UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 10-K

(Mark One)

☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended: December 31, ~~2022~~2023

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from _____________ to _____________

Commission File Number: 001-38190

Panacea Life Sciences Holdings, Inc.

(Exact name of registrant as specified in its charter)

Nevada		27-1085858
(State or other jurisdiction of		(I.R.S. Employer
incorporation or organization)		Identification No.)

5910 S University Blvd, C18-193, Greenwood Village, CO 80121

(Address of principal executive offices, Zip Code)

800-985-0515

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
N/A		N/A		N/A

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange Act. Yes ☐ No ☒

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the past 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically, every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

	Large Accelerated Filer ☐	Accelerated Filer ☐
	Non-Accelerated Filer ☒	Smaller reporting company ☒
		Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

The text associated with those checkboxes is as follows: If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ☐

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

The aggregate market value of the voting and non-voting common equity held by non-affiliates computed by reference to the price at which the common equity was last sold, or the average bid and asked price of such common equity, as of the last business day of the registrant’s most recently completed second fiscal quarter, June 30, ~~2021~~2022, was approximately $113,~~185~~529,~~976~~070. ~~The aggregate market value gives effect to the closing of the Securities Exchange Agreement dated June 30, 2021 and the 1-for-28 reverse stock split on October 28, 2021.~~

State the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date: 1417,~~762~~645,~~342~~352 shares of common stock, par value $0.0001 per share, outstanding as of March 15, ~~2023~~2024.

TABLE OF CONTENTS

PART I		1
Item 1.	Business	1
Item 1A.	Risk Factors	45
Item 1B.	Unresolved Staff Comments	1418
Item 2.	Properties	1418
Item 3.	Legal Proceedings	1518
Item 4.	Mine Safety Disclosures	1518
PART II		1618
Item 5.	Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities	1618
Item 6.	Selected Financial Data	1619
Item 7.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	1619
Item 7A.	Quantitative and Qualitative Disclosures About Market Risk	2024
Item 8.	Financial Statements and Supplementary Data	F-1
Item 9.	Changes in and Disagreements with Accountants on Accounting and Financial Disclosure	2125
Item 9A.	Controls and Procedures	2125
Item 9B.	Other Information	2226
PART III
Item 10.	Directors, Executive Officers and Corporate Governance	2226
Item 11.	Executive Compensation	2327
Item 12.	Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters	2429
Item 13.	Certain Relationships and Related Transactions, and Director Independence	2529
Item 14.	Principal Accounting Fees and Services	2529
PART IV		2630
Item 15.	Exhibits, Financial Statement Schedules	2630
SIGNATURES		2732

Cautionary Statement Regarding Forward-Looking Statements

This Annual Report on Form 10-K and other written and oral statements made from time to time by us may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements about our new operations in the hemp industry through Panacea, our expected revenue growth, our future plans and developments, proposed federal legislation and its potential impact on the CBD industry, our plans to raise capital, and our liquidity. Words such as “expects,” “anticipates,” “plans,” “believes,” “seeks,” “estimates,” “could,” “would,” “may,” “intends,” “targets” and similar expressions or variations of such words are intended to identify forward-looking statements but are not the exclusive means of identifying forward-looking statements in this Report. The identification of certain statements as “forward-looking” is not intended to mean that other statements not specifically identified are not forward-looking. All statements other than statements about historical facts are statements that could be deemed forward-looking statements, including, but not limited to, statements that relate to our future revenue, product development, customer demand, market acceptance, growth rate, competitiveness, gross margins, and expenditures.

Although forward-looking statements in this Report reflect the good faith judgment of our management, such statements can only be based on facts and factors currently known by us. Consequently, forward-looking statements are inherently subject to risks and uncertainties discussed under the heading “Risk Factors” within Part I, Item 1A of this Report, and other documents we file from time-to-time with the Securities and Exchange Commission (“SEC”). Such risks, uncertainties and changes in condition, significance, value, and effect could cause our actual results to differ materially from those expressed herein and in ways not readily foreseeable. Readers are urged not to place undue reliance on these forward-looking statements, which speak only as of the date of this Report and are based on information currently and reasonably known to us. We undertake no obligation to revise or update any forward-looking statements to reflect any event or circumstance that may arise after the date of this Report, other than as required by law. Readers are urged to carefully review and consider the various disclosures made in this Report, which attempt to advise interested parties of the risks and factors that may affect our business, financial condition, results of operations and prospects.

PART I

Item 1. Business

General

Panacea Life Sciences Holdings, Inc. (OTCQB: PLSH) is a holding company ~~structured~~organized toas ~~support~~a ~~the~~plant-based ~~life~~natural ~~sciences and~~ health ~~and~~ingredient ~~wellness industry. Its subsidiary, Panacea Life Sciences, Inc. (PLS) is dedicated to manufacturing, research~~ and ~~producing~~product ~~the highest-quality~~company, ~~hemp-derived~~ ~~cannabinoid,~~specializing ~~functional mushroom, Kratom and nutraceutical products for consumers and pets. Established~~ in ~~2017, PLS is a woman-owned and woman-led company. Panacea operates out of its 51,000 square foot, state-of-~~the~~-art,~~ ~~cGMP facility in Golden Colorado~~development, ~~focusing on natural plant-based extraction,~~ manufacturing, research, ~~testing~~ and ~~fulfillment~~distribution ~~services. Panacea operates in every segment~~ of ~~the~~products ~~manufacturing value~~within ~~chain. From cultivation to finished goods,~~ the ~~company~~$134B ~~ensures its products with stringent GMP standards~~ and ~~testing~~rapidly ~~protocols employed~~growing ~~at every stage of the supply chain. Panacea also offers the purest~~ natural ~~remedies~~health and ~~within~~wellness ~~its~~market ~~branded~~segment ~~product lines~~ for ~~every aspect~~both ofhumans ~~life: PANA Health™, PANA Beauty®, PANA Sport™, PANA Pet®, PANA Pure®~~ and ~~PANA Life™~~animals. ~~If you would like more information, please visit www.panacealife.com.~~

Established in 2017, the company’s first subsidiary, Panacea Life Sciences, Inc. (PLS), is dedicated to the production, distribution, research, and manufacturing of premium-quality nutraceuticals, cannabinoids, mushrooms, kratom, and other natural, plant-based ingredients and products. Operating from a cutting-edge 51,000 square foot cGMP facility located in Golden, Colorado, PLS is committed to delivering high-quality solutions in the field of natural health and well-being. Panacea also offers the purest natural remedies within its branded product lines for every aspect of life: PANA Health™, PANA Beauty®, PANA Sport™, PANA Pet®, PANA Pure® and PANA Life™. If you would like more information, please visit www.panacealife.com.

Panacea Distro, the second subsidiary of Panacea Life Sciences Holdings, Inc., manages six retail locations and a distribution center situated in the Tampa, Florida area. These establishments provide a diverse range of products, including Nitro Kava, Kratom, Hemp, VAPE products, and various beverages, with a primary focus on promoting alternative health and wellness. The Panacea Distro business is segmented into two distinct areas—the retail stores and the cash & carry distribution warehouse. The retail stores are poised to evolve into franchise stores, with the intention of eventually adopting the name “PANA KAVA JAVA.” This strategic move is part of our plan to establish a franchise model based on the success of these existing retail locations.

In the coming months, a third business entity, Pana Kava Java (PKJ), is set to emerge as the franchisor company, with a scheduled launch in Q3-Q4 2024. Pana Kava Java is committed to establishing a unique franchise model, drawing inspiration from the European-style café concept. Patrons will have the opportunity to savor infused coffees and beverages, indulge in vaping, and enjoy an array of infused baked goods in a welcoming atmosphere. Pana Kava Java, as the franchisor, will offer franchise rights to individuals interested in opening stores/cafés, enabling them to sell products or services under the PKJ brand, leveraging our expertise and intellectual property. Currently, active efforts are underway in developing the franchisor plan, encompassing aspects such as business development, flagship store establishment, legal document preparation, marketing and packaging strategies, as well as the recruitment and training of franchisees.

Recent Developments

In June 2022, given the FDA’s lack of clarity regarding the CBD industry, the Company pivoted some of its resources to focus on the nutraceutical industry. The Company made further investments in its softgel line for bovine and vegan softgels. The sales approach has been successful, and we have closed over ~~ten~~40 different nutraceutical contracts. In this same timeframe we have focused on two other natural plant products—functional mushrooms and kratom. These new areas will continue to be a focus area for Panacea in ~~2023~~2024.

On ~~November~~September 1830, ~~2021~~2023, ~~the~~PLSH ~~Company~~completed ~~and~~ an ~~institutional~~asset ~~investor~~purchase ~~signed an~~ agreement for aN7 ~~$1.1~~Enterprises ~~million~~which ~~original~~was ~~issue~~a ~~discount~~rapidly ~~convertible note~~growing ~~(the~~corporation ~~“Note”)~~that ~~financing~~operates a inchain ~~which~~of ~~the~~botanical ~~investor~~tea isbars ~~paying~~focused $1on ~~million~~promoting inhealth ~~gross~~and ~~proceeds~~wellness. The ~~one-year~~company ~~Note~~ is ~~convertible~~dedicated to providing customers with premium ~~into~~quality ~~common~~organic ~~stock~~teas atand ~~$1.40~~wellness ~~per~~products, ~~share~~fostering a culture of well-being and mindful consumption. WeThe ~~also~~core ~~issued~~of ~~the~~N7 ~~investor~~Enterprises ~~785,715~~comprised eight ~~warrants~~meticulously tocurated ~~purchase~~botanical ~~common~~tea ~~stock~~bars atstrategically anlocated ~~exercise~~in ~~price~~the ofTampa ~~$1.40~~Bay metropolitan area, serving as hubs for health-conscious ~~per~~consumers ~~share.~~seeking ~~The~~natural ~~warrants~~and ~~are~~revitalizing ~~exercisable~~beverages. ~~over~~These retail locations offer a ~~five-year~~diverse ~~period~~range ~~beginning~~of ~~May~~handcrafted, 18ethically sourced herbal teas, ~~2022~~blended to cater to various health preferences and dietary needs. ~~The~~Each ~~loan~~store ~~payoff~~is ~~was~~designed ~~made~~to onprovide ~~December~~an ~~15,~~immersive ~~2022~~and tranquil ~~for~~atmosphere, ~~the~~encouraging ~~amount~~customers ofto ~~$1,115,000~~embrace a holistic lifestyle.

In addition to the retail stores, N7 Enterprises operates a robust cash and carry warehouse, which serves as the central distribution center for all retail locations. This strategically positioned facility enables efficient supply chain management, ensuring that each store is consistently stocked with an array of premium organic teas, wellness products, and related merchandise. The warehouse plays a pivotal role in supporting the seamless operation of the retail branches, thereby facilitating the company’s mission to provide accessible and sustainable wellness solutions to its diverse customer base.

N7 Enterprises was renamed to Panacea Distro, Inc. and is a subsidiary of PLSH. The Company plans to separate out the cash and carry/distribution business from the retail stores. The retail stores will be branded under the Pana Kava Java ™ name and they will form the basis for the PKJ Group Franchisor. They will be corporate owned franchises and use as promotion and templates for expanding and acquiring additional franchisees. The retail stores will be reconfigured to infused café lounges as we continue to sell kava and kratom nitro teas, coffee, hemp and Vape products along with infused bakery goods.

Our Competitive Analysis

We believe that our competitive advantages are derived from being vertically integrated that allows for extraction, enrichment and manufacturing under a cGMP quality environment: 1) Using pharmaceutical formulation methods to optimize the delivery of various nutraceutical, hemp, mushroom and kratom products, 2) Developing both full spectrum and THC-free products, 3) hemp supply, and 4) utilize Good Manufacturing Practice to produce goods that ensures safe and quality products that deliver consistent dosing. The ability to produce both full spectrum products (those that contain <0.3%) and THC-free products allows us to optimize dosage and delivery to various human conditions. PLSH subsidiaries control the complete value chain.

Industrial hemp extracts are found to have particular application as neuroprotectants, for example in limiting neurological damage and increasing speed of recovery with traumatic brain injury. The cannabinoids have also been reported to treat human disease conditions where currently multiple pharmacological products are needed, e.g., Post Traumatic Stress Disorder (PTSD), or where there is no current cure such as Alzheimer’s, Parkinson’s Disease, and age-related dementia, to name a few. Cannabinoids have a wide range of possible benefits which we are pursuing through clinical trials and studies.

● Anti-Nausea /Antiemetic ● Anticonvulsant ● Antipsychotic ● Anti-inflammatory ● Anti-oxidant ● Anti-tumoral / Anti-cancer ● Anxiolytic / Anti-depressant ● Reduces nausea and vomiting ● Suppresses seizure activity ● Combats psychosis disorders ● Combats inflammatory disorders ● Combats neurodegenerative disorders ● Combats tumor and cancer cells ● Combats anxiety and depression

Although numerous reports describe cannabis/hemp extract health benefits the industry lacks sufficient clinical data and quality control to provide patient benefit. We are combining human and pet clinical studies with Good Manufacturing Process manufacturing to generate a panel of products tailored and optimized for specific disease treatment. Our products are designed to optimize formulation with delivery method to maximize health benefits including an intellectual property portfolio enabling development of topical creams, sublingual products, oral soft gel capsules, patches, and sprays. Our products are derived from organic practices industrial hemp grown in Colorado.

1Our goals are to research, produce, and distribute products both domestically and internationally that target and treat major categories of medical conditions: pain, cancer, psychological, gastrointestinal, autoimmune, neurological, and sleep disorders. These categories include conditions that affect hundreds of millions of patients and animals worldwide. Another goal is to be a leader in contract manufacturing for end-products, such as nutraceuticals, supplements and pet and farm products.

Our goals are to research, produce, and distribute products both domestically and internationally that target and treat major categories of medical conditions: pain, cancer, psychological, gastrointestinal, autoimmune, neurological, and sleep disorders. These categories include conditions that affect hundreds of millions of patients and animals worldwide.

Our goal is to be a leader in contract manufacturing for end-products, such as nutraceuticals, supplements and pet and farm products.

Our Intellectual Property

We operate in every segment of the cannabinoid product value chain. From the hemp plant to finished goods, we ensure our products with stringent testing protocols employed at every stage of the supply chain. Panacea endeavors to offer pure natural remedies within product lines for every aspect of life,. Our portfolio includes the following trademarks and registrations: PANA Health™, PANA Beauty®, PANA Sport™, PANA Pet®, PANA Life®. In the nutraceutical and supplement business line we are developing unique formulations that will add to our intellectual property.

Research and Development

In October 2021, Panacea Life Sciences’ investment in the Cannabinoid Lab at Colorado State University (“CSU”) was realized. The Cannabinoid Research Center is conducting numerous studies and clinical research that will extend our knowledge of how cannabis extracts affect human and animal health. We will work through the center to form multiple research collaborations as well as perform our own studies in multiple therapeutic areas. The Panacea Life Sciences Cannabinoid Research Center is housed in the Chemistry Building in the heart of the CSU campus. The center is expected to be a leader in cannabinoid research nation and world-wide as the industry continues to grow.

Our Sales Strategy

As previously described, since our cannabinoid products contain little to no THC, we have the ability to sell our products across the United States and internationally. We have established a multi-faceted sales strategy targeting:

	●	global ecommerce platform for fulfilling orders and shipping worldwide where legally permitted;
	●	direct pharmacy placement;
	●	direct placement in retail stores, salons, spas, athletic facilities, etc.
	●	Intelligent vending machines
	●	E-commerce based systems and social media

In addition, we have established several other sales channels via sales reps, e-commerce (selling directly to customers), large bulk sales to suppliers and to dispensaries. The e-commerce sales platform also works with the commissioned based sales. All sales commissions are tracked and paid via the ERP platform.

We also manufacture nutraceutical and other cannabinoid/kratom/mushroom products for several other companies for various white label and contract manufacturing deals. We specialize in bovine and vegan soft gel manufacturing.

Marketing and Distribution

With the acquisition of N7 we now have access to not only our corporate owned stores in the Tampa Florida area but additional access to all the distribution stores in which we sell products.

We distribute our products to various businesses across the United States through channels optimized to the individual needs of customers. Our B2B as well as B2C approach allows much flexibility for healthcare providers the ability to recommend specific treatment options using cannabinoids as a replacement for conventional pharmaceuticals.

Currently we sell over 6040 different product SKUs of CBD and CBG products. In addition, we offer “white label” licensing to retail businesses and contract manufacturing services to smaller CBD companies. We plan to continue to build an integrated healthcare organization by creating products and programs using emerging botanical extracts. We deliver these programs through managed agriculture, pharmaceutical production, physician education, distribution and social media networks. We use our intellectual property in extraction technology, proprietary compounds, delivery systems, and distribution to produce high-quality products in terms of control, consistency, accountability, and packaging.

All our products are stored in a secure distribution area in preparation for delivery to various sales channels, healthcare providers and other retail locations. The laboratory and production facility have the capacity for domestic and international delivery fulfillment and for international export. All products are tracked and securely manifested for delivery to retail and medical offices for distribution.

We are recruiting key service providers to leverage the power of online sales and social media placement. We have placed products on various online retail sales stores and has launched product sales on Amazon.com. As product ambassadors are secured, we intend to increase its online and social media exposure to advance a business-to-consumer and business to business distribution model.

In 2018, we entered into an agreement with Quintel-MC, Inc. to research and define Panacea Life Sciences business and manufacturing processes. The ERPCannabis system based on an SAP architecture was used to develop the base installation. All financial, human resource, payroll, procurement, production planning and materials management business processes are represented in this system. In addition, the system is linked to our e-Commerce web site. This system allows us to update product costing and determine inventory levels which will be critical as the company expands. In addition, sophisticated financial and payroll processing are inherent in the solution; thus, offering investors detailed accounting results related to company investments.

Our Industrial Hemp Supply

Our 2020 and 2021 hemp crop was grown in NeedleRock Farms in Crawford CO. In 2021 XXII was the grower and is using organic practices for the crop. XXII is contractually obligated to provide use with $500,000 of hemp from the 2021 crop. We also have several hemp tolling contracts in which the output of crude and or distillate is shared with the growers.

Biotechnology Goals

We seek to take advantage of an emerging worldwide trend to utilize the production of cannabinoids derived from industrial hemp, such as CBD, CBDA, CBG, CBDV and CBN, to produce consumer products. Hemp is being used in cosmetics, nutritional supplements, and animal feed, where we also intend to focus our efforts. The market for hemp-derived products is expected to increase substantially over the next five years.

The therapeutic potential of cannabinoids is attributable to the valuable overlap between phyto-cannabinoids (i.e., plant-derived cannabinoids) and the endogenous cannabinoid system in humans, termed a “therapeutic handshake”. Clinical trials demonstrate few adverse effects from oral CBD doses of up to 1,500 mg/day. The scientific understanding of the hemp plant’s clinical effects is based mostly on studies in specific indications, like epilepsy. One company, GW Pharmaceuticals pls, a leading company developing pharmaceutical drugs and cannabinoid-based medicines, has sought and obtained US and foreign approvals since 2018. EPIDIOLEX®/EPIDYOLEX® (cannabidiol), the first prescription, plant-derived cannabis-based medicine approved by the U.S. Food and Drug Administration (FDA) for use in the U.S. and the European Commission (EC) for use in Europe, is an oral solution which contains highly purified cannabidiol (CBD). In the U.S., EPIDIOLEX® is indicated for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS), Dravet syndrome or Tuberous Sclerosis Complex (TSC) in patients one year of age and older.

Environmental Matters

Compliance with federal, state and local requirements regulating the discharge of materials into the environment, or otherwise relating to the protection of the environment, have not had, nor are they expected to have, any direct material effect on our capital expenditures, earnings or competitive position, however such factors could indirectly affect us as well as participants in the supply chain for our products, and our business, operations, vendors or suppliers.

Government Regulations

On December 20, 2018, the President of the United States signed the Farm Bill into law. Among other things, this new law changed certain federal authorities relating to the production and marketing of hemp, defined as cannabis (Cannabis sativa L.), and hemp products containing less than 0.3 percent delta-9-tetrahydrocannabinol (THC, including removing hemp and derivatives of hemp from the Controlled Substance Act. January 15, 2021, the USDA issued its final rule regarding the Establishment of a Domestic Hemp Production Program which authorized hemp to be grown and processed legally in the United States and made it legal to transport in interstate commerce.

The Farm Bill recognizes hemp as distinct from its genetic cousin, marijuana, and specifically industrial hemp has been excluded from U.S. drug laws. The Farm Bill allows for each individual state to regulate industrial hemp and industrial hemp-based products or accept the USDA rules. Although no longer a controlled substance under federal law, cannabinoids derived from industrial hemp (other than THC) are still subject to a patchwork of state regulations. We are actively monitoring the regulations and proposed regulations in each state to ensure our operations are compliant.

As of the date of this report, and based upon publicly available information, to our knowledge the FDA has not taken any enforcement actions against CBD companies. The FDA, however, has sent warning letters to companies demanding they cease and desist from the production, distribution, or advertising of CBD products, only relating to instances that such CBD companies have made misleading and unapproved label claims. We will continue to monitor the FDA’s position on CBD as the FDA has now transferred this area to Congress.

We are subject to federal and state consumer protection laws, including laws protecting the privacy of customer non-public information and the handling of customer complaints and regulations prohibiting unfair and deceptive trade practices. The growth and demand for online commerce has and may continue to result in more stringent consumer protection laws that impose additional compliance burdens on online companies. These laws may cover issues such as user privacy, spyware and the tracking of consumer activities, marketing e-mails and communications, other advertising and promotional practices, money transfers, pricing, product safety, content and quality of products and services, taxation, electronic contracts and other communications and information security.

There is also great uncertainty over whether or how existing laws governing issues such as sales and other taxes, auctions, libel, and personal privacy apply to the internet and commercial online services. These issues may take years to resolve. For example, tax authorities in several states, as well as a Congressional advisory commission, are currently reviewing the appropriate tax treatment of companies engaged in online commerce, and new state tax regulations may subject us to additional state sales and income taxes. New legislation or regulation, the application of laws and regulations from jurisdictions whose laws do not currently apply to our business or the application of existing laws and regulations to the internet and commercial online services could result in significant additional taxes or regulatory restrictions on our business. These taxes or restrictions could have an adverse effect on our cash flows, results of operations and overall financial condition. Furthermore, there is a possibility that we may be subject to significant fines or other payments for any past failures to comply with these requirements.

Human Capital

On December 31, ~~2022~~2023, we had 19over 40 full-time employees. There are no collective bargaining agreements covering any of our employees. We ~~believe~~ believe that our success depends on our ability to attract, develop and retain key personnel. We believe that the skills, experience and industry knowledge of our key employees significantly benefit our operations and performance.

Employee health and safety in the workplace is one of our core values. ~~The~~Employee ~~COVID-19~~levels ~~pandemic~~are ~~has~~managed ~~underscored for us the importance of keeping our employees safe and healthy. In response~~ to ~~the~~align ~~pandemic, we have taken actions aligned~~ with the ~~World~~pace ~~Health~~of ~~Organization~~business and ~~the~~management ~~Centers~~believes ~~for~~it ~~Disease~~has ~~Control~~sufficient ~~and~~human ~~Prevention~~capital ~~in an effort~~ to ~~protect~~operate ~~our~~its ~~workforce~~business ~~so they can more safely and effectively perform their work~~successfully.

Employee levels are managed to align with the pace of business and management believes it has sufficient human capital to operate its business successfully.

Additional information

We file annual, quarterly and other reports, proxy statements and other information with the SEC. The SEC maintains a website at www.sec.gov that contains reports, proxy and information statements, and other information regarding issuers such as our company that file electronically with the SEC.

Our corporate website address is www.panacealife.com. We make available free of charge, through the Investor section of our website, annual reports on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC. The information which appears on our corporate website is not part of this report.

Item 1A. Risk Factors

RISK FACTORS

Investing in our common stock involves a high degree of risk. Investors should carefully consider the following Risk Factors before deciding whether to invest in us. Additional risks and uncertainties not presently known to us, or that we currently deem immaterial, may also impair our business operations or our financial condition. If any of the events discussed in the Risk Factors below occur, our business, financial condition, results of operations or prospects could be materially and adversely affected. In such case, the value and marketability of our common stock could decline.

Summary Risk Factors

Our business is subject to numerous risks and uncertainties that you should consider before investing in our common stock. Set forth below is a summary of the principal risks we face:

● We intend to raise capital through the sale of our common stock or securities convertible or exercisable into our common stock soon which will have a dilutive effect on our existing stockholders; ● Our ability to continue as a going concern is in doubt unless we obtain adequate new debt or equity financing and achieve sufficient sales levels; ● Because we require additional capital to execute our business plan and expand our operations, our inability to generate and obtain such capital on acceptable terms, or at all, could harm our business, operating results, financial condition and prospects; ● We are highly dependent on our Chief Executive Officer, and the loss of her services or a conflict of interest arising from her loans to us, and her other business endeavors would adversely affect us; ● Our business and the ~~CBD~~h industry generally are subject to substantial regulation and governmental scrutiny characterized by high compliance costs and uncertainty, including the possibility that laws change in a manner adverse to us; ● Panacea’s operations and our new Chief Executive Officer were not previously subject to SEC reporting obligations, which could render us difficult to evaluate and expose us to risk; ● If we are unable to keep up with rapid technological change, consumer preferences and economic developments in our industry or in general, our products may become obsolete. ● We could become subject to data privacy and security claims or enforcement actions, particularly due to our digital marketing efforts; ● We may become subject to product liability or related claims based on our production and sale of products containing chemical compounds designed to be ingested or applied topically;

	●	Our Chief Executive Officer, directly and through entities she controls, owns a majority of our outstanding common stock and voting power on an as-converted basis, rendering other stockholders’ ability to influence matters before them limited in most cases; and

	●	Operational risks such as material weaknesses and other deficiencies in internal control over financial reporting could result in errors, potentially requiring restatements of our historical financial data, leading investors to lose confidence in our reported results.

~~Risks Related to Our Business and the CBD Industry~~5

Risks Related to Our Business and the Hemp Industry

Because we need to raise additional capital any financing based on our common stock or common stock equivalents will dilute our existing stockholders and the terms of any such financing could impose restrictions on our operations.

We have depended upon loans from our Chief Executive Officer and principal stockholder and have primarily financed our operations by borrowing funds from her.

Because, we are highly dependent on the services of Leslie Buttorff, our sole executive officer, the loss of her and our inability to expand our management team, could harm our business.

Our success is largely dependent on the continued services of Leslie Buttorff, our Chief Executive Officer and principal stockholder. The loss of the services of Ms. Buttorff would leave us without executive leadership, which could diminish our business and growth opportunities. Additionally, Ms. Buttorff has business interests outside our company and a real estate holding company each of which hold shares in us as a result of the recent share exchange under the Exchange Agreement. Accordingly, from time-to-time she may not devote her full time and attention to our affairs, which could have a material adverse effect on our operating results, and there can be no assurance that a conflict of interest will not arise from her other business ventures. Further, as of December 31, ~~2022~~2023, Ms. Buttorff holds demand promissory notes totaling $1411,~~796~~397,~~011~~617 at various interest rates ranging from 0% to 12%. Thus, she has the power to call the notes ~~and~~ and obtain all our assets. Additionally, we have a line of credit with Ms. Buttorff through which it may borrow up to $58 million at a 10% annual interest rate. The fact that she continues to advance money and is our principal stockholder reflects her intent to support us.

The loss of Ms. Buttorff would have a material adverse effect on us. We do not have key man insurance on the life of Ms. Buttorff. Ms. Buttorff’s Employment Agreement with us (the “Employment Agreement”) permits her to resign for good reason which includes our material breach of the Employment Agreement including our failure to pay her. In the event Ms. Buttorff terminates her Employment Agreement for good reason, this would result in the us owing her approximately $760,000 in severance pay plus any deferred compensation and earned bonuses and other benefits and would leave us without an executive officer which may have a material adverse effect upon us, your investment, and hamper our ability to continue operations. If we fail to procure the services of additional executive management or implement and execute an effective contingency or succession plan for Ms. Buttorff, the loss of Ms. Buttorff would significantly disrupt our business from which we may not be able to recover.

If we are unable to develop and maintain our brand and reputation for our product offerings, our business and prospects could be materially harmed.

Our business and prospects depend, in part, on developing and then maintaining and strengthening our brand and reputation in the markets we serve. If problems with our products cause our customers to have a negative experience or failure or delay in the delivery of our products to our customers, our brand and reputation could be diminished. If we fail to develop, promote and maintain our brand and reputation successfully, our business and prospects could be materially harmed.

Because we face intense competition, we may not be able to increase our market share which would materially and adversely affect us.

Our industry is highly competitive. It is possible that future competitors could enter our market, thereby causing us to lose market share and revenues or fail to grow our operations and market presence as intended or at all. In addition, some of our current or future competitors have significantly greater financial, technical, marketing and other resources than we do or may have more experience or advantages in the markets in which we will compete that will allow them to offer lower prices or higher quality products. If we do not successfully compete with these competitors, we could fail to develop a sufficient market share to achieve our goals and our future business prospects could be materially adversely affected.

Because the sale of our products involves the potential for product liability, we may incur significant losses and expenses in excess of our insurance coverage.

We face an inherent risk of exposure to product liability claims if the use of our products results in, or is believed to have resulted in, illness or injury. Our products are designed for ingestible or topical use and contain combinations of ingredients, and there is little experience with or knowledge of the long-term effects of these combinations. In addition, interactions of these ingredients and products with other products, prescription medications and over-the-counter treatments have not been fully explored or understood and may have unintended consequences. Future research or results may lead to the discovery of unknown adverse side effects from ~~CBD~~hemp, ~~which~~KAVA and Kratom, which would harm our business.

5Although we believe all our products will be safe when taken as directed by us, there is little long-term research on the effects of human consumption of certain of the new product ingredients or combinations in concentrated form that we use or may in the future use in developing our hemp products. Any instance of illness or negative side effects of ingesting hemp products or applying them topically on the skin could have a material adverse effect on our business and operations by, among other things, exposing us to the risk of costly litigation and/or governmental sanctions and dramatically reducing the demand for some or all our products.

~~Although~~Any weproduct ~~believe~~liability ~~all~~claims ~~our~~or ~~products~~related ~~will~~developments befrom ~~safe~~our ~~when~~products ~~taken~~or ashemp ~~directed~~in bygeneral ~~us,~~may ~~there~~increase isour ~~little~~costs ~~long-term~~and ~~research~~adversely onaffect ~~the effects of human consumption~~our ofrevenue, ~~certain~~product ofdemand ~~the~~and ~~new~~operating ~~product~~results. ~~ingredients~~Moreover, orliability ~~combinations~~claims inarising ~~concentrated~~from ~~form~~a ~~that~~serious weadverse ~~use~~event or may inincrease ~~the future use in developing~~ our costs ~~CBD~~through ~~products.~~higher ~~Any~~insurance ~~instance~~premiums ofand ~~illness~~deductibles orand ~~negative~~may ~~side~~make ~~effects~~it ofmore ~~ingesting~~difficult ~~CBD~~to ~~products~~secure oradequate ~~applying~~insurance ~~them~~coverage ~~topically~~in on the ~~skin could~~future. ~~have~~In aaddition, ~~material~~our ~~adverse~~product ~~effect~~liability oninsurance ~~our~~may ~~business~~fail ~~and~~to ~~operations~~cover ~~by,~~future ~~among~~product ~~other~~liability ~~things~~claims, ~~exposing~~which, usif toadversely ~~the~~determined, ~~risk of costly litigation and/or~~could ~~governmental~~subject ~~sanctions~~us ~~and~~to ~~dramatically~~substantial ~~reducing~~monetary ~~the demand for some or all our products~~damages.

Any product liability claims or related developments from our products or CBD in general may increase our costs and adversely affect our revenue, product demand and operating results. Moreover, liability claims arising from a serious adverse event may increase our costs through higher insurance premiums and deductibles and may make it more difficult to secure adequate insurance coverage in the future. In addition, our product liability insurance may fail to cover future product liability claims, which, if adversely determined, could subject us to substantial monetary damages.

The success of our business will depend upon our ability to create and expand our brand awareness.

The health and wellness and ~~CBD~~hemp markets we compete in are highly competitive, with many well-known brands leading the industry. Our competitors include ~~CBD~~hemp companies who have a longer history operating in these markets than we do. Our ability to compete effectively and generate revenue will be based upon our ability to create and expand awareness of our products distinct from those of our competitors. It is imperative that we are able to convey to consumers the benefits of our products both in general and as compared to competitive offerings. However, advertising, packaging and labeling of our products is limited by various regulations. Our success will be dependent upon our ability to convey to consumers that our products are superior to those of our competitors while complying with complex and varying regulations in the markets in which we attempt to market and sell them.

If we fail to develop and introduce new products it will adversely affect our future prospects.

Our industry is subject to rapid change. New products are constantly introduced to the market. Our ability to remain competitive depends in part on our ability to enhance existing products, to develop and manufacture new products in a timely and cost-effective manner, to adequately anticipate, prepare and execute strategies for market transitions, and to effectively market our products. Management believes that our future financial results will depend to a great extent on the successful expansion of our current product offerings and on the development and introduction of new products. We cannot be certain that we will be successful in selecting, developing, manufacturing and marketing new products or in improving upon or enhancing the market for existing products.

The success of new product introductions or expansions to new territories depends on various factors, including, without limitation, the following:

●	Successful sales and marketing efforts;
●	Timely delivery of the products;
●	Availability of raw materials and/or sufficient production facilities;
●	Pricing of raw materials and labor;
●	Regulatory allowance and restrictions of the products; and
●	Market acceptance and consumer sentiment.

If we fail to appropriately respond to changing consumer preferences and demand for new products, it could significantly harm our customer relationships and product sales and harm our operating results and financial condition.

Our business is subject to changing consumer trends and preferences, especially with respect to targeted nutrition and natural wellness products. Our success will depend in part on our ability to anticipate and respond to these changes, and we may not respond in a timely or commercially appropriate manner to such changes. Furthermore, the health and wellness industry isare characterized by rapid and frequent changes in ~~demand~~ demand for products and new product introductions and enhancements. Our failure to accurately predict these trends could negatively impact ~~consumer~~ consumer opinion of our products, which in turn could harm our customer relationships and product demands and cause the loss of sales. The success of our product offerings depends upon a number of factors, including our ability to:

●	Accurately anticipate consumer needs;
●	Successfully commercialize new products or product enhancements in a timely manner;
●	Price our products competitively;
●	Arrange for the production and delivery our products in sufficient volumes and in a timely manner;
●	Differentiate our products from those of our competitors; and
●	Innovate and develop new products or product enhancements that meet these trends.

If we do not meet these challenges, some of our products could be rendered obsolete, which could negatively impact our operating results and financial condition.

Adverse publicity associated with our products or ingredients, or those of our competitors or similar businesses, could adversely affect our sales and revenue.

Adverse publicity concerning any actual or purported failure by us or our competitors to comply with applicable laws and regulations or concerning any other aspect of our business or the ~~CBD~~hemp industry could have an adverse effect on the public perception of us and our products. This, in turn, could negatively affect our ability to obtain financing, endorsers and attract distributors, retailers or consumers for our products, which would have a material adverse effect.

6Our distributors and customers’ perception of the safety, utility and quality of our products or even similar products distributed by others can be significantly influenced by national media attention, publicized scientific research or findings, product liability claims and other publicity concerning our products or similar products distributed by others. Adverse publicity, whether accurate or not, that causes a perceived connection between consumption of our products or any similar products and illness or other adverse effects, will likely diminish the public’s perception of and in turn the demand for our products. Claims that any products are ineffective, inappropriately labeled or have inaccurate instructions as to their use, could have a material adverse effect on the market demand for our products, including reducing our sales and revenue, which would have a material adverse effect on our business.

Our distributors’ and customers’ perception of the safety, utility and quality of our products or even similar products distributed by others can be significantly influenced by national media attention, publicized scientific research or findings, product liability claims and other publicity concerning our products or similar products distributed by others. Adverse publicity, whether accurate or not, that causes a perceived connection between consumption of our products or any similar products and illness or other adverse effects, will likely diminish the public’s perception of and in turn the demand for our products. Claims that any products are ineffective, inappropriately labeled or have inaccurate instructions as to their use, could have a material adverse effect on the market demand for our products, including reducing our sales and revenue, which would have a material adverse effect on our business.

If we are unable to manufacture our products in sufficient quantities or at defined quality specifications or are unable to maintain regulatory approvals for our production facility, we may be unable to develop or meet demand for our products and lose time to market and potential revenues.

Commercialization of our products require access to, or development of, facilities to manufacture a sufficient supply of our products. In the future we may face difficulties in the development, production or distribution of our products.

We may face competition for access to any third-party supply sources, development or production partners and facilities such as hemp growers and may be subject to production delays if any of those third parties give their other business partners a higher priority than they give to us. Even if we are able to identify additional or replacement third parties, the delays and costs associated with establishing and maintaining a relationship with such third parties may have a material adverse effect on us. Further, a reduction in the control of our production efforts would be inherent in any such outsourcing, which exposes us to a greater risk of liability, including regulatory enforcement actions for alleged noncompliance with law and product liability claims. This could also result in lower product quality which could negatively impact demand for our offerings or our competitive advantage. Any of these challenges could prevent us from achieving our business objectives and harm your investment in us.

If the market opportunities for our current and potential future products are less lucrative than anticipated, our ability to generate revenues may be adversely affected and our business may suffer.

Our understanding, expectation and estimates of the market for our current and future products may prove to be incorrect, and new test results or studies, reports, legislative or regulatory developments or other factors beyond our control may result in the market for our products being lower than anticipated on a regional, national or global scale. The number of individuals in the U.S. who are willing to purchase our products may be lower than expected, or expectations for repetitive purchases and consumption may prove to be incorrect. These occurrences could materially adversely affect our prospects and operational results.

If we are unable to establish relationships with third parties to carry out sales, marketing, and distribution functions or to create effective marketing, sales, and distribution capabilities, we will be unable to market our products successfully.

Our business strategy includes using third parties to market and sell the products at the retail level. There can be no assurance that we will successfully be able to establish marketing, sales, or distribution relationships with a sufficient number of third parties to meet our goals, that such relationships, if established, will be successful, or that we will be successful in gaining market acceptance for current or future products. To the extent that we enter into any marketing, sales, or distribution arrangements with third parties, our product revenues per unit sold are expected to be lower than

if we marketed, sold, and distributed our products directly, and any revenues we receive will depend upon the efforts of such third parties.

If we are unable to establish such third-party marketing and sales relationships, we would have to establish and grow in-house marketing and sales capabilities. To market any products directly, we would have to build a marketing, sales, and distribution force that has technical expertise and could support a distribution capability. Competition in the health and wellness and cannabinoid industries for technically proficient marketing, sales, and distribution personnel is intense, and attracting and retaining such personnel may significantly increase our costs. There can be no assurance that we will be able to establish internal marketing, sales, or distribution capabilities or that these capabilities will be sufficient to meet our needs.

Because of the Russian Invasion of Ukraine, the effect on the capital markets and the economy is uncertain, and as a result we may have to deal with a recessionary economy and economic uncertainty, including possible adverse effects upon our ability to raise capital as and when needed.

As a result of the Russian invasion of Ukraine, certain events are beginning to affect the global and U.S. economy including increased inflation, substantial increases in the prices of oil and gas, large Western companies ceasing to do business in Russia and uncertain capital markets with declines in leading market indexes. The duration of this war and its impact are at best uncertain. Ultimately the economy may turn into a recession with uncertain and potentially severe impacts upon public companies and us, including our ability to raise capital. We cannot predict how this will affect our operations or the industries in which we operate, however any such impact may be material and adverse.

We have a limited operating history upon which investors can evaluate our future prospects.

Panacea was founded and began operations in the ~~CBD~~hemp industry in 2017 and we therefore have a limited operating history upon which an evaluation of our business plan or performance and prospects can be made. Our business and prospects must be considered in the light of the potential problems, delays, uncertainties and complications encountered in connection with a business which is still in its early stages in a relatively new industry characterized by unexpected change. The risks include, but are not limited to, the possibility that we fail to develop functional and scalable products, or that although functional and scalable, our products will not be economical to market in order to become or remain profitable; that our competitors hold proprietary rights precluding us from marketing such products; that our competitors offer a superior or equivalent product or otherwise achieve or maintain greater market acceptance than us; that we are unable to upgrade or improve our processes and products to accommodate new features and expand our offerings; or that we fail to receive or maintain necessary regulatory clearances and compliance for our products and operations. In order to grow our revenue, we must develop and improve upon our brand name recognition and competitive advantages for our products and expand into new markets. Even if we accomplish such growth, resulting expenses may be greater than estimated, which could reduce or even eliminate any revenue gains for which such endeavors were made. There are no assurances that we can successfully address these challenges. If we are unsuccessful, our business, financial condition and operating results could be materially and adversely affected.

~~If the market for CBD products declines, it would materially and adversely affect our business.~~9

~~Following~~If the ~~passage~~market offor ~~the 2018 Farm Bill described below, our industry experienced an influx of~~ hemp ~~farmers and producers which resulted in a saturated marketplace. As a result, the supply for CBD and related~~ products ~~has in the past exceeded demand. This trend could force us to reduce our prices to remain competitive or could result in lower sales levels than we have experienced in the past~~declines, ~~either~~it ~~of which~~ would ~~result~~materially ~~in a decline in revenue or growth rate~~ and ~~could materially~~ adversely affect our ~~financial condition and prospects~~business.

Following the passage of the 2018 Farm Bill described below, our industry experienced an influx of hemp farmers and producers which resulted in a saturated marketplace. As a result, the supply for hemp and related products has in the past exceeded demand. This trend could force us to reduce our prices to remain competitive or could result in lower sales levels than we have experienced in the past, either of which would result in a decline in revenue or growth rate and could materially adversely affect our financial condition and prospects.

If we fail to attract new customers in a cost-effective manner, our business may be harmed.

A large part of our success depends on our ability to attract new customers in a cost-effective manner. We have made, and may continue to make, significant investments in attracting new customers through increased advertising spends on social media, radio, podcasts, and targeted email communications, other media and events, sponsorships, and influencer sponsorships. Marketing campaigns can be expensive and may not result in the cost-effective acquisition of customers. Further, as our brand becomes more widely known, future marketing campaigns may not attract new customers at the same rate as past campaigns and the cost of acquiring new customers may increase over time. Additionally, regulation, algorithms, or participants in the digital marketing ecosystem may change rules for our industry or access to available demographics which may result in significant changes in the ability to target key demographic pools, impacting our ability to target our customers effectively. If we are unable to attract new customers, or fail to do so in a cost-effective manner, our business may be harmed.

Even if we meet our growth objectives and our enter into new markets as intended, we may face difficulties evaluating our current and future business prospects, and we may be unable to effectively manage any growth associated with these achievements, which would increase the risk of your investment losing value and could harm our business, financial condition, and results of operations.

Our entry into new markets and/or growth in our product offering or consumer base may place a significant strain on our resources and increase demands on our executive management, personnel and operational systems, and our human, administrative and financial resources may be inadequate to meet these demands. We may also be unable to effectively manage any expanded operations or achieve planned growth on a timely or profitable basis, particularly if the number of customers using our products significantly increases within a short period of time. If we are unable to manage expanded operations effectively, we may experience operating inefficiencies, the quality of our products could decline, and our business and results of operations could be materially adversely affected.

If we cannot manage our growth effectively, our results of operations would be materially and adversely affected.

We expect to experience growth as we raise additional capital. Businesses which grow rapidly often have difficulty managing their growth while maintaining their compliance and quality standards. If we grow as rapidly as anticipated, we will need to expand our management by recruiting and employing additional executive and key personnel capable of providing the necessary support. There can be no assurance that management, along with staff, will be able to effectively manage our growth nor can there be any assurance that growth in our product offerings, customer base or contracts will translate to an increase in revenue or profitability. Any failure to meet the challenges associated with rapid growth could materially and adversely affect our business and operating results.

Existing or future governmental regulations relating to cannabinoid products may harm or prevent our ability to produce and/or sell our product offerings.

While a majority of state governments in the United States have legalized the growing, production, and use of ~~CBD~~hemp in some form and subject to certain restrictions, cannabis remains illegal under federal law. In addition, in July 2017, the United States Drug Enforcement Agency issued a statement that certain ~~CBD~~hemp extractions fall within the definition of marijuana and are therefore a Schedule I controlled substance under the Controlled Substances Act of 1970, as amended. Thus, the cannabis industry, including companies which sell products containing ~~CBD~~hemp, faces significant uncertainty surrounding regulation by the federal government, which could claim supremacy over state regulatory regimes including those with a “friendlier” view toward ~~CBD~~hemp products. While the federal government has for several years chosen to not intervene in the cannabis business conducted legally within the states that have legislated such activities, there is, nonetheless, potential that the federal government may at any time choose to begin enforcing its laws against the manufacture, possession, or use of cannabis-based products such as ~~CBD~~hemp. Similarly, there is the possibility that the federal government may enact legislation or rules that authorize the manufacturing, possession or use of those products under specific guidelines. Local, state and federal cannabis laws and regulations are broad in scope and subject to evolving interpretations. In the event the federal government was to tighten its regulation of the industry, we would likely suffer a material adverse effect on our business, including potentially substantial losses.

810

Because laws and regulations affecting our industry are evolving, changes to any regulation may materially affect our ~~CBD~~hemp products.

In conjunction with the enactment of the Agriculture Improvement Act of 2018 (the “Farm Bill”), the Food and Drug Administration (the “FDA”) released a statement about the status of ~~CBD~~hemp as a nutritional supplement, and the agency’s actions in ~~the~~ the short term with regards to ~~CBD~~hemp will guide the industry. As a company whose products contain ~~CBD~~hemp, we intend to meet all FDA guidelines as the regulations evolve. Any difficulties in compliance with future government regulation could increase our operating costs and adversely impact our results of operations in future periods.

In addition, as a result of the Farm Bill’s passage, we expect that there will be a constant evolution of laws and regulations affecting the ~~CBD~~hemp industry which could affect our operations. Local, state and federal hemp laws and regulations may be broad in scope and subject to changing interpretations. These changes may require us to incur substantial costs associated with legal and compliance fees and ultimately require us to alter our business plan. Furthermore, violations of these laws, or alleged violations, could disrupt our business and result in a material adverse effect on our operations. In addition, we cannot predict the nature of any future laws, regulations, interpretations or applications, and it is possible that regulations may be enacted in the future that will be directly applicable to our business.

Unexpected changes in federal and state law could cause any of our current products, as well as products that we intend to develop and launch, containing hemp-derived CBD oil to be illegal, or could otherwise prohibit, limit or restrict any of our products containing CBD.

Our business is based on the production and distribution of products containing hemp-derived CBD. The Farm Bill, which amended various sections of the U.S. Code, and legalized the cultivation and sale of industrial hemp at the federal level, subject to compliance with certain federal requirements and state law. There can be no assurance that the Farm Bill will not be repealed or amended such that our products containing hemp-derived CBD would once again be deemed illegal under federal law.

The Farm Bill delegates the authority to the states to regulate and limit the production of hemp and hemp-derived products within their territories. Although many states have adopted laws and regulations that allow for the production and sale of hemp and hemp-derived products under certain circumstances, no assurance can be given that such state laws may not be repealed or amended such that our intended products containing hemp-derived CBD would once again be deemed illegal under the laws of one or more states now permitting such products, which in turn would render such intended products illegal in those states under federal law even if the federal law is unchanged. In the event of either repeal of federal or of state laws and regulations, or of amendments thereto that are ~~adverse~~averse to our intended products, we ~~may~~ may be restricted or limited with respect to those products that we may sell or distribute, which could adversely impact our intended ~~business~~ business plan with respect to such intended products.

Additionally, the FDA has indicated that certain products containing ~~CBD~~hemp are not permissible under the Federal Food, Drug, and Cosmetic Act (the “FDCA”), notwithstanding the passage of the Farm Bill. On December 20, 2018, after the Farm Bill became law, then FDA Commissioner Scott Gottlieb issued a statement in which he reiterated the FDA’s position that ~~CBD~~hemp products that are marketed with a claim of therapeutic benefit must be approved by the FDA for their intended use before they may be distributed in interstate commerce and that the FDCA prohibits interstate distribution of food products containing ~~CBD~~hemp and marketing products containing ~~CBD~~hemp as a dietary supplement, regardless of whether the substances are hemp-derived. Although we believe our existing and planned ~~CBD~~hemp products comply with applicable federal and state laws and regulations, legal proceedings alleging violations of such laws could have a material adverse effect on our results of operations and financial condition. Sources of hemp-derived CBD depend upon legality of cultivation, processing, marketing and sales of products derived from those plants under state law.

Hemp-derived CBD can only be legally produced in states that have laws and regulations that allow for such production and that comply with the Farm Bill, apart from state laws legalizing and regulating medical and recreational cannabis or marijuana, which remains illegal under federal law. This is one of the reasons why we are based in Colorado. Unexpected changes in federal and state law could cause our current CBD production methods or resulting products, as well as products that we intend to develop and launch, to be illegal or could otherwise prohibit, limit or restrict some or all of our products in the event of repeal or amendment of laws and regulations which are now comparatively favorable to the cannabis/hemp industry in certain states, we would be required to locate new suppliers in states with laws and regulations that qualify under the Farm Bill. If we were to be unsuccessful in arranging new sources of supply of our raw ingredients, or if our raw ingredients were to become legally unavailable, our intended business plan with respect to such products could be adversely impacted.11

Hemp-derived CBD can only be legally produced in states that have laws and regulations that allow for such production and that comply with the Farm Bill, apart from state laws legalizing and regulating medical and recreational cannabis or marijuana, which remains illegal under federal law. This is one of the reasons why we are based in Colorado. Unexpected changes in federal and state law could cause our current hemp production methods or resulting products, as well as products that we intend to develop and launch, to be illegal or could otherwise prohibit, limit or restrict some or all of our products in the event of repeal or amendment of laws and regulations which are now comparatively favorable to the cannabis/hemp industry in certain states, we would be required to locate new suppliers in states with laws and regulations that qualify under the Farm Bill. If we were to be unsuccessful in arranging new sources of supply of our raw ingredients, or if our raw ingredients were to become legally unavailable, our intended business plan with respect to such products could be adversely impacted.

Because we and our distributors may only sell and ship our products containing hemp-derived CBD in states that have adopted laws and regulations qualifying under the Farm Bill, a reduction in the number of states having such qualifying laws and regulations could limit, restrict or otherwise preclude the sale of intended products containing hemp-derived CBD.

The interstate shipment of hemp-derived CBD from one state to another is legal only where both states have laws and regulations that allow for the production and sale of such products and that qualify under the Farm Bill. Therefore, the marketing and sale of our products is limited by such factors and is restricted to such states. Although we believe we may lawfully sell any of our finished products including those containing CBD in a majority of states, a repeal or adverse amendment of laws and regulations that are now favorable to the distribution, marketing and sale of finished products we intend to sell could significantly limit, restrict or prevent us from generating revenue related to our products that contain hemp-derived CBD. Additionally, any such adverse changes or existing legislation in new markets we target may stunt our growth and diminish our prospects. Any such repeal or adverse amendment of laws and regulations could have an adverse impact on our business plan with respect to such products.

Costs associated with compliance with numerous laws and regulations and quality standards could adversely impact our financial results.

The manufacture, labeling and distribution of ~~CBD~~hemp products is regulated by various federal, state and local government agencies. These governmental authorities regulate our products and processes to ensure that the products are not adulterated or misbranded. We are subject to regulation by the federal government and other state and local agencies as a result of our ~~CBD~~hemp products. In addition to the risks associated with the possibility of government enforcement or private litigation due to alleged noncompliance, our compliance costs associated with our day-to-day operations are high and are expected to increase as we expand into new markets and/or develop and market new products. For example, as a “seed to sale” ~~CBD~~hemp business, meaning a business which handles every step of a ~~CBD~~hemp product’s manufacture and sale in-house rather than relying on third parties for some or all the production and distribution steps, we are responsible for the quality of our product, and the means by which it is produced and marketed, at every stage. Compliance with regulations imposed on our business model means we must deploy and maintain an advanced computer monitoring system which allows us to track our production and distribution process. We must train our employees and utilize and maintain security measures to ensure our facility functions properly. Compliance with these and other government requirements for product monitoring, quality, labelling and distribution are costly which may limit our profitability.

Our products or third parties with whom we do business may not comply with health, safety and labelling standards.

We do not have control over all of the third parties involved in the sale of our products and their compliance with government health, safety and labelling standards. Even if our products meet these standards, they could otherwise become contaminated or fail, or the standards could be changed in a manner adverse to our operations or those of our business partners. A failure to meet these standards could occur in our operations or those of our distributors or suppliers. This could result in expensive production interruptions, recalls, regulatory investigations and enforcement actions and liability claims. Moreover, negative publicity could be generated from false, unfounded or nominal liability claims or limited recalls. Any of these failures or occurrences could negatively affect our business and financial performance.

If we fail to comply with U.S. laws related to privacy, data security, and data protection, it could adversely affect our operating results and financial condition.

We rely on a variety of marketing techniques, including email, radio, display advertising, and social media marketing, targeted online advertisements, and postal mailings, and we are or may become subject to various laws and regulations that govern such marketing and advertising practices. A variety of federal and state laws and regulations, including those enforced by various federal government agencies such as the Federal Trade Commission, Federal Communications Commission, and state and local agencies, govern the collection, use, retention, sharing, and security of personal data, particularly in the context of online advertising, which we utilize to attract new customers.

The legislative and regulatory bodies or self-regulatory organizations in various jurisdictions inside the United States may expand current laws or regulations, enact new laws or regulations, or issue revised rules or guidance regarding privacy, data protection, consumer protection, information security, and online advertising. California has enacted the California Consumer Privacy Act of 2018 (the “CCPA”), which became operative on January 1, 2020, and its implementing regulations took effect in August 2020. The CCPA requires companies that process personal information on California residents to make new disclosures to consumers about such companies’ data collection, use, and sharing practices and inform consumers of their personal information rights such as deletion rights, allows consumers to opt out of certain data sharing with third parties, and provides a new cause of action for data breaches. In November 2020, California enacted the California Privacy Rights Act of 2020 (the “CPRA”), which amends and expands the scope of the CCPA, while introducing new privacy protections that extend beyond those included in the CCPA and its implementing regulations. The CCPA, as amended and expanded by the CPRA, is one of the most prescriptive general privacy ~~law~~laws in the United States and may lead to similar laws being enacted in ~~other~~ other U.S. states or at the federal level. For example, the State of Nevada also passed a law effective on October 1, 2019, that amends ~~the~~ the state’s online privacy law to allow consumers to submit requests to prevent websites and online service providers (“Operators”) from selling personally identifiable information that Operators collect through a website or online service. Further, on March 2, 2021, the Governor of Virginia signed into law the Virginia Consumer Data Protection Act (the “VCDPA”). The VCDPA creates consumer rights, similar to the CCPA, but also imposes security and assessment requirements for businesses. In addition, on July 7, 2021, Colorado, the state in which we are headquartered, enacted the Colorado Privacy Act (“CoCPA”), becoming the third comprehensive consumer privacy law to be passed in the United States (after the CCPA and VCDPA). Although the CoCPA closely resembles the VCDPA, both of which do not contain a private right of action and will instead be enforced by the respective states’ Attorney General and district attorneys, the two differ in many ways and once they become enforceable in 2023, we must comply with each if our operations fall within the scope of these newly enacted comprehensive mandates. Prior efforts undertaken to comply with other recent privacy-related laws have proven that these initiatives require time to carefully plan, assess gaps in current compliance mechanisms, and implement new policies, processes and remediation efforts. Additionally, the Federal Trade Commission and state attorneys general are interpreting federal and state consumer protection laws to impose standards for the online collection, use, dissemination, and security of data. Each of these privacy, security, and data protection laws and regulations, and any other such changes or new laws or regulations, could impose significant limitations, require changes to our business model or practices, or restrict our use or storage of personal information, which may increase our compliance expenses and make our business more costly or less efficient to conduct. In addition, any such changes could compromise our ability to develop an adequate marketing strategy and pursue our growth strategy effectively, which, in turn, could adversely affect our business, financial condition, and results of operations.

While we intend to strive to comply with applicable laws and regulations relating to privacy, data security, and data protection, given that the scope, interpretation, and application of these laws and regulations are often uncertain and may be in conflict across jurisdictions, it is possible that these obligations may be interpreted and applied in a manner that is inconsistent from one jurisdiction to another and may conflict with other rules or our practices. Any failure or perceived failure by us or third-party service providers to comply with privacy or security policies or privacy-related legal obligations, or any compromise of security that results in the unauthorized release or transfer of personal data, may result in governmental enforcement actions, litigation, or negative publicity, and could have an adverse effect on our operating results and financial condition.

1013

Our planned expansion into international markets will involve inherent risks that we may not be able to control.

Our business plan includes the eventual marketing and sale of our products in international markets. Specifically, we do not currently have a set time frame for entering these markets. Accordingly, our operating results could be materially and adversely affected by a variety of uncontrollable and changing factors relating to international business operations, including:

●	Economic conditions adversely affecting geographic areas in which we intend to do business;
●	Foreign currency exchange rates;
●	Political or social unrest or economic instability in a specific country or region;
●	Higher costs of doing business in foreign countries;
●	Infringement claims on foreign patents, copyrights or trademark rights;
●	Difficulties in staffing and managing operations across disparate geographic areas;
●	Difficulties associated with enforcing agreements and intellectual property rights through foreign legal systems;
●	Trade protection measures and other regulatory requirements, which may affect our ability to import or export our products from or to various countries;
●	Adverse tax consequences;
●	Unexpected changes in legal and regulatory requirements and challenges in complying with varying requirements across jurisdictions; and
●	Military conflict, terrorist activities, natural disasters and medical epidemics.

If we are unable to overcome these or other challenges in executing our planned expansion into international markets, our prospects would be materially adversely affected.

Risks Related to Intellectual Property

We may become involved in litigation or other proceedings relating to patent and other intellectual property rights.

A third party may sue us or our strategic collaborators for infringing its intellectual property rights. Likewise, we may need to resort to litigation to enforce licensed rights or to determine the scope and validity of third-party intellectual property rights. The cost to us of any litigation or other proceeding relating to intellectual property rights, even if resolved in our favor, could be substantial, and the litigation would divert our efforts. Some of our competitors may be able to sustain the costs of complex patent litigation more effectively than we can because they have substantially greater resources. If we do not prevail in this type of litigation, we or our strategic collaborators may be required to pay monetary damages; stop commercial activities relating to the affected products or services; obtain a license in order to continue manufacturing or marketing the affected products or services; or attempt to compete in the market with a substantially similar product. Uncertainties resulting from the initiation and continuation of any litigation could limit our ability to continue some of our operations. In addition, a court may require that we pay expenses or damages, and litigation could distract management or disrupt our commercial activities.

If we become involved in intellectual property litigation, such litigation is likely to be expensive and time-consuming and could be unsuccessful.

Our commercial success will depend in part on our avoiding infringement on the patents and proprietary rights of third parties for products we license or sell. There is substantial litigation, both within and outside the United States, involving patent and other intellectual property rights in the health and wellness industry, including patent infringement lawsuits, interferences, oppositions, and reexaminations and other post-grant proceedings before the U.S. Patent and Trademark Office, and corresponding foreign patent offices. Numerous U.S. and foreign issued patents and pending patent applications which are owned by third parties may exist with products we may license and sell.

Parties making intellectual property claims against us may obtain injunctive or other equitable relief, which could block our ability to further develop and commercialize one or more products. Defense of these claims, regardless of their merit, involves substantial litigation expense and would be a substantial diversion of our management’s attention from our business. If a claim of infringement against us succeeds, we may have to pay substantial damages, possibly including treble damages and attorneys’ fees for willful infringement, pay royalties, redesign our infringing products or obtain one or more licenses from third parties, which may be impossible or require substantial time and monetary expenditure.

To counter infringement or unauthorized use claims against us, we may be required to file infringement claims in response, or we may be required to defend the validity or enforceability of any such intellectual property rights. In an infringement proceeding, a court may decide that either our or one or more of our licensors’ intellectual property rights are not valid or is unenforceable or may refuse to stop the other party from using the underlying concepts or technology at issue because our intellectual property rights do not cover those elements. In any event, intellectual property litigation is expensive and time consuming and we may be unsuccessful in defending or enforcing such claims, which would materially harm our business.

Any inability to protect our intellectual property rights could reduce the value of our products and brands, which could adversely affect our financial condition, results of operations and business.

Our business is partly dependent upon our trademarks, trade secrets, copyrights and other intellectual property rights. Effective intellectual property rights protection, however, may not be available under the laws of every country in which we and our sub-licensees may operate. There is a risk of certain valuable trade secrets being exposed to potential infringers. Regardless of whether our compounds and technology are or becomes protected by patents or otherwise, there is a risk that other companies may employ such compounds or technology without authorization and without recompensing us.

The efforts we take to protect our proprietary rights may not be sufficient or effective. Any significant impairment of our intellectual property rights could harm our business or our ability to compete. In addition, protecting our intellectual property rights is costly and time consuming. There is a risk that we may have insufficient resources to counter adequately such infringements through negotiation or the use of legal remedies. It may not be practicable or cost effective for us to fully protect our intellectual property rights in some countries or jurisdictions. If we are unable to successfully identify and stop unauthorized use of our intellectual property, we could lose potential revenue and experience increased operational and enforcement costs, which could adversely affect our financial condition, results of operations and business.

The intellectual property behind our products may include unpublished know-how, which is dependent on certain key individuals, as well as existing and pending intellectual property protection.

The commercialization of our products is partially dependent upon know-how and trade secrets held by certain individuals working with and for us. Because the expertise runs deep in these few individuals, if something were to happen to any or all of these individuals, the ability to properly manufacture our products without compromising quality and performance could be diminished greatly. Further, [while our employees and contractors are subject to non-disclosure obligations,] any misappropriation of confidential information including trade secrets and know-how could allow our competitors and others to overcome any advantage we have and reduce our market share and viability.

Risks Related to Our Securities and Our Status as an SEC Reporting Company

Because our Chief Executive Officer, directly and through entities she controls, beneficially owns approximately 61% of our issued and outstanding common stock and voting power on an as-converted basis, she can exert significant control over our business and affairs which may be averse to those of our stockholders, particularly if a conflict of interest arises.

Our Chief Executive Officer and currently one of our two directors, owns approximately 61% of our issued and outstanding shares of common stock and voting power on an as-converted basis. As of December 31, 2022, Ms. Buttorff and or her companies also hold $14.796 million in demand notes which bear interest at a rate ranging from 0 to 12% per annum. The interests of Ms. Buttorff may differ from the interests of our other stockholders, including by virtue of her other businesses operated through her entities and their holdings that are not affiliated with us. As a result, Ms. Buttorff will have significant influence and control over all corporate actions including those actions requiring stockholder approval, irrespective of how our minority stockholders may vote, including the following actions:

●	the election of our directors;
●	charter or bylaw amendments;
●	a merger, asset sale or other fundamental corporate transaction; and
●	any other matter submitted to our stockholders for a vote, subject only to applicable law including the Nevada Revised Statutes.

This concentration of ownership and the conflicts of interest may have the effect of impeding a merger, consolidation, takeover or other business combination or tender offer for our common stock which other stockholders may deem desirable or could reduce our stock price or prevent our stockholders from realizing a premium over our stock price in such a transaction. Further, to the extent our other stockholders disagree with an action Ms. Buttorff elects to take as a stockholder, their ability to prevent such action or avoid the effect on their shareholdings will range from significantly limited to non-existent due to our current capital structure, subject only to applicable law and our charter documents. Therefore, if Ms. Buttorff has an interest adverse to other stockholders, or if other stockholders otherwise disagree with Ms. Buttorff with respect to a matter before the stockholders, they will have little to no control over that matter and the direction we ultimately take.15

This concentration of ownership and the conflicts of interest may have the effect of impeding a merger, consolidation, takeover or other business combination or tender offer for our common stock which other stockholders may deem desirable or could reduce our stock price or prevent our stockholders from realizing a premium over our stock price in such a transaction. Further, to the extent our other stockholders disagree with an action Ms. Buttorff elect to take as a stockholder, their ability to prevent such action or avoid the effect on their shareholdings will range from significantly limited to non-existent due to our current capital structure, subject only to applicable law and our charter documents. Therefore, if Ms. Buttorff has an interest adverse to other stockholders, or if other stockholders otherwise disagree with Ms. Buttorff with respect to a matter before the stockholders, they will have little to no control over that matter and the direction we ultimately take.

The requirements of being a public company may strain our resources and distract our management, which could make it difficult to manage our business.

The federal securities laws require us to comply with SEC reporting requirements relating to our business and securities. Complying with these reporting and other regulatory obligations is time-consuming and will result in increased costs to us which could have a negative effect on our financial condition or business. These increased costs are not reflected in the financial statements contained in this Annual Report on Form 10-K because during the periods covered Panacea was a private company not subject to SEC reporting obligations.

As a public company, we are subject to the reporting requirements of the Exchange Act and the requirements of the Sarbanes-Oxley Act. These requirements may place a strain on our systems and resources. We are required to file annual, quarterly and current reports with the SEC disclosing certain aspects and developments of our business and financial condition. The Sarbanes-Oxley Act requires that we maintain effective disclosure controls and procedures and internal controls over financial reporting. To maintain and improve the effectiveness of our disclosure controls and procedures, we will need to commit significant resources, hire additional executive officers and personnel and provide for additional management oversight. We intend to implement additional procedures and processes for the purpose of addressing the standards and requirements applicable to SEC reporting companies. Sustaining our growth will also require us to commit additional managerial, operational and financial resources to identifying competent professionals to join us and to maintain appropriate operational and financial systems to adequately support our intended expansion. These activities may divert management’s attention from other business concerns, which could have a material adverse effect on our results of operations, financial condition or business.

Due to factors beyond our control, our stock price may be volatile.

Any of the following factors could affect the market price of our common stock:

●	Our failure to generate increasing material revenues from our business;
●	Our failure to enhance our product offerings or expand into new markets;
●	A decline in our revenue or growth rate;
●	Our public disclosure of the terms of any financing which we consummate in the future;
●	A decline in the economy which impacts the demand for our products and our ability to generate revenue and achieve growth metrics;
●	Announcements by us or our competitors of significant contracts, new products, acquisitions, commercial relationships, joint ventures or capital commitments;
●	Changes in laws, regulations or government actions affecting the cannabinoid industry in general or our products in particular;
●	Our ability to list our common stock on a national securities exchange;
●	Our ability to attract analyst coverage;
●	The sale of large numbers of shares of common stock by our shareholders;
●	Short selling activities; or
●	Changes in market valuations of similar companies.

In the past, following periods of volatility in the market price of a company’s securities, securities class action litigation has often been instituted. A securities class action suit against us could result in substantial costs and divert our management’s time and attention, which would otherwise be used to benefit our business. These broad market and industry factors may have a material adverse effect on the market price of our common stock, regardless of our actual operating performance. These factors could have a material adverse effect on our business, financial condition and results of operations.16

These broad market and industry factors may have a material adverse effect on the market price of our common stock, regardless of our actual operating performance. These factors could have a material adverse effect on our business, financial condition and results of operations.

We are subject to the “penny stock” rules which will adversely affect the liquidity of our common stock.

The SEC has adopted regulations which generally define “penny stock” to be an equity security that has a market price of less than $5.00 per share, subject to specific exemptions. The market price of our common stock on the OTCQB is presently less than $5.00 per share and therefore we are considered a “penny stock” company according to SEC rules. While we intend to effect a reverse stock split pending compliance with SEC Rules, including the filing of a Schedule 14C, to increase our stock price, until such time as our stock price rises above $5.00 per share (which may not occur following the reverse stock split or at all), the “penny stock” designation requires any broker-dealer selling our securities to disclose certain information concerning the transaction, obtain a written agreement from the purchaser and determine that the purchaser is reasonably suitable to purchase the securities. These rules limit the ability of broker-dealers to solicit purchases of our common stock and therefore reduce the liquidity of the public market for our shares.

Broker-dealers are increasingly reluctant to permit investors to buy or sell speculative unlisted stock and often impose costs which make it uneconomical for small shareholders to do so. Moreover, as a result of apparent regulatory pressure from the SEC and the Financial Industry Regulatory Authority (“FINRA”) a growing number of broker-dealers decline to permit investors to purchase and sell or otherwise make it difficult to sell shares of penny stocks. The “penny stock” designation may have a depressive effect upon our common stock price which the prospective reverse stock split may not sufficiently overcome.

Our ability to continue as a going concern is in doubt unless we obtain adequate new debt or equity financing and achieve sufficient sales levels.

As noted above, we have incurred significant net losses to date. We anticipate that we will continue to lose money for the foreseeable future. Additionally, we have negative cash flows from operations and we our revenue may exceed our expenses in the next 12 months. Since our inception in 2017, we have generated losses from operations. As of December 31, ~~2021~~2023, our accumulated deficit was $1633.79 million, and we had $30.81 million in cash and liquid stock. Our continued existence is dependent upon generating sufficient working capital and obtaining adequate new debt or equity financing. These factors raise doubt about our ability to continue as a going concern for a period of 12 months from the issuance date of this report. Management cannot provide assurance that we will ultimately achieve or maintain profitable operations or become cash flow positive or raise additional debt and/or equity capital. Because of our continuing losses, without improvements in our cash flow from operations or new financing, we may have to continue to restrict our expenditures. Working capital limitations may impinge on our day-to-day operations, which may contribute to continued operating losses.

Operational risks such as material weaknesses and other deficiencies in internal control over financial reporting could result in errors, potentially requiring restatements of our historical financial data, leading investors to lose confidence in our reported results.

There are a number of factors that may impede our efforts to establish and maintain effective internal controls and a sound accounting infrastructure, including our lacking a Chief Financial Officer, our pace of growth, and general uncertainty regarding the operating effectiveness and sustainability of controls. Controls and procedures, no matter how well designed and operated, provide only reasonable assurance that material errors in our financial statements will be prevented or detected on a timely basis. Any failure to establish and maintain effective internal controls over financial reporting increases the risk of material error and/or delay in our financial reporting. Depending on the nature of a failure and any required remediation, ineffective controls could have a material adverse effect on our business and potentially result in additional restatements of our historical financial results. Financial restatements or other issues arising from ineffective controls and our recent change of our auditors could also cause investors to lose confidence in our reported financial information, which would have an adverse effect on the trading price of our securities. Delays in meeting our financial reporting obligations could affect our ability to maintain the listing of our securities. Although we seek to reduce these risks through active efforts relating to properly documented processes, adequate systems, risk culture, compliance with regulations, corporate governance and other factors supporting internal controls, such procedures may not be effective in limiting each of the operational risks.

~~Potential Impacts of the COVID-19 Pandemic on Our Business Operations~~17

As disclosed in Note 2 to our consolidated financial statements, the COVID-19 pandemic has had a notable impact on general economic conditions, including but not limited to the temporary closures of many businesses, “shelter in place” and other governmental regulations, reduced business and consumer spending due to both job losses and reduced investing activity, among many other effects attributable to the COVID-19 pandemic, and there continue to be many unknowns.

Potential Impacts of Certain Current and Proposed Regulations on Our Business and Operations

AMany ~~bill~~companies ~~titled~~that ~~the~~produce ~~Cannabis Administration and Opportunity Act, put forward by Senate Majority leader Chuck Schumer, D~~hemp-~~NY,~~derived ~~would~~CBD ~~amend~~products ~~the definition~~including ofus aundertake ~~dietary supplement~~ to ~~remove~~abide by the ~~prohibition~~same onregulations ~~marketing CBD~~ as aany other dietary ~~supplement.~~supplements like ~~Management~~ingredient ~~sees~~filings, ~~the~~good ~~bill,~~manufacturing ifpractices ~~enacted~~(GMP), as anand ~~opportunity~~labeling ~~for~~and ~~the~~marketing ~~FDA~~provisions. toWe ~~accelerate~~will ~~their~~continue ~~decision~~ to ~~classify~~sell CBD ~~products~~and other ashemp-derived aproducts ~~dietary~~while ~~supplement.~~still ~~This~~awaiting ~~would be~~ a ~~significant step~~clear ~~for~~path ~~hemp/CBD~~from ~~companies as it would open~~ the ~~door~~FDA toabout ~~new~~how ~~selling opportunities, such as getting into retail stores, who have largely been hesitant to welcome~~ CBD inproducts ~~their~~can ~~doors~~be ~~without~~marketed aand ~~clear position from the FDA~~used.

~~Many~~People ~~people~~ are increasingly turning to ~~CBD~~hemp products for several reasons: CBD is non-psychoactive, so it does not produce a “high” ~~like~~ like THC, there are few known contraindications, the properties of different cannabinoids can positively affect a wide range of ailments, and cannabinoids work directly and indirectly with the body’s endocannabinoid system to create balance known as homeostasis. As demand increases, we believe the FDA must provide more clarity about CBD’s legalization, and this bill is a promising first step.

For now, many companies that produce hemp-derived CBD products including us undertake to abide by the same regulations as any other dietary supplements like ingredient filings, good manufacturing practices (GMP), and labeling and marketing provisions. We will continue to sell CBD and other hemp-derived products while still awaiting a clear path from the FDA about how CBD products can be marketed and used.

Item 1B. Unresolved Staff Comments

None.

Item 2. Properties

XXII has allocated 10 acres of the Needle Rock Farm in Delta County, CO to Panacea. We also lease our laboratory space at 16194 West 45^thDrive, Golden, CO 80403 from J&N Real Estate Company, LLC which is owned by its CEO. See Note 5 to our consolidated financials.

Item 3. Legal Proceedings

~~We have sued Defendants, Mike Fisher, in his official capacity as Osage County District Attorney ex rel~~None. State of Oklahoma as an investigating and/or prosecuting body, Eddie Virden in his official capacity as the Sheriff of the City of Osage as holder of the property, and the City of Pawhuska as the property seizing body, (collectively the “Government Defendants”) for the return of approximately 17,000 pounds of industrial hemp (the “Property”). We believe we were entitled to possession of the Property pursuant to an August 23, 2018, contract between us and Blue Circle Development, LLC (“BCD”), wherein we agreed to pay and BCD agreed to deliver the Property according to certain terms. Plaintiff performed pursuant to the contract and is entitled to possession of the Property. We believe the Government Defendants wrongfully detained the Property and is responsible for damages to the Property and to us. On or about May 4, 2020, the Government Defendants improperly released the Property to BCD in violation of a Court Order. We have asserted claims against the Government Defendants for interference with the Court Order and BCD for improperly intercepting the Property from us. The case is currently set for a trial date in March 2023.

On February 16, 2021, Henley Group, Inc. filed with the Superior Court of the State of California, San Bernardino County, a complaint (Case #: SIV SB 2105771) against us for breach of contract and fraud related to our non-delivery of product. While we refunded the purchase price, the plaintiff seeks damages including lost profits and costs which plaintiff alleged to have incurred in the amount of approximately $45,000 as well as lost profits from expected future contracts with a prospective third-party buyer which plaintiff alleged to be $720,000. The plaintiff also seeks attorney’s fees and costs, consequential damages and punitive damages. This case was dismissed in May, 2022.

On October 7, 2019, CMI Mechanical (“CMI”) agreed to procure, deliver, and install a dehumidification system (the “System”) at our facility located at 16194 W. 45th Drive, Golden, Colorado 80403 (the “Property”). We believe the System has failed to meet the requirements of the subject contract, and CMI has not remedied that failure for us. We withheld certain payments as permitted under the contract. On December 10, 2020, CMI recorded a lien against the Property in the amount of $108,001.48. On January 27, 2021, the Panacea’s attorney notified CMI that its lien was invalid, overstated, and violated the terms of the contract. The letter also demanded that CMI remove the system at CMI’s own cost. The lien was since dropped. We settled this dispute in February 2022.

Item 4. Mine Safety Disclosures

Not applicable.

PART II

Item 5. Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities

Market Information

Our Common Stock is quoted on the OTCQB over-the-counter market under the symbol “PLSH.” Over-the-counter market quotations reflect inter-dealer prices, without retail mark-up, mark-down or commissions and may not necessarily represent actual transactions. On March 28, ~~2023~~2024, the closing bid price on the OTC Markets for our Common Stock was $0.~~249~~19.

Penny Stock

The SEC has adopted rules that regulate broker-dealer practices in connection with transactions in penny stocks. Penny stocks are generally equity securities with a market price of less than $5.00, other than securities registered on certain national securities exchanges or quoted on the NASDAQ system, provided that current price and volume information with respect to transactions in such securities is provided by the exchange or system. The penny stock rules require a broker-dealer, prior to a transaction in a penny stock, to deliver a standardized risk disclosure document prepared by the SEC, that: (a) contains a description of the nature and level of risk in the market for penny stocks in both public offerings and secondary trading; (b) contains a description of the broker’s or dealer’s duties to the customer and of the rights and remedies available to the customer with respect to a violation of such duties or other requirements of the securities laws; (c) contains a brief, clear, narrative description of a dealer market, including bid and ask prices for penny stocks and the significance of the spread between the bid and ask price; (d) contains a toll-free telephone number for inquiries on disciplinary actions; (e) defines significant terms in the disclosure document or in the conduct of trading in penny stocks; and (f) contains such other information and is in such form, including language, type size and format, as the SEC shall require by rule or regulation.

The broker-dealer also must provide, prior to effecting any transaction in a penny stock, the customer with (a) bid and offer quotations for the penny stock; (b) the compensation of the broker-dealer and its salesperson in the transaction; (c) the number of shares to which such bid and ask prices apply, or other comparable information relating to the depth and liquidity of the market for such stock; and (d) a monthly account statement showing the market value of each penny stock held in the customer’s account.

In addition, the penny stock rules require that prior to a transaction in a penny stock not otherwise exempt from those rules, the broker-dealer must make a special written determination that the penny stock is a suitable investment for the purchaser and receive the purchaser’s written acknowledgment of the receipt of a risk disclosure statement, a written agreement as to transactions involving penny stocks, and a signed and dated copy of a written suitability statement.

These disclosure requirements may have the effect of reducing the trading activity for our common stock. Therefore, stockholders may have difficulty selling our securities.

Holders of Our Common Stock

As of March 28, ~~2023~~2024, we had 1417,~~965~~645,~~317~~352 shares of our common stock issued and outstanding, and approximately ~~186~~190 shareholders on record.

Dividends

There are no restrictions in our articles of incorporation or bylaws that prevent us from declaring dividends. The Nevada Revised Statutes, however, do prohibit us from declaring dividends where after giving effect to the distribution of the dividend:

1. We would not be able to pay our debts as they become due in the usual course of business, or;

2. Our total assets would be less than the sum of our total liabilities plus the amount that would be needed to satisfy the rights of shareholders who have preferential rights superior to those receiving the distribution.

We have not declared any dividends and we do not plan to declare any dividends in the foreseeable future.

Item 6. Selected Financial Data

A smaller reporting company is not required to provide the information required by this Item.

Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations Forward-Looking Statements

The following discussion of our financial condition and results of operations should be read in conjunction with the unaudited condensed consolidated financial statements and the notes to those statements that are included elsewhere in this report. Our discussion includes forward-looking statements based upon current expectations that involve risks and uncertainties, such as our plans, objectives, expectations and intentions. Actual results and the timing of events could differ materially from those anticipated in these forward-looking statements because of several factors, including those set forth under the Part I, Item 1A, Risk Factors and Business sections in our 2021 10-K, this report, and our other filings with the Securities and Exchange Commission. We use words such as “anticipate,” “estimate,” “plan,” “project,” “continuing,” “ongoing,” “expect,” “believe,” “intend,” “may,” “will,” “should,” “could,” and similar expressions to identify forward-looking statements. In addition, any statements that refer to projections of our future financial performance, our anticipated growth and trends in our businesses, and other characterizations of future events or circumstances are forward-looking statements. Such statements are based on our current expectations and could be affected by the uncertainties and risk factors described throughout this report.

1619

General

We are a Nevada corporation organized in 2008. Exactus, Inc. was our former name. We have pursued opportunities in hemp-based businesses, which we refer to as “cannabinoids or CBD”. On June 30, 2021, Panacea Life Sciences, Inc. “Panacea” entered into an Exchange Agreement with Exactus and as a result became a seed-to-sale Cannabinoid company. The former Panacea stockholders have assumed majority control of us, and all our operations are now operated through Panacea which because of the share exchange became our wholly owned subsidiary. Leslie Buttorff, became our Chief Executive Officer and a director upon the closing of the share exchange, also became our principal stockholder through common stock and Convertible Preferred Stock issued to her and entities she controls.

Panacea Life Sciences Holdings, Inc. (PLSH) is holding company structured to support the life sciences and health and wellness industry. Panacea, which was founded by Leslie Buttorff in 2017 as a woman-owned business, attracted a $14 million investment from 22nd Century Group, Inc., or XXII, a plant biotechnology company which also has a focus on ~~CBD~~hemp products and technology, during 2019. XXII has retained a 15.19% stake in us following the share exchange. Through Panacea, we are dedicated to developing and producing the highest-quality, most medically relevant, legal, hemp-derived cannabinoid products for consumers and pets. Beginning at a farm Panacea owns a parcel of located at Needle Rock, Colorado and leases laboratory space located within a 51,000 square foot, state-of-the-art, cGMP, extraction, manufacturing, testing and fulfillment center located in Golden, Colorado, Panacea operates in every segment of the ~~CBD~~hemp product value chain. From cultivation to finished goods, Panacea ensures its products with stringent testing protocols employed at every stage of the supply chain. Panacea endeavors to offer pure natural remedies within product lines for every aspect of life: PANA Life®, PANA Beauty®, PANA Sport™, PANA Pet®, PANA PURE™ and PANA Health™.

Its subsidiary, Panacea Life Sciences, Inc. (PLS) is dedicated to manufacturing, research and producing the highest-quality, hemp-derived cannabinoid, functional mushroom, Kratom and nutraceutical products for consumers and pets. From cultivation to finished goods, the company ensures its products with stringent GMP standards and testing protocols employed at every stage of the supply chain.

We are well positioned to develop novel hemp extracts as dietary supplements and topical applications. Our biotechnology plans focus on our research at Colorado State University where we are involved in several health-related research studies.

In 2024, a third business entity, Pana Kava Java (PKJ), is set to emerge as the franchisor company, with a scheduled launch in Q3-Q4 2024. Pana Kava Java is committed to establishing a unique franchise model, drawing inspiration from the European-style café concept. Patrons will have the opportunity to savor infused coffees and beverages, indulge in vaping, and enjoy an array of infused baked goods in a welcoming atmosphere. Pana Kava Java, as the franchisor, will offer franchise rights to individuals interested in opening stores/cafés, enabling them to sell products or services under the PKJ brand, leveraging our expertise and intellectual property. Currently, active efforts are underway in developing the franchisor plan, encompassing aspects such as business development, flagship store establishment, legal document preparation, marketing and packaging strategies, as well as the recruitment and training of franchisees.

Results of Operations

Comparison of the Years Ended December 31, ~~2022~~2023, and ~~2021~~2022.

The following table sets forth our results of operations for the years ended December 31, ~~2022~~2023, and December 31, ~~2021~~2022.

	Years Ended December 31,						Period to
	2022			2021			Period Change
	2023			2022			Period Change
Revenues from cannabinoid sales	$	1,515,448		$	1,933,627		$	(418,179	)
Revenues from nutraceutical and CBD sales	$	1,762,903		$	1,515,448		$	247,455
Revenues from PPE sales	$	~~111,530~~-		$	66111,~~000~~530		$	45(111,530	)
Cost of sales	$	1,230,508		$	1,519,049		$	(288,541	)
Revenues from Pana Distro sales	$	595,549		$	-		$	595,549
Operating expenses	$	4,955,348		$	4,959,059		$	(3,710	)
Cost of sales	$	1,262,979		$	1,230,508		$	(32,471	)
General and administrative	$	1,093,364		$	1,518,687		$	(425,322	)
Production related operating expenses	$	5,211,719		$	4,955,348		$	256,371
Interest expense	$	(2,048,171	)	$	(1,105,243	)	$	(942,928	)
General and administrative	$	1,456,412		$	1,093,364		$	363,048	)
Unrealized gain on marketable securities	$	(2,660,105	)	$	1,008,046		$	(3,668,151	)
Interest expense	$	(1,555,877	)	$	(2,048,171	)	$	(492,294	)
Realized gain on sale of securities	$	22,816		$	160,296		$	(137,480	)
Unrealized gain on marketable securities	$	(1,092,429	)	$	(2,660,105		$	(1,567,676	)
Other income (loss)	$	27,598		$	-		$	27,598
Realized gain on sale of securities	$	-		$	22,816		$	(22,816	)
Employer retention credit	$	253,791		$	396,679		$	(142,888	)
Other income (loss)	$	-		$	27,598		$	(27,598	)
Rental income	$	232,183		$	236,560		$	(4,377	)
Employer retention credit	$	-		$	253,791		$	(253,791	)
Loss on sale of assets	$	-		$	(297,351	)	$	297,351
Rental income	$	178,411		$	232,183		$	(53,772	)
Gain on extinguishment of debt	$	681,546		$	755,782		$	(74,236	)

Year Ended December 31, ~~2022~~2023, and ~~2021~~2022

Net Revenues

We are principally engaged in the business of manufacturing, producing, and selling products for nutraceutical companies and our own products made from industrial hemp. Revenue consists of sales of our five ~~category~~categories of brand products, white label and contract manufacturing sales to other ~~CBD~~hemp companies, raw material sales (distillate and isolate), and tolling arrangements.

Our revenues for the year ended December 31, ~~2022~~2023, ~~decreased~~increased by $~~432~~757,~~649~~978, or 2147%, to $12,~~626~~384,~~978~~956 as compared to $21,~~059~~626,~~627~~978 for the year ended December 31, ~~2021~~2022. The ~~decrease~~increase in sales is in ~~2021~~2023 was due ~~primarily~~ to the ~~decrease~~company’s ofincreased ~~CBD~~focus ~~sales and the continued impact COVID and the economy has had~~ on ~~the CBD business. In 2022, we continued to see many of our CBD customers go out of business, so this continued to impact our white label and~~ contract manufacturing ~~contracts.~~for ~~We expect the decrease in sales activity to continue due to limited capital~~nutraceutical ~~resources until we consummate additional financing~~companies.

Cost of Sales

Cost of sales for the year ended December 31, ~~2022~~2023, ~~correspondingly~~increased ~~decreased~~ by $~~288~~32,~~541~~471, or 193%, to $1,~~230~~262,~~508~~979 as compared to $1,~~519~~230,~~049~~ 508 for the year ended December 31, ~~2021~~2022. The ~~decrease~~increase in cost of sales was due primarily to ~~decrease~~more inmaterial ~~sales~~procurement asfrom ~~well~~increased ~~as the effect of COVID-19 on the materials supply chain~~revenues. The primary components of cost of sales include the cost of ~~manufacturing~~procuring ~~the~~raw ~~CBD~~materials ~~products.~~and ~~The~~the ~~decrease in~~cost ~~costs~~of ~~corresponds~~manufacturing to the ~~decrease~~associated ~~in sales~~products.

Operating Expenses

Operating expenses for the year ended December 31, ~~2021~~2023, ~~decreased~~increased by $~~429~~619,~~032~~419, or 710%, to $6,~~048~~668,~~712~~131 as compared to $6,~~677~~048,~~746~~712 for the year ~~ended~~ ended December 31, ~~2021~~2022. The ~~decrease~~increase in operating expenses was primarily due to aincreased ~~cut~~production ~~back~~related inoperating expenses as well as increased general and administrative expenses ~~of $425,322~~.

The ~~decrease~~increase in ~~general~~production ~~and~~relating ~~administrative~~ expenses of $~~429~~256,~~032~~371 or 75% to $15,~~093~~211,~~364~~719 for the year ended December 31, ~~2022~~2023, as compared to $14,~~518~~955,~~686~~ 348 for the year ended December 31, ~~2021~~2022, was primarily due to ~~decreases~~increased instorage ~~sales~~costs ~~commissions, sales~~ and ~~marketing~~increased ~~activities as~~building ~~well as decreases in professional fees such as legal fees and consulting services~~costs.

Within the total G&A category of expenses, sales and marketing expenses decreased from $0.378 million to $0.169 million for the 12 months ended December 31, 2022 when compared to the 12 months ended December 31, 2021.21

~~Also,~~The ~~within~~increase ~~the~~in ~~total~~general ~~G&A~~and ~~category~~administrative of expenses, ~~professional,~~of ~~legal~~$363,048 ~~and~~or ~~consulting~~33% ~~fees~~to ~~were~~1,456,412 ~~$0.478 million~~ for the 12year ~~months~~ ended December 31, ~~2022~~2023, ~~when~~as compared to $~~0.779~~1,093,364 ~~million~~for the 12year ~~months~~ ended December 31, ~~2021.~~2022, Inwas ~~2021,~~primarily ~~legal~~due ~~fees~~to ~~were~~increased ~~related~~bad todebt ~~the~~write-offs. ~~XXII~~Included ~~farm~~in ~~sale~~this increased bad debt ~~and~~expense ~~investment~~was ~~restructuring,~~a ~~the~~write-off ~~Panacea~~of ~~reverse~~a ~~merger~~$500,000 ~~and~~receivable ~~fees~~representative ~~related~~of hemp due to ~~obtaining~~the acompany ~~trademark~~from ~~for~~XXII. ~~our~~This ~~brand~~receivable was deemed uncollectible and subsequently expensed.

Other income (expense)

Other income for the year ended December 31, ~~2022~~2023, ~~decreased~~increased by $41,~~645~~021,~~111~~196, or ~~402~~29%, to (32,~~490~~469,~~432~~147) as compared to $1(3,~~154~~490,~~769~~432) for the year ended December 31, ~~2021~~2022. This ~~decrease~~increase is due primarily to ~~increased~~decreased interest expense and a ~~decrease~~smaller inunrealized ~~value~~loss related to the value of the shares of XXII held by the company. InOn January 3, 2022, ~~the~~ XXII ~~was~~closed ~~trading~~ at $23.1712 ~~verses~~per share. On January 3, 2023, XXII closed at $0.9291 and on December 29, 2023, closed at ~~year~~$0.20 ~~end~~per share. The stock and was also subject to a reverse share split of 15 to 1 that took place on July 5, 2023.

Summary of Cash Flows

	Years ended December 31,
	2021			2020
	2023			2022
Cash (used in) / provided by
Operating activities	$	(21,~~399~~524,~~579~~463	)	$	(32,~~922~~399,~~090~~579	)
Investing activities		(~~196~~65,~~972~~322	)		~~522~~(196,~~533~~972	)
Financing activities		21,~~583~~683,~~728~~756			32,~~334~~583,~~953~~728
Net decrease in cash and cash equivalents	$	(12,823	)	$	(64,605	)
Net increase (decrease) in cash and cash equivalents	$	93,971		$	(12,823	)

Cash flows from operating activities

Net cash used in operating activities was $21,~~399~~524,~~579~~463 for the year ended December 31, ~~2022~~2023, as compared to $32,~~922~~399,~~090~~579 for the year ended December 31, ~~2021~~2022. The decrease in ~~2022~~2023 was due primarily to decreasing operating and SG&A expenses. The largest source of operating cash is from our customers. ~~Approximately~~CBD ~~one-half~~sales ofare ~~our~~processed ~~revenue~~online ~~comes~~with ~~from~~payment ~~customers~~due ~~who~~at ~~purchase~~checkout, ~~CBD~~and ~~on-line,~~the soassociated credit card payments are ~~collected~~ collected and paid within 1-2 business days. Other white label and contract manufacturing customers generally pay before the products are released inor ~~most~~some ~~cases. Some~~ larger customers ~~have~~are given either net 10, 2% or 30 day net terms.

Cash flows from investing activities

Net cash used in investing activities was $~~196~~65,~~972~~322 for the year ended December 31, ~~2022~~2023, as compared to ~~net cash provided by investing activities of~~ $~~522~~196,~~533~~972 for the year ended December 31, ~~2021~~2022. The decrease of cash ~~provided~~used in ~~2022~~2023 was due primarily to ~~proceeds~~fewer ~~from sales of~~ fixed ~~assets~~ ~~and~~asset ~~marketable securities~~purchases.

Cash flows from financing activities

~~During~~Net ~~the year ended December 31, 2022,~~ cash ~~provided~~used byin financing activities ~~totaled~~was $21,~~583~~683,~~728~~756 ~~which~~for ~~includes~~the ~~proceeds~~year ofended $4December 31,~~090,448~~ ~~from related party notes and $253~~2023,~~791~~ ~~from~~as acompared ~~related~~to ~~party payroll protection loan partially offset by repayments of convertible notes of~~ $12,~~100~~583,~~000~~728 ~~and~~for ~~repayment of related party notes payable in~~ the ~~amount~~year ofending December ~~$660~~31,~~511.~~ In 2022 ~~the primary financing was cash provided by Company’s CEO~~.

During the year ended December 31, ~~2021,~~2023 cash provided by financing activities totaled $31,~~334~~683,~~953~~756 which ~~includes~~included repayment of $2135,~~302~~000 on a convertible note,~~468~~ ~~from~~repayment of related party notes ~~payable,~~in ~~$1,000,000~~the ~~from~~amount ~~convertible~~of ~~notes~~$272,075 and proceeds of $~~243~~2,~~041~~090,831 from ~~other~~related ~~loans~~party notes.

During the year ended December 31, 2022, cash provided by financing activities totaled $2,583,728 which included proceeds of $4,090,448 from related party notes and $253,791 from a related party payroll protection loan partially offset by repayments of convertible notes of $1,100,000 and repayment of related party notes payable in the amount of $660,511. In 2023 the primary financing was cash provided by Company’s CEO.

Liquidity and Capital Resources

On December 31, ~~2022~~2023, we had approximately $~~1.1~~14,933 ~~million~~ of liquid marketable securities and $7100,922 ~~thousand~~ in cash. Our Chief Executive Officer ~~holds~~ holds the XXII shares pursuant to the pledge agreement and has the power at any time to permit us to sell the shares to provide working capital. We have borrowed substantial sums from Leslie Buttorff, our Chief Executive Officer, to meet its working capital obligations. On June 30, 2021, Panacea issued an affiliate of Ms. Buttorff a 12% demand promissory note for $4.063 million and issued Ms. Buttorff a 10% demand promissory note for $1.624 million secured by a pledge of certain XXII common stock owned by Panacea. Additionally, we have a line of credit with Ms. Buttorff through which it may borrow up to $58 million at a 10% annual interest rate.

18We will not have sufficient cash resources to sustain our operations for the next 12 months, particularly if the large sales contracts we have do not result in the revenue anticipated. This raises substantial doubt as a going concern as we are dependent on obtaining financing from one or more debt or equity offerings or further loans from Ms. Buttorff assuming she agrees to advance further funds.

We may not have sufficient cash resources to sustain our operations for the next 12 months, particularly if the large sales contracts we have do not result in the revenue anticipated. This raises substantial doubt as a going concern as we are dependent on obtaining financing from one or more debt or equity offerings or further loans from Ms. Buttorff assuming she agrees to advance further funds.

These consolidated financial statements are presented on the basis that we will continue as a going concern. The going concern concept contemplates the realization of assets and satisfaction of liabilities in the normal course of business. No adjustment has been made to the carrying amount and classification of our assets and the carrying amount of our liabilities based on the going concern uncertainty. These factors raise substantial doubt about our ability to continue as a going concern for a period of 12 months from the issuance date of this report. Management cannot provide assurance that we will ultimately achieve profitable operations or become cash flow positive or raise additional debt and/or equity capital. In addition, due to insufficient revenue, we will need to obtain further funding through public or private equity offerings, debt financing, collaboration arrangements or other sources in order to maintain active business operations. We currently do not have sufficient cash flow to pay our ongoing financial obligations on a consistent basis. The issuance of any additional shares of common stock, preferred stock or convertible securities could be substantially dilutive to our stockholders. In addition, adequate additional funding may not be available to us on acceptable terms, or at all. If we are unable to raise capital, we will be forced to borrow additional sums from our Chief Executive Officer or delay, reduce or eliminate our research and development programs, we may not be able to continue as a going concern, and we may be forced to discontinue operations. These consolidated financial statements do not include any adjustments related to the recoverability and classification of assets or the amounts and classification of liabilities that might be necessary should we be unable to continue as a going concern.

Off Balance Sheet Arrangements

As of December 31, ~~2022~~2023, we had no material off-balance sheet arrangements.

Critical Accounting Estimates and New Accounting Pronouncements

Critical Accounting Estimates

The discussion and analysis of our financial condition and results of operations is based upon our consolidated financial statements, which have been prepared in accordance with US GAAP. The preparation of our consolidated financial statements requires its management to make estimates and judgments that affect the reported amounts of assets, liabilities, revenue and expenses and related disclosures. Our management bases its estimates, assumptions and judgments on historical experience and various other factors that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Different assumptions and judgments would change the estimates used in the preparation of our consolidated financial statements which, in turn, could change the results from those reported. In addition, actual results may differ from these estimates and such differences could be material to our financial position and results of operations.

Critical accounting estimates are those that our management considers the most important to the portrayal of our financial condition and results of operations because they require management’s most difficult, subjective or complex judgments, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Our critical accounting estimates in relation to its consolidated financial statements include those related to:

	●	Goodwill and intangible assets
	●	Fair value of marketable securities
	●	Incremental Borrowing Rate used Right of Use Asset Calculations
	●	Business combinations

Goodwill and Indefinite-Lived Intangibles

We allocate the cost of acquired companies to the identifiable tangible and intangible assets acquired and liabilities assumed, with the remaining amount classified as goodwill. The identification and valuation of these intangible assets and the determination of the estimated useful lives at the time of acquisition, as well as the completion of impairment tests, require significant management judgments and estimates. These estimates are made based on, among other factors, review of projected future operating results and business plans, economic projections, anticipated highest and best use of future cash flows and the cost of capital. The use of alternative estimates and assumptions could increase or decrease the estimated fair value of goodwill and other intangible assets, and potentially result in a different impact to our results of operations. Further, changes in business strategy and/or market conditions may significantly impact these judgments and thereby impact the fair value of these assets, which could result in an impairment of the goodwill or intangible assets.

Goodwill is not amortized but is tested for impairment annually and whenever events or circumstances change that indicate impairment may have occurred. We tested goodwill for impairment and determined there was no impairment and found not impairment charge based on the excess of a reporting unit’s carrying amount over our fair value.

Fair value of marketable securities

Marketable securities are recorded at fair value using the quoted market prices and changes in fair value are recorded as net realized gains or losses in comprehensive income. We monitor these investments for impairment and make appropriate reductions in carrying values as necessary.

Incremental Borrowing Rate used Right of Use Asset Calculations

We determine if a contract is a lease or contains a lease at the inception of the contract and reassess that conclusion if the contract is modified. All leases are assessed for classification as an operating lease or a finance lease. Operating lease right-of-use, or ROU, assets are included in non-current other assets on our consolidated balance sheet. Operating lease liabilities are separated into a current portion, included within other accrued liabilities on our consolidated balance sheet, and a non-current portion, included within other long-term liabilities on our consolidated balance sheet. We do not have any finance lease ROU assets or liabilities. ROU assets represent our right to use an underlying asset for the lease term and lease liabilities represent our obligation to make lease payments arising from the lease. We do not obtain and control the right to use the identified asset until the lease commencement date.

Our lease liabilities are recognized at the applicable lease commencement date based on the present value of the lease payments required to be paid over the lease term. Because the interest rate implicit in the lease is not readily determinable, we generally use our incremental borrowing rate to discount the lease payments to present value. The estimated incremental borrowing rate is derived from information available at the lease commencement date. We factor in publicly available data for instruments with similar characteristics when calculating our incremental borrowing rates. Our ROU assets are also recognized at the applicable lease commencement date. The ROU asset equals the carrying amount of the related lease liability, adjusted for any lease payments made prior to lease commencement and lease incentives provided by the lessor. Variable lease payments are expensed as incurred and do not factor into the measurement of the applicable ROU asset or lease liability.

Business Combinations

We have applied significant estimates and judgments in order to determine the fair value of the identified assets acquired, liabilities assumed and goodwill recognized in connection with our business combinations to ensure the value of the assets and liabilities acquired are recognized at fair value as of the acquisition date. In measuring the fair value, we utilize valuation techniques consistent with the market approach, income approach, or cost approach.

The valuation of the identifiable assets and liabilities includes assumptions made in performing the valuation, such as projected revenue, weighted average cost of capital, discount rates, estimated useful lives, and other relevant assessments. These assessments can be significantly affected by our estimates, judgments, and assumptions. If actual results are not consistent with our estimates, judgments, or assumptions, or if additional or new information arises in the future that affects our fair value estimates, then adjustments to our initial fair value estimates may have a material impact to our purchase accounting or our results of operations. If actual results are not consistent with our estimates, judgments, or assumptions, or if additional or new information arises in the future, beyond our one-year measurement period, that affects our fair value estimates, then adjustments to our initial fair value estimates may have a material impact to our results of operations.

Item 7A. Quantitative and Qualitative Disclosures about Market Risk

A smaller reporting company is not required to provide the information required by this item.

2024

Item 8. Financial Statements and Supplementary Data

Index to Financial Statements Required by Article 8 of Regulation S-X:

Audited Financial Statements:

CONTENTS
CONSOLIDATED FINANCIAL STATEMENTS
Report of Independent Registered Public Accounting Firms (PCAOB ID: 5041)	F-2
Consolidated Balance Sheets as of December 31, 2022 and 2021	F-3
Consolidated Statements of Operations for the years ended December 31, 2022 and 2021	F-4
Consolidated Statements of Stockholders’ Equity (Deficit) for the years ended December 31, 2022 and 2021	F-5
Consolidated Statements of Cash Flows for the years ended December 31, 2022 and 2021	F-6
Notes to the Consolidated Financial Statements	F-7

F-1

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Shareholders of Panacea Life Sciences Holdings, Inc.:

Opinion on the Financial Statements

We have audited the accompanying consolidated balance sheets of Panacea Life Sciences Holdings, Inc. (the “Company”) as of December 31, ~~2022~~2023 and ~~2021~~2022 and the related consolidated statements of operations, shareholders’ equity, and cash flows for the two years in the period ended December 31, ~~2022~~2023, and the related notes and schedules (collectively referred to as the financial statements). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of December 31, ~~2022~~2023 and ~~2021~~2022, and the results of its operations and its cash flows for the two years in the period ended December 31, ~~2022~~2023 and ~~2021~~2022, in conformity with accounting principles generally accepted in the United States of America.

Going Concern Matter

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 2 to the financial statements, the Company has suffered recurring losses from operations that raises substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 2. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

Basis for Opinion

These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial statements based on our audit. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audit, we are required to obtain an understanding of internal control over financial reporting, but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audit included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audit also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audit provide a reasonable basis for our opinion.

Critical Audit Matter

Critical audit matters are matters arising from the current-period audit of the financial statements that were communicated or required to be communicated to the audit committee and that (1) relate to accounts or disclosures that are material to the financial statements and (2) involved our especially challenging, subjective, or complex judgments.

We determined that there are no critical audit matters.

/S/ BF Borgers CPA PC (PCAOB ID 5041) We have served as the Company’s auditor since 2021 Lakewood, CO March 29, ~~2023~~2024

F-2

Panacea Life Sciences Holdings, Inc. and Subsidiary

~~Consolidated~~Unaudited Condensed Consolidated Balance Sheets

	December 31, 2022			December 31, 2021
	December 31, 2023			December 31, 2022
ASSETS
CURRENT ASSETS:
Cash and cash equivalents	$	6100,~~951~~922		$	196,~~774~~951
Accounts receivable, net		~~206~~263,~~127~~970			~~244~~206,~~496~~127
Other receivables, related party		~~500,000~~-			500,000
Inventory		4,~~448~~013,~~725~~525			4,~~264~~448,~~277~~725
Marketable securities related party		114,~~107,362~~933			31,~~791~~107,~~483~~362
Prepaid expenses and other current assets		~~113~~263,~~098~~003			~~278~~113,~~328~~098
TOTAL CURRENT ASSETS		64,~~382~~656,~~263~~353			96,~~098~~382,~~358~~263
Operating lease right-of-use asset, net, related party		3,~~242~~864,~~381~~591			3,~~595~~242,~~100~~381
Property and equipment, net		76,~~675~~448,~~995~~068			87,~~839~~675,~~982~~995
Intangible assets, net		-			~~61,401~~-
Goodwill		23,~~188~~014,~~810~~450			2,188,810
TOTAL ASSETS	$	1917,~~489~~983,~~449~~462		$	2319,~~783~~489,~~651~~449
LIABILITIES AND STOCKHOLDERS’ EQUITY
CURRENT LIABILITIES:
Accounts payable and accrued expenses	$	24,~~666~~629,~~076~~591		$	12,~~685~~666,~~825~~076
Operating lease liability, current portion, related party		2,~~090~~913,~~271~~781			12,~~624,~~090,271
Note payable-current, related party		911,~~871~~397,~~803~~617			69,~~441~~871,~~866~~803
Convertible note payable, net		346,671			220,005
First Bank note payable		292,942			-
Convertible note payable, net		115,000			346,671
Paycheck protection loan, SBA Loan		99,100			99,100
TOTAL CURRENT LIABILITIES:		1519,~~073~~448,~~921~~031			1015,~~070~~073,~~886~~921
Operating lease liability, long-term portion, related party		23,~~987~~254,~~208~~021			32,~~347~~987,~~335~~208
Other long-term liabilities, related party		3,572,864			3,~~263~~572,~~028~~864
TOTAL LIABILITIES		2126,~~633~~274,~~993~~916			1621,~~681~~633,~~249~~993
Commitments and contingencies		-			-
STOCKHOLDERS’ EQUITY
Series A Preferred Stock: $0.0001 Par Value, 1,000 shares designated; 0 and 350 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		-			-
Series A Preferred Stock: $0.0001 Par Value, 1,000 shares designated; 0 and 350 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		-			-
Series B-1 Preferred: $0.0001 Par Value, 32,000,000 shares designated; 1,500,000 and 1,500,000 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		150			150
Series B-1 Preferred: $0.0001 Par Value, 32,000,000 shares designated; 1,500,000 and 1,500,000 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		150			150
Series B-2 Preferred: $0.0001 Par Value, 6,000,000 shares designated; 6,000,000 and 6,000,000 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		600			600
Series B-2 Preferred: $0.0001 Par Value, 6,000,000 shares designated; 6,000,000 and 6,000,000 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		600			600
Series C Preferred: $0.0001 Par Value, 1,000,000 shares designated; 1,000,000 and 1,000,000 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		100			100
Series C Preferred: $0.0001 Par Value, 1,000,000 shares designated; 1,000,000 and 1,000,000 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		100			100
Series C-1 Preferred: $0.0001 Par Value, 10,000 shares designated and 10,000 and 10,000 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		1			1
Series C-1 Preferred: $0.0001 Par Value, 10,000 shares designated and 10,000 and 10,000 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		1			1
Series C-2 Preferred: $0.0001 Par Value, 100 and 0 shares designated and 100 and 0 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		-			1
Series C-2 Preferred: $0.0001 Par Value, 100 and 0 shares designated and 100 and 0 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		-			-
Series D Preferred: $0.0001 Par Value, 10,000 shares designated and 10,000 and 10,000 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		1			1
Series D Preferred: $0.0001 Par Value, 10,000 shares designated and 10,000 and 10,000 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		1			1
Preferred Stock, Value
Series E Preferred: $0.0001 Par Value, 3,853,000 shares designated and issued on December 31, 2023.		385			-
Common Stock: $0.0001 Par Value, 650,000,000 shares authorized; 14,965,317 and 14,073,708 shares issued and outstanding on December 31, 2022 and December 31, 2021 respectively.		1,497			1,407
Preferred stock, value		385			-
Additional paid in capital		23,760,704			23,865,155
Common Stock: $0.0001 Par Value, 650,000,000 shares authorized; 17,645,352 and 14,965,317 shares issued and outstanding on December 31, 2023 and December 31, 2022 respectively.		1,765			1,497
Accumulated deficit		(25,907,597	)		(16,765,013	)
Additional paid in capital		25,628,442			23,760,704
TOTAL STOCKHOLDERS’ EQUITY		(2,144,544	)		7,102,402
Accumulated deficit		(33,922,898	)		(25,907,597	)
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY	$	19,489,449		$	23,783,651
TOTAL STOCKHOLDERS’ EQUITY		(8,291,454	)		(2,144,544	)
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY	$	17,983,462		$	19,489,449

The accompanying notes are an integral part of these consolidated financial statements.

F-3

Panacea Life Sciences Holdings, Inc. and Subsidiary

~~Consolidated~~Unaudited Condensed Consolidated Statements of Operations

	2022			2021
	2023			2022
	For the year ending December 31,
	For the year ending December 31
	2022			2021
	2023			2022
REVENUE	$	12,~~626~~384,~~978~~956		$	21,~~059~~626,~~627~~978
COST OF SALES		1,~~230~~262,~~508~~979			1,~~519~~230,~~049~~508
GROSS PROFIT		~~396~~1,~~470~~121,977			~~540~~396,~~578~~470
OPERATING EXPENSES
Production related operating expenses		45,~~955~~211,~~348~~719			4,~~959~~955,~~059~~348
General and administrative expenses		1,~~093~~456,~~364~~412			1,~~518~~093,~~687~~364
TOTAL OPERATING EXPENSES		6,~~048~~668,~~712~~131			6,~~477~~048,~~746~~712
LOSS FROM OPERATIONS		(5,~~652~~546,~~242~~154	)		(5,~~937~~652,~~168~~242	)
OTHER INCOME (EXPENSES)
Interest expense		(21,~~048~~555,~~171~~877	)		(12,~~105~~048,~~243~~171	)
Unrealized gain (loss) on marketable securities, net		(21,~~660~~092,~~105~~429	)		1(2,~~008~~660,~~046~~105	)
Realized gain on sale of securities		~~22,816~~-			~~160~~22,~~296~~816
Other income (loss)		~~27,598~~-			-27,598
Employer retention credit		~~253,791~~-			~~396~~253,~~679~~791
Rental Income		~~232~~178,~~183~~411			~~236~~232,~~560~~183
Loss on sale of assets		-			(297,351	)
Gain on extinguishment of debt		748			681,546
Gain on extinguishment of debt		681,546			755,782
TOTAL OTHER INCOME (EXPENSE)		(2,469,147	)		(3,490,342	)
TOTAL OTHER INCOME (EXPENSE)		(3,490,342	)		1,154,769
INCOME (LOSS) BEFORE INCOME TAXES		(8,015,301	)		(9,142,584	)
INCOME (LOSS) BEFORE INCOME TAXES		(9,142,584	)		(4,782,399	)
TAXES		-			-
NET INCOME (LOSS)	$	(98,~~142~~015,~~584~~301	)	$	(49,~~782~~142,~~399~~584	)
Per-share data
Basic and diluted loss per share	$	(0.6248	)	$	(0.2862	)
Weighted average number of common shares outstanding		1416,~~862~~627,~~077~~458			1614,~~915~~862,~~706~~077

The accompanying notes are an integral part of these consolidated financial statements.

F-4

~~Panacea Life~~PANACEA ~~Sciences~~LIFE SCIENCES HOLDINGS, ~~Inc~~INC. AND SUBSIDIARY

~~Statements of~~CONDENSED ~~Stockholders~~CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ ~~Equity~~(DEFICIT) EQUITY

	Shares			Amount		Shares		Amount		Capital			Deficit			Equity
	Preferred Stock					Common Stock				Additional Paid-in			Accumulated			Total Stockholder’s
	Shares			Amount		Shares		Amount		Capital			Deficit			Equity
Balance as of December 31, 2021		8,530,350		$	853		14,073,708	$	1,407	$	23,865,155		$	(16,765,013	)	$	7,102,402
Shares issued in respect of the merger		-			-		834,331		83		(83	)		-			-
Issuance of common shares for services							57,278		6		54,994						55,000
Conversion of Series A Preferred to convertible debt and warrants		(350	)								(159,362	)					(159,362	)
Net Loss		-			-		-		-		-			(9,142,584	)		(9,142,584	)
Balance as of December 31, 2022		8,530,000		$	853		14,965,317	$	1,497	$	23,760,704		$	(25,907,597	)	$	(2,144,544	)

(unaudited)

The accompanying notes are an integral part of these consolidated financial statements

	Shares		Amount		Shares		Amount		Capital			Deficit			Equity
	Preferred Stock				Common Stock				Additional Paid-in			Accumulated			Total Stockholder’s
	Shares		Amount		Shares		Amount		Capital			Deficit			Equity
Balance as of December 31, 2022		8,530,350	$	853		14,965,317	$	1,497	$	23,760,704		$	(25,907,597	)	$	(2,144,544	)
Balance		8,530,350	$	853		14,965,317	$	1,497	$	23,760,704		$	(25,907,597	)	$	(2,144,544	)
Sale of shares to investors		-		-		454,545		46		74,955						75,000
Issuance of common shares for services						275,490		28		23,069						23,097
Issuance of restricted shares to employees						1,410,000		141		(141	)					-
Shares issued in settlement of convertible note		-		-		540,000		54		134,946						135,000
Preferred Series E shares issued in acquisition		3,853,000		385		-		-		1,634,909						1,635,295
Net Loss		-		-		-		-		-			(8,015,301	)		(8,015,301	)
Balance as of December 31, 2023		12,383,350	$	1,238		17,645,352	$	1,765	$	25,628,442		$	(33,922,898	)	$	(8,291,454	)
Balance		12,383,350	$	1,238		17,645,352	$	1,765	$	25,628,442		$	(33,922,898	)	$	(8,291,454	)

~~F-5~~The accompanying notes are an integral part of these consolidated financial statements

~~Panacea Life Sciences, Inc.~~ F-5

~~Statements~~Panacea ofLife ~~Cash~~Sciences, ~~Flows~~Inc.

	2022			2021
	For the years ended December 31
	2022			2021
Cash flows from operating activities
Net income (loss)	$	(9,142,584	)	$	(4,782,399	)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation		1,669,690			1,675,786
Realized gain on sale of securities		(22,816	)		(160,296	)
Unrealized (gain)/loss on marketable securities		2,660,105			(1,008,046	)
Fixed Asset Disposal Loss		-			297,351
Non cash settlement of convertible note and accrued interest		(253,791	)		(755,782	)
Amortization of intangible assets		61,401			61,400
Amortization of debt discount and non-cash interest expense		1,067,304			117,515
Changes in operating assets and liabilities
Accounts receivable		38,369			(97,194	)
Inventory		(184,448	)		(547,910	)
Prepaid expense and other assets		165,230			(250,953	)
Accounts payable and accrued expenses		1,083,188			1,069,668
Operating lease liability, net		458,773			458,770
Net cash used in operating activities		(2,399,579	)		(3,922,090	)
Cash flows from investing activities
Net cash received from acquisition		-			9,157
Proceeds from sale of marketable securities		46,832			230,296
Proceeds from sale of fixed assets		-			446,026
Net fixed asset acquisitions		(243,804	)		(162,946	)
Net Cash provided by (used in) investing activities		(196,972	)		522,533
Cash flows from financing activities
Repayment of notes payable		(1,100,000	)		(75,556	)
Proceeds from payroll protection loan, SBA loan		253,791			243,041
Payments of principal on notes payable		(660,511	)		(135,000	)
Proceeds from Notes payable - related party		4,090,448			2,302,468
Proceeds from issuance of convertible notes, net of discount		-			1,000,000
Cash provided by financing activities		2,583,728			3,334,953
Net increase (decrease) in Cash and Cash Equivalents		(12,823	)		(64,605	)
Cash and Cash Equivalents, Beginning of Period		19,774			84,379
Cash and Cash Equivalents, End of Period	$	6,951		$	19,774
Supplemental Disclosure of Cash Flow Information
Cash paid for income taxes during the year	$	-		$	-
Interest payments during the year	$	-		$	-
Noncash investing and financing activity
Non-cash Receivable - related party	$	-		$	500,000
Related party loan repayment with inventory	$	-		$	4,693,367
Non-cash fixed asset disposal as part of the reverse acquisition	$	-		$	3,058,457
Conversion of Preferred A shares to Note Payable	$	385,000		$	-
Issuance of Common Stock for services	$	55,000		$	-
Capitalized assets purchased on account - related party	$	261,899		$	564,369
Liabilities from acquisition	$	-		$	1,096,782
Debt retired in merger, related party	$	-		$	12,718,441
Preferred Series B-1 Issuance in Acquisition	$	-		$	150
Preferred Series B-2 Issuance in Acquisition	$	-		$	600
Common stock issued for the reverse merger with Exactus	$	-		$	4,369,085
Discounts related to issuance of convertible debt and warrants	$	-		$	997,510

Statements of Cash Flows

The accompanying notes are an integral part of these consolidated financial statements.

	2023			2022
	For the years ended December 31
	2023			2022
Cash flows from operating activities
Net income (loss)	$	(8,015,301	)	$	(9,142,584	)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation		1,712,969			1,669,690
Realized gain on sale of securities		-			(22,816	)
Unrealized (gain)/loss on marketable securities		1,092,429			2,660,105
Inventory Insurance Disposal		538,583			-
Non cash settlement of convertible note and accrued interest		74,999			(253,791	)
Amortization of intangible assets		-			61,401
Amortization of debt discount and non-cash interest expense		38,329			1,067,304
Changes in operating assets and liabilities
Accounts receivable		431,317			38,369
Inventory		297,391			(184,448	)
Prepaid expense and other assets		(149,905	)		165,230
Accounts payable and accrued expenses		1,986,613			1,083,188
Operating lease liability, net		468,113			458,773
Net cash used in operating activities		(1,524,463	)		(2,399,579	)

Cash flows from investing activities
Proceeds from sale of marketable securities		-			46,832
Net fixed asset acquisitions		(65,322	)		(243,804	)
Net Cash provided by (used in) investing activities		(65,322	)		(196,972	)

Cash flows from financing activities
Repayment of notes payable		(135,000	)		(1,100,000	)
Proceeds from payroll protection loan, SBA loan		-			253,791
Payments of principal on notes payable		(272,075	)		(660,511	)
Proceeds from Notes payable - related party		1,797,889			4,090,448
Proceeds from notes payable		292,942			-
Cash provided by financing activities		1,683,756			2,583,728

Net increase (decrease) in Cash and Cash Equivalents		93,971			(12,823	)
Cash and Cash Equivalents, Beginning of Period		6,951			19,774
Cash and Cash Equivalents, End of Period	$	100,922		$	6,951

Supplemental Disclosure of Cash Flow Information
Cash paid for income taxes during the year	$	-		$	-
Interest payments during the year	$	-		$	-

Noncash investing and financing activity
Goodwill recorded in acquisition	$	825,640		$	-
Preferred shares issued in acquisition	$	1,646,134		$	-
Inventory recorded in acquisition	$	(400,774	)	$	-
Assets from acquisition	$	(419,720	)	$	-
Conversion of Preferred A shares to Note Payable				$	385,000
Issuance of Common Stock for services	$	-		$	55,000
Capitalized assets purchased on account - related party	$	-		$	261,899

~~F-6~~The accompanying notes are an integral part of these consolidated financial statements.

~~PANACEA LIFE SCIENCES HOLDINGS, INC. AND SUBSIDIARY~~F-6

~~NOTES~~PANACEA TOLIFE ~~CONSOLIDATED~~SCIENCES ~~FINANCIAL~~HOLDINGS, ~~STATEMENTS~~INC. AND SUBSIDIARY

~~DECEMBER~~NOTES ~~31,~~TO ~~2022~~CONSOLIDATED FINANCIAL STATEMENTS

~~NOTE~~DECEMBER 131, ~~- NATURE OF ORGANIZATION~~2023

~~Organization~~NOTE ~~and~~1 ~~Business~~- ~~Description~~NATURE OF ORGANIZATION

~~Panacea~~Organization Life Sciences Holdings, Inc. (the “Company”, “Panacea Holdings”, “Exactus”, “we”, “us”, “our”) was incorporated on January 18, 2008, in the State of Nevada. In January 2019, the Company added to the scope of its business activities, efforts to produce, market and ~~sell~~Business products made from industrial hemp containing cannabidiol (“CBD”). On June 30, 2021, the Company entered into a Securities Exchange Agreement (the “Exchange Agreement”) with Panacea Life Sciences, Inc. (“Panacea”) a CBD company, and the stockholders of Panacea. Pursuant to the Exchange Agreement, the former Panacea stockholders assumed majority control of the Exactus and all operations are now operated by Panacea, which as a result of the share exchange became a wholly-owned subsidiary of the Exactus. In October 2021 the Company changed its name from Exactus, Inc. to Panacea Life Sciences Holdings, Inc.Description

~~The~~Panacea ~~Company~~Life ~~operates~~Sciences inHoldings, ~~one~~Inc. ~~segment~~(the ~~with~~“Company”, a“Panacea ~~focus~~Holdings”, “we”, “us”, “our”) was incorporated on ~~developing~~January ~~and~~18, ~~producing~~2008, ~~high-quality~~in the State of Nevada. In January 2019, ~~medically~~the ~~relevant~~Company added to the scope of its business activities, efforts ~~legal~~to produce, ~~hemp-derived~~market ~~cannabinoid~~ and sell products ~~for~~made ~~consumers~~from ~~and~~industrial ~~pets~~hemp containing cannabidiol (“CBD”).

~~NOTE~~Panacea 2Life –Sciences ~~SUMMARY~~Holdings, OFInc. ~~SIGNIFICANT~~is ~~ACCOUNTING~~a ~~POLICIES~~holding company organized as a plant-based natural health ingredient and product company, specializing in the development, manufacturing, research, and distribution of products within the $134B and rapidly growing natural health and wellness market segment for both humans and animals.

~~Basis~~The company’s first subsidiary, Panacea Life Sciences, Inc. (PLS), is dedicated to the production, distribution, research, and manufacturing of ~~presentation~~premium-quality nutraceuticals, cannabinoids, mushrooms, kratom, and ~~principles~~other natural, plant-based ingredients and products. Operating from a cutting-edge 51,000 square foot cGMP facility located in Golden, Colorado, PLS is committed to delivering high-quality solutions in the field of ~~consolidation~~natural health and well-being.

OnPanacea ~~June 30~~Distro, ~~2021~~ the ~~Company~~second ~~merged~~subsidiary ~~with~~of Panacea. ~~The~~Life ~~merger~~Sciences ~~is accounted for as a reverse acquisition and recapitalization in accordance with the Financial Accounting Standards Board (ASC 805~~Holdings, ~~Business Combinations)~~Inc., ~~Management~~manages ~~evaluated~~six ~~the~~retail ~~guidance~~locations ~~contained~~and ina ~~ASC~~distribution ~~805 with~~center ~~respect to the identification of the acquirer~~ situated in the ~~merger and concluded~~Tampa, ~~based~~Florida ~~on a consideration of the pertinent facts and circumstances, that Panacea acquired Exactus for financial accounting purposes~~area. ~~This~~These ~~determination~~establishments isprovide ~~primarily based on Panacea stockholders comprising~~ a ~~relative~~diverse ~~majority~~range of ~~the~~products, ~~voting~~including ~~power~~Nitro ofKava, ~~the~~Kratom, ~~Company and having the ability to nominate the members of the board of directors of Exactus after the Merger~~Hemp, ~~Panacea’s~~VAPE ~~operations~~and ~~prior to the Merger comprising the only ongoing operations of the Company following the~~mushroom ~~Merger~~products, and ~~Panacea’s~~various ~~senior management prior to the Merger comprising a majority of the senior management of the Company following the Merger. Accordingly~~beverages, ~~for accounting purposes, the financial statements of the Company represent a continuation of the financial statements of Panacea~~ with ~~the Merger being treated as the equivalent of Panacea issuing stock for the net assets of Exactus, accompanied by~~ a ~~recapitalization whereby~~primary nofocus ~~goodwill~~on orpromoting ~~other~~alternative ~~intangible~~health ~~assets are recorded. Transactions~~ and ~~balances prior to the Merger are those of Panacea~~wellness. The shares and net loss per share available to holders of Panacea’s common stock prior to the Merger have been retroactively restated as shares reflecting the exchange ratio established in the Exchange Agreement.

~~The~~NOTE ~~consolidated~~2 ~~financial~~– ~~statements~~SUMMARY ~~represent~~OF ~~the~~SIGNIFICANT ~~accounts~~ACCOUNTING and balances for Panacea through June 30, 2021, and the consolidated balances and activities of the Company and its wholly owned subsidiary, Panacea, from that date forward. All significant consolidated transactions and balances have been eliminated in consolidation.POLICIES

~~All~~Basis ~~share~~of presentation and ~~per~~principles ~~share~~of ~~numbers have been retroactively adjusted to give effect to a 1-for-28 reverse stock split effective October 25, 2021.~~consolidation

~~F-7~~On September 30, 2023 the Company completed an Asset Purchase Agreement with N7 Enterprises. The results for N7 for the 4th quarter were consolidated.

Going concern

These audited consolidated financial statements are presented on the basis that the Company will continue as a going concern. ~~Panacea has merged with Exactus, so the below items reflect stand-alone historical results of Panacea through June 30, 2021 and the combined financial information thereafter.~~ The going concern concept contemplates the realization of assets and satisfaction of liabilities in the normal course of business. Since our inception in later 2017, we have generated losses from operations, except for some slight profits in a few quarters. As of December 31, ~~2022~~2023, our accumulated deficit was $2533.9 million, and we had $10.1 million in cash and liquid stock. As of December 31, 2022 the 1,203,000 shares of common stock we hold in 22nd Century Group, Inc. (NASDAQ:XXII) (“XXII”) were valued at approximately $1.1 million. The XXII stock is pledged to secure a $4,062,713 promissory note in favor of Quintel-MC, Incorporated (“Quintel”) and a $1,685,685 promissory note in favor of Leslie Buttorff, CEO of the Company, but can be used in operations as the CEO determines. Quintel-MC, Inc. is wholly owned Company of the CEO. These items are shown on the balance sheet as related party loans. The current plan with respect to the XXII stock is to hold this stock during the short-term. We also currently do not have sufficient ~~cash~~ cash flow to pay our ongoing financial obligations on a consistent basis.

These factors raise doubt about the Company’s ability to continue as a going concern for a period of 12 months from the issuance date of these financial statements. Management plans to raise additional capital to fund operations, until the Company achieves and maintains profitable operations and cash flows. Management cannot provide assurance that the issuance of any additional shares of common stock, preferred stock or convertible securities could be substantially dilutive to our shareholders. In addition, adequate additional funding may not be available to us on acceptable terms, or at all. These audited consolidated financial statements do not include any adjustments related to the recoverability and classification of assets or the amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

~~COVID~~F-197

~~The~~Use ~~COVID-19 pandemic has resulted in a global slowdown~~ of economic activity which is likely to continue to reduce the future demand for a broad variety of goods and services, while also disrupting sales channels, marketing activities and supply chains for an unknown period of time until the virus is fully contained. The Company’s business operations have been negatively impacted by the COVID-19 pandemic and related events and the Company expects this impact on its revenue and results of operations, the size and duration of which is currently difficult to predict. However, adverse consequences from COVID-19 and recent supply chain disruptions and delays may hinder our ability to continue our operations and generate revenue. The impact to date has included a decline in CBD product and sales demand.Estimates

~~Use~~The audited consolidated financial statements have been prepared in conformity with US GAAP and required management of ~~Estimates~~the Company to make estimates and assumptions in preparation of these statements. Actual results may differ significantly from those estimates. Significant estimates made by management include but are not limited to the useful life of property and equipment, incremental borrowing rate used in the calculation of right of use asset and lease liability, reserves for inventory, allowance for doubtful accounts, revenue allocations, valuation allowance on deferred tax assets, assumptions used in assessing impairment of long-term assets, assumptions used in the calculation of net realizable value of inventory and fair value of non-cash equity transactions.

~~The~~Cash ~~audited consolidated financial statements have been prepared in conformity with US GAAP~~ and ~~required~~Cash management of the Company to make estimates and assumptions in preparation of these statements. Actual results may differ significantly from those estimates. Significant estimates made by management include but are not limited to the useful life of property and equipment, incremental borrowing rate used in the calculation of right of use asset and lease liability, reserves for inventory, allowance for doubtful accounts, revenue allocations, valuation allowance on deferred tax assets, assumptions used in assessing impairment of long-term assets, assumptions used in the calculation of net realizable value of inventory and fair value of non-cash equity transactions.Equivalents

FFor purposes of balance sheet presentation and reporting of cash flows, the Company considers all unrestricted demand deposits, money market funds and highly liquid debt instruments with an original maturity of less than 90 days to be cash and cash equivalents. There were no cash equivalents. The Company places its cash and cash equivalents with high-8quality financial institutions. At times, balances in the Company’s cash accounts may exceed the Federal Deposit Insurance Corporation (“FDIC”) limit. On December 31, 2023 and 2022, the Company’s cash balances did not exceed the FDIC limit.

~~Cash~~Accounts ~~and Cash Equivalents~~Receivable

~~For~~Accounts ~~purposes~~receivable ofare ~~balance~~generally ~~sheet~~unsecured. ~~presentation~~The ~~and~~Company ~~reporting~~establishes ofan ~~cash~~allowance ~~flows,~~for ~~the~~doubtful ~~Company~~accounts ~~considers~~receivable ~~all~~based ~~unrestricted~~on ~~demand~~the ~~deposits,~~age ~~money~~of ~~market~~outstanding ~~funds~~invoices and ~~highly~~management’s ~~liquid~~evaluation ~~debt~~of ~~instruments~~collectability. ~~with~~Accounts anare ~~original~~written ~~maturity~~off ofafter ~~less~~all ~~than~~reasonable 90collection ~~days~~efforts tohave bebeen exhausted ~~cash~~ and ~~cash~~management ~~equivalents~~concludes that likelihood of collection is remote. ~~There~~Any ~~were~~future norecoveries are applied against the allowance for ~~cash~~doubtful ~~equivalents~~accounts. The Company’s ~~places~~accounts ~~its~~receivable ~~cash~~policy ~~and~~changed ~~cash~~in ~~equivalents~~2020 ~~with~~to ~~high-quality~~only ~~financial~~provide ~~institutions. At times~~larger, ~~balances~~well-established ~~in the~~companies ~~Company’s~~with ~~cash~~Net ~~accounts~~30 ~~may~~payment ~~exceed~~terms. ~~the~~For ~~Federal~~all ~~Deposit~~other ~~Insurance~~sales ~~Corporation~~they ~~(“FDIC”)~~are ~~limit.~~paid Onby ~~December~~credit ~~31,~~card ~~2022~~or ~~and 2021,~~wires ~~the~~received ~~Company’s~~before ~~cash~~the ~~balances~~product ~~did~~is ~~not~~shipped ~~exceed~~to the ~~FDIC limit~~customer.

~~Accounts Receivable~~Inventory

~~Accounts~~Inventories ~~receivable~~ are ~~generally~~stated ~~unsecured.~~at ~~The~~lower ~~Company~~of ~~establishes~~cost anor ~~allowance~~net ~~for~~realizable ~~doubtful~~value. ~~accounts~~Inventories ~~receivable~~of ~~based~~purchased onmaterials ~~the~~are ~~age~~valuated ofusing ~~outstanding invoices~~a moving average method and managed ~~management’s~~by ~~evaluation~~first ofin ~~collectability~~first out basis (FIFO). ~~Accounts~~Inventories ~~are~~of ~~written~~internally ~~off~~manufactured ~~after~~materials ~~all~~are ~~reasonable~~valuated ~~collection~~using ~~efforts~~a ~~have~~standard ~~been exhausted~~costing method and ~~management~~are ~~concludes~~also ~~that~~managed ~~likelihood~~on ofa ~~collection~~FIFO ~~is remote~~basis. ~~Any~~Production ~~future~~related ~~recoveries~~costs that are ~~applied~~capitalized ~~against~~as ~~the~~inventory ~~allowance~~as ~~for doubtful~~part ~~accounts.~~of Asthe ofstandard ~~December~~cost ~~31,~~valuation include ~~2022~~the ~~and~~direct ~~December~~materials 31consumed, ~~2021,~~direct welabor ~~did~~used, ~~not~~indirect ~~believe~~labor weused, ~~needed~~and tomanufacturing ~~reserve~~overhead. ~~for~~Overhead ~~any~~is ~~doubtful~~calculated ~~accounts,~~based ~~respectively.~~on ~~The~~specific ~~Company’s~~manufacturing ~~accounts~~process ~~receivable~~and ~~policy~~allocated ~~changed~~on inan ~~2020 to only provide larger, well~~order-~~established~~by-order ~~companies~~basis. ~~with Net~~Production 30variances ~~payment~~that ~~terms.~~occur ~~For~~between ~~all~~standard ~~other~~cost ~~sales~~valuation and ~~they~~actual costs are ~~paid~~expensed byas ~~credit~~incurred ~~card~~in orthe ~~wires~~income ~~received~~statement ~~before~~as ~~the~~part ~~product~~of iscost ~~shipped~~of togoods ~~the customer~~sold.

~~Inventory~~Marketable securities

~~Inventories~~The ~~are~~Company’s ~~stated~~marketable atsecurities ~~lower~~consist of ~~cost~~80,200 orand ~~net~~1,203,000 ~~realizable~~shares ~~value.~~of ~~Inventories~~XXII as of ~~purchased~~December ~~materials~~31, ~~are~~2023 ~~valuated~~and ~~using~~2022, arespectively, which ~~moving~~are ~~average~~classified ~~method~~as available-for-sale and ~~managed~~ byincluded ~~first~~ in ~~first~~current ~~out~~assets. ~~basis~~ (~~FIFO).~~see ~~Inventories~~Note of2 ~~internally~~– ~~manufactured~~Going ~~materials~~Concern). Securities are valued ~~valuated~~based ~~using~~on amarket ~~standard~~prices ~~costing~~for ~~method and~~identical ~~are~~assets ~~also~~using ~~managed~~third onparty acertified ~~FIFO~~pricing ~~basis~~sources. ~~Production~~Available-for-sale ~~related~~securities ~~costs that~~ are ~~capitalized~~carried at asfair ~~inventory~~value aswith ~~part~~unrealized ofand ~~the~~realized ~~standard~~gains ~~cost~~and ~~valuation include~~losses ~~the~~reported ~~direct~~as ~~materials~~a ~~consumed,~~component ~~direct~~of ~~labor~~income ~~used,~~(loss). ~~indirect~~Realized ~~labor~~gains ~~used,~~ and ~~manufacturing~~losses, ~~overhead.~~if ~~Overhead~~any, are is calculated ~~based~~ on the specific ~~manufacturing~~identification ~~process~~method and ~~allocated on an order-by-order basis. Production variances that occur between standard cost valuation and actual costs~~ are ~~expensed~~included ~~as incurred~~ in ~~the~~other income ~~statement~~in asthe ~~part~~consolidated ofstatements ~~cost~~ of ~~goods sold~~operations.

~~Marketable securities~~F-8

~~The~~Fair ~~Company’s~~Value marketable securities consist of 1,227,017 and 1,203,000 shares of XXII as of December 31, 2022 and 2021, respectively, which are classified as available-for-sale and included in current assets. (see Note 2 – Going Concern). Securities are valued based on market prices for identical assets using third party certified pricing sources. Available-for-sale securities are carried at fair value with unrealized and realized gains and losses reported as a component of income (loss). Realized gains and losses, if any, are calculated on the specific identification method and are included in other income in the consolidated statements of operations.Measurements

~~Fair~~The Company adopted the provisions of Accounting Standard Codification (“ASC”) Topic 820, “Fair Value Measurements and Disclosures”, which defines fair value as used in numerous accounting pronouncements, establishes a framework for measuring fair value, and expands disclosure of fair value measurements. The guidance prioritizes the inputs used in measuring fair value and establishes a three-tier value hierarchy that distinguishes among the following:

~~The Company~~● ~~adopted~~Level ~~the~~1—Valuations ~~provisions~~based ofon ~~Accounting~~unadjusted ~~Standard~~quoted ~~Codification~~prices ~~(“ASC”)~~in ~~Topic~~active ~~820,~~markets ~~“Fair~~for ~~Value~~identical ~~Measurements~~assets ~~and Disclosures”,~~or ~~which~~liabilities ~~defines~~that ~~fair~~the ~~value~~Company ashas ~~used~~the inability ~~numerous~~to ~~accounting~~access. ~~pronouncements,~~● ~~establishes~~Level a2—Valuations ~~framework~~based on quoted prices for ~~measuring~~similar ~~fair value,~~assets ~~and~~or ~~expands~~liabilities ~~disclosure~~in ofactive ~~fair~~markets, ~~value~~quoted ~~measurements.~~prices ~~The~~for ~~guidance~~identical ~~prioritizes~~or ~~the~~similar ~~inputs~~assets ~~used~~or liabilities in ~~measuring~~markets ~~fair~~that ~~value~~are not active and ~~establishes a~~models ~~three-tier~~for ~~value~~which ~~hierarchy~~all significant inputs are observable, either directly or indirectly. ● Level 3—Valuations based on inputs that ~~distinguishes~~are ~~among~~unobservable and significant to the ~~following:~~overall fair value measurement.

●The following ~~Level~~table ~~1—Valuations~~shows, ~~based~~by onlevel ~~unadjusted~~within ~~quoted~~the ~~prices~~fair invalue ~~active~~hierarchy, ~~markets~~the ~~for~~Company’s ~~identical~~ assets orand liabilities ~~that~~at ~~the~~fair ~~Company~~value ~~has the ability to access. ● Level 2—Valuations based~~ on ~~quoted~~a ~~prices~~recurring basis ~~for~~as ~~similar~~of ~~assets~~December or31, ~~liabilities in active markets~~2023, ~~quoted prices for identical or similar assets or liabilities in markets that are not active~~ and ~~models~~December ~~for which all significant inputs are observable~~31, ~~either directly or indirectly. ● Level 3—Valuations based on inputs that are unobservable and significant to the overall fair value measurement.~~2022:

~~F-9~~SCHEDULE OF FAIR VALUE ASSETS MEASURED ON RECURRING BASIS

The following table shows, by level within the fair value hierarchy, the Company’s assets and liabilities at fair value on a recurring basis as of December 31, 2022, and December 31, 2021:

	December 31, 2023								December 31, 2022
	Total		Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3
Marketable securities	$	14,933	$	14,933	$	-	$	-	$	1,107,362	$	1,107,362	$	-	$	-
Total	$	14,933	$	14,933	$	-	$	-	$	1,107,362	$	1,107,362	$	-	$	-

~~SCHEDULE~~There OFwere ~~FAIR~~no ~~VALUE~~transfers ~~ASSETS~~of ~~MEASURED~~marketable ONsecurities ~~RECURRING~~into ~~BASIS~~or out of Level 1 during the years ended December 31, 2023, or 2022.

	December 31, 2022								December 31, 2021
	Total		Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3
Marketable securities	$	1,107,362	$	1,107,362	$	-	$	-	$	3,791,483	$	3,791,483	$	-	$	-
Total	$	1,107,362	$	1,107,362	$	-	$	-	$	3,791,483	$	3,791,483	$	-	$	-

SCHEDULE OF MARKETABLE SECURITIES

There were no transfers of marketable securities into or out of Level 1 during the years ended December 31, 2022, or 2021.

	December 31, 2023
Balance at beginning of year	$	1,107,362
Unrealized gain (loss) on marketable securities, net		(1,092,429	)
Balance at end of period	$	14,933

~~SCHEDULE~~As OFof ~~MARKETABLE~~December ~~SECURITIES~~31, 2023, the Company has no liabilities that are re-measured at fair value.

	December 31, 2022
Balance at beginning of year	$	3,791,483
Sale of securities		(46,832	)
Realized gain on sale of securities		22,816
Unrealized gain on marketable securities, net		(2,660,105	)
Balance at end of period	$	1,107,362

Property and Equipment

AsProperty ofand ~~December~~equipment 31are stated at cost less accumulated depreciation. Depreciation is calculated using the straight–line method on the various asset classes over their estimated useful lives, ~~2022~~which range from three to ten years when placed in service. The cost of repairs and maintenance is expensed as incurred; major replacements and improvements are capitalized. When assets are retired or disposed of, the cost and accumulated depreciation are removed from the ~~Company~~accounts, ~~has~~and noany ~~liabilities~~resulting ~~that~~gains or losses are ~~re-measured~~included atin ~~fair~~income ~~value~~in the year of disposition.

~~Property~~Intangible Assets and ~~Equipment~~Goodwill

~~Property~~Goodwill ~~and~~is ~~equipment~~comprised ~~are~~of ~~stated~~the atpurchase ~~cost~~price ~~less~~of ~~accumulated~~business ~~depreciation.~~combinations ~~Depreciation~~in isexcess ~~calculated~~of ~~using~~ the ~~straight–line~~fair ~~method~~market onvalue assigned at acquisition to the tangible ~~various~~and ~~asset~~intangible ~~classes~~assets ~~over~~acquired. ~~their~~Goodwill ~~estimated~~is ~~useful~~not ~~lives,~~amortized. ~~which~~The ~~range~~Company ~~from~~tests ~~three~~goodwill tofor ~~ten~~impairment ~~years~~on ~~when~~an ~~placed~~annual ~~in service~~basis. The ~~cost~~Company performed ofits ~~repairs and~~most ~~maintenance~~recent isgoodwill ~~expensed~~impairment asusing ~~incurred;~~a ~~major~~discounted ~~replacements~~cash ~~and~~flow ~~improvements~~analysis ~~are~~and ~~capitalized.~~found ~~When~~that ~~assets~~the ~~are~~fair ~~retired~~value orexceeded ~~disposed~~the ~~of,~~carrying ~~the~~value. ~~cost~~It ~~and~~has ~~accumulated~~$2.189 ~~depreciation~~million ~~are~~of ~~removed~~goodwill from the ~~accounts,~~acquisition ~~and~~of ~~any~~the ~~resulting~~assets ~~gains~~of orPhoenix ~~losses~~Life ~~are~~Sciences, ~~included~~Inc. in ~~income~~October in2017 ~~the~~and 0.825 ~~year~~million offrom ~~disposition~~the N7 acquisition.

~~Intangible~~SCHEDULE ~~Assets~~OF ~~and~~INTANGIBLE ~~Goodwill~~ASSETS AND GOODWILL

The Company has intangible assets. Goodwill is comprised of the purchase price of business combinations in excess of the fair market value assigned at acquisition to the tangible and intangible assets acquired. Goodwill is not amortized. The Company tests goodwill for impairment on an annual basis. The Company performed its most recent goodwill impairment using a discounted cash flow analysis and found that the fair value exceeded the carrying value. It has $2.189 million of goodwill from the acquisition of the assets of Phoenix Life Sciences, Inc. in October 2017, and intangible assets of $0 as of December 31, 2022 and $0.061 million for as of December 31, 2021. In the acquisition of Phoenix, the Company acquired product formulas which is classified as an intangible asset.

		Estimated Life
Goodwill from Phoenix Acquisition		Tested Yearly for Impairment
Goodwill from N7 Acquisition		Tested Yearly for Impairment

~~SCHEDULE OF INTANGIBLE ASSETS AND GOODWILL~~F-9

	Estimated Life
	December 31, 2023		December 31, 2022
Goodwill from Phoenix Acquisition	~~Tested Yearly for Impairment~~$	2,188,810	$	2,188,810
Intangibles – Formulations	5 Years
Goodwill from N7 Acquisition		825,640		-
Total	$	3,014,450	$	2,188,810

	December 31, 2022			December 31, 2021
Goodwill	$	2,188,810		$	2,188,810
Intangibles – Formulations		307,001			307,001
Less accumulated amortization		(307,001	)		(245,600	)
Net intangible assets	$	-		$	61,401

Leases

FThe Company determines if an arrangement is a lease at inception. Contracts containing a lease are further evaluated for classification as an operating or finance lease. In determining the leases classification, the Company assesses among other criteria: (i) 75% or more of the remaining economic life of the underlying asset is a major part of the remaining economic life of that underlying asset; and (ii) 90% or more of the fair value of the underlying asset comprises substantially all of the fair value of the underlying asset. Operating leases are included in operating lease right-10of-use (“ROU”) assets, other current liabilities and long-term operating lease liabilities in the Company’s consolidated balance sheets. Finance leases are included in property, plant and equipment, net, other current liabilities, and long-term finance lease liabilities in the Company’s consolidated balance sheets. ROU assets represent the right to use an underlying asset for the lease term and lease liabilities represent the Company’s obligation to make lease payments arising from the lease. For leases with terms greater than 12 months, the Company records the ROU asset and liability at commencement date based on the present value of lease payments according to their term.

~~Leases~~The Company uses incremental borrowing rates based on the estimated rate of interest for collateralized borrowing over a similar term of the lease payments at commencement date. The ROU asset also includes any lease payments made and excludes lease incentives. Lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise that option. Lease expenses are recognized on a straight-line basis over the lease term or the useful life of the leased asset.

~~The Company determines if an arrangement is a lease at inception. Contracts containing a lease are further evaluated for classification as an operating or finance lease.~~ In ~~determining the leases classification~~ addition, the ~~Company~~carrying ~~assesses~~amount ~~among other criteria: (i) 75% or more~~ of ~~the~~ ~~remaining economic life of~~ the ~~underlying~~ROU ~~asset is a major part of the remaining economic life of that underlying asset;~~ and ~~(ii) 90%~~lease orliabilities ~~more of the fair value of the underlying asset comprises substantially all of the fair value of the underlying asset. Operating leases~~ are ~~included~~remeasured inif ~~operating~~there ~~lease~~is ~~right-of-use~~a ~~(“ROU”) assets~~modification, ~~other~~a ~~current~~change ~~liabilities and long-term operating lease liabilities~~ in the ~~Company’s~~lease ~~consolidated balance sheets. Finance leases are included in property~~term, ~~plant and equipment, net, other~~ ~~current~~a ~~liabilities,~~change ~~and long-term finance lease liabilities~~ in the ~~Company’s~~in-substance ~~consolidated~~fixed ~~balance sheets. ROU assets represent the right to use an underlying asset for the~~ lease ~~term~~payments ~~and~~or ~~lease~~a ~~liabilities~~change ~~represent~~in the ~~Company’s~~assessment ~~obligation~~ to ~~make~~purchase ~~lease payments arising from~~ the ~~lease.~~underlying ~~For leases with terms greater than 12 months, the Company records the ROU~~ asset ~~and liability at commencement date based on the present value of lease payments according to their term~~.

~~The~~Convertible ~~Company~~Notes uses incremental borrowing rates based on the estimated rate of interest for collateralized borrowing over a similar term of the lease payments at commencement date. The ROU asset also includes any lease payments made and excludes lease incentives. Lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise that option. Lease expenses are recognized on a straight-line basis over the lease term or the useful life of the leased asset.Payable

In addition, the carrying amount of the ROU and lease liabilities are remeasured if there is a modification, a change in the lease term, a change in the in-substance fixed lease payments or a change in the assessment to purchase the underlying assetNone.

~~Convertible~~Revenue ~~Notes Payable~~Recognition

The Company ~~has~~accounts ~~issued~~for ~~convertible~~revenue ~~notes,~~in ~~which~~accordance ~~contain~~with ~~variable~~ASC ~~conversion~~Topic ~~features~~606, ~~whereby~~Revenue ~~the~~from ~~outstanding~~Contracts ~~principal~~with ~~and accrued interest automatically convert into common shares at a fixed price which may be a discount to the common stock at the time of conversion~~Customers. ~~Some of the conversion features of these notes are contingent upon future events, whereby, the holder agreed not to convert until the contingent future event has occurred.~~

The Company accounts for a contract when it has been approved and committed to, each party’s rights regarding the goods or services to be transferred have been identified, the payment terms have been identified, the contract has commercial substance, and collectability is probable. Revenue is generally recognized net of allowances for returns and any taxes collected from customers and subsequently remitted ~~Recognition~~to governmental authorities. However, the Company’s sales are primarily through retail stores, purchase orders or ecommerce; thus, currently contract liabilities are negligible. The Company does not have any multiple-element arrangements.

~~The~~Some of the Company’s ~~accounts~~contract liabilities consist of advance customer payments. Contract liability results from transactions in which the Company has been paid for products by customers, but for which all revenue recognition criteria have not yet been met. Once all revenue recognition criteria have been met, the contract liabilities are recognized. The Company recorded $349,705 and $368,065 in ~~accordance~~advanced ~~with~~customer payments ~~ASC~~as ~~Topic~~of ~~606~~December 31, ~~Revenue~~2023, ~~from~~and ~~Contracts~~December ~~with~~31, ~~Customers~~2022, respectively, and these amounts are included in the balance sheet line item of accounts payable and accrued expenses. The customer payments have increased as the nutraceutical manufacturing business results in larger contracts.

The Company accounts for a contract when it has been approved and committed to, each party’s rights regarding the goods or services to be transferred have been identified, the payment terms have been identified, the contract has commercial substance, and collectability is probable. Revenue is generally recognized net of allowances for returns and any taxes collected from customers and subsequently remitted to governmental authorities. However, the Company’s sales are primarily through retail stores, purchase orders or ecommerce; thus, currently contract liabilities are negligible. The Company does not have any multipleF-~~element arrangements.~~10

~~Some~~SCHEDULE ofOF ~~the~~REVENUE ~~Company’s~~FROM ~~contract~~CONTRACT ~~liabilities~~WITH consist of advance customer payments. Contract liability results from transactions in which the Company has been paid for products by customers, but for which all revenue recognition criteria have not yet been met. Once all revenue recognition criteria have been met, the contract liabilities are recognized. The Company recorded $368,065 and $24,585 in advanced customer payments as of December 31, 2022, and December 31, 2021, respectively, and these amounts are included in the balance sheet line item of accounts payable and accrued expenses. The customer payments have increased as the nutraceutical manufacturing business results in larger contracts.CUSTOMER

SCHEDULE OF REVENUE FROM CONTRACT WITH CUSTOMER

	December 31, 2023		December 31, 2022
Balance, beginning of period	$	368,065	$	24,585
Payments received for unearned revenue		156,298		412,891
Revenue earned		174,658		69,411
Balance, end of period	$	349,705	$	368,065

	December 31, 2022		December 31, 2021
Balance, beginning of period	$	24,585	$	121,300
Payments received for unearned revenue		412,891		41,465
Revenue earned		69,411		138,180
Balance, end of period	$	368,065	$	24,585

Revenue is recognized when a customer obtains control of promised goods or services and is recognized in an amount that reflects the consideration that an entity expects to receive in exchange for those goods or services. In addition, the standard requires disclosure of the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers. The amount of revenue that is recorded reflects the consideration that the Company expects to receive in exchange for those goods. The Company applies the following five-step model in order to determine this amount: (i) identification of the promised goods in the contract; (ii) determination of whether the promised goods are performance obligations, including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation.

Revenue isrelated ~~recognized~~to ~~when~~the asale ~~customer obtains control~~ of ~~promised~~products ~~goods or services and~~ is recognized inonce angoods ~~amount~~have ~~that~~been ~~reflects~~sold ~~the consideration that an entity expects~~ to ~~receive~~the incustomer ~~exchange~~and ~~for~~the ~~those~~performance ~~goods~~obligation orhas ~~services.~~been completed. In ~~addition,~~both ~~the~~contracted ~~standard~~purchase ~~requires~~and ~~disclosure~~retail ~~of the nature~~sales, ~~amount,~~ ~~timing,~~we ~~and~~offer ~~uncertainty~~consumer ofproducts ~~revenue~~through ~~and~~our ~~cash~~online ~~flows arising from contracts with customers~~stores. ~~The~~Revenue ~~amount~~is ofrecognized ~~revenue~~when ~~that is recorded~~control ~~reflects~~of the ~~consideration~~goods ~~that~~is ~~the~~transferred ~~Company expects~~ to ~~receive~~the incustomer. ~~exchange~~This ~~for~~generally ~~those~~occurs ~~goods.~~upon ~~The~~our ~~Company~~delivery ~~applies~~to ~~the~~a ~~following five~~third-~~step model~~party incarrier ~~order~~or, to ~~determine this amount: (i) identification of~~ the ~~promised~~customer ~~goods~~directly. Revenue infrom ~~the~~tolling ~~contract;~~services ~~(ii)~~is ~~determination~~recognized ofwhen ~~whether~~ the ~~promised~~ ~~goods are~~ performance ~~obligations~~obligation, ~~including~~such ~~whether~~as ~~they~~processing ~~are distinct in the context~~ of the ~~contract; (iii) measurement of the transaction price~~material, ~~including~~has ~~the~~been ~~constraint~~completed onand output ~~variable~~material ~~consideration;~~has ~~(iv)~~been ~~allocation~~transferred ~~of the transaction price~~ to the ~~performance obligations; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation~~customer.

Revenue ~~related~~is togenerally ~~the~~recognized ~~sale~~net of ~~products~~allowances isfor ~~recognized~~returns ~~once~~and ~~goods~~any ~~have~~taxes ~~been~~collected ~~sold~~from tocustomers ~~the customer~~ and ~~the~~subsequently ~~performance~~remitted ~~obligation~~to ~~has been completed.~~governmental Inauthorities. ~~both~~Some ~~contracted~~of ~~purchase~~the ~~and~~Company’s ~~retail~~contract ~~sales,~~liabilities weconsist ~~offer~~of ~~consumer~~advance ~~products~~customer ~~through our online stores~~payments. ~~Revenue~~A iscontract ~~recognized~~liability ~~when~~results ~~control~~from oftransactions ~~the~~in ~~goods~~which isthe ~~transferred~~Company tohas ~~the~~been ~~customer.~~paid ~~This~~for ~~generally~~products ~~occurs~~by ~~upon~~customers, ~~our~~but ~~delivery~~for towhich aall ~~third-party~~revenue ~~carrier~~recognition ~~or,~~criteria tohave ~~the~~not ~~customer~~yet been ~~directly~~met. ~~Revenue~~ ~~from~~Once ~~tolling~~all ~~services~~revenue isrecognition ~~recognized~~criteria ~~when~~have been met, the ~~performance~~contract ~~obligation~~liabilities are recognized. However, ~~such~~the asCompany’s sales ~~processing~~are ofprimarily ~~the~~through ~~material~~retail stores, ~~has~~purchase ~~been~~orders ~~completed~~or ~~and output~~ecommerce. ~~material~~The ~~has~~Company ~~been~~does ~~transferred~~not tohave ~~the~~any ~~customer~~multiple-element arrangements.

~~F-11~~Shipping and Handling Costs

~~Revenue~~The isCompany ~~generally~~accounts ~~recognized net of allowances~~ for ~~returns~~shipping and ~~any~~handling ~~taxes~~fees ~~collected~~in ~~from~~accordance ~~customers~~with ~~and~~ASC ~~subsequently remitted to governmental authorities~~606. ~~Some~~The ofamounts ~~the~~charged ~~Company’s~~to ~~contract~~customers ~~liabilities~~for ~~consist~~shipping ofproducts ~~advance customer payments. A contract liability results from~~are ~~transactions~~recognized inas ~~which~~revenues and the ~~Company~~related ~~has~~freight ~~been~~costs ~~paid~~of ~~for~~shipping products byare ~~customers,~~classified ~~but~~in ~~for~~general ~~which~~and ~~all~~administrative ~~revenue~~costs ~~recognition~~as ~~criteria~~incurred. Shipping ~~have~~costs ~~not~~are ~~yet been~~included ~~met.~~as ~~Once~~a ~~all~~component ~~revenue~~of ~~recognition~~general ~~criteria~~and ~~have~~administrative ~~been~~and ~~met~~were $97,911 ~~the~~and ~~contract~~$84,507 ~~liabilities~~for ~~are~~December ~~recognized.~~31, ~~However~~2023, ~~the~~and ~~Company’s~~December ~~sales~~31, ~~are primarily through retail stores~~2022, ~~purchase~~respectively. ~~orders~~The orincrease ~~ecommerce.~~is ~~The~~due ~~Company~~to ~~does~~higher ~~not~~postage ~~have~~costs ~~any~~and ~~multiple-element~~larger ~~arrangements~~freight shipments.

~~Shipping~~Advertising ~~and~~& ~~Handling Costs~~Marketing

~~The~~Advertising ~~Company~~costs ~~accounts~~are ~~for~~expensed ~~shipping~~when ~~and~~incurred. ~~handling~~Included ~~fees~~ in ~~accordance~~this ~~with~~category ~~ASC~~are ~~606.~~expenses ~~The~~related ~~amounts charged~~ to ~~customers~~public ~~for~~relations, ~~shipping~~investor ~~products~~relations, ~~are~~new package ~~recognized~~design, aswebsite ~~revenues~~design, ~~and~~design ~~the~~of ~~related~~promotional ~~freight~~materials, ~~costs~~cost of ~~shipping~~trade ~~products~~shows, ~~are~~cost ~~classified~~of inproducts ~~general~~given ~~and~~away ~~administrative~~as ~~costs~~promotional assamples, ~~incurred.~~and ~~Shipping~~paid ~~costs~~advertising. ~~are~~The ~~included~~Company asrecorded aadvertising ~~component~~costs ofincluded in general and administrative ~~and~~costs ~~were~~of $4017,~~409~~947 and $16209,~~564~~254 for the years ended December 31, ~~2022~~2023, and ~~December 31~~2022, ~~2021,~~ respectively. ~~The increase is due to higher postage costs and larger freight shipments.~~

~~Advertising~~Segment ~~& Marketing~~Information

~~Advertising~~The ~~costs~~Company ~~are~~follows ~~expensed~~the ~~when~~provisions ~~incurred~~of ASC 280-10 Segment Reporting. ~~Included~~This standard requires that companies disclose operating segments based on the manner in ~~this~~which ~~category~~management ~~are~~disaggregates ~~expenses~~the ~~related~~Company toin ~~public~~making ~~relations,~~internal ~~investor~~operating ~~relations,~~decisions. ~~new~~Segment ~~package~~identification and ~~design,~~selection ~~website~~is ~~design,~~consistent ~~design~~with ofthe ~~promotional~~management ~~materials,~~structure ~~cost~~used ofby ~~trade~~the ~~shows~~Company’s chief operating decision maker to evaluate performance and make decisions regarding resource allocation, ~~cost~~as well as the materiality of ~~products~~financial ~~given~~results ~~away~~consistent aswith ~~promotional~~that ~~samples,~~structure. ~~and~~Based ~~paid~~on ~~advertising~~the Company’s management structure and method of internal reporting, the Company has one operating segment. The Company’s chief ~~recorded~~operating ~~advertising~~decision ~~costs~~maker ~~included~~does innot ~~general~~review ~~and~~operating ~~administrative~~results ~~costs~~on ofa ~~$209,254~~disaggregated ~~and~~basis; ~~$377~~rather,~~916~~ ~~for~~ the ~~years~~ ~~ended~~chief ~~December~~operating ~~31,~~decision ~~2022~~maker reviews ~~and~~operating ~~2021,~~results ~~respectively~~on an aggregate basis.

~~Segment Information~~F-11

~~The~~Earnings ~~Company~~per follows the provisions of ASC 280-10 Segment Reporting. This standard requires that companies disclose operating segments based on the manner in which management disaggregates the Company in making internal operating decisions. Segment identification and selection is consistent with the management structure used by the Company’s chief operating decision maker to evaluate performance and make decisions regarding resource allocation, as well as the materiality of financial results consistent with that structure. Based on the Company’s management structure and method of internal reporting, the Company has one operating segment. The Company’s chief operating decision maker does not review operating results on a disaggregated basis; rather, the chief operating decision maker reviews operating results on an aggregate basis.Share

~~Earnings~~The Company computes basic and diluted earnings per share amounts in accordance with ASC Topic 260, “Earnings per Share”. Basic earnings per share is computed by dividing net income (loss) available to common stockholders by the weighted average number of common shares outstanding during the reporting period. Diluted earnings per share reflects the potential dilution that could occur if preferred stock converted to common stock and warrants are exercised. Preferred stock and warrants are excluded from the diluted earnings per share calculation if their effect is anti-dilutive.

~~The~~SCHEDULE ~~Company~~OF ~~computes~~ANTI-DILUTIVE ~~basic~~DILUTED ~~and~~LOSS ~~diluted~~PER earnings per share amounts in accordance with ASC Topic 260, “Earnings per Share”. Basic earnings per share is computed by dividing net income (loss) available to common stockholders by the weighted average number of common shares outstanding during the reporting period. Diluted earnings per share reflects the potential dilution that could occur if preferred stock converted to common stock and warrants are exercised. Preferred stock and warrants are excluded from the diluted earnings per share calculation if their effect is anti-dilutive.SHARE

The Business Combination on December 31, 2021 was accounted for as a recapitalization of equity structure. In October 2021 the Company completed 1-for-28 reverse stock split. Pursuant to GAAP, the Company retrospectively recasted the weighted-average shares included within its consolidated statements of operations for the years ended December 31, 2022, and December 31, 2021. The basic and diluted weighted-average Panacea ordinary shares are retroactively converted to shares of the Company’s common stock to conform to the recasted consolidated statements of stockholders’ equity (deficit ).

	2023		2022
	Years ended December 31,
	2023		2022
Restricted Stock		1,793,483		107,993
Options to purchase common stock		551,854		346,854
Warrants to purchase common stock		1,104,243		1,117,094
Series B-1 Convertible Preferred		6,679		6,679
Series B-2 Convertible Preferred		26,786		26,786
Series C Convertible Preferred		2,289,220		2,289,220
Series C-1 Convertible Preferred		1,064,908		1,064,908
Series C-2 Convertible Preferred		2,050,000		2,050,000
Series D Convertible Preferred		1,628,126		1,628,126
Series E Convertible Preferred		3,853,000		-
Total		14,368,299		8,637,660
Anti-dilutive securities		14,368,299		8,637,660

~~SCHEDULE~~Income ~~OF ANTI-DILUTIVE DILUTED LOSS PER SHARE~~taxes

	2022		2021
	Years ended December 31,
	2022		2021
Convertible note payable		-		-
Restricted Stock		-		-
Options to purchase common stock		-		-
Warrants to purchase common stock		-		-
Series A Convertible Preferred		-		250,000
Series B-1 Convertible Preferred		6,679		6,679
Series B-2 Convertible Preferred		26,786		26,786
Series C Convertible Preferred		2,289,220		2,289,220
Series C-1 Convertible Preferred		1,064,908		1,064,908
Series C-2 Convertible Preferred		2,050,000		2,050,000
Series D Convertible Preferred		1,628,126		1,628,126
Total		-		-

The Company accounts for income taxes in accordance with ASC 740, “Income Taxes”. ASC 740 requires an asset and liability approach for financial accounting and reporting for income taxes and established for all the entities a minimum threshold for financial statement recognition of the benefit of tax positions and requires certain expanded disclosures. The provision for income taxes is based upon income or loss after adjustment for those permanent items that are not considered in the determination of taxable income. Deferred income taxes represent the tax effects of differences between the financial reporting and tax basis of the Company’s assets and liabilities at the enacted tax rates in effect for the years in which the differences are expected to reverse. The Company evaluates the recoverability of deferred tax assets and establishes a valuation allowance when it is more likely than not that some portion or all the deferred tax assets will not be realized. Management makes judgments as to the interpretation of the tax laws that might be challenged upon an audit and cause changes to previous estimates of tax liability. In management’s opinion, adequate provisions for income taxes have been made. If actual taxable income by tax jurisdiction varies from estimates, additional allowances or reversals of reserves may be necessary.

~~F-12~~Recently Issued Accounting Standards

~~Income~~In ~~taxes~~August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2020-06, Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging-Contracts in Entity’s Own Equity (Subtopic 815-40), Accounting for Convertible Instruments and Contract’s in an Entity’s Own Equity. The ASU simplifies accounting for convertible instruments by removing major separation models required under current GAAP. Consequently, more convertible debt instruments will be reported as a single liability instrument with no separate accounting for embedded conversion features. The ASU removes certain settlement conditions that are required for equity contracts to qualify for the derivative scope exception, which will permit more equity contracts to qualify for it. The ASU simplifies the diluted net income per share calculation in certain areas. The ASU is effective for annual and interim periods beginning after December 31, 2021, and early adoption is permitted for fiscal years beginning after December 15, 2020, and interim periods within those fiscal years. The Company is currently evaluating the impact that this new guidance will have on its consolidated financial statements.

~~Recently~~In ~~Issued~~May 2021, the Financial Accounting Standards Board (“FASB”) issued ASU 2021-04 “Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation— Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815- 40) Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options” which clarifies and reduces diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. An entity should measure the effect of a modification or an exchange of a freestanding equity-classified written call option that remains equity classified after modification or exchange as follows: i) for a modification or an exchange that is a part of or directly related to a modification or an exchange of an existing debt instrument or line-of-credit or revolving-debt arrangements (hereinafter, referred to as a “debt” or “debt instrument”), as the difference between the fair value of the modified or exchanged written call option and the fair value of that written call option immediately before it is modified or exchanged; ii) for all other modifications or exchanges, as the excess, if any, of the fair value of the modified or exchanged written call option over the fair value of that written call option immediately before it is modified or exchanged. The amendments in this Update are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company is currently evaluating the impact of this standard on its consolidated financial statements.

In August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2020-06, Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging-Contracts in Entity’s Own Equity (Subtopic 815-40), Accounting for Convertible Instruments and Contract’s in an Entity’s Own Equity. The ~~ASU simplifies accounting~~ ~~for~~Company ~~convertible~~does ~~instruments~~not bydiscuss ~~removing~~recent ~~major~~pronouncements separation models required under current GAAP. Consequently, more convertible debt instruments will be reported as a single liability instrument with no separate accounting for embedded conversion features. The ASU removes certain settlement conditions that are ~~required~~not ~~for~~anticipated ~~equity contracts~~ to ~~qualify~~have ~~for~~an ~~the~~impact ~~derivative~~on ~~scope~~or ~~exception,~~are ~~which~~unrelated ~~will permit more equity contracts~~ to ~~qualify~~its ~~for~~financial ~~it. The ASU simplifies the diluted net income per share calculation in certain areas. The ASU is effective for~~condition, ~~annual~~results ~~and~~of ~~interim periods beginning after December 31~~operations, ~~2021,~~cash ~~and~~flows ~~early~~or ~~adoption is permitted for fiscal years beginning after December 15, 2020, and interim periods within those fiscal years~~disclosures. ~~The Company is currently evaluating the impact that this new guidance will have on its consolidated financial statements.~~

InNOTE ~~May~~3 ~~2021,~~– ~~the Financial Accounting Standards Board (“FASB”) issued ASU 2021-04 “Earnings Per Share (Topic 260)~~PROPERTY, ~~Debt—Modifications and Extinguishments (Subtopic 470-50)~~EQUIPMENT, ~~Compensation—~~NET ~~Stock~~OF ~~Compensation~~ACCUMULATED (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815- 40) Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options” which clarifies and reduces diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. An entity should measure the effect of a modification or an exchange of a freestanding equity-classified written call option that remains equity classified after modification or exchange as follows: i) for a modification or an exchange that is a part of or directly related to a modification or an exchange of an existing debt instrument or line-of-credit or revolving-debt arrangements (hereinafter, referred to as a “debt” or “debt instrument”), as the difference between the fair value of the modified or exchanged written call option and the fair value of that written call option immediately before it is modified or exchanged; ii) for all other modifications or exchanges, as the excess, if any, of the fair value of the modified or exchanged written call option over the fair value of that written call option immediately before it is modified or exchanged. The amendments in this Update are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company is currently evaluating the impact of this standard on its consolidated financial statements.DEPRECIATION

~~The~~Property ~~Company~~and ~~does~~equipment, ~~not~~net ~~discuss~~including ~~recent~~any ~~pronouncements~~major ~~that~~improvements, are ~~not~~recorded ~~anticipated~~at tohistorical ~~have~~cost. anThe ~~impact~~cost onof orrepairs ~~are~~and ~~unrelated~~maintenance tois ~~its~~charged against ~~financial~~operations ~~condition, results~~as incurred. Depreciation is calculated using the straight-line method over the estimated useful lives of ~~operations~~the related assets, ~~cash~~generally ~~flows~~as ~~or disclosures.~~follows:

~~NOTE~~SCHEDULE 3OF – PROPERTY, ~~EQUIPMENT,~~PLANT ~~NET~~AND OFEQUIPMENT ~~ACCUMULATED~~USEFUL ~~DEPRECIATION~~LIVES

Property and equipment, net including any major improvements, are recorded at historical cost. The cost of repairs and maintenance is charged against operations as incurred. Depreciation is calculated using the straight-line method over the estimated useful lives of the related assets, generally as follows:

			Estimated Life
Computers and technological assets			3 – 5 Years
Furniture and fixtures			3 – 5 Years
Machinery and equipment			5 – 10 Years
Leasehold improvement			10 Years

~~SCHEDULE~~Property OFand ~~PROPERTY~~equipment, ~~PLANT~~net ~~AND~~consists ~~EQUIPMENT~~of ~~USEFUL~~the ~~LIVES~~following:

			Estimated Life
Computers and technological assets			3 – 5 Years
Furniture and fixtures			3 – 5 Years
Machinery and equipment			5 – 10 Years
Leasehold improvement			10 Years

SCHEDULE OF PROPERTY AND EQUIPMENT

Property and equipment, net consists of the following:

	December 31, 2023			December 31, 2022
Computers and technological assets	$	3,776,320		$	3,776,320
Furniture and fixtures		161,830			55,950
Machinery and equipment		7,846,788			7,765,466
Land		92,222			92,222
Leasehold Improvements		1,806,755			1,508,915
Total		13,683,915			13,198,873
Total Property and equipment, gross		13,683,915			13,198,873
Less accumulated depreciation		(7,235,847	)		(5,522,878	)
Total Property and equipment, net	$	6,448,068		$	7,675,995

~~SCHEDULE~~Depreciation OFexpenses ~~PROPERTY~~for ~~AND~~the ~~EQUIPMENT~~years ended December 31, 2023 and 2022 were $1,712,969 and $1,669,690 respectively.

	December 31, 2022			December 31, 2021
Computers and technological assets	$	3,776,320		$	3,514,421
Furniture and fixtures		55,950			55,950
Machinery and equipment		7,765,466			7,530,787
Land		92,222			92,222
Leasehold Improvements		1,508,915			1,508,915
Total		13,198,873			12,702,295
Less accumulated depreciation		(5,522,878	)		(3,862,313	)
Total Property and equipment, net	$	7,675,995		$	8,839,982

F-13

~~Depreciation~~NOTE ~~expenses~~4 ~~for~~– ~~the years ended December 31, 2022 and 2021 were $1,669,690 and $1,675,786 respectively.~~INVENTORY

~~F-13~~Inventory consists of the following components:

~~NOTE~~SCHEDULE 4OF – INVENTORY

Inventory consists of the following components:

	December 31, 2023		December 31, 2022
Raw Materials	$	850,362	$	870,530
Semi-Finished		1,870,978		1,863,501
Finished Goods		1,262,674		1,694,574
Packaging		29,511		20,120
Total	$	4,013,525	$	4,448,725

~~SCHEDULE~~NOTE 5 –OPERATING LEASE RIGHT-OF-USE ~~INVENTORY~~ASSETS AND OPERATING LEASE LIABILITIES – RELATED PARTY

	December 31, 2022		December 31, 2021
Raw Materials	$	870,530	$	970,393
Semi-Finished		1,863,501		1,466,763
Finished Goods		1,694,574		1,805,779
Packaging		20,120		15,549
Trading		-		5,793
Total	$	4,448,725	$	4,264,277

Right of Use

~~NOTE~~The 5Company ~~–OPERATING~~adopted ~~LEASE~~Accounting ~~RIGHT~~Standards Update (“ASU”) No. 2016-OF02, “Leases” (“ASC 842”) on January 1, 2019, the start of our 2019 fiscal year. The Company has one lease arrangement with a related party entered into on December 22, 2018, for a 3-~~USE~~year ~~ASSETS~~term ~~AND~~commencing ~~OPERATING~~January ~~LEASE~~1, ~~LIABILITIES~~2019, –for ~~RELATED~~certain ~~PARTY~~laboratory facilities with a nine-year extension option. This lease was extended and now expires on December 31, 2030. At inception, the Company recognized a Right of Use Asset and a corresponding lease liability in the amount of $4,595,509. The Company’s lease arrangements may contain both lease and non-lease components. The Company has elected to combine and account for lease and non-lease components as a single lease component. The Company has incorporated residual value obligations in leases for which there is such occurrences. Regarding short-term leases, ASC 842-10-25-2 permits an entity to make a policy election not to apply the recognition requirements of ASC 842 to Short-term leases. The Company has elected not to apply the ASC 842 recognition criteria to any leases that qualify as Short-Term Leases.

~~Right~~The Company, as of ~~Use~~January 1, 2019, leases a portion of the property (formerly the Environmental Protection Agency building) in Golden, CO from J&N Real Estate, owned by the CEO, a related party with a term expiring on December 31, 2030. The lease consists of all laboratory space including testing facilities, water treatment, extraction and production. The lease of the property is based on the fair market rent and triple net lease (NNN) values competitive in the marketplace for a cGMP facility. The Company also subleases some of its laboratory space to other CBD companies. This income is presented under the Other Income line items of the income statement. The leases vary from short-term monthly leases to 3-year leases but are all month to month. The Company also has seven different leases in the Tampa, FL area for the Panacea Distro warehouse, cash and carry distribution facility, and six different retail store locations.

~~The~~SCHEDULE ~~Company~~OF ~~adopted~~RIGHT ~~Accounting~~OF ~~Standards~~USE ~~Update~~ASSET ~~(“ASU”)~~AND No. 2016-02, “Leases” (“ASC 842”) on January 1, 2019, the start of our 2019 fiscal year. The Company has one lease arrangement with a related party entered into on December 22, 2018 for a 3-year term commencing January 1, 2019 for certain laboratory facilities with a nine-year extension option. This lease was extended and now expires on December 31, 2030. At inception, the Company recognized a Right of Use Asset and a corresponding lease liability in the amount of $4,595,509. The Company’s lease arrangements may contain both lease and non-lease components. The Company has elected to combine and account for lease and non-lease components as a single lease component. The Company has incorporated residual value obligations in leases for which there is such occurrences. Regarding short-term leases, ASC 842-10-25-2 permits an entity to make a policy election not to apply the recognition requirements of ASC 842 to Short-term leases. The Company has elected not to apply the ASC 842 recognition criteria to any leases that qualify as Short-Term Leases.LIABILITY

The Company, as of January 1, 2019, leases a portion of the property (formerly the Environmental Protection Agency building) in Golden, CO from J&N Real Estate, owned by the CEO, a related party with a term expiring on December 31, 2030. The lease consists of all laboratory space including testing facilities, water treatment, extraction and production. The lease of the property is based on the fair market rent and triple net lease (NNN) values competitive in the marketplace for a cGMP facility. The Company also subleases some of its laboratory space to other CBD companies. This income is presented under the Other Income line items of the income statement. The leases vary from short-term monthly leases to 3-year leases but are all month to month.

	December 31, 2023			December 31, 2022
Right-of-use assets	$	3,864,591		$	3,242,381

Present value of operating lease liabilities	$	3,972,696		$	3,347,331
Less: Long-term portion of operating lease liability		(3,254,021	)		(2,987,208	)
Short-term portion of operating lease liability		718,675			360,123
Unpaid balances		2,195,106			1,730,136
Total short-term lease liability obligations	$	2,913,781		$	2,090,259
Weighted-average remaining lease term (Ends December 31, 2030)		5.95 years			8 years

Weighted-average discount rate					3.0	%

~~SCHEDULE~~During OFyears ~~RIGHT~~ended OFDecember ~~USE~~31, ~~ASSET~~2023, ~~AND~~and ~~LIABILITY~~2022, we recognized approximately $560,626 and $458,772, respectively in operating lease costs. Operating lease costs are included in operating expenses in our consolidated statement of operations.

	December 31, 2022			December 31, 2021
Right-of-use assets	$	3,242,381		$	3,595,100
Present value of operating lease liabilities	$	3,347,331		$	3,692,392
Less: Long-term portion of operating lease liability		(2,987,208	)		(3,347,335	)
Short-term portion of operating lease liability		360,123			345,057
Unpaid balances		1,730,136			1,279,033
Total short-term lease liability obligations	$	2,090,259		$	1,624,090
Weighted-average remaining lease term (Ends December 31, 2030)		8 years			9 years
Weighted-average discount rate					3.0	%

F-14

~~During~~Approximate ~~years~~future ~~ended~~minimum ~~December~~lease ~~31,~~payments ~~2022~~for ~~and~~our ~~2021,~~right weof ~~recognized~~use ~~approximately~~assets ~~$458,772~~over ~~and~~the ~~$458,772,~~remaining ~~respectively~~lease inperiods ~~operating~~as ~~lease~~of ~~costs.~~December ~~Operating lease~~31, ~~costs~~2023, are ~~included~~as ~~in operating expenses in our consolidated statement of operations.~~follows:

~~Approximate~~Maturity ~~future~~of ~~minimum~~operating lease ~~payments~~liabilities for ~~our right of use assets over~~ the ~~remaining~~following ~~lease~~years ~~periods as of December 31, 2022, are as follows~~ended:

~~Maturity~~SCHEDULE ofOF ~~operating~~MATURITY ~~lease~~OF ~~liabilities~~OPERATING ~~for~~LEASE ~~the following years ended:~~LIABILITIES

SCHEDULE OF MATURITY OF OPERATING LEASE LIABILITIES


2024	$	827,996
2025	$	830,307
2026	$	764,830
2027	$	474,122
Thereafter	$	1,451,002
Total undiscounted operating lease payments	$	4,348,257
Less: Imputed interest	$	(375,561	)
Present value of operating lease liabilities	$	3,972,696

2023	$	455,622
2024	$	460,178
2025	$	464,780
2026	$	469,427
2027	$	474,122
Thereafter	$	1,451,002
Total undiscounted operating lease payments	$	3,775,131
Less: Imputed interest	$	(427,800	)
Present value of operating lease liabilities	$	3,347,331

NOTE 6 – NOTES PAYABLE

~~F-14~~Paycheck Protection Program Funding U.S. Small Business Administration Loan

~~NOTE~~On 6May –28, ~~NOTES~~2020, ~~PAYABLE~~the Company received a secured, 30-year, Economic Injury Disaster Loan in the amount of $99,100 from the U.S. Small Business Administration. The loan carries interest at a rate of 3.75% per year, requires monthly payments of principal and interest, and matures in 30 years. Installment payments, including principal and interest, of $483 monthly, will begin 12 months from the date of the promissory Note. The SBA loan is secured by a security interest in the Company’s tangible and intangible assets. As of December 31, 2023, the current principal balance of this note amounted to $99,100 and accrued interest was approximately $2,047 total for the current and non-current total.

~~Convertible~~First ~~Note~~Bank ~~Payable~~Loan

On ~~November~~July 186, ~~2021~~2023, the ~~Company~~company ~~entered~~completed ~~into~~ a ~~Securities~~promissory ~~Purchase~~note ~~Agreement (“SPA”)~~ with ~~Lincoln~~its ~~Park Capital Fund~~bank, ~~LLC~~First ~~(the “Purchaser”)~~Bank. ~~pursuant~~The tomaturity ~~which~~on the ~~Company~~loan ~~agreed~~is toJuly ~~sell a 10% original issue discount senior convertible promissory note in the principal amount of $~~1,~~100,000~~ ~~(the “Convertible Note”) and five-year warrants to purchase 785~~2030,~~715~~ ~~shares~~at ofa ~~the Company’s~~6.82% ~~common~~annual ~~stock,~~interest ~~par value $0~~rate.~~0001~~ ~~per~~The ~~share~~loan atwas anused ~~exercise~~for ~~price~~additional ofproduction ~~$1.40~~manufacturing ~~per~~equipment ~~share~~totaling ~~(the “Warrants”) pursuant to the terms~~$298,761. Principal and ~~conditions~~interest ofmonthly ~~the~~payments ~~SPA~~are ~~for a total purchase price of~~ $14,~~000,000~~627.38 and ~~The~~commenced ~~note was repaid~~ in ~~full~~October ~~on December 20, 2022~~2023.

~~Paycheck~~Note ~~Protection~~payable-current, ~~Program~~related ~~Funding U.S. Small Business Administration Loan~~party

OnAs ~~May~~part ~~28,~~of ~~2020,~~ the ~~Company~~agreement ~~received a secured, 30-year, Economic Injury Disaster Loan~~ in the ~~amount~~reverse ofmerger ~~$99~~transaction,~~100~~ ~~from~~certain ~~the~~loan ~~U.S.~~balances ~~Small~~(“J&N ~~Business Administration.~~Loans”) ~~The~~from ~~loan~~J&N ~~carries~~Real ~~interest~~Estate Company, atLLC aan ~~rate~~affiliate of ~~3.75%~~the ~~per~~Company’s ~~year~~CEO, ~~requires~~(“J&N”) ~~monthly~~and ~~payments~~historical ofinterest ~~principal~~owed ~~and~~of ~~interest~~$1,932,358 ~~and~~were ~~matures~~combined ininto 30a ~~years.~~new ~~Installment~~promissory ~~payments,~~note ~~including~~with the principal ~~and~~amount ~~interest,~~ of $~~483~~4.062 ~~monthly,~~million ~~will~~(“J&N ~~begin 12 months from the date of the promissory~~ Note”). The ~~SBA~~J&N ~~loan~~Note isbears ~~secured~~annual ~~by a security~~ interest at in12% ~~the Company’s tangible~~ and ~~intangible~~was ~~assets.~~secured ~~The loan proceeds are to be used as working capital to alleviate economic injury caused~~ by ~~the~~a ~~Covid-19~~pledge ~~disaster occurring in the month~~ of ~~January~~certain ~~31,~~XXII ~~2020,~~common ~~and continuing~~stock ~~thereafter.~~owned Asby ofPanacea ~~December~~(See ~~31,~~Note ~~2022 the current principal balance of this note amounted to $99,100 and accrued interest was approximately $~~2~~,047~~ ~~total~~Going ~~for the current and non-current total~~concern).

~~Employer~~On ~~Retention~~June ~~Credit~~30, 2021, Panacea issued the Company’s CEO, Ms. Buttorff, a 10% promissory note in the amount of $1,685,685 (the “Buttorff Note”). The Buttorff Note was secured by a pledge of certain XXII common stock owned by Panacea (See Note 2 Going concern). This demand note replaced a prior working capital note that Panacea had issued on January 1, 2021. The Company has an additional line of credit note from Ms. Buttorff of $8,000,000 on July 1, 2021. The terms include an annual interest rate of 10% and a maturity date in 2024.

OnSCHEDULE ~~February~~OF ~~16,~~NOTES ~~2022,~~PAYABLE ~~Panacea~~RELATED ~~received an employer retention credit from the federal government of $253,791.~~PARTY

Note payable-current, related party

	December 31, 2023		December 31, 2022
J&N Note	$	4,062,713	$	4,062,713
CEO Note		7,334,904		5,809,090
Total related party notes	$	11,397,617	$	9,871,803

AsOther ~~part of the agreement in the reverse merger transaction, certain loan balances (“Quintel Loans”) from Quintel~~long-MCterm ~~Incorporated~~liabilities, an ~~affiliate~~related of the Company’s CEO, (“Quintel”) and historical interest owed of $1,932,358 were combined into a new promissory note with the principal amount of $4.062 million (“Quintel Note”). The Quintel Note bears annual interest at 12% and was secured by a pledge of certain XXII common stock owned by Panacea (See Note 2 Going concern).party

OnThe ~~June~~Company ~~30,~~has ~~2021,~~recorded ~~Panacea~~a ~~issued~~related ~~the~~party ~~Company’s~~liability ~~CEO,~~(“Fixed ~~Ms.~~Asset ~~Buttorff,~~Loan”) ~~a 10% promissory note~~ in the amount of $13,~~624~~059,~~000~~474, ~~(the~~as ~~“Buttorff Note”).~~of ~~The~~December ~~Buttorff~~31, ~~Note~~2023, ~~was~~and ~~secured~~2022, byrelating ato ~~pledge~~building ofleasehold ~~certain~~improvements ~~XXII~~and ~~common~~SAP ~~stock~~software ~~owned~~and ~~by Panacea (See Note 2 Going concern).~~support ~~This~~fees ~~demand~~which ~~note~~were ~~replaced~~paid aby ~~prior working capital note that Panacea had issued on January 1, 2021. The Company has~~ an ~~additional~~affiliate ~~line of~~company ~~credit note from Ms. Buttorff~~ of ~~$5,000,000~~the ~~on July 1, 2021~~CEO. The ~~terms~~balance ~~include~~bears ~~an annual~~ interest ~~rate~~ of 106% , and athe maturity date in ~~2023~~has not yet been determined.

~~SCHEDULE OF NOTES PAYABLE RELATED PARTY~~F-15

	December 31, 2022		December 31, 2021
Quintel Note	$	4,062,713	$	4,062,713
CEO Note		5,809,090		2,379,153
Total related party notes	$	9,871,803	$	6,441,866

In 2020, the Company recorded an additional related party liability in the amount of $513,390 in respect of certain building improvements, due to J&N Real Estate Company (a company owned by the CEO) (“J&N Building Loan”). The balance bears no interest, and the maturity date has not yet been determined.

Other long-term liabilities, related party are summarized as follows.

~~The~~SCHEDULE ~~Company~~OF ~~has~~NOTES recorded a related party liability (“Fixed Asset Loan”) in the amounts of $3,059,474 and $2,749,638, as of December 31, 2022, and 2021, respectively, relating to building leasehold improvements and SAP software and support fees which were paid by an affiliate company of the CEO. The balance bears interest of 6%, and the maturity date has not yet been determined.PAYABLE

In 2020, the Company recorded an additional related party liability in the amount of $513,390 in respect of certain building improvements ,due to J&N Real Estate Company (a company owned by the CEO) (“J&N Building Loan”). The balance bears no interest, and the maturity date has not yet been determined.

	December 31, 2023		December 31, 2022
Other long-term liabilities, related party
Fixed Asset Loan	$	3,059,474	$	3,059,474
J&N Building Loan		513,390		513,390
Total	$	3,572,864	$	3,572,864

~~Notes~~NOTE ~~payable~~7 is- ~~summarized~~STOCKHOLDERS’ ~~as follows.~~EQUITY

~~SCHEDULE~~Common ~~OF NOTES PAYABLE~~stock

	December 31, 2022		December 31, 2021
Other long-term liabilities, related party
Fixed Asset Loan	$	3,059,474	$	2,749,638
J&N Building Loan		513,390		513,390
Total	$	3,572,864	$	3,263,028

The Company’s authorized common stock consists of 650,000,000 shares with a par value of $0.0001 per share.

~~NOTE~~On 7March -3, ~~STOCKHOLDERS’~~2022, ~~EQUITY~~the Series A preferred stock was converted to a convertible loan for $385,000, due in March 2023. In February 2023, the balance of the note payable was reduced by $270,000 through a cash payment of $135,000 and an issuance of 540,000 shares of common stock. The outstanding amount of $115,000 was due as of June 2023, but the Company was unable to pay off the debt. (See subsequent events).

Common stock options

~~The~~Stock ~~Company’s~~Option ~~authorized common stock consists of 650,000,000 shares with a par value of $0.0001 per share.~~Plan

~~During~~On June 30, 2021 the ~~year~~Company’s ~~ended~~stockholders ~~December~~approved ~~31,~~the 2021 Equity Incentive Plan (the “2021 Plan”). The 2021 Plan provides for the issuance of 339,522 ~~100~~incentive ~~shares~~awards in the form of ~~Series~~non-qualified Aand ~~Preferred~~incentive ~~Shares~~stock ~~were~~options, ~~converted~~restricted ~~into~~stock 71awards,~~429~~ ~~shares~~restricted stock ofunit ~~common~~awards, warrants and preferred stock. The awards may be granted by the Company’s Board of Directors to its employees, directors and officers and to consultants, agents, advisors and independent contractors who provide services to the Company or to a subsidiary of the Company. The exercise price for stock options must not be less than the fair market value of the underlying shares on ~~March~~the date 3,of ~~2022~~grant. The incentive awards shall either be fully vested and exercisable from the ~~Series~~date Aof ~~preferred~~grant or shall vest and become exercisable in such installments as the Board of Directors or Compensation Committee may specify. Stock options expire no later than ten years from the date of grant. The aggregate number of shares of common stock ~~was~~which ~~converted~~may be issued pursuant to athe ~~convertible~~Plan ~~loan~~is ~~for~~144,621. ~~$385~~Unless sooner terminated,~~000,~~ ~~due~~the Plan shall terminate in ~~March~~10 ~~2023~~years.

FAs part of the merger of Exactus, Panacea assumed the Exactus 2018 Equity Incentive Plan (the “2018 Plan”). The 2018 Plan provides for the issuance of incentive awards in the form of non-15qualified and incentive stock options, stock appreciation rights, restricted stock awards, and restricted stock unit awards. The awards may be granted by the Company’s Board of Directors to its employees, directors and officers and to consultants, agents, advisors and independent contractors who provide services to the Company or to a subsidiary of the Company. The exercise price for stock options must not be less than the fair market value of the underlying shares on the date of grant. The incentive awards shall either be fully vested and exercisable from the date of grant or shall vest and become exercisable in such installments as the Board or Compensation Committee may specify. Stock options expire no later than ten years from the date of grant. The aggregate number of shares of common stock which may be issued pursuant to the Plan is 339,286. Unless sooner terminated, the Plan shall terminate in 10 years. This plan had 196,491 fully vested options outstanding at the time of the merger. There have been no options granted under this plan subsequent to the merger.

~~Common stock options~~F-16

Stock ~~Option Plan~~Options

OnA ~~June~~summary ~~30, 2021 the Company’s stockholders approved the 2021 Equity Incentive Plan (the “2021 Plan”). The 2021 Plan provides for the issuance~~ of ~~339,522 incentive awards in~~ the ~~form of non-qualified and incentive~~ stock ~~options,~~option ~~restricted~~activity stock awards, restricted stock unit awards, warrants and preferred stock. The awards may be granted by the Company’s Board of Directors to its employees, directors and officers and to consultants, agents, advisors and independent contractors who provide services to the Company or to a subsidiary of the Company. The exercise price for stock options must not be less than the fair market value of the underlying shares on the date of grant. The incentive awards shall either be fully vested and exercisable from the date of grant or shall vest and become exercisable in such installments as the Board of Directors or Compensation Committee may specify. Stock options expire no later than ten years from the date of grant. The aggregate number of shares of common stock which may be issued pursuant to the Plan is ~~144,621.~~presented ~~Unless sooner terminated, the Plan shall terminate in 10 years.~~below:

~~As part~~SCHEDULE ofOF ~~the~~STOCK merger of Exactus, Panacea assumed the Exactus 2018 Equity Incentive Plan (the “2018 Plan”). The 2018 Plan provides for the issuance of incentive awards in the form of non-qualified and incentive stock options, stock appreciation rights, restricted stock awards, and restricted stock unit awards. The awards may be granted by the Company’s Board of Directors to its employees, directors and officers and to consultants, agents, advisors and independent contractors who provide services to the Company or to a subsidiary of the Company. The exercise price for stock options must not be less than the fair market value of the underlying shares on the date of grant. The incentive awards shall either be fully vested and exercisable from the date of grant or shall vest and become exercisable in such installments as the Board or Compensation Committee may specify. Stock options expire no later than ten years from the date of grant. The aggregate number of shares of common stock which may be issued pursuant to the Plan is 339,286. Unless sooner terminated, the Plan shall terminate in 10 years. This plan had 196,491 fully vested options outstanding at the time of the merger. There have been no options granted under this plan subsequent to the merger.OPTIONS

Stock Options

	Options Outstanding as of December 31, 2023
	Number of Shares Subject to Options		Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (in years)		Aggregate Intrinsic Value
Balance at December 31, 2022		346,854	$	2.80		3.57		-
Options granted		205,000		0.21		4.11		-
Options exercised		-		-		-		-
Options canceled / expired		-		-		-		-
Balance at December 31, 2023		551,854	$	1.841		3.04	$	-

Vested and exercisable at December 31, 2023		551,854	$	1.84		3.70	$	2,500

AStock ~~summary of the stock option activity is presented below:~~Warrants

~~SCHEDULE~~On November OF18, ~~STOCK~~2021, ~~OPTIONS~~ the Company entered into a Securities Purchase Agreement (“SPA”) with Lincoln Park Capital Fund, LLC (the “Purchaser”) pursuant to which the Company agreed to sell a 10% original issue discount senior convertible promissory note in the principal amount of $1,100,000 (the “Convertible Note”) and five-year warrants to purchase 785,715 shares of the Company’s common stock, par value $0.0001 per share at an exercise price of $1.40 per share (the “Warrants”) pursuant to the terms and conditions of the SPA for a total purchase price of $1,000,000. The Note was due November 18, 2022, which is one year from the issuance date and was paid.

	Options Outstanding as of December 31, 2022
	Number of Shares Subject to Options		Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (in years)		Aggregate Intrinsic Value
Balance at December 31, 2021	-		-		-		-
Options assumed in merger		196,486	$	3.51		3.20	$	2,500
Options granted		-		-		-		-
Options exercised		-		-		-		-
Options canceled / expired		-		-		-		-
Balance at December 31, 2022		196,486	$	3.51		2.20	$	2,500
Vested and exercisable at December 31, 2022		196,486	$	3.51		3.70	$	2,500

On March 3, 2022, the Company entered in an Exchange Agreement with an institutional investor pursuant to which the Company issued a 10% original issue discount senior convertible promissory note in the principal amount of $385,000 (the “Note”) and five-year warrants to purchase 275,000 shares of the Company’s common stock, par value $0.0001 per share at an exercise price of $1.40 per share in exchange for 350 shares of the Company’s Series A Convertible Preferred Stock. As of December 31, 2022, the Company also had outstanding warrants to purchase an aggregate of 56,377 shares of common stock. These warrants were previously issued by the Company prior to the exchange agreement.

~~Stock~~The ~~Warrants~~Company’s outstanding warrants as of December 31, 2023, are summarized as follows, and all were exercisable at that date.

OnA ~~March~~summary 3, 2022, the Company entered in an Exchange Agreement with an institutional investor pursuant to which the Company issued a 10% original issue discount senior convertible promissory note in the principal amount of ~~$385,000 (~~the ~~“Note”) and five-year warrants to purchase 275,000 shares of the~~ Company’s common stock, par value $0.0001 per share at an exercise price of $1.40 per share in exchange for 350 shares of the Company’s Series A Convertible Preferred Stock. As of December 31, 2022, the Company also had outstanding warrants tois ~~purchase~~presented ~~an aggregate of 56,377 shares of common stock. These warrants were previously issued by the Company prior to the exchange agreement.~~below:

~~The~~SCHEDULE ~~Company’s~~OF ~~outstanding~~WARRANTS ~~warrants as of December 31, 2022 are summarized as follows, and all were exercisable at that date.~~OUTSTANDING

A summary of the Company’s outstanding warrants is presented below:

	Warrants Outstanding as of December 31, 2023
	Number of Shares Subject to Warrants		Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (in years)		Aggregate Intrinsic Value

Balance on December 31, 2022		1,117,092	$	2.02		4.05		-
Options granted		-		-		-		-
Options exercised		-		-		-		-
Options canceled / expired		12,851		-		-		-
Balance at December 31, 2023		1,104,243	$	1.79		3.10	$	-

Vested and exercisable at December 31, 2023		1,104,243	$	1.79		3.10	$	-

~~SCHEDULE~~As OFof ~~WARRANTS~~December ~~OUTSTANDING~~31, 2023, the outstanding warrants have no intrinsic value.

	Warrants Outstanding as of December 31, 2022
	Number of Shares Subject to Warrants		Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Life (in years)		Aggregate Intrinsic Value
Balance on December 31, 2021		56,377	$	13.64		2.01		-
Options granted		275,000		-		-		-
Options exercised		-		-		-		-
Options canceled / expired		-		-		-		-
Balance at December 31, 2022		331,377	$	3.48		3.67	$	-
Vested and exercisable at December 31, 2022		331,377	$	3.48		3.67	$	-

F-17

AsRestricted ~~of December 31, 2022, the outstanding warrants have no intrinsic value.~~Stock

~~F-16~~A summary of the restricted stock activity is presented below:

~~Restricted~~SUMMARY ~~Stock~~OF RESTRICTED STOCK

A summary of the restricted stock activity is presented below:

	Restricted Stock Common Stock
Balance at December 31, 2022		107,993
Balance at December 31, 2023		1,793,483

~~SUMMARY~~As OFof ~~RESTRICTED~~December ~~STOCK~~31, 2023, there were no unamortized or unvested stock-based compensation costs related to restricted share arrangements. These shares are included in the total of outstanding shares as of December 31, 2023.

	Restricted Stock Common Stock
Balance at December 31, 2021		-
Assumed in merger		107,993
Balance at December 31, 2022		107,993

Preferred Stock

AsThe ofCompany’s ~~December~~authorized ~~31,~~preferred ~~2022, there were no unamortized or unvested~~ stock~~-based~~ ~~compensation~~consists ~~costs~~of ~~related~~50,000,000 ~~to restricted share arrangements. These~~ shares ~~are~~with ~~included~~a inpar ~~the~~value ~~total~~ of ~~outstanding share as of December 31, 2022~~$0.0001.

~~Preferred~~On ~~Stock~~September 30, 2023, an asset purchase agreement with N7 Enterprises was closed. The original agreement was to award N7 785 shares of preferred E stock. Each share is convertible into 10,000 shares of common stock. The agreement contained a provision permitting the total number of shares to be adjusted based on projected sales targets being achieved. Due to these sales targets not being met, subsequent to the original award, the preferred shares were reduced to 385.

~~The~~NOTE ~~Company’s~~8 ~~authorized~~- ~~preferred~~COMMITMENTS ~~stock~~AND ~~consists of 50,000,000 shares with a par value of $0.0001.~~CONTINGENCIES

OnLegal March 3, 2022, the Company entered into an Exchange Agreement with the Investor pursuant to which the company agreed to issue the Note in the principal amount of $385,000 and the Warrants in exchange for 350 shares of the Company’s Series A Convertible Preferred Stock. On April 19, 2022, the Company filed a Withdrawal of Designation of the Series A Convertible Preferred Stock with the Secretary of State and the State of Nevada.Matters

~~NOTE~~In 8the -ordinary ~~COMMITMENTS~~course ~~AND~~of ~~CONTINGENCIES~~business, the Company enters into agreements with third parties that include indemnification provisions which, in its judgment, are normal and customary for companies in the Company’s industry sector. These agreements are typically with business partners, and suppliers. Pursuant to these agreements, the Company generally agrees to indemnify, hold harmless, and reimburse indemnified parties for losses suffered or incurred by the indemnified parties with respect to the Company’s products, use of such products, or other actions taken or omitted by us. The maximum potential number of future payments the Company could be required to make under these indemnification provisions is unlimited. The Company has not incurred material costs to defend lawsuits or settle claims related to these indemnification provisions. As a result, the estimated fair value of liabilities relating to these provisions is minimal. Accordingly, the Company has no liabilities recorded for these provisions as of December 31, 2022.

~~Legal Matters~~Concentrations

In the ordinary course of business, the Company enters into agreements with third parties that include indemnification provisions which, in its judgment, are normal and customary for companies in the Company’s industry sector. These agreements are typically with business partners, and suppliers. Pursuant to these agreements, the Company generally agrees to indemnify, hold harmless, and reimburse indemnified parties for losses suffered or incurred by the indemnified parties with respect to the Company’s products, use of such products, or other actions taken or omitted by us. The ~~maximum potential number of future payments the Company could be required to make under~~ ~~these indemnification provisions is unlimited. The~~ Company has ~~not~~no ~~incurred~~concentration ~~material costs to defend lawsuits or settle claims related to these indemnification provisions. As a result, the estimated fair value~~ of ~~liabilities~~vendors ~~relating~~that towould ~~these~~impact ~~provisions~~production iscosts ~~minimal.~~in ~~Accordingly,~~ the ~~Company~~longer ~~has no liabilities recorded for these provisions as of December 31, 2022~~term.

~~Concentrations~~On the revenue side, for the year ended December 31, 2023, there was a concentration of two customers. Both were nutraceutical contract manufacturing customers who represent 15% and 9% of revenue.

~~The~~For ~~Company~~the ~~has~~year noended December 31, 2022, there was a concentration of ~~vendors~~two ~~that~~customers. ~~would~~Both ~~impact~~are ~~production~~tolling ~~costs~~partners inwho ~~the~~represent ~~longer~~16% ~~term~~and 10% of total revenue.

OnThe other concentration is in the ~~revenue~~accounts ~~side~~receivable category, where three customer accounts for 68% of the ~~year~~accounts ~~ended~~receivable ~~December~~in 312023. One of the three customer contracts is unique in that the company produced all the products for them to sell, and they pay Panacea as the items are sold in the ecommerce marketplace. Thus, until their inventory is depleted, we will have accounts receivable. This customer receivable is 27% of the 68%. In 2022, ~~there~~this ~~was~~same customer accounted for 33% of our total receivables. One customer is a ~~concentration~~nutraceutical contract manufacturing customer whose receivables represent 12% of ~~two~~the ~~customers~~68%. ~~Both~~The ~~are~~other ~~tolling~~customer ~~partners~~concentration is represented by a tenant who ~~represent~~subleases space ~~16%~~in the building and 10represents 29% of ~~total~~the ~~revenue~~68%.

In the 3rd Quarter of 2021, we signed a large contract with a convenience store chain. The revenues from the first shipment of CBD products are 16% of the 2021 revenue. We also have a tolling partner concentration and this contract was F-18~~.8% of revenue in 2021.~~

The ~~other~~Company ~~concentration~~has isno inother ~~the accounts receivable category~~contingencies, ~~where~~material ~~two customer accounts for 50% of the accounts receivable in 2021. One of the three customer contracts is unique in that we produced all the products for them to sell~~commitments, ~~and~~or ~~they~~purchase ~~pay~~obligations ~~Panacea~~or assales ~~the items are sold in the ecommerce marketplace~~obligations. ~~Thus, until their inventory is depleted, we will have accounts receivable. This customer receivable is 33% of the 50%. In 2021, this same customer was 31% of our total receivables.~~

~~The~~Executive ~~Company~~Employment ~~has no other contingencies, material commitments, or purchase obligations or sales obligations.~~Agreement

On December 31, 2021, the Company entered into an updated Employment Agreement with Leslie Buttorff pursuant to which Ms. Buttorff serves as the Company’s Chief Executive Officer for an initial term of July 1, 2021, to December 31, 2024 (the “Employment Agreement). Under her Employment Agreement, Ms. Buttorff receives an annual base salary of $380,000. Ms. Buttorff is also entitled to receive (i) a sales commission of 2% of revenue from sales generated by Ms. Buttorff after revenue exceeds $500,000 for three consecutive months, (ii) an award of $2.2 million of shares of common stock upon approval of the Company’s common stock for listing on The Nasdaq Capital Market prior to expiration of the term of the Employment Agreement, and (iii) an annual cash performance bonus of up to 100% of her base salary based on the achievement of performance metrics for the applicable fiscal year to be set by the Board of Directors. To date, Ms. Buttorff has not taken a salary, payments have accrued commencing in January 2021, and the amount due is included in accounts payable.

On December 31, 2021 the Company entered into an updated Employment Agreement with Leslie Buttorff pursuant to which Ms. Buttorff serves as the Company’s Chief Executive Officer for an initial term of July 1, 2021 to December 31, 2024 (the “Employment Agreement). Under her Employment Agreement, ~~Ms.~~she ~~Buttorff receives an annual base salary of $380,000. Ms. Buttorff~~ is ~~also~~ entitled to ~~receive~~severance ~~(i) a~~payments ~~sales~~under ~~commission~~termination ofprovisions 2%which ofare ~~revenue~~intended ~~from~~to ~~sales~~comply ~~generated~~with ~~by Ms. Buttorff after revenue exceeds $500,000 for three consecutive months,~~Section ~~(ii)~~409A ~~an award~~ of ~~$2.2 million of shares of common stock upon approval of~~ the ~~Company’s~~Internal ~~common~~Revenue ~~stock~~Code ~~for listing on The Nasdaq Capital Market prior to expiration~~ of ~~the term of the Employment Agreement~~1986, ~~and~~or ~~(iii) an annual cash performance bonus of up to 100% of her base salary based on~~ the ~~achievement of performance metrics for the applicable fiscal year to be set by the Board of Directors. To date~~Code, ~~Ms. Buttorff has not taken a salary, payments have accrued commencing in January, 2021,~~ and the ~~amount~~Regulations ~~due is included in accounts payable~~thereunder.

~~Under~~In ~~her~~the ~~Employment~~event ~~Agreement~~of termination by the Company without “cause” or resignation by Ms. Buttorff for “good reason,” ~~she~~Ms. Buttorff is entitled to ~~severance~~receive ~~payments~~two ~~under~~years’ ~~termination~~base ~~provisions~~salary, ~~which~~or ~~are~~$780,000, ~~intended~~all unreimbursed business expenses and other accrued but unpaid compensation, and any annual bonus earned but not yet paid for any fiscal year ending prior to ~~comply~~the ~~with~~fiscal ~~Section~~year in which the date of termination ~~409A~~occurs. In addition, in the event of termination by the ~~Internal~~Company ~~Revenue~~without ~~Code~~“cause,” subject to execution of ~~1986,~~a general release Ms. Buttorff will be entitled to (i) a settlement amount equal to another two years’ base salary (or ~~the~~a ~~Code~~total of $1,560,000) and (ii) an amount equal to the ~~Regulations~~annual ~~thereunder~~bonus which Ms. Buttorff would have been entitled to receive in respect of the year of termination based on the achievement of any performance objectives for the Company.

FGenerally, “good reason” is defined as (i) any material breach of the Employment Agreement by the Company, (ii) the Company’s assignment of Ms. Buttorff to a position that has materially less authority, status, or functional responsibility than the position with the Company as of the commencement date, or the assignment to her of duties that are not those of an executive at the management level, (iii) the reduction of Ms. Buttorff’s base salary, (iv) the requirement that Ms. Buttorff move her primary place of employment more than 30 miles from her initial place of employment, or (v) upon any change of control event as defined in Treasury Regulation Section 1.409A-173(i)(5) provided that within 12 months of the change of control event the Company terminates Ms. Buttorff or fails to obtain an agreement from any successor to perform the Employment Agreement.

InUnder the ~~event~~terms of ~~termination~~her byEmployment ~~the~~Agreement, ~~Company without “cause” or resignation by~~ Ms. Buttorff ~~for “good reason,” Ms. Buttorff~~ is ~~entitled~~subject to ~~receive~~non-competition ~~two years’ base salary, or $780,000, all unreimbursed business expenses~~ and ~~other~~non-solicitation ~~accrued~~covenants ~~but~~during ~~unpaid compensation, and any annual bonus earned but not yet paid for any fiscal year ending prior to~~ the ~~fiscal~~term ~~year in which the date~~ of ~~termination~~her ~~occurs.~~employment Inand ~~addition,~~following intermination ~~the event~~ of ~~termination~~employment bywith the Company ~~without “cause,” subject to execution of a general release Ms~~. ~~Buttorff~~The ~~will~~Employment beAgreement ~~entitled~~also tocontains ~~(i)~~customary ~~a settlement amount equal to another two years’ base salary (or a total of $1,560,000) and~~confidentiality ~~(ii)~~and annon-disparagement ~~amount equal to the annual bonus which Ms~~covenants. ~~Buttorff would have been entitled to receive in respect of the year of termination based on the achievement of any performance objectives for the Company.~~

~~Generally,~~NOTE ~~“good~~9 reason” is defined as (i) any material breach of the Employment Agreement by the Company, (ii) the Company’s assignment of Ms. Buttorff to a position that has materially less authority, status, or functional responsibility than the position with the Company as of the commencement date, or the assignment to her of duties that are not those of an executive at the management level, (iii) the reduction of Ms. Buttorff’s base salary, (iv) the requirement that Ms. Buttorff move her primary place of employment more than 30 miles from her initial place of employment, or (v) upon any change of control event as defined in Treasury Regulation Section 1.409A-~~3(i)(5)~~ ~~provided~~RELATED ~~that~~PARTY ~~within 12 months of the change of control event the Company terminates Ms. Buttorff or fails to obtain an agreement from any successor to perform the Employment Agreement.~~TRANSACTIONS

~~Under~~Notes ~~the~~Payable ~~terms of her Employment Agreement, Ms. Buttorff is subject to non-competition~~ and ~~non-solicitation~~Accrued ~~covenants~~Interest ~~during~~– ~~the~~Related ~~term of her employment and following termination of employment with the Company. The Employment Agreement also contains customary confidentiality and non-disparagement covenants.~~Parties

~~NOTE~~For 9information -on ~~RELATED~~related ~~PARTY~~party ~~TRANSACTIONS~~loans to the Company and other related party transactions, see Notes 5 and 6, Operating Lease and Notes Payable.

~~Notes~~The ~~Payable~~accrued interest and ~~Accrued~~interest ~~Interest~~expenses –recorded ~~Related~~for ~~Parties~~related party loans are shown below.

~~For~~SCHEDULE ~~information~~OF onRELATED ~~related~~PARTY ~~party~~TRANSACTIONS ~~loans to the Company and other related party transactions, see Notes 5 and 6, Operating Lease and Notes Payable.~~LOANS

The accrued interest and interest expenses recorded for related party loans are shown below.

	December 31, 2023		December 31, 2022
Accrued Interest
Related party loan J&N	$	1,413,210	$	796,891
Related party loan-CEO loan		476,536		271,585
Related party loan – Line of credit		966,105		282,869
Accrued Interest		966,105		282,869

~~SCHEDULE OF RELATED PARTY TRANSACTIONS LOANS~~F-19

	December 31, 2022		December 31, 2021
	Year ended December 31, 2023		Year ended December 31, 2022
Accrued Interest
Interest Expense
Related party loan J&N	$	~~796~~616,~~891~~319	$	~~249~~546,~~939~~952
Related party loan-CEO loan		~~271~~204,~~585~~952		86185,~~060~~525
Related party loan – Line of credit		282,869		29,235
Related party loan – Line of Credit		683,237		253,634
Accrued Interest		282,869		29,235
Interest Expense		683,237		253,634

	Year ended December 31, 2022		Year ended December 31, 2021
Interest Expense
Related party loan J&N	$	546,952	$	772,463
Related party loan-CEO loan		185,525		146,245
Related party loan – Line of Credit		253,634		29,235
Interest Expense		253,634		29,235

NOTE 10 – INCOME TAXES

~~Other~~The Company has incurred aggregate net operating losses of approximately $33,922,898 million for income tax purposes as of December 31, 2023. The net operating losses carry forward for United States income taxes, which may be available to reduce future years’ taxable income. Management believes that the realization of the benefits from these losses appears not more than likely due to the Company’s limited operating history and continuing losses for United States income tax purposes. Accordingly, the Company has provided a 100% valuation allowance on the deferred tax asset to reduce the asset to zero. Management will review this valuation allowance periodically and make adjustments as necessary.

The ~~Company~~following ~~continues~~table tosummarizes ~~hold~~the ~~1,203,000~~significant ~~shares~~differences ofbetween ~~XXII~~the ~~stock~~U.S. ~~which~~Federal isstatutory ~~available~~tax rate and the Company’s effective tax rate for ~~trading.~~financial Asstatement ofpurposes for the years ended December 31, ~~2021,~~2023 ~~XXII~~and is2022. aThe ~~common~~company ~~shareholder of~~has ~~the~~yet ~~Company.~~to ~~See~~file ~~Subsequent~~income ~~Events~~taxes for the ~~additional~~year ~~details~~ended ~~related~~December to31, ~~XXII resolution~~2023.

~~NOTE~~SCHEDULE 10OF –EFFECTIVE ~~INCOME~~TAX ~~TAXES~~RATE

The Company has incurred aggregate net operating losses of approximately $30.604 million for income tax purposes as of December 31, 2021. The net operating losses carry forward for United States income taxes, which may be available to reduce future years’ taxable income. Management believes that the realization of the benefits from these losses appears not more than likely due to the Company’s limited operating history and continuing losses for United States income tax purposes. Accordingly, the Company has provided a 100% valuation allowance on the deferred tax asset to reduce the asset to zero. Management will review this valuation allowance periodically and make adjustments as necessary.

	December 31, 2023
U.S. federal statutory rate		21.0	%
Increase (decrease) in taxes resulting from:
Increase in valuation allowance		(21.9	)%
ROU Assets/Liabilities		(2.7	)%
State taxes		3.6	%
Income tax (expense) benefit		-	%

~~F-18~~The Company provided a valuation allowance equal to the deferred income tax asset for the year ended December 31, 2023, because it was not known whether future taxable income will be sufficient to utilize the loss carryforward. The increase in the allowance was $8.015 million in fiscal 2023. Additionally, the future utilization of the net operating loss carryforward to offset future taxable income may be subject to an annual limitation, based upon IRC Section 382/383 Ownership change rules that may have or could occur in the future. The Company does not have any uncertain tax positions or events leading to uncertainty in a tax position.

~~The~~NOTE ~~following~~13 ~~table~~– ~~summarizes~~SUBSEQUENT the significant differences between the U.S. Federal statutory tax rate and the Company’s effective tax rate for financial statement purposes for the years ended December 31, 2022 and 2021. The company has yet to file income taxes for the year ended December 31, 2021.EVENTS

~~SCHEDULE~~On OFJanuary ~~EFFECTIVE~~1, ~~TAX~~2024 ~~RATE~~Company decided to not move forward with the Pur Life Medical deal as the deal terms could not be met. The Company was sold to a private company owned by PLSH CEO and President of which they own 35% each.

	December 31, 2022
U.S. federal statutory rate		21.0	%
Increase (decrease) in taxes resulting from:
Increase in valuation allowance		(21.9	)%
ROU Assets/Liabilities		(2.7	)%
State taxes		3.6	%
Income tax (expense) benefit		-	%

In March 5, 2024 the Company came to agreement with its previous Preferred A shareholder to resolve the $100,000 debt outstanding. The Company agreed to settle this debt for 666,000 restricted common shares.

The Company provided a valuation allowance equal to the deferred income tax asset for the year ended December 31, 2022, because it was not known whether future taxable income will be sufficient to utilize the loss carryforward. The increase in the allowance was $9.997 million in fiscal 2022. Additionally, the future utilization of the net operating loss carryforward to offset future taxable income may be subject to an annual limitation, based upon IRC Section 382/383 Ownership change rules that may have or could occur in the future. The Company does not have any uncertain tax positions or events leading to uncertainty in a tax position. The Company’s 2017, 2018, 2019 and 2020 Corporate Income Tax Returns are subject to Internal Revenue Service examination.F-20

~~NOTE~~Item 139. –Changes ~~SUBSEQUENT~~In ~~EVENTS~~and Disagreements with Accountants on Accounting and Financial Disclosure

~~Panacea Life Sciences Holdings, Inc~~None. announced on January 30, 2023 that the Company has executed a letter of intent to acquire N7 Enterprises, Inc. Pursuant to the terms of the letter of intent, Panacea would acquire all of the outstanding membership interests of N7 Enterprises in consideration for the issuance of common shares of the Company to the existing shareholders of N7 Enterprises. N7 Enterprises operates an expanding Florida chain of kava and kratom lounges under the Lizard Juice™ and N7 Nitro Kava™ brands founded in 2012, and is also a distributor of CBD, hemp, kratom and kava related products through its New Age Distribution subsidiary, founded in 2022. For its two business segments, N7 Enterprises showed $4.1 million in revenue for the 2022 fiscal year and is estimating that net income for the year will exceed $1 million.

~~PLSH~~Item ~~settled~~9A. aControls ~~contract with XXII that it would exchange the common shares XXII holds~~ and ~~the $500,000 of hemp to reduce the J&N Panacea loan on the building.~~Procedures

~~F-19~~Evaluation of Disclosure Controls and Procedures

~~Item~~Our 9.management ~~Changes~~carried Inout ~~and~~an ~~Disagreements~~evaluation, with ~~Accountants~~the participation of our principal executive officer (who currently also serves as our principal financial officer) and our former principal financial officer, required by Rule 13a-15 or 15d-15 of the Securities Exchange Act of 1934 (the “Exchange Act”) of the effectiveness of our disclosure controls and procedures as defined in Rule 13a-15(e) or 15d-15(e) under the Exchange Act. Based on ~~Accounting~~their evaluation, our principal executive officer and ~~Financial~~our ~~Disclosure~~former principal financial officer concluded that our disclosure controls and procedures were ineffective as of the end of the period covered by this report to ensure that information required to be disclosed by us in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms and is accumulated and communicated to our management, including our principal executive officer and former principal financial officer, as appropriate to allow timely decisions regarding required disclosure.

~~None.~~Management’s Annual Report on Internal Control over Financial Reporting

~~Item~~Our 9Amanagement is responsible for establishing and maintaining adequate internal control over financial reporting (as defined in Rule 13a-15(f) under the Exchange Act). ~~Controls~~Our management, under the supervision and ~~Procedures~~with the participation of our principal executive officer and financial officer, evaluated the effectiveness of our internal control over financial reporting as of the end of the period covered by this report. Our management’s evaluation of our internal control over financial reporting was based on the framework in Internal Control-Integrated Framework (2013), issued by the Committee of Sponsoring Organizations of the Treadway Commission. In designing and evaluating the disclosure controls and procedures, management recognizes that because of inherent limitations, any controls and procedures, no matter how well designed and operated, may not prevent or detect misstatements and can provide only reasonable assurance of achieving the desired control objectives. In addition, the design of disclosure controls and procedures must reflect the fact that there are resource constraints, and that management is required to apply its judgment in evaluating the benefits of possible controls and procedures relative to their costs.

~~Evaluation~~Our ofinternal ~~Disclosure~~control ~~Controls~~over financial reporting includes those policies and ~~Procedures~~procedures that:

~~Our management~~● ~~carried~~pertain ~~out~~to ~~an evaluation, with~~ the ~~participation~~maintenance of ~~our~~records ~~principal~~that, ~~executive~~in ~~officer~~reasonable ~~(who~~detail, ~~currently~~accurately ~~also serves as our principal financial officer)~~ and ~~our~~fairly ~~former~~reflect ~~principal financial officer, required by Rule 13a-15 or 15d-15 of~~ the ~~Securities~~transactions ~~Exchange~~and ~~Act~~dispositions of ~~1934 (the~~our ~~“Exchange~~assets; ~~Act”)~~● ofprovide ~~the~~reasonable ~~effectiveness~~assurance ofthat ~~our~~transactions ~~disclosure~~are ~~controls~~recorded ~~and procedures~~ as ~~defined~~necessary into ~~Rule~~permit ~~13a-15(e)~~preparation orof ~~15d-15(e) under~~financial ~~the~~statements ~~Exchange~~in ~~Act.~~accordance ~~Based~~with ongenerally ~~their~~accepted ~~evaluation~~accounting principles, ~~our principal executive officer~~ and ~~our former principal financial officer concluded~~ that our ~~disclosure~~receipts ~~controls~~ and ~~procedures~~expenditures ~~were~~are ~~ineffective~~being asmade ofonly ~~the~~in ~~end~~accordance ofwith ~~the~~authorizations ~~period~~of ~~covered~~our bymanagement ~~this~~and ~~report~~directors; toand ~~ensure~~● ~~that~~provide ~~information required~~reasonable toassurance beregarding ~~disclosed~~prevention ~~by us in the reports that we file~~ or ~~submit~~timely ~~under~~detection ~~the~~of ~~Exchange~~unauthorized ~~Act is recorded~~acquisition, ~~processed,~~use ~~summarized~~or ~~and~~disposition ~~reported within~~of ~~the time periods specified in the SEC’s rules and forms and is accumulated and communicated to~~ our ~~management,~~assets ~~including our~~that ~~principal~~could ~~executive~~have ~~officer~~a ~~and~~material ~~former~~effect ~~principal~~on the financial ~~officer, as appropriate to allow timely decisions regarding required disclosure~~statements.

Management’s ~~Annual~~Assessment ~~Report~~of onthe ~~Internal~~Effectiveness of the Company’s internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting (as defined in Rule 13a-15(f) under the Exchange Act). Our management, under the supervision and with the participation of our principal executive officer and ~~principal~~ financial officer, ~~evaluated~~concluded ~~the~~that ~~effectiveness of~~ our ~~internal~~disclosure ~~control~~controls ~~over~~and ~~financial~~procedures ~~reporting~~were asnot ofeffective ~~the~~to ~~end~~ensure that of the ~~period~~information ~~covered~~relating ~~by this~~to ~~report.~~us ~~Our~~is ~~management’s~~required ~~evaluation~~to ofbe ~~our~~disclosed ~~internal control over financial reporting was based on the framework~~ in ~~Internal Control-Integrated~~our ~~Framework~~SEC reports (~~2013~~i), ~~issued~~is byrecorded, ~~the~~processed, ~~Committee~~summarized ~~of Sponsoring Organizations of the Treadway Commission. In designing~~ and reported ~~evaluating~~within the ~~disclosure~~time ~~controls~~periods ~~and~~specified ~~procedures,~~in ~~management~~SEC ~~recognizes~~rules ~~that because of inherent limitations, any controls~~ and ~~procedures~~forms, no ~~matter how well designed~~ and ~~operated,~~(ii) ~~may~~is ~~not~~accumulated ~~prevent or detect misstatements~~ and ~~can~~communicated ~~provide~~to ~~only~~our ~~reasonable~~management ~~assurance~~to ofallow ~~achieving~~timely ~~the~~decisions ~~desired~~regarding ~~control~~required ~~objectives.~~disclosure Inas ~~addition,~~a ~~the~~result ~~design~~ of ~~disclosure controls and procedures must reflect~~ the ~~fact~~following ~~that~~material ~~there~~weaknesses ~~are resource constraints, and that management is required to apply its judgment~~ in ~~evaluating~~our ~~the~~internal ~~benefits~~control ofover ~~possible~~financial ~~controls and procedures relative to their costs.~~reporting:

~~Our internal~~● ~~control~~The ~~over~~Company ~~financial~~does ~~reporting~~not ~~includes~~have ~~those~~sufficient segregation of duties within accounting functions due to only having two officers and limited resources. ● The Company does not have an audit committee; and ● The Company does not have written documentation of our internal control policies and procedures ~~that:~~.

●We plan ~~pertain~~ to ~~the~~rectify ~~maintenance~~these ofweaknesses ~~records~~by ~~that,~~establishing inwritten ~~reasonable~~policies ~~detail, accurately~~ and ~~fairly~~procedures ~~reflect~~for ~~the transactions and dispositions of~~ our ~~assets;~~internal ●control ~~provide reasonable assurance that transactions are recorded as necessary to permit preparation~~ of financial ~~statements~~reporting inand hiring ~~accordance~~additional ~~with generally accepted~~ accounting ~~principles,~~personnel ~~and~~at ~~that~~such ~~our~~time ~~receipts~~as ~~and~~we ~~expenditures~~raise ~~are~~sufficient ~~being~~capital ~~made~~to ~~only~~do in accordance with authorizations of our management and directors; and ● provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of our assets that could have a material effect on the financial statementsso.

2125

~~Management’s~~Changes ~~Assessment~~in ofInternal ~~the~~Controls ~~Effectiveness of the Company’s internal Control~~ over Financial Reporting

~~Our~~There ~~principal~~have ~~executive~~been ~~officer~~no ~~and~~changes ~~our~~in ~~former~~the ~~principal~~internal ~~financial~~control ~~officer~~over ~~concluded~~financial ~~that~~reporting ~~our~~(as ~~disclosure~~such ~~controls~~term ~~and procedures were not effective to ensure that the information relating to us~~ is ~~required~~defined ~~to be disclosed~~ in ~~our~~Rules ~~SEC reports~~ 13a-15(if) ~~is recorded, processed, summarized~~ and ~~reported~~15d-15(f) ~~within~~ under the ~~time~~Exchange ~~periods~~Act) ~~specified~~during inthe ~~SEC~~quarter ~~rules~~ended ~~and~~December ~~forms~~31, ~~and~~2022, ~~(ii)~~that ishave ~~accumulated~~materially ~~and~~affected, ~~communicated~~or tois ~~our~~reasonably ~~management~~likely to ~~allow~~ ~~timely~~materially ~~decisions regarding required disclosure as a result of the following material weaknesses in~~ affect, our internal control over financial reporting:.

~~● The Company does not have sufficient segregation of duties within accounting functions due to only having two officers and limited resources~~Item 9B. ●Other ~~The Company does not have an audit committee; and ● The Company does not have written documentation of our internal control policies and procedures.~~Information

We plan to rectify these weaknesses by establishing written policies and procedures for our internal control of financial reporting and hiring additional accounting personnel at such time as we raise sufficient capital to do soNone.

~~Changes~~Item in10. ~~Internal~~Directors, ~~Controls~~Executive ~~over~~Officers ~~Financial~~and ~~Reporting~~Corporate Governance

~~There~~The ~~have~~following ~~been~~information nosets ~~changes~~forth in the ~~internal~~names, ~~control~~ages, ~~over~~and ~~financial~~positions ~~reporting~~of ~~(as~~our ~~such~~current ~~term~~directors ~~is defined in Rules 13a-15(f)~~ and ~~15d-15(f)~~executive ~~under the~~officers ~~Exchange~~as ~~Act)~~of ~~during~~March ~~the quarter ended December 31~~15, ~~2022, that have materially affected, or is reasonably likely to materially affect, our internal control over financial reporting~~2023.

Item 9B. Other Information

Name	Age	Present Positions
Leslie Buttorff	66	CEO and Chairman
Lawrence J. Wert	66	Director
Nick Cavarra	59	President
Nathan Berman	36	Controller

~~None.~~Directors

~~Item~~Our 10Board is currently comprised of two (2) members. ~~Directors~~The following biographical information discloses each director’s age, ~~Executive~~business experience ~~Officers~~and other directorships held during the past five years. It also includes the experiences, qualifications, attributes and skills ~~Corporate~~that ~~Governance~~led to the conclusion that the individual should serve as our director.

~~The~~Leslie ~~following~~Buttorff ~~information~~is ~~sets~~our ~~forth~~Chief Executive Officer and director since June 30, 2021. Ms. Buttorff has been the ~~names~~Chief Executive Officer of Panacea Life Sciences Holding s, ~~ages~~Inc., a company which manufactures and ~~positions~~develops pharma-grade hemp-related products since 2017. In addition, Ms. Buttorff has been the Chairman of ~~our~~the ~~current~~Board ~~directors~~of Quintel-MC, Inc. a company that focuses on SAP ERP (Enterprise Resource Planning) implementations since 2002. Ms. Buttorff formed Quintel-MC, Inc. in 2002. Before establishing Quintel, Ms. Buttorff was the global practice leader for Arthur D. Little’s Utilities and ~~executive~~Energy ~~officers~~practice and was responsible for the alliance with Perot Systems. Ms. Buttorff is also a member of the Boards of Active Youth Network (provides revenue and enables information for sports teams, high schools and clubs) and JobZology (a CSU spinoff focused on matching people and jobs for employers). Ms. Buttorff was appointed to our Board as a result of ~~March~~her 15knowledge of the business, ~~2023~~ownership and position with the Company.

Name	Age	Present Positions
Leslie Buttorff	65	CEO and Chairman
Lawrence J. Wert	65	Director
Nick Cavarra	58	Senior Vice President Marketing and Sales
Nathan Berman	35	Controller
James Baumgartner	58	Chief Science Officer and Quality Control

Lawrence J. Wert was appointed to our Board on April 29, 2020. Mr. Wert has over 40 years in broadcasting. Mr. Wert served as the President of Broadcast Media for Tribune Media Company from 2013 through September of 2019. Mr. Wert previously served on the NAB TV Board of Directors, Fox Board and the CBS Board of Governors. In 2017, Mr. Wert was named “Broadcaster of the Year” by the Illinois Broadcaster’s Association. Currently, he serves on the Board of Directors for several charities, including the Children’s Brittle Bone Foundation, Catholic Charities, the Chicagoland Chamber of Commerce and the 100 Club. Mr. Wert is a member of the Governing Board of Gilda’s Club of Chicago, an advisor to the Chicago Chapter of Make-A-Wish Foundation and an honorary board member of RAINBOWS, an organization that helps children cope with loss. In 2018, Mr. Wert was inducted into the Chicago Catholic League Hall of Fame. Mr. Wert also sits on Board of Trustees for Fenwick High School in Oak Park, Ill. Mr. Wert was appointed as a director as a result of his prior experience with Exactus, Inc.

~~Directors~~26

~~Our~~Executive Board is currently comprised of two (2) members. The following biographical information discloses each director’s age, business experience and other directorships held during the past five years. It also includes the experiences, qualifications, attributes and skills that led to the conclusion that the individual should serve as our director.Officers

~~Leslie~~The ~~Buttorff~~following is our Chief Executive Officer and director since June 30, 2021. Ms. Buttorff has been the Chief Executive Officer of Panacea Life Sciences, Inc., a company which manufactures and develops pharma-grade hemp-related products since 2017. In addition, Ms. Buttorff has been the Chairman of the Board of Quintel-MC, Inc. a company that focuses on SAP ERP (Enterprise Resource Planning) implementations since 2002. Ms. Buttorff formed Quintel-MC, Inc. in 2002. Before establishing Quintel, Ms. Buttorff was the global practice leader for Arthur D. Little’s Utilities and Energy practice and was responsible for the alliance with Perot Systems. Ms. Buttorff is also a member of the Boards of Active Youth Network (provides ~~revenue~~certain ~~and~~biographical ~~enables~~ information ~~for~~with ~~sports~~respect ~~teams, high schools and clubs) and JobZology (a CSU spinoff focused on matching people and jobs for employers). Ms. Buttorff was appointed~~ to ~~our~~each ~~Board~~executive asofficer ~~a result~~ of ~~her knowledge of~~ the ~~business,~~Company ~~ownership~~who ~~and~~is ~~position~~not ~~with~~a ~~the Company~~director.

~~Lawrence~~See J. Wert was appointed to our Board on April 29, 2020. Mr. Wert has over 40 years in broadcasting. Mr. Wert served as the President of Broadcast Media for Tribune Media Company from 2013 through September of 2019. Mr. Wert previously served on the NAB TV Board of Directors, Fox Board and the CBS Board of Governors. In 2017, Mr. Wert was named “~~Broadcaster of the Year~~Directors” byabove ~~the Illinois Broadcaster’s Association. Currently, he serves on the Board of Directors~~ for ~~several charities, including the Children’s Brittle Bone Foundation, Catholic Charities, the Chicagoland Chamber of Commerce and the 100 Club~~Ms. ~~Mr. Wert is a member of the Governing Board of Gilda~~Buttorff’s ~~Club~~ ofbiographical ~~Chicago, an advisor to the Chicago Chapter of Make-A-Wish Foundation and an honorary board member of RAINBOWS, an organization that helps children cope with loss~~information. In 2018, Mr. Wert was inducted into the Chicago Catholic League Hall of Fame. Mr. Wert also sits on Board of Trustees for Fenwick High School in Oak Park, Ill. Mr. Wert was appointed as a director as a result of his prior experience with Exactus, Inc.

~~Executive~~Nick ~~Officers~~Cavarra is our President of the Company since 2019. Mr. Cavarra brings over 25 years of management, leadership and sales experience at the local and national level in the broadcast/digital media, software and web/mobile development marketplace. His previous career positions include C-Level management experience with AYN and Zapotech Inc., and senior account management positions at KUSA-TV and KMGH-TV.

~~The~~Nathan ~~following~~Berman ~~provides~~is ~~certain~~our ~~biographical~~Controller ~~information~~since ~~with~~June ~~respect~~30, 2021. Mr. Berman works as the controller for Panacea Life Sciences since December 2019. Prior to ~~each~~Panacea, ~~executive~~Mr. ~~officer~~Berman worked for Quintel-MC, Inc, and Media Audits International providing audit and management services on behalf of large broadcast corporations. Prior to this, Mr. Berman began his career in the ~~Company~~banking ~~who~~industry iswhile ~~not~~pursuing ahis ~~director~~CFA designation through the CFA Institute.

~~See~~Employees ~~“Directors”~~and ~~above~~Contractual ~~for Ms. Buttorff’s biographical information.~~Arrangements

~~Nick~~As ~~Cavarra~~of isJanuary ~~our~~1, ~~President~~2018, ofwe ~~the~~employ ~~Company~~management ~~since~~and ~~2019.~~support ~~Mr.~~staff, ~~Cavarra~~chemists, ~~brings~~extraction ~~over~~specialists, 25lab ~~years~~technicians oforder ~~management,~~fulfillment ~~leadership~~ and sales ~~experience~~ atexecutives. ~~the~~We ~~local~~are ~~and~~building ~~national~~our ~~level~~culture inaround ~~the~~a ~~broadcast/digital~~performance-based ~~media~~system, ~~software~~and unlike other cannabinoid companies we offer our employees personal time off (PTO) and ~~web/mobile~~health ~~development~~and ~~marketplace~~dental benefits. ~~His~~We ~~previous~~believe ~~career positions~~this ~~include~~is ~~C-Level~~important ~~management~~in ~~experience~~order ~~with~~to ~~AYN~~attract ~~and~~the ~~Zapotech~~best ~~Inc~~individuals for these roles. Overall, ~~and~~we ~~senior~~currently ~~account~~have ~~management~~over ~~positions~~45 atindividuals ~~KUSA-TV~~working ~~and~~under ~~KMGH-TV~~PLSH.

22Family Relationships

~~Nathan~~There ~~Berman~~are isno ~~our~~family ~~Controller~~relationships ~~since~~between ~~June~~or ~~30,~~among ~~2021. Mr. Berman works as~~ the ~~controller for Panacea Life Sciences since December 2019~~directors. ~~Prior to~~There ~~Panacea,~~are ~~Mr.~~family ~~Berman~~relationships ~~worked~~between ~~for~~our ~~Quintel-MC~~CEO, ~~Inc,~~brother and ~~Media Audits International providing audit and management services on behalf of large broadcast corporations~~niece. ~~Prior to this, Mr. Berman began his career in the banking industry while pursuing his CFA designation through the CFA Institute.~~

~~James~~Involvement ~~“Jamie” W. Baumgartner is our Chief Science Officer and Quality Control since 2017. Mr. Baumgartner has recently lead two science-based businesses resulting~~ in ~~marked~~Certain ~~increases~~Legal in revenue, productivity and profitability. Mr. Baumgartner adds over 20 years of drug discovery experience to PLS and reinforces the company’s commitment to its foundation in scientific research and development in the healthcare and biotech industries.Proceedings

~~Employees~~To the best of our knowledge, during the past ten years, none of the following occurred with respect to a present or former director, executive officer, or employee: (1) any bankruptcy petition filed by or against any business of which such person was a general partner or executive officer either at the time of the bankruptcy or within two years prior to that time; (2) any conviction in a criminal proceeding or being subject to a pending criminal proceeding (excluding traffic violations and ~~Contractual~~other ~~Arrangements~~minor offenses); (3) being subject to any order, judgment or decree, not subsequently reversed, suspended vacated, of any court of competent jurisdiction, permanently or temporarily enjoining, barring, suspending or otherwise limiting his or her involvement in any type of business, securities or banking activities; and (4) being found by a court of competent jurisdiction (in a civil action), the SEC or the Commodities Futures Trading Commission to have violated a federal or state securities or commodities law, and the judgment has not been reversed, suspended or vacated.

AsAudit ofCommittee ~~January~~Financial 1, 2018, we employ management and support staff, chemists, extraction specialists, lab technicians order fulfillment and sales executives. We are building our culture around a performance-based system, and unlike other CBD companies we offer our employees personal time off (PTO) and health and dental benefits. We believe this is important in order to attract the best individuals for these roles. We also have an outsourcing agreement with Canna Software, LLC (ERPCannabis solution based on SAP) to provide back-office operations assistance in the financial, human resources, procurement and payroll and tax areas. We also have under contract ten sales territory managers that have many sales reps reporting in each sales territory. Overall, we currently has over 20 individuals working under PLS.Expert

~~Family~~Leslie ~~Relationships~~Buttorff serves as the chairman of the audit committee. Our Board has determined that Leslie Buttorff is qualified as an “audit committee financial expert”, as that term is defined under the rules of the SEC and in compliance with the Sarbanes-Oxley Act of 2002.

~~There~~Code ~~are~~of ~~no family relationships between or among the directors. There are family relationships between our CEO, brother and niece.~~Ethics

~~Involvement~~On inJanuary ~~Certain~~9, ~~Legal~~2019, ~~Proceedings~~our Board adopted a Code of Business Conduct and Ethics applicable to all our directors, executive officers, and employees.

ToItem ~~the~~11. ~~best~~Executive of our knowledge, during the past ten years, none of the following occurred with respect to a present or former director, executive officer, or employee: (1) any bankruptcy petition filed by or against any business of which such person was a general partner or executive officer either at the time of the bankruptcy or within two years prior to that time; (2) any conviction in a criminal proceeding or being subject to a pending criminal proceeding (excluding traffic violations and other minor offenses); (3) being subject to any order, judgment or decree, not subsequently reversed, suspended vacated, of any court of competent jurisdiction, permanently or temporarily enjoining, barring, suspending or otherwise limiting his or her involvement in any type of business, securities or banking activities; and (4) being found by a court of competent jurisdiction (in a civil action), the SEC or the Commodities Futures Trading Commission to have violated a federal or state securities or commodities law, and the judgment has not been reversed, suspended or vacated.Compensation

~~Audit~~Compensation ~~Committee~~Discussion ~~Financial~~and ~~Expert~~Analysis

~~Leslie~~With ~~Buttorff~~regard ~~serves~~to asour full-time executive officer, the ~~chairman~~goal of the ~~audit~~salary ~~committee.~~component ~~CFO~~of ~~Squad~~our ~~was~~compensation ~~previously~~policy ~~retained~~is to ~~assist~~provide ~~with~~reasonable ~~the~~compensation for ~~audit~~their ~~and~~full-time ~~SEC~~service ~~filings~~within ~~and provide~~the ~~other~~constraints ~~accounting~~faced ~~advice.~~by ~~Our~~a ~~Board~~rapidly ~~has~~developing ~~determined~~business ~~that~~with ~~Leslie~~significant ~~Buttorff~~cash isneeds ~~qualified~~for asits anplanned expansion. ~~“audit~~Equity ~~committee~~grants ~~financial~~for ~~expert”, as~~our ~~that~~full-time ~~term~~executive isofficers ~~defined~~are currently under review by the ~~rules~~compensation committee. The goal of ~~the~~our anticipated ~~SEC~~equity ~~and~~grants inwill ~~compliance~~be ~~with~~to ~~the~~provide ~~Sarbanes-Oxley~~an ~~Act~~appropriate mixture of ~~2002~~short term and long-term incentives to increase shareholder value.

~~Code of Ethics~~27

On ~~January~~December 931, ~~2019~~2021, ~~our~~we ~~Board~~entered ~~adopted~~into aan ~~Code~~updated ofEmployment ~~Business~~Agreement ~~Conduct~~with ~~and~~Leslie ~~Ethics~~Buttorff ~~applicable~~pursuant to ~~all~~which Ms. Buttorff serves as our Chief ~~directors~~Executive Officer for an initial term of July 1, ~~executive~~2021, ~~officers~~to December 31, 2024 (the “Employment Agreement). Under her Employment Agreement, Ms. Buttorff receives an annual base salary of $380,000. To date, Ms. Buttorff has not taken a salary and ~~employees~~payments have accrued commencing in January 2021. In 2023, Ms. Buttorff received restricted stock in lieu of any employment compensation.

~~Item~~Ms. 11Buttorff is also entitled to receive (i) a sales commission of 2% of revenue from sales generated by Ms. ~~Executive~~Buttorff ~~Compensation~~after revenue exceeds $500,000 for three consecutive months, (ii) an award of $2.2 million of shares of common stock upon approval of our common stock for listing on The Nasdaq Capital Market prior to expiration of the term of the Employment Agreement, and (iii) an annual cash performance bonus of up to 100% of her base salary based on the achievement of performance metrics for the applicable fiscal year to be set by our Board.

~~Compensation~~Director ~~Discussion and Analysis~~Compensation

~~With~~Compensation ~~regard to our full-time executive officer, the goal~~ of ~~the~~Directors salary component of our compensation policy is to provide reasonable compensation for their full-time service within the constraints faced by a rapidly developing business with significant cash needs for its planned expansion. Equity grants for our full-time executive officers are currently under review by the compensation committee. The goal of our anticipated equity grants will be to provide an appropriate mixture of short term and long-term incentives to increase shareholder value.Table

OnThe ~~December~~following ~~31,~~table ~~2021,~~shows wethe ~~entered~~compensation ~~into~~paid anduring ~~updated~~the ~~Employment~~year ~~Agreement~~ended ~~with Leslie Buttorff pursuant to which Ms. Buttorff serves as our Chief Executive Officer for an initial term of July 1, 2021, to~~ December 31, ~~2024~~2023 ~~(the~~to ~~“Employment~~our ~~Agreement).~~non-employee ~~Under her Employment Agreement, Ms~~director. ~~Buttorff receives an annual base salary of $380,000. To date, Ms. Buttorff has not taken a salary and payments have accrued commencing in January 2021.~~

Ms. Buttorff is also entitled to receive (i) a sales commission of 2% of revenue from sales generated by Ms. Buttorff after revenue exceeds $500,000 for three consecutive months, (ii) an award of $2.2 million of shares of common stock upon approval of our common stock for listing on The Nasdaq Capital Market prior to expiration of the term of the Employment Agreement, and (iii) an annual cash performance bonus of up to 100% of her base salary based on the achievement of performance metrics for the applicable fiscal year to be set by our Board.

Name		Stock Awards (No.)		Option Awards (No.)		Fees Earned or Paid in Cash ($)		Non-Equity Incentive Plan Compensation ($)		Non-Qualified Deferred Compensation Earnings ($)		All Other Compensation ($)		Total Shares

Leslie Buttorff	(a)		760,000		0		0		0		0		0		760,000
Executive Chairman
Lawrence J. Wert	(a)		300,000		0		0		0		0		0		300,000
Board Member

23(a) Compensation was awarded in common stock.

~~Director~~Equity ~~Compensation~~Awards at Year End

~~Compensation of Directors Table~~None.

~~The~~Option ~~following~~Exercises ~~table~~and ~~shows~~Stock ~~the compensation paid during the year ended December 31, 2022 to our non-employee director.~~Vested

Name		Stock Awards (No.)		Option Awards (No.)		Fees Earned or Paid in Cash ($)		Non-Equity Incentive Plan Compensation ($)		Non-Qualified Deferred Compensation Earnings ($)		All Other Compensation ($)		Total ($)
Leslie Buttorff	(a)		0		0		0		0		0		380,000		380,000
Executive Chairman
Lawrence J. Wert	(b)		0		0		0		0		0		0		0
Board Member

Our named executive officers did not exercise any stock option awards during the year ended December 31, 2023.

~~(a) Compensation is deferred.~~28

~~Equity~~Item ~~Awards~~12. AtSecurity ~~Year~~Ownership ~~End~~of Certain Beneficial Owners and Management and Related Stockholder Matters

~~None~~The following table sets forth information as of December 31, 2023, regarding the number of shares of our common stock beneficially owned by each director, each named executive officer and by all directors and executive officers as a group. Unless otherwise noted, each shareholder’s address is 5910 S. University Blvd, Suite C18-193, Greenwood Village, CO 80121, and each shareholder has sole voting power and investment power with respect to securities shown in the table below.

Option Exercises and Stock Vested

Title of class	Name of beneficial owner	Amount and Nature of Beneficial Ownership (1)		Percent of Class (1)
Named Executive Officers:

Common Stock	Leslie Buttorff (2)		1,359,899		7.71	%

Common Stock	Nathan Berman (3)		67,749		0.38	%

Common Stock	Nicholas J Cavarra (4)		796,957		4.52	%

Directors:

Common Stock	Lawrence J. Wert (5)		607,868		3.45	%

Common Stock	All directors and executive officers as a group (4 persons) (6)		2,035,516		16.06	%

5% Stockholders:
Common Stock	J&N Real Estate Company LLC (7)		7,297,627		41.36	%

Our named executive officers did not exercise any stock option awards during the year ended December 31, 2022.

(1)	Applicable percentages are based on 17,645,352 of common stock outstanding as of the March 15, 2023, excluding securities held by or for the account of the Company. Beneficial ownership is determined under the rules of the SEC and generally includes voting or investment power with respect to securities. A person is deemed to be the beneficial owner of securities that can be acquired by such person within 60 days after March 31, 2023, whether upon the exercise of options, warrants or conversion of notes. Unless otherwise indicated in the footnotes to this table, we believe that each of the stockholders named in the table has sole voting and investment power with respect to the shares of common stock indicated as beneficially owned by them. This table does not include any unvested stock options except for those vesting within 60 days.
(2)	Ms. Buttorff is our Chief Executive Officer, Chief Financial Officer and director.
(3) (4)	Mr. Berman is our Controller. Mr. Cavarra is our President.
(5)	Mr. Wert is a director.
(6)	Directors and Executive Officers as a group. This amount includes ownership by all directors and all current executive officers including those who are not Named Executive Officers under the SEC’s disclosure rules.
(7)	J & N Real Estate Company, LLC Ms. Buttorff is the owner. Address is 5910 South University Suite C18-193, Greenwood Village, CO 80121.

Item 1213. ~~Security Ownership of~~ Certain ~~Beneficial~~Relationships ~~Owners~~ and ~~Management~~Related Transactions, and ~~Related~~Director ~~Stockholder Matters~~Independence

~~The~~Our ~~following~~CEO ~~table~~is ~~sets forth information as of December 31, 2022, regarding~~ the ~~number~~owner of ~~shares~~related ofparties ~~our~~J&N ~~common~~Real ~~stock~~Estate ~~beneficially~~LLC. ~~owned by~~J&N ~~each~~is ~~director,~~a ~~each~~major ~~named~~shareholder ~~executive officer~~ and byholds ~~all directors and executive officers as~~ a ~~group.~~note ~~Unless~~of ~~otherwise~~Panacea ~~noted,~~and ~~each shareholder’s address~~ is ~~5910~~the S.leaseholder for ~~University~~the ~~Blvd,~~laboratory ~~Suite~~in ~~C18-193,~~Golden. ~~Greenwood~~See ~~Village,~~Note CO6: ~~80121,~~Notes ~~and~~for ~~each~~Related ~~shareholder~~Party ~~has sole voting power and investment power with respect to securities shown in the table below~~Transactions.

Title of class	Name of beneficial owner	Amount and Nature of Beneficial Ownership (1)		Percent of Class (1)
Named Executive Officers:
Common Stock	Leslie Buttorff (2)		4,646,953		31.5	%
Common Stock	Nathan Berman (3)		17,749		*
Directors:
Common Stock	Lawrence J. Wert (4)		307,868		2.1	%
Common Stock	All directors and executive officers as a group (4 persons) (5)		5,043,564		31.5	%
5% Stockholders:
Common Stock	Quintel-MC Incorporated (7)		4,047,054		27.4	%
Common Stock	22nd Century Group Inc. (8)		3,250,573		22.0	%

Director Independence

(1)	Applicable percentages are based on 14,762,342 of common stock outstanding as of the March 15, 2022, excluding securities held by or for the account of the Company. Beneficial ownership is determined under the rules of the SEC and generally includes voting or investment power with respect to securities. A person is deemed to be the beneficial owner of securities that can be acquired by such person within 60 days after March 31, 2022, whether upon the exercise of options, warrants or conversion of notes. Unless otherwise indicated in the footnotes to this table, we believe that each of the stockholders named in the table has sole voting and investment power with respect to the shares of common stock indicated as beneficially owned by them. This table does not include any unvested stock options except for those vesting within 60 days.
(2)	Ms. Buttorff is our Chief Executive Officer, Chief Financial Officer and director. Includes 4,047,054 shares of common stock held by Quintel-MC Incorporated. Ms. Buttorff is the President of Quintel-MC, Incorporated.
(3)	Mr. Berman is our Controller.
(4)	Mr. Wert is a director.
(5)	Directors and Executive Officers as a group. This amount includes ownership by all directors and all current executive officers including those who are not Named Executive Officers under the SEC’s disclosure rules.
(6)	Quintel-MC Incorporated. Ms. Buttorff was the President of Quintel-MC Incorporated. Address is 5910 South University Suite C18-193, Greenwood Village, CO 80121. Quintel was sold and is in the process of closure.
(8)	22nd Century Group Inc. Based on Schedule 13G filed on July 9, 2021. Address is 500 Seneca Street, Suite 507, Buffalo NY 14204.

We are not a “listed issuer” within the meaning of Item 407 of Regulation S-K and there are no applicable listing standards for determining the independence of our directors. Applying the definition of independence set forth in Rule 4200(a)(15) of The Nasdaq Stock Market, Inc., we believe that Larry Wert is an independent director.

24Item 14. Principal Accountant Fees and Services

~~Item~~The ~~13.~~following ~~Certain~~table ~~Relationships~~presents ~~and~~the ~~Related~~aggregate ~~Transactions~~fees billed for each of the last two fiscal years by our independent registered public accounting firm, Borgers, in connection with the audit of our consolidated financial statements and ~~Director~~other ~~Independence~~professional services rendered.

Our CEO is the owner of related parties J&N Real Estate LLC. J&N is a major shareholder and holds a note of Panacea and is the leaseholder for the laboratory in Golden. See Note 6: Notes for Related Party Transactions.

Year Ended:	Audit Services		Tax Fees	Other Fees
December 31, 2023	$	201,000	n/a	n/a
December 31, 2022	$	135,000	n/a	n/a

~~Director~~Pre–Approval ~~Independence~~Policy of Services Performed by Independent Registered Public Accounting Firm

WeThe ~~are~~Board ~~not~~policy ais ~~“listed~~to ~~issuer”~~pre–approve ~~within~~all ~~the~~audit ~~meaning~~and ofnon–audit ~~Item~~related ~~407~~services, oftax ~~Regulation~~services ~~S-K~~and other services. The independent registered public accounting firm and ~~there~~management are norequired ~~applicable~~to ~~listing~~periodically ~~standards for~~report ~~determining~~to the ~~independence~~full ofAudit ~~our~~Committee ~~directors.~~regarding ~~Applying~~ the ~~definition~~ extent of ~~independence~~services ~~set~~provided ~~forth~~by inthe ~~Rule~~independent ~~4200(a)(15)~~registered ofpublic ~~The~~accounting ~~Nasdaq Stock~~firm ~~Market,~~in ~~Inc.,~~accordance wewith ~~believe~~this ~~that~~pre–approval ~~Larry~~and ~~Wert~~the isfees anfor the ~~independent~~services ~~director~~performed to date.

~~Item 14. Principal Accountant Fees and Services~~29

~~The~~PART following table presents the aggregate fees billed for each of the last two fiscal years by our independent registered public accounting firm, Borgers, in connection with the audit of our consolidated financial statements and other professional services rendered.IV

Year Ended:	Audit Services		Tax Fees	Other Fees
December 31, 2022	$	110,000	n/a	n/a
December 31, 2021	$	25,000	n/a	n/a

Item 15. Exhibits, Financial Statements Schedules

~~The~~(a) ~~following~~Financial ~~table~~Statements presents the aggregate fees billed for each of the last two fiscal years by our independent registered public accounting firm, RBSM LLP, in connection with the audit of our consolidated financial statements and ~~other professional services rendered.~~Schedules

Year Ended:	Audit Services		Tax Fees	Other Fees
December 31, 2022	$	-	n/a	n/a
December 31, 2021	$	165,000	n/a	n/a

The following financial statements and schedules listed below are included in this Form 10-K.

~~Pre–Approval~~Financial ~~Policy~~Statements of(See ~~Services~~Item ~~Performed by Independent Registered Public Accounting Firm~~8)

The Board policy is to pre–approve all audit and non–audit related services, tax services and other services. The independent registered public accounting firm and management are required to periodically report to the full Audit Committee regarding the extent of services provided by the independent registered public accounting firm in accordance with this pre–approval and the fees for the services performed to date.

		Incorporated by Reference			Filed or Furnished
Exhibit #	Exhibit Description	Form	Date	Number	Herewith
3.1	Amended Articles of Incorporation	8-K	7/7/21	3.1	Filed
3.2	Certificate of Amendment to its Amended and Restated Articles of Incorporation – name change and reverse stock split	8-K	10/29/21	3.1	Filed
3.3	Certificate of Designation for Series B-1 Preferred Stock	8-K	3/4/16	3.1	Filed
3.4	Certificate of Designation for Series B-2 Preferred Stock	8-K/A	2/17/16	3.2	Filed
3.5	Certificate of Designation for Series C Preferred Stock	10-Q	8/23/21	3.7	Filed
3.6	Certificate of Designation for Series C-1 Preferred Stock	10-Q	8/23/21	3.8	Filed
3.7	Certificate of Designation for Series C-2 Preferred Stock	8-K	10/29/21	3.2	Filed
3.8	Certificate of Designation for Series D Preferred Stock	10-Q	8/23/21	3.9	Filed
3.9	Certificate of Withdrawal for Series A Preferred Stock	10-Q	4/29/22	3.9	Filed
3.10	Certificate of Designation for Series N-7 Convertible Preferred Stock				Filed
3.11	Amended and Restated Bylaws	10-K	3/30/23	3.11	Filed
10.1	Form of Exchange Agreement**	8-K	3/4/22	10.1	Filed
10.2	Form of Original Issue Discount Senior Convertible Promissory Note	8-K	3/4/22	10.2	Filed
10.3	Form of Warrant	8-K	3/4/22	10.3	Filed
10.4	Form of Registration Rights Agreement**	8-K	3/4/22	10.4
10.5	Share Exchange Agreement	8-K	2/14/23		Furnished
10.6	Asset Purchase Agreement dated as of July 3, 2023**	8-K	7/10/23	10.1	Filed
10.7	Form of Pledge and Security Agreement	8-K	10/5/23	10.3	Filed
10.8	Form of Offset Agreement	8-K	10/5/23	10.5	Filed
10.9	Form of Leakout Agreement	8-K	10/5/23	10.6	Filed
10.10	Asset Purchase Agreement dated as of September 26, 2023**				Furnished
10.11	Release and Assignment Agreement dated November 10, 2023, by and between the Issuer and PUR Life Medical, Inc.	8-K	2/5/24	10.2	Filed

2530

PART IV

10.12	Asset Purchase Agreement dated January 29, 2024, by and between the Issuer and PLM Holdings, Inc.	8-K	2/5/24	10.3	Filed
10.13	Ex. 10.14 to 10-K__Form of Amendment No. 1 to Promissory Note dated March 5, 2024 by and between the Issuer and FirstFire Global Opportunities Fund LLC				Furnished
23.1	Consent of BF Borgers CPA PC				Filed
31.1	Certification of Principal Executive Officer and Principal Financial Officer (302)				Filed
32.1	Certification of Principal Executive and Principal Financial Officer (906)				Furnished***
101.INS	Inline XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document
101.SCH	Inline XBRL Taxonomy Extension Schema Document				Filed
101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document				Filed
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document				Filed
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document				Filed
101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document				Filed
104	Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)

~~Item~~* ~~15.~~Management ~~Exhibits,~~contract ~~Financial~~or ~~Statements~~compensatory ~~Schedules~~plan or arrangement.

~~(a)~~** ~~Financial~~Exhibits ~~Statements~~ and/or Schedules have been omitted. The Company hereby agrees to furnish to the Securities and Exchange Commission upon request any omitted information.

~~The~~*** ~~following~~This ~~financial~~exhibit ~~statements~~is being furnished rather than filed and ~~schedules~~shall ~~listed~~not ~~below~~be ~~are~~deemed ~~included~~incorporated by reference into any filing, in ~~this~~accordance ~~Form~~with Item 10601 of Regulation S-K.

~~Financial~~+Portions ~~Statements~~of this exhibit have been omitted as permitted by the rules of the SEC. The information excluded is both (~~See~~i) ~~Item~~not 8material and (ii) the type that the Company customarily and actually treats as private or confidential. The Company undertakes to submit a marked copy of this exhibit for review by the SEC Staff, to the extent it has not been previously provided, and provide supplemental materials to the SEC Staff promptly upon request.

		Incorporated by Reference			Filed or Furnished
Exhibit #	Exhibit Description	Form	Date	Number	Herewith
3.1	Amended Articles of Incorporation	8-K	7/7/21	3.1
3.1(a)	Certificate of Amendment to its Amended and Restated Articles of Incorporation – name change and reverse stock split	8-K	10/29/21	3.1
3.2	Amended and Restated Bylaws				Filed
3.3	Certificate of Designation for Series A Preferred Stock	8-K	2/18/21	4.1
3.4	Certificate of Designation for Series B-1 Preferred Stock	8-K	3/4/16	3.1
3.5	Certificate of Designation for Series B-2 Preferred Stock	8-K/A	2/17/16	3.2
3.6	Certificate of Designation for Series C Preferred Stock	10-Q	8/23/21	3.7
3.7	Certificate of Designation for Series C-1 Preferred Stock	10-Q	8/23/21	3.8
3.8	Certificate of Designation for Series C-2 Preferred Stock	8-K	10/29/21	3.2
3.9	Certificate of Designation for Series D Preferred Stock	10-Q	8/23/21	3.9
3.10	Certificate of Withdrawal for Series A	10-Q	4/29/22	3.10
4.1	Description of securities registered under Section 12 of the Exchange Act of 1934				Filed
10.1	Agreement (redacted) with Dr. Krassen Dimitrov, Digital Diagnostic, Inc. and KD Innovation, Ltd.+	8-K	1/27/21	10.2
10.2	Securities Purchase Agreement (redacted)+	8-K	2/18/21	10.1
10.3	Exchange Agreement	8-K	2/18/21	10.2
10.5	Settlement and Release Agreement with Creed2Med, LLC	10-K/A	4/23/21	10.6
10.6	Supply Agreement	10-K	4/15/21	10.3
10.7	Note and Loan Agreement	8-K	4/26/21	10.1
10.8	Form of Securities Exchange Agreement	8-K	7/7/21	10.1
10.9	Form of Indemnification Agreement*	8-K	7/7/21	10.2
10.10	Employment Agreement dated June 30, 2021 – Leslie Buttorff*	10-Q	8/23/21	10.2
10.11	Form of Promissory Note issued to Quintel-MC Incorporated (Panacea)	10-Q	8/23/21	10.5
10.12	Form of Promissory Note issued to Leslie Buttorff (Panacea)	10-Q	8/23/21	10.6
10.13	Form of Promissory Note issued to Leslie Buttorff (Exactus)	10-Q	8/23/21	10.7
10.14	Note Exchange Agreement+**	10-Q	8/23/21	10.8
10.15	Assignment of lease	10-Q	8/23/21	10.9
10.16	Form of Securities Purchase Agreement**	8-K	11/24/21	10.1
10.17	Form of Original Issue Discount Senior Convertible Promissory Note	8-K	11/24/21	10.2
10.18	Form of Warrant	8-K	11/24/21	10.3
10.19	Form of Registration Rights Agreement**	8-K	11/24/21	10.4
10.20	Amended and Restated 2021 Equity Incentive Plan*				Filed
16.1	Letter from RBSM LLP, dated December 28, 2021	8-K	12/29/21	16.1
23.1	Consent of BF Borgers CPA PC				Filed
31.1	Certification of Principal Executive Officer and Principal Financial Officer (302)				Filed
32.1	Certification of Principal Executive and Principal Financial Officer (906)				Furnished***
101.INS	Inline XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document
101.SCH	Inline XBRL Taxonomy Extension Schema Document				Filed
101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document				Filed
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document				Filed
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document				Filed
101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document				Filed
104	Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101)

Copies of this Report (including the financial statements) and any of the exhibits referred to above will be furnished at no cost to our shareholders who make a written request to Panacea Life Sciences Holdings, Inc., at the address on the cover page of this Report, Attention: Corporate Secretary.

*Item ~~Management~~16. ~~contract~~Form or10-K ~~compensatory plan or arrangement.~~Summary

**Not ~~Exhibits and/or Schedules have been omitted~~applicable. ~~The Company hereby agrees to furnish to the Securities and Exchange Commission upon request any omitted information.~~

*** This exhibit is being furnished rather than filed and shall not be deemed incorporated by reference into any filing, in accordance with Item 601 of Regulation S-K.31

+Portions of this exhibit have been omitted as permitted by the rules of the SEC. The information excluded is both (i) not material and (ii) the type that the Company customarily and actually treats as private or confidential. The Company undertakes to submit a marked copy of this exhibit for review by the SEC Staff, to the extent it has not been previously provided, and provide supplemental materials to the SEC Staff promptly upon request.SIGNATURES

~~Copies~~Pursuant ofto ~~this~~the ~~Report~~requirements ~~(including~~of ~~the~~Section ~~financial~~13 ~~statements~~or 15(d) ~~and any~~ of the ~~exhibits~~Securities ~~referred~~Exchange toAct ~~above~~of ~~will~~1934, bethe ~~furnished~~registrant athas noduly ~~cost~~caused tothis ~~our~~report ~~shareholders who make a written request~~ to ~~Panacea~~be ~~Life~~signed on ~~Sciences~~its ~~Holdings,~~behalf ~~Inc.,~~by at the ~~address on the cover page of this Report~~undersigned, ~~Attention:~~thereunto ~~Corporate Secretary~~duly authorized.

Item 16. Form 10-K Summary

	Panacea Life Sciences Holdings, Inc.

Date: April 1, 2024	By:	/s/ Leslie Buttorff
		Leslie Buttorff
		Chief Executive Officer and Chief Financial Officer (Principal Executive Officer and Principal Financial Officer)

~~Not applicable.~~32

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

	Panacea Life Sciences Holdings, Inc.
Date: March 30, 2023	By:	/s/ Leslie Buttorff
		Leslie Buttorff
		Chief Executive Officer and Chief Financial Officer (Principal Executive Officer and Principal Financial Officer)

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