Reitan Colleen F 4

4 · ALNYLAM PHARMACEUTICALS, INC. · Filed Sep 11, 2025

Insider Transaction Report

Form 4

Period: 2025-09-09

ALNYLAM PHARMACEUTICALS, INC.ALNY

Reitan Colleen F

Director

Transactions

Exercise/Conversion
Common Stock
[F1]
2025-09-09$100.65/sh+18,000$1,811,700→ 18,775 total
Sale
Common Stock
[F1][F2]
2025-09-09$457.44/sh−1,645$752,489→ 17,130 total
Sale
Common Stock
[F1][F3]
2025-09-09$458.86/sh−1,888$866,328→ 15,242 total
Sale
Common Stock
[F1][F4]
2025-09-09$459.73/sh−1,403$645,001→ 13,839 total
Sale
Common Stock
[F1][F5]
2025-09-09$460.71/sh−473$217,916→ 13,366 total
Sale
Common Stock
[F1][F6]
2025-09-09$461.92/sh−2,290$1,057,797→ 11,076 total
Sale
Common Stock
[F1][F7]
2025-09-09$463.00/sh−1,652$764,876→ 9,424 total
Sale
Common Stock
[F1][F8]
2025-09-09$464.36/sh−799$371,024→ 8,625 total
Sale
Common Stock
[F1][F9]
2025-09-09$471.25/sh−222$104,618→ 8,403 total
Sale
Common Stock
[F1][F10]
2025-09-09$472.82/sh−823$389,131→ 7,580 total
Sale
Common Stock
[F1][F11]
2025-09-09$474.22/sh−838$397,396→ 6,742 total
Sale
Common Stock
[F1][F12]
2025-09-09$474.85/sh−951$451,582→ 5,791 total
Sale
Common Stock
[F1][F13]
2025-09-09$476.31/sh−972$462,973→ 4,819 total
Sale
Common Stock
[F1][F14]
2025-09-09$477.47/sh−1,183$564,847→ 3,636 total
Sale
Common Stock
[F1][F15]
2025-09-09$478.67/sh−1,450$694,072→ 2,186 total
Sale
Common Stock
[F1][F16]
2025-09-09$479.55/sh−1,386$664,656→ 800 total
Sale
Common Stock
[F1]
2025-09-09$480.98/sh−25$12,025→ 775 total
Exercise/Conversion
Stock Option (right to buy)
[F1][F17]
2025-09-09−18,000→ 0 total
Exercise: $100.65Exp: 2028-06-01→ Common Stock (18,000 underlying)

Footnotes (17)

[F1]This transaction was made pursuant to a Rule 10b5-1(c) trading plan adopted by the Reporting Person on June 10, 2025.
[F10]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $472.37 to $473.30. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F11]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $473.48 to $474.48. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F12]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $474.58 to $475.06. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F13]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $475.85 to $476.79. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F14]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $477.05 to $477.88. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F15]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $478.33 to $479.30. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F16]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $479.35 to $479.90. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F17]This stock option was fully vested and exercisable as of June 1, 2021.
[F2]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $456.93 to $457.91. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F3]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $458.22 to $459.09. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F4]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $459.29 to $460.22. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F5]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $460.35 to $461.26. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F6]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $461.42 to $462.41. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F7]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $462.73 to $463.52. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F8]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $464.18 to $464.96. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.
[F9]The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $470.77 to $471.75. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

Signature

By: Brett Budzinski, Attorney-in-Fact For: Colleen F. Reitan|2025-09-11

Documents

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