v3.25.1

Equity Incentive Plans and Stock-based Compensation - Narrative (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024	Jan. 01, 2025	Dec. 31, 2024
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expense	$ 12.3
Unrecognized compensation expense, period for recognition (in years)	2 years 6 months
2021 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for grant (in shares)	28,564,059			23,784,439
Additional shares authorized (in shares)	18,672,200
Percentage of outstanding stock maximum	5.00%
Increase in shares available for grant (in shares)			6,305,308
Award expiration period (in years)	10 years
2021 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for grant (in shares)	5,769,421			4,508,360
Offering purchase period (in months)	6 months
Additional shares authorized (in shares)	3,734,500
Percentage of outstanding stock maximum	1.00%
Increase in shares available for grant (in shares)			1,261,061
Employee Stock Purchase Plan \| 2021 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, maximum employee subscription rate (as percent)	15.00%
Purchase price of common stock (as percent)	85.00%
Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected dividend rate (as percent)	0.00%	0.00%

Share-based Compensation Arrangement by Share-based Payment Award, Increase in Number of Shares Available for Grant

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The highest percentage of annual salary that an employee is permitted to utilize with respect to the plan.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Nautilus Biotechnology, Inc. 10-Q