Opaleye Management Inc. 4

What Happened

• Opaleye Management Inc., reported as a 10% owner/manager, made two purchases of Alpha Cognition (ACOG) common stock. On May 20, 2026 it acquired 8,431 shares at $5.89 each ($49,659). On May 21, 2026 it acquired 15,945 shares at $5.70 each ($90,887). Total purchased: 24,376 shares for $140,546. These transactions are coded as purchases (P) on the Form 4.

Key Details

• Transaction dates and prices:
  • 2026-05-20: 8,431 shares @ $5.89 = $49,659
  • 2026-05-21: 15,945 shares @ $5.70 = $90,887
• Transaction code: P = Purchase (reported as open-market or private purchases).
• Shares owned after transaction: Not specified in the provided excerpt of the filing.
• Footnotes from the filing:
  • F1: Securities are owned directly by Opaleye, L.P. (the Fund); Opaleye Management is the Fund’s investment manager and may be deemed to beneficially own those securities.
  • F2: Some securities are owned by a separately managed account; Opaleye is the portfolio manager and may be deemed to beneficially own those securities.
  • F3: Opaleye Management disclaims beneficial ownership except to the extent of its pecuniary interest.
• Filing timeliness: Report filed 2026-05-22 for transactions on 2026-05-20 and 05-21 — within standard Form 4 reporting timeframes (timely).

Context

• This filing reflects institutional activity by a 10% owner/manager rather than an individual executive. Purchases by an investment manager typically indicate an investment decision by the fund/managed account; the filing’s footnotes clarify managerial relationships and a limited ownership disclaimer. No options, awards, gifts, or tax-withholding events are reported in this filing.