third-party payors for our microarray tests drove higher revenues per test in our reproductive health segment, thereby resulting in a higher percentage increase in total diagnostic services revenues compared to the percentage increase in diagnostic testing volumes.

20Diagnostic services revenues are recognized based on: i) contractual rates billed to our customers and certain third party payors; and ii) amounts that we expect to collect from non-contracted third-party payors, which include adjustments for changes in estimates of contractual allowances as well as from receiving cash payments in excess of amounts previously recognized. Because approximately 71% of our diagnostic revenues in 2017 resulted from billings to third-party payors, most of which are non-contracted, it is likely that we will be required to make adjustments to these accounting estimates in the future, which may positively or adversely affect our revenues and results of operations.

~~Diagnostic~~Royalties. ~~services~~In ~~revenues~~2010, ~~are~~we ~~recognized~~entered ~~based~~into ~~on:~~an i)exclusive ~~contractual~~licensing ~~rates~~agreement ~~billed~~with toCustomArray, ~~our~~Inc. ~~customers~~(“CA”), ~~and~~a ~~certain~~private ~~third~~company ~~party payors; and ii)~~located ~~amounts~~in ~~that~~Washington weState, ~~expect~~ to ~~collect~~license from ~~non-contracted~~us ~~third-party~~certain ~~payors,~~of ~~which~~our ~~include~~patents ~~adjustments~~and ~~for~~intellectual ~~changes~~property indeveloped ~~estimates~~as part of ~~contractual~~ ~~allowances~~our asprior ~~well~~microarray manufacturing asbusiness. ~~from~~This ~~receiving~~agreement ~~cash~~requires ~~payments~~CA into ~~excess~~pay ofus ~~amounts~~royalties ~~previously~~as ~~recognized.~~a ~~Because~~percentage ~~approximately 72%~~ of ~~our~~their ~~diagnostic~~gross revenues, inwith ~~2017~~a ~~resulted~~minimum floor ~~from~~of ~~billings~~not toless ~~third-party~~than ~~payors~~$25,000 ~~most~~per ofquarter. ~~which~~The ~~are~~changes ~~non-contracted,~~in itroyalty isrevenues ~~likely that~~reported wereflect ~~will~~changes bein ~~required~~CA’s torevenues. ~~make~~It is ~~adjustments~~uncertain towhether ~~these~~CA’s ~~accounting~~revenues ~~estimates~~will inincrease ~~the~~or ~~future,~~continue ~~which~~at ~~may~~the ~~positively~~minimum orcontractual ~~adversely~~amounts ~~affect our~~in ~~revenues~~future ~~and results of operations~~periods.

Royalties. In 2010, we entered into an exclusive licensing agreement with CustomArray, Inc. (“CA”), a private company located in Washington State, to license from us certain of our patents and intellectual property developed as part of our prior microarray manufacturing business. This agreement requires CA to pay us royalties as a percentage of their gross revenues, with a minimum floor of not less than $25,000 per quarter. The changes in royalty revenues reported reflect changes in CA’s revenues. It is uncertain whether in future periods, CA’s revenues will increase or continue at the minimum contractual amounts.

Cost of Services. Cost of services relating to our diagnostic tests performed include direct materials such as microarray slides, reagents and related laboratory materials, direct laboratory labor (wages and benefits), allocation of administrative overhead and stock-compensation expenses. Increases in cost of services for all periods presented were due primarily to increased diagnostic testing volumes previously discussed. Non-cash stock compensation expenses were not significant for the periods presented.

Operating Expenses (dollars in thousands):

	Three Months Ended										~~Six~~Nine Months Ended
	June 30,				Change						June 30,				Change
	September 30,				Change						September 30,				Change
	2017		2016		$			%			2017		2016		$			%
Research and development	$	8590	$	~~149~~88	$	~~(64~~2	)		~~(43%~~2	)%	$	~~170~~260	$	~~292~~380	$	(~~122~~120	)		(~~42%~~32	%)
Sales and marketing		~~1,016~~967		1,~~141~~055		(~~125~~88	)		(~~11%~~8	%)		23,~~038~~005		23,~~477~~532		(~~439~~527	)		(~~18%~~15	%)
General and administrative		1,~~855~~930		1,~~586~~450		~~269~~480			~~17%~~33	%		35,~~519~~449		34,~~112~~562		~~407~~887			~~13%~~19	%

Research and Development. These expenses include labor (wages and benefits), non-cash stock compensation expenses and laboratory supply costs associated with investigating and validating new tests and technology platforms, costs to maintain and improve our existing suite of diagnostic tests offered and process improvement projects. Prior to launching a new test or technology, or modifying an existing test, appropriate clinical trials and extensive laboratory validations, consistent with the various regulations that govern our industry, must be performed. These costs are classified as research and development for all periods presented. For the three and six months ended June 30, 2017, research and development expenses decreased from the comparable 2016 periods due primarily to greater efforts during 2016 in launching a next generation sequencing platform for our PGS testing services coupled with validating new microarray testing platforms for our miscarriage analysis tests. These efforts were not repeated during the three and six month periods ended June 30, 2017. Non-cash stock compensation expenses were not significant for the periods presented.20

~~Sales~~Research and ~~Marketing~~Development. These expenses include ~~salaries and~~labor (wages and benefits), non-cash stock compensation expenses and laboratory supply costs associated with investigating and validating new tests and technology platforms, costs to maintain and improve our ~~sales~~existing suite ~~force~~of diagnostic tests offered and ~~marketing~~process ~~resources~~improvement projects. Prior to launching a new test or technology, ~~sales~~or ~~commissions~~modifying an existing test, extensive laboratory validations and ~~other~~appropriate ~~expenses~~clinical ~~associated~~testing, consistent with ~~promotional~~the various ~~and~~regulations ~~advertising~~that ~~efforts~~govern asour ~~well~~industry, must be performed. These costs are classified as ~~non-cash~~research ~~stock~~and ~~compensation~~development ~~expenses~~for all periods presented. For the three months ended September 30, 2017, the small increase in research and ~~six~~development expenses reflects essentially equivalent efforts for these comparable periods and reflects what management believes is a baseline level of research and development for the Company. For the nine months ended ~~June~~September 30, 2017, ~~sales~~ research and ~~marketing~~development expenses decreased from the comparable 2016 ~~periods~~period due primarily to ~~reduced~~greater ~~headcount~~efforts induring ~~sales~~2016 ~~representatives coupled~~in ~~with~~launching ~~newer~~a ~~sales~~next ~~representatives~~generation ~~earning~~sequencing ~~lower~~platform ~~base~~for ~~salaries~~our ~~compared~~PGS totesting services ~~the~~coupled ~~prior~~with ~~year~~validating ~~mix~~new ofmicroarray ~~sales~~testing ~~representatives, coupled~~platforms ~~with~~for ~~reduced~~our ~~travel~~miscarriage ~~and~~analysis ~~entertainment~~tests. ~~costs~~These ~~from~~efforts ~~fewer~~were ~~sales~~not ~~headcount~~repeated during in the ~~2017~~nine month periods ~~compared~~ended toSeptember ~~the~~30, ~~2016 periods presented~~2017. Non-cash stock compensation expenses were not significant for the periods presented.

~~General~~Sales and ~~Administrative~~Marketing. These expenses include ~~compensation~~ salaries and ~~benefit~~wages ~~costs~~associated ofwith our ~~administrative~~sales ~~staff,~~force ~~client billing~~ and ~~collections,~~marketing ~~information technology~~resources, ~~executive~~sales commissions ~~management,~~and ~~human~~other ~~resources~~expenses associated with promotional and ~~accounting~~advertising ~~personnel,~~efforts as well as ~~facilities~~non-~~related~~cash ~~costs,~~stock ~~insurance,~~compensation ~~legal, audit and other professional services~~expenses. For the three and ~~six~~nine months ended ~~June~~September 30, 2017, ~~general~~sales and ~~administrative~~marketing expenses ~~increased~~decreased from the comparable 2016 periods due primarily to ~~increased~~reduced ~~legal~~headcount ~~and bad debt expenses. Also included~~ in ~~general~~sales ~~and~~representatives ~~administrative~~coupled ~~expenses~~with ~~are non-cash~~newer ~~stock-based~~sales ~~compensation~~representatives ~~expenses,~~earning ~~which~~lower ~~were~~base ~~$128,000,~~salaries ~~$294,000,~~compared ~~$169,000 and $341,000 for~~ to the ~~three~~prior ~~and~~year ~~six~~mix ~~months ended~~of ~~June~~sales 30representatives, ~~2017~~coupled ~~and~~with ~~2016,~~reduced ~~respectively.~~travel ~~Changes~~and toentertainment ~~stock-based~~costs ~~compensation~~from ~~expenses~~fewer ~~are~~sales ~~driven~~headcount ~~by timing of when newer option~~in ~~awards~~the ~~are~~2017 ~~granted~~periods compared to ~~when older awards become fully vested or expire due to forfeitures, as well as by~~ the ~~differences in~~2016 ~~valuations~~periods ~~attributed to individual awards at the time they are granted~~presented. ~~See Note 2 to our consolidated interim financial statements included in Part I, Item 1 of this report for a detailed description of the amounts of non~~Non-cash stock compensation ~~expense~~expenses ~~recognized~~ were not significant for the periods presented.

21General and Administrative. These expenses include compensation and benefit costs of our administrative staff, client billing and collections, information technology, executive management, human resources and accounting personnel, as well as facilities-related costs, insurance, legal, audit and other professional services. In addition, all of our one-time, merger-related expenses, which are primarily legal and accounting related, are also included in general and administrative expenses. For the three and nine months ended September 30, 2017, general and administrative expenses increased from the comparable 2016 periods due primarily to increased merger-related costs, which were $391,000 and $601,000, respectively. Also included in general and administrative expenses are non-cash stock-based compensation expenses, which were $137,000, $431,000, $153,000 and $494,000 for the three and nine months ended September 30, 2017 and 2016, respectively. Changes to stock-based compensation expenses are driven by the timing of when newer option awards are granted compared to when older awards become fully vested or expire due to forfeitures, as well as by the differences in valuations attributed to individual awards at the time they are granted. See Note 2 to our consolidated interim financial statements included in Part I, Item 1 of this report for a detailed description of the amounts of non-cash stock compensation expense recognized for the periods presented.

Inflation

Inflation has not had a significant impact on our business, results of operations or financial condition.

Liquidity and Capital Resources

At ~~June~~September 30, 2017, cash and cash equivalents totaled $32.04 million, compared to $3.7 million at December 31, 2016. Cash is held ~~primarily~~ primarily in general checking accounts as well as in money market mutual funds backed by U.S. government securities. When held, short-term investments typically are comprised primarily of certificates of deposits issued by U.S. financial institutions. Working ~~capital~~ capital was $54.69 million and $6.1 million at ~~June~~September 30, 2017 and December 31, 2016, respectively. The primary reason for the decrease in working capital was due to lower overall cash balances at ~~June~~September 30, 2017 compared to December 31, 2016, driven by operating, investing and financing activities described below.

The net change in cash and cash equivalents for the periods presented was comprised of the following (in thousands):

	Six Months Ended
	Nine Months Ended
	June 30,
	September 30,
	2017			2016			Change
Net cash provided by (used in):
Operating activities	$	(~~607~~995	)	$	(23,~~544~~361	)	$	12,~~937~~366
Investing activities		~~996~~989			23,~~603~~102			(12,~~607~~113	)
Financing activities		(94339	)		43,~~015~~951			(4,~~109~~290	)
Increase in cash and cash equivalents	$	~~295~~(345	)	$	43,~~074~~692		$	(34,~~779~~037	)

Operating Activities. Higher cash inflows from improved cash collections coupled with slightly lower overall operating expenses during the six months ended June 30, 2017 resulted in lower cash used in operating activities compared to the six months ended June 30, 2016.21

~~Investing~~Operating Activities. ~~The~~Higher ~~decrease in net~~ cash ~~flows~~inflows from ~~investing~~improved ~~activities~~cash ~~was~~collections ~~due to reduced net sales of available-for-sale short-term investments made~~ during the ~~six~~nine months ended ~~June~~September 30, 2017 resulted in lower cash used in operating activities compared to the ~~comparable~~nine ~~period~~months inended September 30, 2016.

~~Financing~~Investing Activities. The decrease in net cash flows from ~~financing~~investing activities was due ~~primarily~~ to ~~the~~reduced ~~$6.9 million of~~ net ~~proceeds received~~sales ~~from the March 2016 Series F Financing, partially offset by the $2.8 million repurchase~~ of ~~Series~~available-for-sale ~~E preferred stock and~~short-term ~~dividends~~investments ~~paid~~made toduring the ~~Series~~nine Emonths ~~investors~~ended ~~commensurate~~September ~~with the 2016 Series F Financing~~30, 2017 compared to nothe ~~sales~~comparable orperiod ~~repurchases of CombiMatrix securities~~ in ~~2017~~2016.

~~Future~~Financing ~~Liquidity~~Activities. WeThe ~~have~~decrease ain ~~history of incurring~~ net ~~losses and net operating~~ cash ~~flow~~flows ~~deficits.~~from Wefinancing ~~are~~activities ~~also~~was ~~deploying~~due ~~new~~primarily ~~services and continue~~ to ~~develop~~the ~~commercial technologies and services. We believe that our cash and cash equivalents as of June 30, 2017, which totaled~~ $36.09 million, ~~will~~of benet ~~sufficient to meet our expected cash requirements for current operations through and beyond~~proceeds ~~the~~received ~~fourth~~from ~~quarter of 2017, when we anticipate achieving cash flow break-even status. If~~ the ~~Merger~~March is2016 ~~terminated,~~Series ~~however,~~F ~~and we have to pay termination fees and transaction expenses~~Financing, wepartially ~~may~~offset ~~not~~by ~~have~~the ~~sufficient funds to make such payments~~$2.8 Inmillion ~~order~~repurchase ~~for us~~of toSeries ~~continue~~E aspreferred astock ~~going concern beyond this point~~ and dividends topaid ~~ultimately achieve profitability, we may be required~~ to ~~obtain~~the ~~capital from~~Series ~~external~~E ~~sources,~~investors ~~increase~~commensurate ~~revenues~~with ~~and~~the ~~reduce~~2016 ~~operating~~Series ~~costs.~~F ~~However~~Financing, ~~there~~compared ~~can~~to be no ~~assurance~~sales ~~that our operations will become profitable~~ or ~~that~~repurchases ~~external sources~~ of ~~financing, including the issuance of debt and/or equity securities, will be available~~ ~~at times and on terms acceptable to us, or at all. The issuance of additional equity or convertible debt securities will also cause dilution to~~ our ~~stockholders. Also, in order to issue~~ securities ~~at a price below the exercise prices of our outstanding warrants issued~~ in ~~connection with our past preferred stock private placement financings~~2017, webut ~~must~~instead ~~obtain~~is ~~the~~comprised ~~affirmative~~primarily ~~consent~~ of ~~holders~~the of$230,000 atrepurchase ~~least 67%~~ of ~~each~~one-half ~~series~~ of ~~such outstanding warrants. If we are unable to obtain~~ the ~~consent~~Warrants ofdescribed ~~these holders in connection with future financings, we may be unable to raise additional capital on acceptable terms, or at all~~above. If external financing sources are not available or are inadequate to fund our operations, we will be required to reduce operating costs, including research projects and personnel, which could compromise our future strategic initiatives and business plans.

22Future Liquidity. We have a history of incurring net losses and net operating cash flow deficits. We also incur expenses from deploying new services and from continuing to develop commercial technologies and services. We believe that our cash and cash equivalents as of September 30, 2017, which totaled $2.4 million, will be sufficient to meet our expected cash requirements for current operations through and beyond the first quarter of 2018, when we anticipate achieving cash flow break-even status. If the Merger is terminated, however, and we have to pay termination fees and transaction expenses, we may not have sufficient funds to make such payments. In order for us to continue as a going concern beyond this point and to ultimately achieve profitability, we may be required to obtain capital from external sources, increase revenues and reduce operating costs. However, there can be no assurance that our operations will become profitable or that external sources of financing, including the issuance of debt and/or equity securities, will be available at times and on terms acceptable to us, or at all. The issuance of additional equity or convertible debt securities will also cause dilution to our stockholders. Also, in order to issue securities at a price below the exercise prices of our outstanding warrants issued in connection with our past preferred stock private placement financings, we must obtain the affirmative consent of holders of at least 67% of each series of such outstanding warrants. If we are unable to obtain the consent of these holders in connection with future financings, we may be unable to raise additional capital on acceptable terms, or at all. If external financing sources are not available or are inadequate to fund our operations, we will be required to reduce operating costs, including research projects and personnel, which could compromise our future strategic initiatives and business plans.

Capital Requirements. We may also encounter unforeseen difficulties that may deplete our capital resources more rapidly than anticipated. As a result, we may be required to seek additional funding through equity, debt or other external financing, and there can be no assurance that additional funding will be available on favorable terms, in a timely fashion or at all. At this time, we have no significant commitments for capital expenditures in 2017 or beyond. However, our long-term capital requirements could be substantial and the adequacy of available funds will depend upon many factors, including:

	●	the costs of commercialization activities, including sales and marketing costs and capital equipment;

	●	competing technological developments;

	●	the creation and formation of strategic partnerships;

	●	variability in third-party reimbursement for our diagnostic tests;

	●	the costs associated with leasing and improving our Irvine, California facility; and

	●	other factors that may not be within our control.

Off-Balance Sheet Arrangements

As of ~~June~~September 30, 2017, we did not have any significant off-balance sheet arrangements, as defined in Item 303(a)(4)(ii) of Regulation S-K promulgated by the SEC. We have entered into an operating lease for our laboratory space and corporate offices, totaling approximately 12,200 square feet, expiring in early 2020. We have no significant commitments for capital expenditures for the remainder of 2017 or beyond. We currently have ~~eight~~seven active capital leases totaling $~~236~~271,000 for certain laboratory and IT-related equipment, with lease payments continuing through ~~February~~September 2021.

Recent Accounting Pronouncements

See Note 2 to the consolidated interim financial statements included in Part I, Item 1 of this report for a discussion on recent accounting pronouncements.

Item 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Not required for smaller reporting companies.

Item 4. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

Under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, we conducted an evaluation of our disclosure controls and procedures, as such term is defined under Rules 13a-15(e) and 15d-15(e) promulgated under the Securities Exchange Act of 1934, as amended (the “Exchange Act”). Based on this evaluation, our principal executive officer and our principal financial officer concluded that as of ~~June~~September 30, 2017, our disclosure controls and procedures were effective in ensuring that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is (i) recorded, processed, summarized and reported within the time periods prescribed by the SEC and (ii) accumulated and communicated to our management, including our principal executive and principal financial officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) that occurred during our last fiscal quarter (the quarter ended ~~June~~September 30, 2017) that have materially affected, or are ~~reasonably~~ reasonably likely to materially affect, our internal control over financial reporting.

PART II—OTHER INFORMATION

Item 1. LEGAL PROCEEDINGS

From time to time, we are involved in other litigation arising in the normal course of business. Management believes that resolution of these other matters will not result in any payment that, in the aggregate, would be material to our financial position or results of operations.

Item 1A. RISK FACTORS

The following risk factors include any and all material changes to, and should be read in conjunction with, the risk factors contained in Part 1, Item 1A of our Annual Report on Form 10-K for the fiscal year ended December 31, 2016, filed with the SEC on March 3, 2017.

The completion of the proposed Merger is subject to a number of conditions ~~beyond~~that are outside our control., ~~Failure~~and tothere ~~complete~~can be no assurance that the proposed Merger ~~within~~will ~~the~~be ~~expected~~completed ~~time~~in ~~frame~~ a timely manner or at all. ~~could~~If ~~adversely~~the ~~affect~~Merger is not consummated, our ~~stock~~business ~~price~~could suffer materially and our ~~future~~stock ~~business~~price ~~and~~could ~~financial results~~decline.

The consummation of the proposed Merger between Invitae and us is subject to a number of closing conditions, ~~beyond~~including ~~our~~but ~~control~~not ~~that~~limited to ~~may~~(i) ~~prevent,~~the ~~delay~~approval orby ~~otherwise~~our ~~materially~~stockholders ~~adversely~~and ~~affect~~(ii) ~~its~~ completion~~, including,~~ ~~without~~of ~~limitation,~~the ~~obtaining~~Series ~~certain~~F ~~regulatory~~Warrant ~~approvals,~~exchange ~~the~~offer ~~absence~~being ofconducted aby ~~material adverse effect~~Invitae ~~upon~~in ~~either~~connection ~~party,~~with ~~approval~~the ~~from our stockholders~~Merger, ~~Invitae’s~~which ~~registration~~requires of(a) ~~common~~a ~~stock~~minimum toparticipation belevel ~~used~~by toholders ~~acquire~~of ~~us, and~~ at least 90% ~~participation~~of inthe a Series F ~~Warrants~~warrants outstanding ~~exchange~~immediately ~~offer~~prior ~~that~~to ~~will~~the bedate ~~conducted~~of bythe ~~Invitae~~Merger inAgreement ~~connection~~(however, ~~with~~any ~~the Merger.~~Series WeF ~~cannot~~warrants ~~predict~~that ~~whether~~are ~~and~~exercised ~~when~~prior ~~these~~to expiration ~~conditions~~of ~~will~~the bewarrant ~~satisfied.~~exchange ~~Any~~offer ~~delay~~(including inexercises ~~completing~~contingent ~~the~~solely ~~Merger~~upon ~~could~~closing ~~cause~~ of the ~~combined~~Merger) ~~company~~will ~~not~~be tocounted ~~realize~~by Invitae ~~some~~towards orthe ~~all~~90% threshold of ~~the~~participation), ~~synergies~~and ~~expected~~(b) toother beclosing ~~achieved.~~conditions Weto ~~will~~the ~~also~~Series ~~incur~~F ~~certain~~Warrant ~~transaction~~exchange offer are ~~costs~~satisfied. ~~whether~~The orcompletion ~~not~~of the Merger is ~~completed.~~also Insubject ~~addition,~~to ifa ~~the~~number ~~Merger~~of isother ~~terminated~~conditions, ~~due~~including to certain ~~circumstances~~governmental approvals and wethe ~~have to~~absence ~~pay~~of ~~termination~~a ~~fees~~material ~~and~~adverse ~~transaction~~effect ~~expenses,~~upon weeither ~~may~~party. ~~not~~There ~~have~~is ~~sufficient~~no ~~funds~~assurance tothat ~~make~~all ~~such~~of ~~payments.~~the ~~Any~~conditions ~~failure~~will tobe ~~complete~~satisfied or waived. If the ~~Merger~~conditions ~~could~~are ~~have~~not asatisfied ~~material~~or ~~adverse~~waived, ~~effect~~the onMerger ~~our~~may ~~stock~~not ~~price~~occur ~~and~~or ~~our~~will ~~future~~be ~~business~~delayed, and ~~financial~~we ~~results~~may lose some or all of the intended benefits of the Merger.

~~Uncertainty~~If ~~about~~ the proposed Merger ~~and~~is ~~diversion~~not ofconsummated, ~~management~~we ~~could~~may ~~harm~~be ussubject orto ~~the~~a ~~combined~~number ~~company~~of material risks, ~~whether~~and orour ~~not~~business ~~the~~and ~~Merger~~stock isprice ~~completed.~~could be adversely affected, as follows:

The announcement of the Merger or the pendency of the proposed transaction may disrupt our current plans and operations and could result in current and prospective employees, customers, payers, partners and suppliers experiencing uncertainty about their future with us or the combined company. These uncertainties may impair our ability to retain, recruit or motivate key personnel or to increase our customers, payers and partners. Completion of the Merger will also require a significant amount of time and attention from our management. The diversion of management’s attention away from ongoing operations could adversely affect our business relationships. If the Merger is not consummated during the fourth quarter of 2017, as currently anticipated, the adverse effects of these uncertainties and the diversion of management’s attention could be exacerbated by the delay. Even if the Merger is consummated, integration of operations will require substantial time after consummation of the Merger, and the combined company may lose management personnel and other key employees and be unable to attract and retain such personnel and employees.23

	●	we have incurred and expect to continue to incur significant expenses related to the proposed Merger even if the Merger is not consummated;

	●	If the Merger Agreement is terminated under certain circumstances, we may be required to pay Invitae a termination fee of $1,400,000 (net of any expense reimbursement previously paid);

	●	If the Merger Agreement is terminated under certain circumstances, we may be required to reimburse Invitae for various expenses incurred in connection with the Merger up to a maximum of $400,000;

	●	If the Merger Agreement is terminated under circumstances that require us to pay Invitae a termination fee and/or expense reimbursement, we may not have sufficient funds to make such payments to Invitae; or

	●	The market price of our common stock may decline to the extent that the current market price reflects a market assumption that the proposed Merger will be completed.

The proposed Merger could disrupt our business and harm our financial condition.

The announcement of the Merger or the pendency of the proposed transaction may disrupt our current plans and operations and may divert management’s time and resources from our core business. Furthermore, we may not realize the expected benefits, synergies and growth prospects resulting from the proposed Merger, or they may not be achieved in a timely manner. Invitae has limited experience with respect to acquisitions and may not be successful in integrating our business following the closing or in managing their growth effectively. We may experience potential difficulties in employee retention as a result of the announcement and pendency of the proposed acquisition. Additionally, the reaction of customers and potential customers, payers, partners and competitors to the announcement of the proposed transaction may disrupt our business. Any cash Invitae may spend as part of the integration activities relating to us after closing of the proposed Merger could divert that cash from other uses.

Neither the merger exchange ratio nor the amount that will be offered to our Series F warrant holders in the warrant exchange offer is adjustable based on the market price of Invitae common stock so the Merger consideration at the closing may have a greater or lesser value than at the time the Merger Agreement was signed.

The Merger Agreement establishes the exchange ratio for our common stock and preferred stock and establishes a minimum amount that will be offered to our Series F warrant holders in the warrant exchange offer, and any changes in the market price of Invitae common stock before the completion of the Merger will not affect the number of shares our securityholders will be entitled to receive pursuant to the Merger Agreement. Therefore, if before the completion of the Merger the market price of Invitae common stock declines from the market price on the date of the Merger Agreement, then our securityholders could receive Merger consideration with substantially lower value. Similarly, if before the completion of the Merger the market price of Invitae common stock increases from the market price on the date of the Merger Agreement, then our securityholders could receive Merger consideration with substantially more value for their shares of our capital stock than the parties had negotiated for in the establishment of the exchange ratio. Additionally, the Merger Agreement does not include a termination right based solely on price. Because the exchange ratio does not adjust as a result of changes in the value of Invitae common stock, for each one percentage point that the market value of Invitae common stock rises or declines, there is a corresponding one percentage point rise or decline, respectively, in the value of the total Merger consideration issued to our securityholders.

If the combined organization is unable to realize the full strategic and financial benefits currently anticipated from the Merger, our stockholders may not receive consideration in the Merger which is commensurate with or greater than the value of their pre-Merger ownership, or they may receive only part of the commensurate benefit to the extent the combined organization is able to realize only part of the strategic and financial benefits currently anticipated from the Merger.

The results of operations of the combined company after the Merger may be affected by factors different from those currently affecting our results of operations.

The business of Invitae differs from ours in important respects and, accordingly, the results of operations of the combined company and the market price of the combined company’s common stock may be affected by factors different from those currently affecting our independent results of operations.

The principal form of Merger consideration is shares of Invitae common stock, the price of which is volatile and could fluctuate substantially, whether before or after the consummation of the Merger.

The market price of Invitae common stock that our stockholders will receive in the Merger may be volatile and could fluctuate substantially due to many factors, including, among other things:

	●	actual or anticipated fluctuations in Invitae’s results of operations;

	●	competition from existing tests or new tests that may emerge;

	●	announcements by Invitae or its competitors of significant acquisitions, strategic partnerships, joint ventures, collaborations, or capital commitments;

	●	failure to meet or exceed financial estimates and projections of the investment community or that Invitae provides to the public;

	●	issuance of new or updated research or reports by securities analysts or changed recommendations for Invitae common stock;

	●	Invitae’s focus on long-term goals over short-term results;

	●	the timing of Invitae’s investments in the growth of its business;

	●	actual or anticipated changes in regulatory oversight of Invitae’s business;

	●	additions or departures of key management or other personnel;

	●	disputes or other developments related to Invitae’s intellectual property or other proprietary rights, including litigation;

	●	sale of common stock or other securities in the future;

	●	the trading volume of Invitae common stock;

	●	changes in reimbursement by current or potential payers;

	●	changes in Invitae’s pricing policies or the pricing policies of its competitors; and

	●	general economic and market conditions.

Share price changes may result from a variety of factors, including general market and economic conditions, changes in Invitae’s and our respective businesses, operations and prospects, and regulatory considerations, among other things. Many of these factors are beyond the control of Invitae and us. In addition, the stock market in general has experienced extreme price and volume fluctuations that have often been unrelated or disproportionate to the operating performance of companies whose shares are traded on the stock market. These broad market factors may materially harm the market price of Invitae common stock, regardless of Invitae’s operating performance.

Our stockholders will generally have a reduced ownership and voting interest in Invitae after the Merger and will exercise less influence over management.

Upon the completion of the Merger, except for stockholders who own common stock in both Invitae and us, each of our stockholders will be a stockholder of Invitae with a percentage ownership of Invitae that is smaller than such stockholder’s current percentage ownership of us. Because of this, our stockholders will generally have less influence on the management and policies of the combined company than they now have on our management and policies.

The market price of the combined organization’s common stock may decline as a result of the Merger.

The market price of the combined organization’s common stock may decline as a result of the Merger for a number of reasons, including:

	●	investors react negatively to the prospects of the combined organization’s business and prospects from the Merger;

	●	the effect of the Merger on the combined organization’s business and prospects is not consistent with the expectations of financial or industry analysts;

	●	Invitae stockholders will experience substantial dilution as a result of the additional securities to be issued in the Merger; or

	●	the combined organization does not achieve the perceived benefits of the Merger as rapidly or to the extent anticipated by financial or industry analysts.

Regulatory approvals may not be received, may take longer than expected or may impose conditions that are not presently anticipated or cannot be met.

Before the transactions contemplated by the Merger Agreement, including the Merger, may be completed, various approvals must be obtained from governmental and self-regulatory authorities, including the expiration or early termination of any applicable waiting period under the HSR Act. These authorities may impose conditions on the granting of such approvals. Such conditions or changes and the process of obtaining regulatory approvals could have the effect of delaying completion of the Merger or of imposing additional costs or limitations on the combined company following the Merger. The regulatory approvals may not be received at all, may not be received in a timely fashion, and may contain conditions on the completion of the Merger that are not anticipated or cannot be met. Furthermore, such conditions on completion may constitute a burdensome condition that may allow Invitae to refuse to consummate the Merger. If the consummation of the Merger is delayed, including by a delay in receipt of necessary governmental approvals, or if it is not approved, our business, financial condition and results of operations may also be materially adversely affected.

Sales of substantial amounts of Invitae common stock in the open market by our former stockholders could depress Invitae’s share price.

Invitae common stock issued to our stockholders in the Merger will be freely tradable without restrictions or further registration under the Securities Act. If the Merger is completed and if our former stockholders sell substantial amounts of Invitae common stock in the public market following completion of the Merger, the market price of Invitae common stock may decrease. These sales might also make it more difficult for Invitae to sell equity or equity-related securities at a time and price that it otherwise would deem appropriate. This in turn may reduce the value of the Merger to our stockholders.

The anticipated benefits of the Merger may not be realized fully or at all or may take longer to realize than expected.

The Merger involves the integration of two companies that have previously operated independently. Prior to the announcement of the signing of the Merger Agreement, we and Invitae did not conduct any integration planning for the two companies, and our ability to do so prior to consummation of the Merger ismay be substantially limited by applicable law. After the Merger, the two companies will devote significant management attention and resources to integrating the two companies. Delays in this process could adversely affect the combined company’s business, financial results, financial condition and stock price. Even if we ~~are~~and Invitae are able to integrate our business operations successfully, there can be no assurance that ~~this~~ the integration will result in the realization of the full benefits of synergies, cost savings, innovation and operational efficiencies that we currently expect from ~~this~~the integration or that these benefits will be achieved within the anticipated time frame.

The combined company may also be unable to use our current net operating loss carryforwards to offset future taxable income for U.S. federal income tax purposes. Changes in services, changes in sources of revenue, and branding or rebranding initiatives may involve substantial costs and may not be favorably received by customers, resulting in an adverse impact on the combined company’s financial results, financial condition and stock price.

2426

Neither the Merger exchange ratio nor the amount that will be offered to Series F Warrant holders in the Series F Warrants exchange offer is adjustable based on the market price of Invitae common stock so the Merger consideration at the closing may have a greater or lesser value than at the time the Merger Agreement was signed.

The Merger Agreement establishes the exchange ratio for our common stock and preferred stock and establishes the amount that will be offered to Series F Warrant holders in the Series F Warrants exchange offer, and any changes in the market price of Invitae common stock before the completion of the Merger will not affect the number of shares our security holders will be entitled to receive pursuant to the Merger Agreement. Therefore, if before the completion of the Merger the market price of Invitae common stock declines from the market price on the date of the Merger Agreement, then our security holders could receive Merger consideration with substantially lower value. Similarly, if before the completion of the Merger the market price of Invitae common stock increases from the market price on the date of the Merger Agreement, then our security holders could receive Merger consideration with substantially more value for their shares of our capital stock than the parties had negotiated for in the establishment of the exchange ratio. Because the exchange ratio does not adjust as a result of changes in the value of Invitae common stock, for each one percentage point that the market value of Invitae common stock rises or declines, there is a corresponding one percentage point rise or decline, respectively, in the value of the total Merger consideration issued to our security holders.

The Merger may be completed even though material adverse changes may result from the announcement of the Merger, industry-wide changes and other causes.

In general, either weInvitae or ~~Invitae~~we can refuse to complete the Merger if there is a material adverse change affecting the other party between the date of the Merger Agreement and the closing. However, certain types of changes do not permit either party to refuse to complete the Merger, even if such change could be said to have a material adverse effect on usInvitae or ~~Invitae~~us, including:

● conditions generally affecting the industries in which we and Invitae operate or the United States or global economy or capital markets as a whole; ● any natural disaster or any acts of terrorism, sabotage, military action or war or any escalation ofor worsening thereof; ● changes in regulatory, legislative or political conditions in the United States or any other country or region in the world; ● changes in conditions in the financial markets, credit markets or capital markets in the United States or any other country or region in the world; ● any effect resulting from the execution, delivery, announcement or performance of the obligations under the Merger Agreement or the announcement, pendency or anticipated consummation of the Merger; ● any failure by usInvitae or ~~Invitae~~us to meet internal projections or forecasts or third -party revenue or earnings predictions for any period ending on or after the date of the Merger Agreement; ● any changes in U.S. GAAP or applicable legal requirements after the date of the Merger Agreement; ● any rejection by a governmental body of a registration or filing by us relating to certain intellectual property rights; or ● any change in our cash position which results from operations in the ordinary course of business.

If adverse changes occur and wethe ~~and~~parties ~~Invitae~~ still complete the Merger, ~~the~~Invitae’s ~~combined organization~~ stock price may suffer. This in turn may reduce the value of the Merger ~~consideration~~ to our ~~security holders~~stockholders.

25Some of our executive officers and directors have interests in the Merger that are different from our stockholders.

WeOur ~~may~~executive ~~not~~officers benegotiated ~~able~~the toterms ~~meet~~of ~~our~~the ~~cash~~Merger ~~requirements~~Agreement ~~beyond~~with ~~August~~Invitae, ofand ~~2018~~our ~~without~~board ~~obtaining~~of ~~additional~~directors ~~capital~~approved ~~from~~the ~~external~~Merger ~~sources~~ and recommended that our ~~current~~stockholders ~~outstanding~~vote ~~private~~to ~~placement~~approve ~~warrants~~and ~~may~~adopt ~~prevent~~the usMerger ~~from~~Agreement ~~issuing~~and ~~new~~the ~~securities~~transactions contemplated thereby, including the Merger. IfSome wemembers ~~are~~of ~~unable~~our tomanagement ~~raise~~and ~~additional capital~~certain ~~through~~members ~~future~~of ~~financings~~our orboard of directors have economic interests in the Merger that are different from ~~external~~our ~~sources~~stockholders, weincluding ~~may~~with ~~not~~respect to compensation to be ~~able~~received by certain of our directors and executives under Transaction Bonus Payout Agreements, and pursuant to ~~continue~~certain asconsulting aagreements ~~going~~between ~~concern~~Invitae and each of our chief executive officer and chief financial officer.

AsDuring ~~of June 30, 2017, we had $3.0 million in cash and cash equivalents, which we anticipate will meet our cash requirements through and beyond~~ the ~~fourth~~pendency ~~quarter~~ of ~~2017.~~the ~~However~~Merger, ~~in order for us to continue as a going concern beyond that point,~~ we ~~will have to increase revenue and cash reimbursement, continue to control operating expenses and~~ may not be ~~required~~able to ~~obtain~~enter ~~capital~~into ~~from external~~a ~~sources.~~business ~~Our~~combination ~~ability~~with toanother ~~continue~~party asat a ~~going~~favorable ~~concern~~price ~~is dependent upon our ability~~ (subject to ~~further~~certain ~~implement~~exceptions) ~~our~~because ~~business~~of ~~plan, generate~~restrictions ~~sufficient~~in ~~revenues~~the ~~and~~Merger ~~cash reimbursement and to control operating expenses~~Agreement, of which ~~there~~could ~~can~~adversely beaffect noour ~~assurance~~business.

Covenants in the Merger Agreement impede our ability to make acquisitions, subject to certain exceptions relating to fiduciaries duties, or complete other transactions that are not in the ordinary course of business pending completion of the Merger. As a result, we may be at a disadvantage to our competitors during that period. In addition, while the Merger Agreement is in effect, we are generally prohibited from soliciting, initiating, encouraging or entering into certain extraordinary transactions, such as a merger, sale of assets or other business combination outside the ordinary course of business, with any third party. Any such transactions could be favorable to our stockholders.

Certain provisions of the Merger Agreement limit our ability to pursue an alternative transaction and may discourage third parties from submitting alternative takeover proposals, including proposals that may be superior to the arrangements contemplated by the Merger Agreement.

The terms of the Merger Agreement prohibit us from soliciting alternative takeover proposals or cooperating with persons making unsolicited takeover proposals, except in limited circumstances when our board of directors determines in good faith, after consultation with our independent financial advisor, if any, and our outside legal counsel, that an unsolicited alternative takeover proposal is or is reasonably likely to lead to a superior takeover proposal and is reasonably capable of being consummated and that failure to cooperate with the proponent of the proposal is reasonably likely to result in a breach of our board’s fiduciary duties. If the Merger Agreement is terminated under certain circumstances, we may be required to pay Invitae a termination fee of $1,400,000 (net of any expense reimbursement previously paid), and, under specified circumstances, reimburse Invitae for various expenses incurred in connection with the Merger, up to a maximum of $400,000. This termination fee may discourage third parties from submitting alternative takeover proposals to us or our stockholders. It should be noted that the failure of our stockholders to approve the Merger Proposal will not in and of itself trigger our obligation to pay the termination fee, unless other factors, including a third-party acquisition proposal for us, also exist.

If the Merger Agreement is terminated by Invitae as a result of a breach of our representations, warranties or covenants, or because the occurrence of a material adverse effect applicable to us was the sole failed condition to closing, then we will be obligated to reimburse Invitae’s third-party expenses up to a maximum of $400,000.

The shares of Invitae common stock to be received by our stockholders as a result of the Merger will have different rights from the shares of our common stock.

Upon the completion of the Merger, our stockholders will become Invitae stockholders and their rights as stockholders will be governed by the organizational documents of Invitae. The rights associated with our common stock are different from the rights associated with Invitae common stock.

If the Merger is not completed, we will have incurred substantial expenses without realizing the expected benefits of the Merger.

We have incurred and will incur substantial expenses in connection with the negotiation and completion of the transactions contemplated by the Merger Agreement, as well as the costs and expenses of filing, printing and mailing the proxy statement/prospectus, and all filing and other fees paid to the SEC in connection with the Merger. If the Merger is not completed, we would have to recognize these expenses without realizing the expected benefits of the Merger.

Any litigation relating to the Merger could require us to incur significant costs and suffer management distraction, as well as delay and/or enjoin the Merger.

Lawsuits related to the Merger may be filed against us, Invitae and/or the directors and officers of either company. The outcome of any such litigation is uncertain. Such lawsuits could prevent or delay completion of the Merger and may adversely affect our business, financial condition, results of operations and/or cash flows.

We may not be able to meet our cash requirements beyond the first quarter of 2018 without obtaining additional capital from external sources and our current outstanding private placement warrants may prevent us from issuing new securities. If we are unable to raise additional capital through future financings or from external sources, we may not be able to continue as a going concern.

As of September 30, 2017, we had $2.4 million in cash and cash equivalents, which we anticipate will be sufficient to meet our expected cash requirements for current operations through and beyond the first quarter of 2018, when we anticipate achieving cash flow break-even status. However, in order for us to continue as a going concern beyond that point, we will have to increase revenue and cash reimbursement, continue to control operating expenses and may be required to obtain capital from external sources. Our ability to continue as a going concern is dependent upon our ability to further implement our business plan, generate sufficient revenues and cash reimbursement and to control operating expenses, of which there can be no assurance.

In order to issue securities at a price below the exercise prices of our outstanding warrants issued in connection with our past preferred stock private placement financings, we must obtain the affirmative consent of holders of at least 67% of each series of such outstanding warrants. If we are unable to obtain the consent of these holders in connection with future financings, we may be unable to raise additional capital on acceptable terms, or at all. If external financing sources are not available in a timely manner or at all, or are inadequate to fund our operations, we could experience reduced revenues and cash flows from the sales of our diagnostic services and our ability to launch, market and sell additional services necessary to grow and sustain our operations could be jeopardized.

Our stock price could decline because of the potentially dilutive effect of future financings and from the exercises of certain common stock warrants.

As of ~~June~~September 30, 2017, we had approximately 2.9 million shares of common stock issued and outstanding. Assuming exercise in full of of all options, warrants and convertible securities outstanding as of ~~June~~September 30, 2017, approximately 5.8 million shares of our common stock would be outstanding. Any additional equity or convertible debt financings in the future could result in further ~~dilution~~ dilution to our stockholders.

Item 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

Item 3. DEFAULTS UPON SENIOR SECURITIES

None.

Item 4. MINE SAFETY DISCLOSURES

Not applicable.

Item 5. OTHER INFORMATION

None.

Item 6. EXHIBITS

An index of exhibits is found on page 28 of this report.

Exhibit Number		Description

2.1		Agreement and Plan of Merger and Reorganization by and among the Company, Invitae and Merger Sub, dated as of July 31, 2017. Incorporated by reference to Exhibit 2.1 to the Company’s Current Report on Form 8-K (SEC File No. 001-33523) filed with the SEC on July 31, 2017.
3.1		Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Registration Statement on Form S-1 (SEC File No. 333-139679) filed with the SEC on December 26, 2006.
3.2		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1A to the Company’s Quarterly Report on Form 10-Q (File No. 001-33523) filed with the SEC on August 14, 2008.
3.3		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on December 4, 2012.
3.4		Certificate of Designation of Preferences, Rights and Limitations of Series A 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on October 1, 2012.
3.5		Certificate of Designation of Preferences, Rights and Limitations of Series B 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on March 20, 2013.
3.6		Certificate of Designation of Preferences, Rights and Limitations of Series C 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on May 6, 2013.

2629

Exhibit Number		Description

3.7		Certificate of Designation of Preferences, Rights and Limitations of Series D Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on December 23, 2013.
3.8		Certificate of Designation of Preferences, Rights and Limitations of Series E 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on February 13, 2015.
3.9		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on April 29, 2015.
3.10		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on January 29, 2016.
3.11		Certificate of Designation of Preferences, Rights and Limitations of Series F Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on March 24, 2016.
3.12		Second Amended and Restated Bylaws. Incorporated by reference to Exhibit 3.2 to the Company’s Annual Report on Form 10-K (File No. 001-33523) filed with the SEC on March 18, 2010.
10.1		Marketing and Laboratory Services Agreement dated as of September 25, 2017, by and between Invitae Corporation, Good Start Genetics, Inc. and CombiMatrix Molecular Diagnostics, Inc. Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on September 27, 2017.
31.1		Certification of Chief Executive Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002 (*)
31.2		Certification of Chief Financial Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002 (*)
32.1		Certification of Chief Executive Officer pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith)
32.2		Certification of Chief Financial Officer pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith)
101.0		The following materials from CombiMatrix Corporation’s Quarterly Report on Form 10-Q for the quarter and nine month periods ended September 30, 2017, formatted in XBRL (eXtensible Business Reporting Language): (i) Consolidated Balance Sheets as of September 30, 2017 and December 31, 2016; (ii) Consolidated Statements of Operations for the three and nine months ended September 30, 2017 and 2016; (iii) Consolidated Statements of Comprehensive Loss for the three and nine months ended September 30, 2017 and 2016; (iv) Consolidated Statements of Cash Flows for the nine months ended September 30, 2017 and 2016; and (v) Notes to Consolidated Financial Statements.(*)

(*)	Included herewith.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	COMBIMATRIX CORPORATION
	By:	/s/ MARK MCDONOUGH
		Mark McDonough
		Chief Executive Officer
		(Principal Executive Officer)
	By:	/s/ SCOTT R. BURELL
		Scott R. Burell
		Chief Financial Officer
		(Principal Financial and Accounting Officer)
Date: August 11, 2017

	COMBIMATRIX CORPORATION

	By:	/s/ MARK MCDONOUGH
		Mark McDonough
		Chief Executive Officer
		(Principal Executive Officer)

	By:	/s/ SCOTT R. BURELL
		Scott R. Burell
		Chief Financial Officer
		(Principal Financial and Accounting Officer)

27Date: November 6, 2017

~~EXHIBIT INDEX~~31

Exhibit Number		Description
2.1		Agreement and Plan of Merger and Reorganization by and among the Company, Invitae and Merger Sub, dated as of July 31, 2017. Incorporated by reference to Exhibit 2.1 to the Company’s Current Report on Form 8-K (SEC File No. 001-33523) filed with the SEC on July 31, 2017.
3.1		Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Registration Statement on Form S-1 (SEC File No. 333-139679) filed with the SEC on December 26, 2006.
3.2		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1A to the Company’s Quarterly Report on Form 10-Q (File No. 001-33523) filed with the SEC on August 14, 2008.
3.3		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on December 4, 2012.
3.4		Certificate of Designation of Preferences, Rights and Limitations of Series A 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on October 1, 2012.
3.5		Certificate of Designation of Preferences, Rights and Limitations of Series B 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on March 20, 2013.
3.6		Certificate of Designation of Preferences, Rights and Limitations of Series C 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on May 6, 2013.
3.7		Certificate of Designation of Preferences, Rights and Limitations of Series D Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on December 23, 2013.
3.8		Certificate of Designation of Preferences, Rights and Limitations of Series E 6% Convertible Preferred Stock. Incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on February 13, 2015.
3.9		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on April 29, 2015.
3.10		Certificate of Amendment to Amended and Restated Certificate of Incorporation. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on January 29, 2016.
3.11		Certificate of Designation of Preferences, Rights and Limitations of Series F Convertible Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on March 24, 2016.
3.12		Second Amended and Restated Bylaws. Incorporated by reference to Exhibit 3.2 to the Company’s Annual Report on Form 10-K (File No. 001-33523) filed with the SEC on March 18, 2010.
10.1		Amended and Restated 2017 Executive Performance Bonus Plan. Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K (File No. 001-33523) filed with the SEC on June 19, 2017.
31.1		Certification of Chief Executive Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002 (*)
31.2		Certification of Chief Financial Officer pursuant to section 302 of the Sarbanes-Oxley Act of 2002 (*)
32.1		Certification of Chief Executive Officer pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith)
32.2		Certification of Chief Financial Officer pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith)
101.0		The following materials from CombiMatrix Corporation’s Quarterly Report on Form 10-Q for the quarter and six month periods ended June 30, 2017, formatted in XBRL (eXtensible Business Reporting Language): (i) Consolidated Balance Sheets as of June 30, 2017 and December 31, 2016; (ii) Consolidated Statements of Operations for the three and six months ended June 30, 2017 and 2016; (iii) Consolidated Statements of Comprehensive Loss for the three and six months ended June 30, 2017 and 2016; (iv) Consolidated Statements of Cash Flows for the six months ended June 30, 2017 and 2016; and (v) Notes to Consolidated Financial Statements.(*)

(*) Included herewith.

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