Opaleye Management Inc. 4

What Happened

• Opaleye Management Inc., reported as a 10% owner/portfolio manager, sold 5,000 Harrow, Inc. (HROW) shares on February 27, 2026 at $54.18 per share, generating $270,900 in proceeds. This was a sale (disposition) rather than a purchase—sales by institutional holders are often routine portfolio activity rather than a direct signal about company fundamentals.

Key Details

• Transaction date and price: 2026-02-27, 5,000 shares @ $54.18 each (total $270,900).
• Shares owned after transaction: Not stated in the information provided in this summary (not disclosed here).
• Filing date/timeliness: Form 4 filed 2026-03-03; this appears to be within the standard two-business-day reporting window for Section 16 filers.
• Footnotes of note:
  • F1: Some securities are owned by a separately managed account; Opaleye is portfolio manager and may be deemed to beneficially own those holdings.
  • F2: Some securities are owned directly by Opaleye, L.P. (the Fund); Opaleye Management Inc. is the Fund’s investment manager and may be deemed to beneficially own those holdings.
  • F3: Opaleye Management Inc. disclaims beneficial ownership except to the extent of its pecuniary interest.
• No 10b5-1 plan, tax-withholding, gift, or option-exercise language was reported for this transaction.

Context

• This filing reflects institutional selling by a reported 10% owner/manager (not an individual executive). Institutional sales frequently reflect portfolio rebalancing or cash needs rather than insider sentiment about near-term firm prospects. Purchases generally carry more weight for signaling than routine sales.