Opaleye Management Inc. 4

What Happened
Opaleye Management Inc., reported as a 10% owner/manager for related investment vehicles, acquired a total of 152,533 Alpha Cognition (ACOG) shares in open-market purchases on June 25–26, 2026. The filing lists a 197-share purchase at $6.50 on June 25 (≈ $1,281) and a larger purchase (reported as 152,336 shares) at a weighted average price (reported as $6.40) on June 26 (≈ $975,209). Total reported consideration for these transactions is about $976,490. These were purchases (a net buy), which retail investors often view as a more informative signal than routine sales.

Key Details

• Transaction dates and prices:
  • 2026-06-25: 197 shares @ $6.50 = $1,281.
  • 2026-06-26: 152,336 shares @ $6.40 (weighted avg; range $6.335–$6.50) = $975,209 (filing offers to provide per-price breakdown on request).
• Total acquired: 152,533 shares for approximately $976,490.
• Shares owned after transaction: Not specified in this Form 4.
• Footnotes of note:
  • F1/F2: Shares are held by related vehicles (Opaleye, L.P. and a separately managed account); Opaleye Management acts as investment/portfolio manager and may be deemed to beneficially own those securities.
  • F3: June 26 price is a weighted average; specific per-lot prices can be provided on request.
  • F4: Opaleye Management disclaims beneficial ownership except for its pecuniary interest.
• Timeliness: Form 4 was filed on 2026-06-29 for transactions on 2026-06-25 and 2026-06-26; the filing was timely under Section 16 reporting rules.

Context
Opaleye is an institutional 10% owner/manager rather than an individual executive; such filings reflect purchases by investment vehicles managed by Opaleye rather than insider executives. The filing is purely transactional and includes standard disclosures (manager/managed-account relationships and a disclaimer of broader beneficial ownership). There is no indication of derivative transactions, option exercises, gifts, or tax-withholding in this report.