Segment Reporting - Schedule of Reconciliation of Condensed Consolidated Operating Expenses and Loss (Details) - USD ($)	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Segment Reporting Information [Line Items]
Total research and development expense	$ 7,657,321	$ 8,146,070
Total general and administrative expenses	3,114,781	4,189,121
Total operating expenses	10,772,102	12,335,191
Operating Segments [Member]
Segment Reporting Information [Line Items]
Total direct research and development expenses	6,078,227	5,311,654
Indirect research and development expenses	1,246,805	2,618,065
Total research and development expense	7,657,321	8,146,070
Total general and administrative expenses	3,114,781	4,189,121
Total operating expenses	10,772,102	12,335,191
Operating Segments [Member] \| Share based Compensation [Member]
Segment Reporting Information [Line Items]
Total research and development expense	332,289	216,351
Total general and administrative expenses	280,662	401,094
Research and Development Salaries and Benefits [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total direct research and development expenses	2,651,894	1,878,218
Clinical Trial Expense [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total direct research and development expenses	1,927,208	806,060
Lab Supplies and Animal Care [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total direct research and development expenses	556,421	650,495
Lab Services Consulting and Other Direct Research Costs [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total direct research and development expenses	942,704	1,976,881
Administrative Payroll [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total general and administrative expenses	1,352,628	1,777,659
Professional Fees and Travel [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total general and administrative expenses	425,638	652,580
Insurance Office Expense and Other Administrative Expenses [Member] \| Operating Segments [Member]
Segment Reporting Information [Line Items]
Total general and administrative expenses	$ 1,055,853	$ 1,357,788

SAB Biotherapeutics, Inc. 10-Q