Exhibit 32.1

CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350 AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Apple Hospitality REIT, Inc., (the “Company”) on Form 10-Q for the quarter ended September 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 that: (1) the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and (2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company as of September 30, 2025 and for the period then ended.

Apple Hospitality REIT, Inc.

       /s/    Justin G. Knight     

    

     Justin G. Knight

    

     Chief Executive Officer

    

      /s/    Elizabeth S. Perkins     

    

     Elizabeth S. Perkins

    

     Chief Financial Officer

    

      /s/    Rachel S. Labrecque     

    

     Rachel S. Labrecque

    

     Chief Accounting Officer

    

     Date: November 3, 2025

    

Apple Hospitality REIT, Inc. 10-Q