Insider Trading Arrangements

3 Months Ended

Sep. 30, 2025

shares

E
				Trading Arrangement
Name	Title	Action	Effective Date	Rule 10b5-1	Non Rule 10b5-1	Scheduled Expiration Date of Trading Plan⁽¹⁾	Maximum Shares Subject to Trading Plan
John Paolini	EVP, Chief Medical Officer	Adoption	July 30, 2025	X		October 31, 2026	111,867⁽²⁾
Mark Ragosa	EVP, Chief Financial Officer	Adoption	August 14, 2025	X		December 1, 2026	129,708⁽²⁾⁽³⁾
Barry Quart	Director	Adoption	September 11, 2025	X		December 15, 2026	58,889