Exhibit 10.4

THIRD AMENDMENT TO Promissory note

THIS tHIRD Amendment (THE “THIRD AMENDMENT”) DATED january 5, 2026, shall amend the Promissory note dated AS OF september 16, 2022 (THE “NOTE”) and amended on august 15, 2023 (THE “fIRST aMENDMENT”) AND jULY 25, 2025 (THE “SECOND AMENDMENT”) AMONG NON-INVASIVE MONITORING SYSTEMS, INC. (THE “MAKER”) AND Jane hsiao (THE “PAYEE”) AS NOTED BELOW.

RECITALS

WHEREAS, Maker and Payee (collectively, the “Parties”) are parties to the Note which became effective on September 16, 2022 and which was amended by the First Amendment and Second Amendment; and

WHEREAS, the Parties desire to amend the Note to extend the Maturity Date from December 31, 2025 until June 30, 2026.

NOW THEREFORE, in consideration of the mutual covenants and promises contained in the Note and this Third Amendment and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows:

AMENDMENT

Section 1 of the Note is hereby amended and restated in its entirety as follows:

The principal amount of the loan evidenced hereby, together with any accrued and unpaid interest, and any and all unpaid costs, fees and expenses accrued, shall be due and payable on June 30, 2026 (the “Maturity Date”).

2. Governing Law. This Third Amendment shall be governed by the laws of the State of Florida without regard to its conflict of laws rules or principles.

3. Amendments. Except as expressly amended hereby, the Note, the First Amendment and Second Amendment shall remain unmodified and in full force and effect.

4. Entire Agreement. This Third Amendment, the Second Amendment, the First Amendment and the Note constitute the entire agreement of the Parties with respect to the subject matter hereof and supersede all prior understandings and writings between the Parties relating thereto.

5. Interpretation. Any capitalized terms used in this Third Amendment but not otherwise defined shall have the meaning provided in the Note.

6. Counterparts. This Third Amendment may be executed manually, electronically in PDF file format, via an e-signature format, or by facsimile by the Parties, in any number of counterparts, each of which shall be considered one and the same amendment and shall become effective when a counterpart hereof shall have been signed by each of the Parties and delivered to the other Party.

IN WITNESS WHEREOF, Borrower has duly executed this Third Amendment to the Note as of the 5th day of January, 2026.

	NON-INVASIVE MONITORING SYSTEMS, INC.

	By:	/s/ James J. Martin
	Name:	James J. Martin
	Title:	Chief Financial Officer

Agreed and Accepted:

By:	/s/ Jane Hsiao
Name:	Jane Hsiao, Ph.D.

NON INVASIVE MONITORING SYSTEMS INC /FL/ 8-K