v3.25.3

Document and Entity Information	Oct. 13, 2025
Cover [Abstract]
Amendment Flag	false
Entity Central Index Key	0001636282
Document Type	8-K
Document Period End Date	Oct. 13, 2025
Entity Registrant Name	SPYRE THERAPEUTICS, INC.
Entity Incorporation State Country Code	DE
Entity File Number	001-37722
Entity Tax Identification Number	46-4312787
Entity Address, Address Line One	221 Crescent Street
Entity Address, Address Line Two	Building 23
Entity Address, Address Line Three	Suite 105
Entity Address, City or Town	Waltham
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02453
City Area Code	617
Local Phone Number	651-5940
Written Communications	false
Soliciting Material	false
Pre Commencement Tender Offer	false
Pre Commencement Issuer Tender Offer	false
Security 12b Title	Common Stock, $0.0001 Par Value Per Share
Trading Symbol	SYRE
Security Exchange Name	NASDAQ
Entity Emerging Growth Company	false

Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.

+ References

No definition available.

+ Details

Name:	dei_AmendmentFlag
Namespace Prefix:	dei_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration

- Definition

Area code of city

+ References

No definition available.

+ Details

Name:	dei_CityAreaCode
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Cover page.

+ References

No definition available.

+ Details

Name:	dei_CoverAbstract
Namespace Prefix:	dei_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

- Definition

For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.

+ References

No definition available.

+ Details

Name:	dei_DocumentPeriodEndDate
Namespace Prefix:	dei_
Data Type:	xbrli:dateItemType
Balance Type:	na
Period Type:	duration

- Definition

The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.

+ References

No definition available.

+ Details

Name:	dei_DocumentType
Namespace Prefix:	dei_
Data Type:	dei:submissionTypeItemType
Balance Type:	na
Period Type:	duration

- Definition

Address Line 1 such as Attn, Building Name, Street Name

+ References

No definition available.

+ Details

Name:	dei_EntityAddressAddressLine1
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Address Line 2 such as Street or Suite number

+ References

No definition available.

+ Details

Name:	dei_EntityAddressAddressLine2
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Address Line 3 such as an Office Park

+ References

No definition available.

+ Details

Name:	dei_EntityAddressAddressLine3
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Name of the City or Town

+ References

No definition available.

+ Details

Name:	dei_EntityAddressCityOrTown
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Code for the postal or zip code

+ References

No definition available.

+ Details

Name:	dei_EntityAddressPostalZipCode
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Name of the state or province.

+ References

No definition available.

+ Details

Name:	dei_EntityAddressStateOrProvince
Namespace Prefix:	dei_
Data Type:	dei:stateOrProvinceItemType
Balance Type:	na
Period Type:	duration

- Definition

A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2

+ Details

Name:	dei_EntityCentralIndexKey
Namespace Prefix:	dei_
Data Type:	dei:centralIndexKeyItemType
Balance Type:	na
Period Type:	duration

- Definition

Indicate if registrant meets the emerging growth company criteria.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2

+ Details

Name:	dei_EntityEmergingGrowthCompany
Namespace Prefix:	dei_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration

- Definition

Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.

+ References

No definition available.

+ Details

Name:	dei_EntityFileNumber
Namespace Prefix:	dei_
Data Type:	dei:fileNumberItemType
Balance Type:	na
Period Type:	duration

- Definition

Two-character EDGAR code representing the state or country of incorporation.

+ References

No definition available.

+ Details

Name:	dei_EntityIncorporationStateCountryCode
Namespace Prefix:	dei_
Data Type:	dei:edgarStateCountryItemType
Balance Type:	na
Period Type:	duration

- Definition

The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2

+ Details

Name:	dei_EntityRegistrantName
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b-2

+ Details

Name:	dei_EntityTaxIdentificationNumber
Namespace Prefix:	dei_
Data Type:	dei:employerIdItemType
Balance Type:	na
Period Type:	duration

- Definition

Local phone number for entity.

+ References

No definition available.

+ Details

Name:	dei_LocalPhoneNumber
Namespace Prefix:	dei_
Data Type:	xbrli:normalizedStringItemType
Balance Type:	na
Period Type:	duration

- Definition

Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 13e
-Subsection 4c

+ Details

Name:	dei_PreCommencementIssuerTenderOffer
Namespace Prefix:	dei_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration

- Definition

Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 14d
-Subsection 2b

+ Details

Name:	dei_PreCommencementTenderOffer
Namespace Prefix:	dei_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration

- Definition

Title of a 12(b) registered security.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection b

+ Details

Name:	dei_Security12bTitle
Namespace Prefix:	dei_
Data Type:	dei:securityTitleItemType
Balance Type:	na
Period Type:	duration

- Definition

Name of the Exchange on which a security is registered.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 12
-Subsection d1-1

+ Details

Name:	dei_SecurityExchangeName
Namespace Prefix:	dei_
Data Type:	dei:edgarExchangeCodeItemType
Balance Type:	na
Period Type:	duration

- Definition

Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Exchange Act
-Number 240
-Section 14a
-Subsection 12

+ Details

Name:	dei_SolicitingMaterial
Namespace Prefix:	dei_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration

- Definition

Trading symbol of an instrument as listed on an exchange.

+ References

No definition available.

+ Details

Name:	dei_TradingSymbol
Namespace Prefix:	dei_
Data Type:	dei:tradingSymbolItemType
Balance Type:	na
Period Type:	duration

- Definition

Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Securities Act
-Number 230
-Section 425

+ Details

Name:	dei_WrittenCommunications
Namespace Prefix:	dei_
Data Type:	xbrli:booleanItemType
Balance Type:	na
Period Type:	duration

Spyre Therapeutics, Inc. 8-K