Stock-Based Compensation - Schedule of Stock Awards Granted Under all Equity Incentive and Inducement Plans (Details) - $ / shares	3 Months Ended
	Mar. 31, 2026	Mar. 31, 2025
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock options, Grants (in shares)	2,578,605	1,897,917
Stock options, Weighted Average Grant Date Fair Value (in dollars per share)	$ 31.00	$ 21.45
Restricted Stock Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Restricted stock units, Grants (in shares)	125,400	0
Restricted stock units, Weighted Average Grant Date Fair Value (in dollars per share)	$ 30.61	$ 0

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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+ Details

Spyre Therapeutics, Inc. 10-Q