ISALY SAMUEL D

ACCELERON PHARMA INC

Former 10% Owner

Adaptimmune Therapeutics PLC

Director

ALPINE IMMUNE SCIENCES, INC.

Director, 10% Owner

AMARIN CORP PLC\UK

Director

AMBIT BIOSCIENCES CORP

10% Owner

Anthera Pharmaceuticals Inc

Director, 10% Owner

ARYx Therapeutics, Inc.

10% Owner

ATHERSYS, INC / NEW

Director, 10% Owner

Audentes Therapeutics, Inc.

Director, 10% Owner

AVANIR PHARMACEUTICALS, INC.

Director

Cartesian Therapeutics, Inc.

Director, 10% Owner

ChemoCentryx, Inc.

10% Owner

COMPLETE GENOMICS INC

10% Owner

Corvus Pharmaceuticals, Inc.

Director

CRYOCOR INC

10% Owner

CTI BIOPHARMA CORP

10% Owner

Dimension Therapeutics, Inc.

Director, 10% Owner

GIVEN IMAGING LTD

Director, 10% Owner

GLAUKOS Corp

Director, 10% Owner

Intellia Therapeutics, Inc.

Director

INTERCEPT PHARMACEUTICALS, INC.

10% Owner

KALA BIO, Inc.

10% Owner, See Remarks

Kun Run Biotechnology, Inc.

10% Owner

Loxo Oncology, Inc.

10% Owner

MEMORY PHARMACEUTICALS CORP

Director

Mirati Therapeutics, Inc.

10% Owner

Nabriva Therapeutics plc

Director, 10% Owner

NxStage Medical, Inc.

Director

OTONOMY, INC.

10% Owner

Pacira BioSciences, Inc.

10% Owner

PALVELLA THERAPEUTICS, INC.

Director, 10% Owner

PROJECT SAGE OLDCO, INC.

10% Owner

Relypsa Inc

10% Owner

RESPONSE BIOMEDICAL CORP

10% Owner

RHYTHM PHARMACEUTICALS, INC.

10% Owner

scPharmaceuticals Inc.

10% Owner

Sierra Oncology, Inc.

Director

Sorrento Tech, Inc.

10% Owner

Spyre Therapeutics, Inc.

10% Owner

SteadyMed Ltd.

10% Owner

SUPERNUS PHARMACEUTICALS, INC.

10% Owner

SYNLOGIC, INC.

Director

ViewRay, Inc.

10% Owner

Volcano Corp

Director

Whitehawk Therapeutics, Inc.

Director, 10% Owner

X4 Pharmaceuticals, Inc

10% Owner

Xtant Medical Holdings, Inc.

10% Owner