Insider · CIK 0001622769

Manke Isaac

Reports to the SEC for 5 companies · DORADO, PR

sec.gov

Transactions

Companies

Filings

CIK

0001622769

Forms 4 and 5

Insider transactions

27 trades

Date	Company	Role	Code	Shares	Price	Value	Shares after
2026-09-02	ADXNAddex Therapeutics Ltd.D Disposition to Issuer	Director	DDisposition to Issuer	−220K sh	—	—	0
2026-09-02	ADXNAddex Therapeutics Ltd.A Award	Director	AAward	+220K sh	—	—	219,561
2026-09-02	ADXNAddex Therapeutics Ltd. · Stock-option (Right to Buy)D Disposition to Issuer	Director	DDisposition to Issuer	−50K sh	—	—	0
2026-09-02	ADXNAddex Therapeutics Ltd. · Stock-option (Right to Buy)A Award	Director	AAward	+50K sh	—	—	50,000
2026-08-07	OKUROnKure Therapeutics, Inc. · Stock Option (right to buy)A Award	Director	AAward	+300K sh	—	—	300,000
2026-08-07	OKUROnKure Therapeutics, Inc. · Stock Option (right to buy)D Disposition to Issuer	Director	DDisposition to Issuer	−15.3K sh	—	—	0
2026-08-07	OKUROnKure Therapeutics, Inc. · Stock Option (right to buy)A Award	Director	AAward	+15.3K sh	—	—	15,300
2026-06-30	QTTBQ32 Bio Inc.M Exercise/Conversion	Director	MExercise/Conversion	+53.5K sh	$2.80	+$150K	53,521
2026-06-30	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)M Exercise/Conversion	Director	MExercise/Conversion	−53.5K sh	—	—	0
2026-06-12	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+10.8K sh	—	—	10,826
2026-06-12	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+9,810 sh	—	—	9,810
2025-12-31	OKUROnKure Therapeutics, Inc.A Award	Director	AAward	+5,258 sh	—	—	20,583
2025-10-23	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+53.5K sh	—	—	53,521
2025-09-30	OKUROnKure Therapeutics, Inc.A Award	Director	AAward	+5,545 sh	—	—	15,325
2025-06-30	OKUROnKure Therapeutics, Inc.A Award	Director	AAward	+6,311 sh	—	—	9,780
2025-05-28	OKUROnKure Therapeutics, Inc. · Stock Option (right to buy)A Award	Director	AAward	+7,650 sh	—	—	7,650
2025-03-31	OKUROnKure Therapeutics, Inc.A Award	Director	AAward	+3,469 sh	—	—	3,469
2025-02-24	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)D Disposition to Issuer	Director	DDisposition to Issuer	−12.8K sh	—	—	0
2025-02-24	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+12.8K sh	—	—	12,767
2025-02-24	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)D Disposition to Issuer	Director	DDisposition to Issuer	−2,627 sh	—	—	0
2025-02-24	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+2,627 sh	—	—	2,627
2025-02-24	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)D Disposition to Issuer	Director	DDisposition to Issuer	+19K sh	—	—	0
2025-02-24	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+19K sh	—	—	19,008
2025-01-15	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+19K sh	—	—	19,008
2024-10-04	OKUROnKure Therapeutics, Inc. · Stock Option (right to buy)A Award	Director	AAward	+15.3K sh	—	—	15,300
2024-04-01	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+2,627 sh	$13.42	+$35.3K	2,627
2024-03-25	QTTBQ32 Bio Inc. · Stock Option (Right to Buy)A Award	Director	AAward	+12.8K sh	—	—	12,767

Recent filings

Accepted (ET)
Sep 44
Manke Isaac0001104659-26-105491
SEC(opens sec.gov)
Aug 114
Manke Isaac0001622769-26-000002
SEC(opens sec.gov)
Jul 214/A
Manke Isaac0001193125-26-310969
SEC(opens sec.gov)
Jul 24
Manke Isaac0001193125-26-294694
SEC(opens sec.gov)
Jun 164
Manke Isaac0001193125-26-272698
SEC(opens sec.gov)
Jan 24
Manke Isaac0001622769-26-000001
SEC(opens sec.gov)
Oct 274
Manke Isaac0001193125-25-251993
SEC(opens sec.gov)
Oct 24
Manke Isaac0001622769-25-000003
SEC(opens sec.gov)
Jul 24
Manke Isaac0001415889-25-019052
SEC(opens sec.gov)
May 304
Manke Isaac0001415889-25-015018
SEC(opens sec.gov)
Apr 24
Manke Isaac0001415889-25-009659
SEC(opens sec.gov)
Feb 274
Manke Isaac0000950170-25-028306
SEC(opens sec.gov)

Companies

Address

405 DORADO BEACH EAST

DORADO, PR, 00646